Etiology, baseline characteristics, and biochemical diagnosis of GH deficiency in the adult: are there regional variations?

abstract：BACKGROUND:Differences in circulating steroid hormone levels have been hypothesized to explain ethnic differences in steroid-related diseases. The aim of this study was to determine the serum levels of a wide panel of steroid hormones, both androgens and estrogens, in healthy middle-aged African-Caribbean and European ...

journal_title：European journal of endocrinology

authors： Giton F,Fiet J,Cornu JN,Cussenot O,Bélanger A,Urien S,Oliva A,Blanchet P,Multigner L

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:A limited number of mutations in the GH secretagogue receptor gene (GHSR) have been described in patients with short stature. Objective To analyze GHSR in idiopathic short stature (ISS) children including a subgroup of constitutional delay of growth and puberty (CDGP) patients. SUBJECTS AND METHODS:The GHSR...

journal_title：European journal of endocrinology

authors： Pugliese-Pires PN,Fortin JP,Arthur T,Latronico AC,Mendonca BB,Villares SM,Arnhold IJ,Kopin AS,Jorge AA

更新日期：2011-08-01 00:00:00

abstract：:This is a brief review of the normal changes in adolescent behaviour and the interplay between biology and social factors that occur at and around puberty, in an attempt to explain when this transition may become problematic The onset of puberty is a biological marker for an individual's transition from a non-reproduc...

journal_title：European journal of endocrinology

authors： Waylen A,Wolke D

更新日期：2004-11-01 00:00:00

abstract：OBJECTIVE:Most studies on treatment of microprolactinoma have focused on clinical and biochemical outcome rather than on functional and mental well-being. We evaluated this topic in female patients with microprolactinoma, because other pituitary adenomas are associated with decreased quality of life. DESIGN:We conduct...

journal_title：European journal of endocrinology

authors： Kars M,van der Klaauw AA,Onstein CS,Pereira AM,Romijn JA

更新日期：2007-08-01 00:00:00

abstract：OBJECTIVE:To determine the benefit of periodical clinical screening of carriers of a mutation in the multiple endocrine neoplasia type 1 (MEN-1) gene, because any useful discussion requires more concrete data. DESIGN AND METHODS:Our study population consisted of all the patients with MEN-1 (n=58) who were treated at t...

journal_title：European journal of endocrinology

authors： Geerdink EA,Van der Luijt RB,Lips CJ

更新日期：2003-12-01 00:00:00

abstract：:We studied the roles played by the renin-angiotensin system in inducing hypertension in nine patients with Cushing's syndrome (CS) resulting from adrenocortical adenoma, and compared them with those in patients with primary aldosteronism (PA), renovascular hypertension (RVH) and essential hypertension (EH). In the CS ...

journal_title：European journal of endocrinology

authors： Yasuda G,Shionoiri H,Umemura S,Takasaki I,Ishii M

更新日期：1994-12-01 00:00:00

abstract：OBJECTIVE:Several factors either predisposing or protecting from the onset of diabetes mellitus type 2 (DM2) have been proposed. Two specific polymorphisms of toll-like receptor 4 (TLR4; Asp299Gly and Thr399Ile) have recently been identified either as candidate protector genes against DM2 and associated neuropathy or r...

journal_title：European journal of endocrinology

authors： Manolakis AC,Kapsoritakis AN,Tiaka EK,Sidiropoulos A,Gerovassili A,Satra M,Vamvakopoulou D,Tsiopoulos F,Papanas N,Skoularigis I,Potamianos SP,Vamvakopoulos N

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVE:Cushing's disease (CD) is usually caused by ACTH-secreting pituitary microadenomas, while silent corticotroph adenomas (SCA) are macroadenomas without Cushingoid features. However, the molecular mechanism(s) underlying their different tumor growth remains unknown. The aim of the current study was to evaluate ...

journal_title：European journal of endocrinology

authors： Tani Y,Inoshita N,Sugiyama T,Kato M,Yamada S,Shichiri M,Hirata Y

更新日期：2010-10-01 00:00:00

abstract：:The reproductive hormonal profile was evaluated in female rats with experimental nephrotic syndrome induced with a single subcutaneous dose of puromycin aminonucleoside (PAN). Serum concentrations of luteinizing hormone (LH), follicle-stimulating hormone (FSH), progesterone (P4), testosterone and 17 beta-estradiol (E2...

journal_title：European journal of endocrinology

authors： Menjívar M,Vilchis F,Cárdenas M,Cruz C,Merchant H,Pérez-Palacios G,Pedraza-Chaverri J

更新日期：1995-04-01 00:00:00

abstract：OBJECTIVE:To i) compare incretin responses to oral glucose and mixed meal of diabetic patients with the normoglycaemic population and ii) to investigate whether incretin responses are associated with hypertriglyceridaemia and alanine aminotransferase (ALT) as liver fat marker. DESIGN:A population-based study. METHODS...

journal_title：European journal of endocrinology

authors： Alssema M,Rijkelijkhuizen JM,Holst JJ,Teerlink T,Scheffer PG,Eekhoff EM,Gastaldelli A,Mari A,Hart LM,Nijpels G,Dekker JM

更新日期：2013-09-12 00:00:00

abstract：BACKGROUND:Few published data link overweight and obesity with measures of quality of life (QoL) including sexual health in men. OBJECTIVE:To assess the association of overweight/obesity with impairment of physical and psychological QoL and sexual functions in men. DESIGN AND SETTING:Cross-sectional, multicentre surv...

journal_title：European journal of endocrinology

authors： Han TS,Tajar A,O'Neill TW,Jiang M,Bartfai G,Boonen S,Casanueva F,Finn JD,Forti G,Giwercman A,Huhtaniemi IT,Kula K,Pendleton N,Punab M,Silman AJ,Vanderschueren D,Lean ME,Wu FC,EMAS group.

更新日期：2011-06-01 00:00:00

abstract：CONTEXT:Both acromegaly and adult growth hormone deficiency (GHD) are associated with increased fracture risk. Sufficient data are lacking regarding cortical bone microarchitecture and bone strength, as assessed by microfinite element analysis (µFEA). OBJECTIVE:To elucidate both cortical and trabecular bone microarchi...

journal_title：European journal of endocrinology

authors： Silva PPB,Amlashi FG,Yu EW,Pulaski-Liebert KJ,Gerweck AV,Fazeli PK,Lawson E,Nachtigall LB,Biller BMK,Miller KK,Klibanski A,Bouxsein M,Tritos NA

更新日期：2017-11-01 00:00:00

abstract：INTRODUCTION:Activating mutations of the BRAF oncogene are frequently detected in papillary thyroid carcinoma (PTC) and have been associated with a worse prognosis. The amino acid substitution V600E accounts for 90% of all oncogenic BRAF mutations and is typically detected in classic PTCs, whereas other less frequent B...

journal_title：European journal of endocrinology

authors： Barzon L,Masi G,Boschin IM,Lavezzo E,Pacenti M,Casal Ide E,Toniato A,Toppo S,Palù G,Pelizzo MR

更新日期：2008-07-01 00:00:00

abstract：:Administration of growth hormone (GH) to patients with growth hormone deficiency (GHD) has beneficial effects, but so far has been employed only empirically. We have, therefore, investigated the dose-dependent effect of GH on target tissue by studying biochemical markers of bone and collagen turnover in GHD. Then pati...

journal_title：European journal of endocrinology

authors： Bollerslev J,Møller J,Thomas S,Djøseland O,Christiansen JS

更新日期：1996-12-01 00:00:00

abstract：OBJECTIVE:This study evaluated the short- and long-term cardiovascular- and cancer-related morbidities during cross-sex hormone therapy in a large sample of trans persons. SUBJECTS AND METHODS:A specialist center cross-sectional study compared 214 trans women (male-to-female transsexual persons) and 138 trans men (fem...

journal_title：European journal of endocrinology

authors： Wierckx K,Elaut E,Declercq E,Heylens G,De Cuypere G,Taes Y,Kaufman JM,T'Sjoen G

更新日期：2013-09-13 00:00:00

abstract：BACKGROUND:Phytosterolaemia (sitosterolaemia) is a rare autosomal recessive condition caused by mutations on the ABCG5 and ABCG8 gut transporter proteins. This leads to accumulation of plant-derived cholesterol-like molecules in blood and tissues. CASE:We describe a family of Bangladesh origin, where three siblings (t...

journal_title：European journal of endocrinology

authors： Mushtaq T,Wales JK,Wright NP

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:Cross-sectional studies have shown that more than 50% of patients with congestive heart failure (CHF) have decreased bone mineral density (BMD). There is limited knowledge about the longitudinal changes of BMD and how to treat bone loss in patients with CHF. METHODS:The present study was a prospective, long...

journal_title：European journal of endocrinology

authors： Frost RJ,Sonne C,Wehr U,Stempfle HU

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVE:There are limited data on cardiometabolic risk factors and the prevalence of metabolic syndrome (MetS) across the different PCOS phenotypes in Caucasian population. Lipid accumulation product (LAP) is a clinical surrogate marker that could be used for evaluation of MetS in clinical practice. The aim of the st...

journal_title：European journal of endocrinology

authors： Božić-Antić I,Ilić D,Bjekić-Macut J,Bogavac T,Vojnović-Milutinović D,Kastratovic-Kotlica B,Milić N,Stanojlović O,Andrić Z,Macut D

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:The association of hyperparathyroidism (HPT) with thyroid disease has long been known, but the mechanisms underlying such an association have not yet been clarified. OBJECTIVE:To elucidate the main factors determining this combination of endocrine diseases, in a retrospective multicenter study. METHODS:We ...

journal_title：European journal of endocrinology

authors： dell'Erba L,Baldari S,Borsato N,Bruno G,Calò-Gabrieli G,Carletto M,Ciampolillo A,Dondi M,Erba P,Gerundini P,Lastoria S,Marinelli P,Santoro M,Scarano B,Zagni P,Bagnasco M,Mariani G

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:Some cases of apparently idiopathic GH deficiency (GHD) may be caused by pituitary autoimmunity. OBJECTIVE:To study the variations in pituitary function and antipituitary antibodies (APA) from childhood to transition age in patients with apparently idiopathic GHD. DESIGN:We conducted a longitudinal study. ...

journal_title：European journal of endocrinology

authors： De Bellis A,Bellastella G,Maiorino MI,Aitella E,Lucci E,Cozzolino D,Bellastella A,Bizzarro A,Giugliano D,Esposito K,Italian Autoimmune Hypophysitis Network Group.

更新日期：2016-03-01 00:00:00

abstract：Objective:With increasing migration to Europe, diabetes diagnosis and treatment of refugees became challenging. To describe the current experience with pediatric refugees in Germany and Austria. Design and Methods:43,137 patients (<21 years) with type 1 diabetes from the diabetes patient follow-up registry (DPV) were ...

journal_title：European journal of endocrinology

authors： Prinz N,Konrad K,Brack C,Hahn E,Herbst A,Icks A,Grulich-Henn J,Jorch N,Kastendieck C,Mönkemöller K,Razum O,Steigleder-Schweiger C,Witsch M,Holl RW

更新日期：2019-07-01 00:00:00

abstract：:Gene therapy for endocrine diseases represents an exciting new type of molecular intervention that may be a curative one. Endocrine disorders that might be treated by gene therapy include monogenic diseases, such as GH deficiency and hypothalamic diabetes insipidus, and multifactorial diseases, such as diabetes mellit...

journal_title：European journal of endocrinology

authors： Barzon L,Bonaguro R,Palù G,Boscaro M

更新日期：2000-10-01 00:00:00

abstract：OBJECTIVE:Secreted protein acidic and rich in cysteine (SPARC) also known as BM-40 which has been studied in various pathological conditions, has recently been suggested as a key player in the pathology of obesity and type 2 diabetes mellitus (T2DM). However, there are few studies on putative pathophysiologic roles of ...

journal_title：European journal of endocrinology

authors： Wu D,Li L,Yang M,Liu H,Yang G

更新日期：2011-10-01 00:00:00

abstract：:To study the involvement of gonadotropin-releasing hormone (GnRH) in glycosylation of circulating gonadotropin isoforms in anorexia nervosa (AN), 14 amenorrhoic patients with AN, 14 age-matched volunteers in early follicular phase, and five normal-weight re-fed patients with AN were investigated under baseline conditi...

journal_title：European journal of endocrinology

authors： Savastano S,Tommaselli AP,Valentino R,Luciano A,Gigante M,Randazzo G,Contaldo F,Scalfi L,Lombardi G

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVE:According to the 2015 American Thyroid Association (ATA) guidelines, thyroid ablation by iodine-131 (I-131) therapy is absolutely recommended only in patients with high-risk differentiated thyroid cancer (DTC). Often distant metastases are not recognized early and they can stay silent for long time. The aim o...

journal_title：European journal of endocrinology

authors： Albano D,Bertagna F,Bonacina M,Durmo R,Cerudelli E,Gazzilli M,Panarotto MB,Formenti AM,Mazziotti G,Giustina A,Giubbini R

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Pubertal onset is usually defined by breast development in girls and testicular growth in boys. Pubarche is defined as the attainment of pubic hair and is considered as a sign of pubertal transition. Pubarche is preceded by a gradual increase in production of adrenal androgens, DHEA and Δ4-androstenedione (A...

journal_title：European journal of endocrinology

authors： Mouritsen A,Aksglaede L,Soerensen K,Hagen CP,Petersen JH,Main KM,Juul A

更新日期：2012-12-31 00:00:00

abstract：:A 27-year-old woman with no previous personal or family history of thyroid disease was referred to us for the evaluation of thyroid nodule, five months postpartum. Thyroid scintigraphy demonstrated a left cold nodule. Fine needle aspiration cytology of the nodule showed a mixture of colloid, follicular cells and lymph...

journal_title：European journal of endocrinology

authors： Luboshitzky R,Qupti G,Ishai A,Dharan M

更新日期：1998-05-01 00:00:00

abstract：OBJECTIVE:We measured the total and nonphosphorylated insulin-like growth factor-binding protein (IGFBP)-1 concentrations in obese children to determine the effect of obesity on the status of IGFBP-1 phosphorylation. We also measured the serum levels of insulin, total and free IGF-I, and IGFBP-3 to investigate their re...

journal_title：European journal of endocrinology

authors： Kamoda T,Saitoh H,Nakahara S,Inudoh M,Hirano T,Matsui A

更新日期：1999-12-01 00:00:00

abstract：:The best test for the assessment of the hypothalamic-pituitary-adrenal (HPA) axis remains a matter of controversy. We compared the performance of the short synacthen test (SST, 250 microg) with the insulin stress test (IST) to assess the reliability of the former as a first line test. Patients with pituitary disease u...

journal_title：European journal of endocrinology

authors： Bangar V,Clayton RN

更新日期：1998-12-01 00:00:00

abstract：OBJECTIVE:To investigate the effect of Rosiglitazone in three patients treated with bilateral adrenalectomy followed by hyperpigmentation and hypersecretion of ACTH. PATIENTS AND METHODS:One patient had increasing ACTH after previous transsphenoidal surgery for Nelson's syndrome, and two patients without pituitary ade...

journal_title：European journal of endocrinology

authors： Andreassen M,Kristensen LØ

更新日期：2005-10-01 00:00:00