MRI T2 signal intensity and tumor response in patients with GH-secreting pituitary macroadenoma: PRIMARYS post-hoc analysis.


:Objective Pituitary adenoma MRI T2 signal intensity associates with tumor characteristics including responsiveness to somatostatin analogs (SSAs). These analyses determined whether baseline T2 signal intensity predicts response to primary medical treatment with long-acting SSA. Design Post-hoc analyses of the prospective multicenter, open-label, single-arm PRIMARYS study in which patients with treatment-naïve GH-secreting pituitary macroadenomas received fixed-dose lanreotide autogel (120mg) every 4-weeks for 48-weeks. Methods Associations were investigated between adenoma T2-signal hypo/iso/hyperintensity and treatment responses at week 48/last visit: hormonal control (GH ≤2.5μg/L and IGF-1 normalization); tumor response (tumor volume reduction [TVR] ≥20%); separate GH/IGF-1 control; and change-from-baseline in GH/IGF-1 and tumor volume. Results Adenomas were hypointense at baseline in 50/85 (59%) patients using visual assessment. Of these, 40% achieved hormonal control and 76% achieved a tumor response. Significant univariate associations arose for hypo- vs isointensity with tumor response and achievement of GH ≤2.5 μg/L, but not IGF-1 normalization or overall hormonal control. In multivariate analysis, tumor response was 6-times more likely for hypo- vs isointense tumors (=6.15; 95% CI [1.36;27.88]). In univariate change-from-baseline analyses, hypo- vs isointensity was associated with greater TVR and IGF-1 reduction but not change in GH. In multivariate analysis, IGF-1 decreased by an estimated additional 65 μg/L [P=0.0026]) for hypo- vs isointense. Conclusions Patients with hypointense vs isointense GH-secreting macroadenomas had greater reductions in IGF-1 following primary treatment with lanreotide autogel, and were more likely to achieve tumor response. Assessment of T2 signal intensity at baseline may help to predict long-term responses to primary treatment with SSAs.


Eur J Endocrinol


Bonneville F,Rivière LD,Petersenn S,Bevan J,Houchard A,Sert C,Caron PJ,PRIMARYS Study group.




Has Abstract


2018-12-01 00:00:00








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    abstract:OBJECTIVE:Disturbed renal function may play an important role in the clinico-pathological presentation of primary hyperparathyroidism (pHPT). We studied the influence of renal function on the clinico-pathological characteristics of 141 patients (123 women and 18 men) with surgically proven pHPT. METHODS:The 141 patien...

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    pub_type: 杂志文章


    authors: Yamashita H,Noguchi S,Uchino S,Watanabe S,Murakami T,Ogawa T,Masatsugu T,Takamatsu Y,Miyatake E,Yamashita H

    更新日期:2003-06-01 00:00:00

  • Increased reverse triiodothyronine is associated with shorter survival in independently-living elderly: the Alsanut study.

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    pub_type: 杂志文章


    authors: Forestier E,Vinzio S,Sapin R,Schlienger JL,Goichot B

    更新日期:2009-02-01 00:00:00

  • Is the effect of testosterone on body composition modulated by the androgen receptor gene CAG repeat polymorphism in elderly men?

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    journal_title:European journal of endocrinology

    pub_type: 杂志文章


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    更新日期:2007-03-01 00:00:00

  • Therapy of endocrine disease: Perspectives on the management of adrenal insufficiency: clinical insights from across Europe.

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    authors: Grossman A,Johannsson G,Quinkler M,Zelissen P

    更新日期:2013-10-21 00:00:00

  • Multiple endocrine neoplasia type 1 in Northern Finland; clinical features and genotype phenotype correlation.

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    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Vierimaa O,Ebeling TM,Kytölä S,Bloigu R,Eloranta E,Salmi J,Korpi-Hyövälti E,Niskanen L,Orvola A,Elovaara E,Gynther A,Sane T,Välimäki M,Ignatius J,Leisti J,Salmela PI

    更新日期:2007-09-01 00:00:00

  • New perspectives for gene therapy in endocrinology.

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    journal_title:European journal of endocrinology

    pub_type: 杂志文章,评审


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    更新日期:2000-10-01 00:00:00

  • Hypothalamic-pituitary-gonadal axis in two men with aromatase deficiency: evidence that circulating estrogens are required at the hypothalamic level for the integrity of gonadotropin negative feedback.

    abstract:BACKGROUND:In men, the feedback of gonadotropins is regulated by estrogens that come from the aromatization of testosterone, but the relative contribution to the inhibition of LH and FSH secretion by the amount of locally produced estrogens within the hypothalamus and/or the pituitary, and the amount of circulating est...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


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    更新日期:2006-10-01 00:00:00

  • Increase in human placental glucose transporter-1 during pregnancy.

    abstract::Glucose transporter-1 (GLUT1) has been found in high abundance in human placentas. The purpose of this study was to analyze the changes in the level of GLUT1 during pregnancy. We have analyzed the gestational changes in human placental GLUT1 by [3H]cytochalasin B binding assay, immunoblot analysis and Northern blot an...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Sakata M,Kurachi H,Imai T,Tadokoro C,Yamaguchi M,Yoshimoto Y,Oka Y,Miyake A

    更新日期:1995-02-01 00:00:00

  • Transsphenoidal surgery in acromegaly investigated by intraoperative high-field magnetic resonance imaging.

    abstract:OBJECTIVE:The aim of the study was to evaluate the effect of intraoperative high-field (1.5 Tesla) magnetic resonance imaging (MRI) on the results of transsphenoidal surgery of GH-secreting pituitary macroadenomas. METHODS:Twenty-three acromegalic patients (mean tumor size, 25 +/- 12 mm; untreated preoperative GH, 4.2...

    journal_title:European journal of endocrinology

    pub_type: 临床试验,杂志文章


    authors: Fahlbusch R,Keller Bv,Ganslandt O,Kreutzer J,Nimsky C

    更新日期:2005-08-01 00:00:00

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    abstract::Exogenous growth hormone (hGH) administration in humans attenuates the endogenous growth hormone (GH) response to some pharmacological stimuli; in particular, pretreatment with hGH completely blocks the serum GH response to growth hormone-releasing hormone. In order to evaluate the mechanism(s) whereby opiods induce G...

    journal_title:European journal of endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验


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    更新日期:1996-01-01 00:00:00

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    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Casu M,Cappi C,Patrone V,Repetto E,Giusti M,Minuto F,Murialdo G

    更新日期:2005-06-01 00:00:00

  • ESE audit on management of Adult Growth Hormone Deficiency in clinical practice.

    abstract::Guidelines recommend adults with pituitary disease in whom GH therapy is contemplated, to be tested for GH deficiency (AGHD); however, clinical practice is not uniform. AIMS:1) To record current practice of AGHD management throughout Europe and benchmark it against guidelines; 2) To evaluate educational status of hea...

    journal_title:European journal of endocrinology

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    authors: Martel-Duguech LM,Jorgensen JOL,Korbonits M,Johannsson G,Webb SM,Amadidou F,Mintziori G,Arosio M,Giavoli C,Badiu C,Boschetti M,Ferone D,Ricci Bitti S,Brue T,Albarel F,Cannavò S,Cotta OR,Carvalho D,Salazar D,Christ E

    更新日期:2020-12-01 00:00:00

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    authors: Cawood TJ,Hunt PJ,O'Shea D,Cole D,Soule S

    更新日期:2009-10-01 00:00:00

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    abstract:OBJECTIVE:To estimate morbidity in Denmark in all patients with GH deficiency (GHD). DESIGN:Morbidity was analyzed in 1794 GHD patients and 8014 controls matched on age and gender. All records in the GHD patients were studied and additional morbidity noted. Diagnoses and dates of admissions were identified in the Nati...

    journal_title:European journal of endocrinology

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    authors: Stochholm K,Laursen T,Green A,Laurberg P,Andersen M,Kristensen LØ,Feldt-Rasmussen U,Christiansen JS,Frydenberg M,Gravholt CH

    更新日期:2008-04-01 00:00:00

  • Androgen receptor gene GGN repeat length and reproductive characteristics in young Swedish men.

    abstract:BACKGROUND:The human androgen receptor (AR) gene contains two polymorphisms of CAG and GGN repeats respectively. The GGN repeat function is still largely unknown and to date there are no in vivo data on this segment with respect to the general population. METHODS:We investigated the impact of CAG and GGN repeats on ma...

    journal_title:European journal of endocrinology

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    authors: Lundin KB,Giwercman YL,Rylander L,Hagmar L,Giwercman A

    更新日期:2006-08-01 00:00:00

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    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Miao Z,Gao Y,Bindels RJ,Yu W,Lang Y,Chen N,Ren H,Sun F,Li Y,Wang X,Shao L

    更新日期:2009-08-01 00:00:00

  • Prospective evaluation of autoimmune and non-autoimmune subclinical hypothyroidism in Down syndrome children.

    abstract:Objective:To evaluate the prevalence and natural course of autoimmune and non-autoimmune subclinical hypothyroidism (SH) in Down syndrome (DS) children and adolescents. Design:Prospective multicenter study. Methods:For the study, 101 DS patients with SH (TSH 5-10 mIU/L; FT4 12-22 pmol/L), aged 2-17 years at SH diagno...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,多中心研究


    authors: Pepe G,Corica D,De Sanctis L,Salerno M,Faienza MF,Tessaris D,Tuli G,Scala I,Penta L,Alibrandi A,Pajno GB,Aversa T,Wasniewska M,Thyroid Study Group of the Italian Society of Pediatric Endocrinology and Diabetology (ISPED).

    更新日期:2020-04-01 00:00:00

  • Diabetes in acromegaly, prevalence, risk factors, and evolution: data from the French Acromegaly Registry.

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    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Fieffe S,Morange I,Petrossians P,Chanson P,Rohmer V,Cortet C,Borson-Chazot F,Brue T,Delemer B,French Acromegaly Registry.

    更新日期:2011-06-01 00:00:00

  • Prevalence, incidence and associated comorbidities of treated hypothyroidism: an update from a European population.

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    journal_title:European journal of endocrinology

    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Matikainen N,Taskinen MR,Stennabb S,Lundbom N,Hakkarainen A,Vaaralahti K,Raivio T

    更新日期:2012-03-01 00:00:00

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    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Weber MM,Kiess W,Beikler T,Simmler P,Reichel M,Adelmann B,Kessler U,Engelhardt D

    更新日期:1994-03-01 00:00:00

  • Screening for mutations in 17β-hydroxysteroid dehydrogenase and androgen receptor in women presenting with partially virilised 46,XY disorders of sex development.

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    pub_type: 杂志文章


    authors: Phelan N,Williams EL,Cardamone S,Lee M,Creighton SM,Rumsby G,Conway GS

    更新日期:2015-06-01 00:00:00

  • A novel OTX2 mutation in a patient with combined pituitary hormone deficiency, pituitary malformation, and an underdeveloped left optic nerve.

    abstract::Orthodenticle homolog 2 (OTX2) is a homeobox family transcription factor required for brain and eye formation. Various genetic alterations in OTX2 have been described, mostly in patients with severe ocular malformations. In order to expand the knowledge of the spectrum of OTX2 mutation, we performed OTX2 mutation scre...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,多中心研究


    authors: Gorbenko Del Blanco D,Romero CJ,Diaczok D,de Graaff LC,Radovick S,Hokken-Koelega AC

    更新日期:2012-09-01 00:00:00

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    journal_title:European journal of endocrinology

    pub_type: 杂志文章,多中心研究,评审


    authors: Delgrange E,Raverot G,Bex M,Burman P,Decoudier B,Devuyst F,Feldt-Rasmussen U,Andersen M,Maiter D

    更新日期:2013-11-22 00:00:00

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    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Karaca Z,Tanriverdi F,Unluhizarci K,Kelestimur F

    更新日期:2010-03-01 00:00:00

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    journal_title:European journal of endocrinology

    pub_type: 杂志文章


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    journal_title:European journal of endocrinology

    pub_type: 杂志文章,评审


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    更新日期:2019-01-01 00:00:00

  • BclI glucocorticoid receptor polymorphism in relation to cardiovascular variables: the Hoorn and CODAM studies.

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    journal_title:European journal of endocrinology

    pub_type: 杂志文章


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    更新日期:2015-10-01 00:00:00

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    journal_title:European journal of endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验


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    journal_title:European journal of endocrinology

    pub_type: 临床试验,杂志文章


    authors: Garcia-Lorda P,Nash W,Roche A,Pi-Sunyer FX,Laferrere B

    更新日期:2003-06-01 00:00:00