MRI T2 signal intensity and tumor response in patients with GH-secreting pituitary macroadenoma: PRIMARYS post-hoc analysis.

Abstract:

:Objective Pituitary adenoma MRI T2 signal intensity associates with tumor characteristics including responsiveness to somatostatin analogs (SSAs). These analyses determined whether baseline T2 signal intensity predicts response to primary medical treatment with long-acting SSA. Design Post-hoc analyses of the prospective multicenter, open-label, single-arm PRIMARYS study in which patients with treatment-naïve GH-secreting pituitary macroadenomas received fixed-dose lanreotide autogel (120mg) every 4-weeks for 48-weeks. Methods Associations were investigated between adenoma T2-signal hypo/iso/hyperintensity and treatment responses at week 48/last visit: hormonal control (GH ≤2.5μg/L and IGF-1 normalization); tumor response (tumor volume reduction [TVR] ≥20%); separate GH/IGF-1 control; and change-from-baseline in GH/IGF-1 and tumor volume. Results Adenomas were hypointense at baseline in 50/85 (59%) patients using visual assessment. Of these, 40% achieved hormonal control and 76% achieved a tumor response. Significant univariate associations arose for hypo- vs isointensity with tumor response and achievement of GH ≤2.5 μg/L, but not IGF-1 normalization or overall hormonal control. In multivariate analysis, tumor response was 6-times more likely for hypo- vs isointense tumors (=6.15; 95% CI [1.36;27.88]). In univariate change-from-baseline analyses, hypo- vs isointensity was associated with greater TVR and IGF-1 reduction but not change in GH. In multivariate analysis, IGF-1 decreased by an estimated additional 65 μg/L [P=0.0026]) for hypo- vs isointense. Conclusions Patients with hypointense vs isointense GH-secreting macroadenomas had greater reductions in IGF-1 following primary treatment with lanreotide autogel, and were more likely to achieve tumor response. Assessment of T2 signal intensity at baseline may help to predict long-term responses to primary treatment with SSAs.

journal_name

Eur J Endocrinol

authors

Bonneville F,Rivière LD,Petersenn S,Bevan J,Houchard A,Sert C,Caron PJ,PRIMARYS Study group.

doi

10.1530/EJE-18-0254

subject

Has Abstract

pub_date

2018-12-01 00:00:00

eissn

0804-4643

issn

1479-683X

pii

EJE-18-0254.R2

pub_type

杂志文章
  • Influence of renal function on clinico-pathological features of primary hyperparathyroidism.

    abstract:OBJECTIVE:Disturbed renal function may play an important role in the clinico-pathological presentation of primary hyperparathyroidism (pHPT). We studied the influence of renal function on the clinico-pathological characteristics of 141 patients (123 women and 18 men) with surgically proven pHPT. METHODS:The 141 patien...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1480597

    authors: Yamashita H,Noguchi S,Uchino S,Watanabe S,Murakami T,Ogawa T,Masatsugu T,Takamatsu Y,Miyatake E,Yamashita H

    更新日期:2003-06-01 00:00:00

  • Increased reverse triiodothyronine is associated with shorter survival in independently-living elderly: the Alsanut study.

    abstract:OBJECTIVE:Increased reverse tritiodothyronine (T(3)) used to be described as a part of euthyroid sick syndrome (ESS). It was demonstrated to be associated with increased mortality in acutely ill patients. It can also be found with low or normal T(3) in non-severely ill subjects but its significance remains unclear. PA...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/EJE-08-0519

    authors: Forestier E,Vinzio S,Sapin R,Schlienger JL,Goichot B

    更新日期:2009-02-01 00:00:00

  • Is the effect of testosterone on body composition modulated by the androgen receptor gene CAG repeat polymorphism in elderly men?

    abstract:OBJECTIVE:The androgen receptor (AR) gene contains a CAG repeat polymorphism coding for a polyglutamine chain, the length of which is inversely correlated with AR transcriptional activity. We explored whether this polymorphism modulates the activities of testosterone (T) related to body composition in elderly men. DES...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/EJE-06-0607

    authors: Lapauw B,Goemaere S,Crabbe P,Kaufman JM,Ruige JB

    更新日期:2007-03-01 00:00:00

  • Therapy of endocrine disease: Perspectives on the management of adrenal insufficiency: clinical insights from across Europe.

    abstract:BACKGROUND:Conventional glucocorticoid (GC) replacement for patients with adrenal insufficiency (AI) is inadequate. Patients with AI continue to have increased mortality and morbidity and compromised quality of life despite treatment and monitoring. OBJECTIVES:i) To review current management of AI and the unmet medica...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1530/EJE-13-0450

    authors: Grossman A,Johannsson G,Quinkler M,Zelissen P

    更新日期:2013-10-21 00:00:00

  • Multiple endocrine neoplasia type 1 in Northern Finland; clinical features and genotype phenotype correlation.

    abstract:OBJECTIVE:The existence of genotype-phenotype correlation in multiple endocrine neoplasia type 1 (MEN1) is controversial. Two founder mutations of the MEN1 gene in Northern Finland gave us an opportunity to compare clinical features among heterozygotes of different mutations. DESIGN AND METHODS:Study cohort included 8...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/EJE-07-0195

    authors: Vierimaa O,Ebeling TM,Kytölä S,Bloigu R,Eloranta E,Salmi J,Korpi-Hyövälti E,Niskanen L,Orvola A,Elovaara E,Gynther A,Sane T,Välimäki M,Ignatius J,Leisti J,Salmela PI

    更新日期:2007-09-01 00:00:00

  • New perspectives for gene therapy in endocrinology.

    abstract::Gene therapy for endocrine diseases represents an exciting new type of molecular intervention that may be a curative one. Endocrine disorders that might be treated by gene therapy include monogenic diseases, such as GH deficiency and hypothalamic diabetes insipidus, and multifactorial diseases, such as diabetes mellit...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1530/eje.0.1430447

    authors: Barzon L,Bonaguro R,Palù G,Boscaro M

    更新日期:2000-10-01 00:00:00

  • Hypothalamic-pituitary-gonadal axis in two men with aromatase deficiency: evidence that circulating estrogens are required at the hypothalamic level for the integrity of gonadotropin negative feedback.

    abstract:BACKGROUND:In men, the feedback of gonadotropins is regulated by estrogens that come from the aromatization of testosterone, but the relative contribution to the inhibition of LH and FSH secretion by the amount of locally produced estrogens within the hypothalamus and/or the pituitary, and the amount of circulating est...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.1.02254

    authors: Rochira V,Zirilli L,Genazzani AD,Balestrieri A,Aranda C,Fabre B,Antunez P,Diazzi C,Carani C,Maffei L

    更新日期:2006-10-01 00:00:00

  • Increase in human placental glucose transporter-1 during pregnancy.

    abstract::Glucose transporter-1 (GLUT1) has been found in high abundance in human placentas. The purpose of this study was to analyze the changes in the level of GLUT1 during pregnancy. We have analyzed the gestational changes in human placental GLUT1 by [3H]cytochalasin B binding assay, immunoblot analysis and Northern blot an...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1320206

    authors: Sakata M,Kurachi H,Imai T,Tadokoro C,Yamaguchi M,Yoshimoto Y,Oka Y,Miyake A

    更新日期:1995-02-01 00:00:00

  • Transsphenoidal surgery in acromegaly investigated by intraoperative high-field magnetic resonance imaging.

    abstract:OBJECTIVE:The aim of the study was to evaluate the effect of intraoperative high-field (1.5 Tesla) magnetic resonance imaging (MRI) on the results of transsphenoidal surgery of GH-secreting pituitary macroadenomas. METHODS:Twenty-three acromegalic patients (mean tumor size, 25 +/- 12 mm; untreated preoperative GH, 4.2...

    journal_title:European journal of endocrinology

    pub_type: 临床试验,杂志文章

    doi:10.1530/eje.1.01970

    authors: Fahlbusch R,Keller Bv,Ganslandt O,Kreutzer J,Nimsky C

    更新日期:2005-08-01 00:00:00

  • Effect of exogenous growth hormone administration on endogenous growth hormone secretion induced by a met-enkephalin analog.

    abstract::Exogenous growth hormone (hGH) administration in humans attenuates the endogenous growth hormone (GH) response to some pharmacological stimuli; in particular, pretreatment with hGH completely blocks the serum GH response to growth hormone-releasing hormone. In order to evaluate the mechanism(s) whereby opiods induce G...

    journal_title:European journal of endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1530/eje.0.1340073

    authors: Fanciulli G,Oliva O,Tomasi PA,Pala A,Bertoncelli A,Dettori A,Delitala G

    更新日期:1996-01-01 00:00:00

  • Sympatho-vagal control of heart rate variability in patients treated with suppressive doses of L-thyroxine for thyroid cancer.

    abstract:OBJECTIVE:This study aimed to analyze the autonomic control of heart rate variability (HRV) in subjects receiving chronic l-thyroxine (l-T4) treatment after total thyroidectomy and (131)I therapy for differentiated thyroid carcinoma. METHODS:Blood pressure (BP) and sympatho-vagal activity (evaluated by power spectral ...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.1.01918

    authors: Casu M,Cappi C,Patrone V,Repetto E,Giusti M,Minuto F,Murialdo G

    更新日期:2005-06-01 00:00:00

  • ESE audit on management of Adult Growth Hormone Deficiency in clinical practice.

    abstract::Guidelines recommend adults with pituitary disease in whom GH therapy is contemplated, to be tested for GH deficiency (AGHD); however, clinical practice is not uniform. AIMS:1) To record current practice of AGHD management throughout Europe and benchmark it against guidelines; 2) To evaluate educational status of hea...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/EJE-20-1180

    authors: Martel-Duguech LM,Jorgensen JOL,Korbonits M,Johannsson G,Webb SM,Amadidou F,Mintziori G,Arosio M,Giavoli C,Badiu C,Boschetti M,Ferone D,Ricci Bitti S,Brue T,Albarel F,Cannavò S,Cotta OR,Carvalho D,Salazar D,Christ E

    更新日期:2020-12-01 00:00:00

  • Recommended evaluation of adrenal incidentalomas is costly, has high false-positive rates and confers a risk of fatal cancer that is similar to the risk of the adrenal lesion becoming malignant; time for a rethink?

    abstract:OBJECTIVE:To assess the performance of current clinical recommendations for the evaluation of an adrenal incidentaloma. DESIGN AND METHODS LITERATURE REVIEW: Electronic databases (Pubmed, Ovid and citation searches from key articles) from 1980 to 2008 were searched. Eligible studies were those deemed most applicable to...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/EJE-09-0234

    authors: Cawood TJ,Hunt PJ,O'Shea D,Cole D,Soule S

    更新日期:2009-10-01 00:00:00

  • Morbidity and GH deficiency: a nationwide study.

    abstract:OBJECTIVE:To estimate morbidity in Denmark in all patients with GH deficiency (GHD). DESIGN:Morbidity was analyzed in 1794 GHD patients and 8014 controls matched on age and gender. All records in the GHD patients were studied and additional morbidity noted. Diagnoses and dates of admissions were identified in the Nati...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/EJE-07-0523

    authors: Stochholm K,Laursen T,Green A,Laurberg P,Andersen M,Kristensen LØ,Feldt-Rasmussen U,Christiansen JS,Frydenberg M,Gravholt CH

    更新日期:2008-04-01 00:00:00

  • Androgen receptor gene GGN repeat length and reproductive characteristics in young Swedish men.

    abstract:BACKGROUND:The human androgen receptor (AR) gene contains two polymorphisms of CAG and GGN repeats respectively. The GGN repeat function is still largely unknown and to date there are no in vivo data on this segment with respect to the general population. METHODS:We investigated the impact of CAG and GGN repeats on ma...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.1.02204

    authors: Lundin KB,Giwercman YL,Rylander L,Hagmar L,Giwercman A

    更新日期:2006-08-01 00:00:00

  • Coexistence of normotensive primary aldosteronism in two patients with Gitelman's syndrome and novel thiazide-sensitive Na-Cl cotransporter mutations.

    abstract:BACKGROUND:Primary aldosteronism (PA) is the most common form of secondary hypertension, while Gitelman's syndrome (GS) is the most common inherited renal tubular disease. However, coexistence of these two diseases has never been previously reported. AIM AND SUBJECTS: The aim of our study was to describe the associatio...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/EJE-09-0271

    authors: Miao Z,Gao Y,Bindels RJ,Yu W,Lang Y,Chen N,Ren H,Sun F,Li Y,Wang X,Shao L

    更新日期:2009-08-01 00:00:00

  • Prospective evaluation of autoimmune and non-autoimmune subclinical hypothyroidism in Down syndrome children.

    abstract:Objective:To evaluate the prevalence and natural course of autoimmune and non-autoimmune subclinical hypothyroidism (SH) in Down syndrome (DS) children and adolescents. Design:Prospective multicenter study. Methods:For the study, 101 DS patients with SH (TSH 5-10 mIU/L; FT4 12-22 pmol/L), aged 2-17 years at SH diagno...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,多中心研究

    doi:10.1530/EJE-19-0823

    authors: Pepe G,Corica D,De Sanctis L,Salerno M,Faienza MF,Tessaris D,Tuli G,Scala I,Penta L,Alibrandi A,Pajno GB,Aversa T,Wasniewska M,Thyroid Study Group of the Italian Society of Pediatric Endocrinology and Diabetology (ISPED).

    更新日期:2020-04-01 00:00:00

  • Diabetes in acromegaly, prevalence, risk factors, and evolution: data from the French Acromegaly Registry.

    abstract:OBJECTIVES:The French Acromegaly Registry records data of acromegalic patients' since 1992 in French, Belgian (Liège), and Swiss (Lausanne) centers. We studied the prevalence of diabetes in this population looking for risk factors. Patients from one of the centers (Reims) were then analyzed more thoroughly. METHODS:Th...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/EJE-10-1050

    authors: Fieffe S,Morange I,Petrossians P,Chanson P,Rohmer V,Cortet C,Borson-Chazot F,Brue T,Delemer B,French Acromegaly Registry.

    更新日期:2011-06-01 00:00:00

  • Prevalence, incidence and associated comorbidities of treated hypothyroidism: an update from a European population.

    abstract:OBJECTIVE:Estimates of the prevalence of hypothyroidism in unselected populations date from the late 1990s. We present an update on the prevalence and incidence of overt hypothyroidism in Piedmont, northwest Italy and examine the association between hypothyroidism and multiple chronic comorbidities. DESIGN AND METHODS...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/EJE-16-0559

    authors: Giorda CB,Carnà P,Romeo F,Costa G,Tartaglino B,Gnavi R

    更新日期:2017-05-01 00:00:00

  • Decrease in circulating fibroblast growth factor 21 after an oral fat load is related to postprandial triglyceride-rich lipoproteins and liver fat.

    abstract:BACKGROUND:Elevated levels of circulating fibroblast growth factor 21 (FGF21) are commonly encountered in type 2 diabetes, dyslipidemia, and non-alcoholic fatty liver disease, all of which share exaggerated postprandial lipemia as a common proatherogenic feature. How FGF21 responds to an oral fat load in man is unknown...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/EJE-11-0783

    authors: Matikainen N,Taskinen MR,Stennabb S,Lundbom N,Hakkarainen A,Vaaralahti K,Raivio T

    更新日期:2012-03-01 00:00:00

  • Identification and characterization of insulin-like growth factor I (IGF-I) and IGF-II/mannose-6-phosphate (IGF-II/M6P) receptors in bovine adrenal cells.

    abstract::We have identified and characterized insulin-like growth factor I (IGF-I) and IGF-II/mannose-6-phosphate (IGF-II/M6P) receptors in bovine adrenal cells. Iodine-125-labeled IGF-I ([125I]IGF-I) binding was characteristic of the IGF-I receptor, and binding kinetics as well as receptor densities were similar in cortical a...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1300265

    authors: Weber MM,Kiess W,Beikler T,Simmler P,Reichel M,Adelmann B,Kessler U,Engelhardt D

    更新日期:1994-03-01 00:00:00

  • Screening for mutations in 17β-hydroxysteroid dehydrogenase and androgen receptor in women presenting with partially virilised 46,XY disorders of sex development.

    abstract:CONTEXT AND OBJECTIVE:The precise diagnosis of partially virilised women with 46,XY disorders of sex development (DSD) is often obscure. In practice, this group often comes under the poorly defined, clinically based label of partial androgen insensitivity syndrome (PAIS). In a previous study, we found that 5α-reductase...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/EJE-14-0994

    authors: Phelan N,Williams EL,Cardamone S,Lee M,Creighton SM,Rumsby G,Conway GS

    更新日期:2015-06-01 00:00:00

  • A novel OTX2 mutation in a patient with combined pituitary hormone deficiency, pituitary malformation, and an underdeveloped left optic nerve.

    abstract::Orthodenticle homolog 2 (OTX2) is a homeobox family transcription factor required for brain and eye formation. Various genetic alterations in OTX2 have been described, mostly in patients with severe ocular malformations. In order to expand the knowledge of the spectrum of OTX2 mutation, we performed OTX2 mutation scre...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,多中心研究

    doi:10.1530/EJE-12-0333

    authors: Gorbenko Del Blanco D,Romero CJ,Diaczok D,de Graaff LC,Radovick S,Hokken-Koelega AC

    更新日期:2012-09-01 00:00:00

  • Giant prolactinomas in women.

    abstract:OBJECTIVE:To characterise distinctive clinical features of giant prolactinomas in women. DESIGN:A multicentre, retrospective case series and literature review. METHODS:We collected data from 15 female patients with a pituitary tumour larger than 4 cm and prolactin levels above 1000 μg/l and identified 19 similar case...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,多中心研究,评审

    doi:10.1530/EJE-13-0503

    authors: Delgrange E,Raverot G,Bex M,Burman P,Decoudier B,Devuyst F,Feldt-Rasmussen U,Andersen M,Maiter D

    更新日期:2013-11-22 00:00:00

  • Pregnancy and pituitary disorders.

    abstract::Major hormonal changes emerge during pregnancy. The pituitary gland is one of the most affected organs with altered anatomy and physiology. The pituitary gland is enlarged as a result of lactotroph hyperplasia. Due to physiological changes in the pituitary and target hormone levels, binding globulins, and placental ho...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/EJE-09-0923

    authors: Karaca Z,Tanriverdi F,Unluhizarci K,Kelestimur F

    更新日期:2010-03-01 00:00:00

  • Effects of sex steroids on bone in women with subclinical or overt endogenous hypercortisolism.

    abstract:OBJECTIVE:Glucocorticoid-induced osteoporosis is the most frequent cause of secondary osteoporosis. Nevertheless, limited data are available on bone status in patients with endogenous cortisol excess. This study is aimed at investigating the role of sex steroids and severity of hypercortisolism on bone mineral density ...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/EJE-07-0137

    authors: Tauchmanovà L,Pivonello R,De Martino MC,Rusciano A,De Leo M,Ruosi C,Mainolfi C,Lombardi G,Salvatore M,Colao A

    更新日期:2007-09-01 00:00:00

  • MECHANISMS IN ENDOCRINOLOGY: Anorexia nervosa and endocrinology: a clinical update.

    abstract::Anorexia nervosa is a syndrome, that is collections of symptoms, which is not defined by its etiology. The severe cases are intractable. The syndrome is associated with multiple, profound endocrine alterations which may be adaptive, reactive or etiologic. Adaptive changes potentially may be inappropriate in clinical s...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1530/EJE-18-0596

    authors: Støving RK

    更新日期:2019-01-01 00:00:00

  • BclI glucocorticoid receptor polymorphism in relation to cardiovascular variables: the Hoorn and CODAM studies.

    abstract:OBJECTIVE:Excess glucocorticoids are known to cause hypertension and cardiovascular disease (CVD). The BclI glucocorticoid receptor (GR) polymorphism increases glucocorticoid sensitivity and is associated with adverse metabolic effects. Previous studies investigating cardiovascular implications have shown inconsistent ...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/EJE-15-0381

    authors: van Moorsel D,van Greevenbroek MM,Schaper NC,Henry RM,Geelen CC,van Rossum EF,Nijpels G,'t Hart LM,Schalkwijk CG,van der Kallen CJ,Sauerwein HP,Dekker JM,Stehouwer CD,Havekes B

    更新日期:2015-10-01 00:00:00

  • Metabolic and endocrine effects of treatment with peroral or transdermal oestrogens in conjunction with peroral cyproterone acetate in women with polycystic ovary syndrome.

    abstract:OBJECTIVE:To compare the influence of transdermal and peroral oestrogen treatments in conjunction with cyproterone acetate (CPA) on metabolic and hormonal parameters in women with polycystic ovary syndrome (PCOS). PATIENTS AND METHODS:Twenty-four women with PCOS, aged 25.4+/-4.3 (mean+/-s.d.) years, body mass index 24...

    journal_title:European journal of endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1530/eje.0.1500215

    authors: Vrbíková J,Stanická S,Dvoráková K,Hill M,Vondra K,Bendlová B,Stárka L

    更新日期:2004-02-01 00:00:00

  • Intralipid/heparin infusion suppresses serum leptin in humans.

    abstract:BACKGROUND/AIM:Our previous studies showed that administration of dexamethasone plus food increased serum leptin levels 100% more than dexamethasone alone. We hypothesized that this increase in leptin from the meal could result directly from the provision of fuel metabolites rather than from the meal-induced rise in in...

    journal_title:European journal of endocrinology

    pub_type: 临床试验,杂志文章

    doi:10.1530/eje.0.1480669

    authors: Garcia-Lorda P,Nash W,Roche A,Pi-Sunyer FX,Laferrere B

    更新日期:2003-06-01 00:00:00