Abstract：
:Based on experimental and animal models, epidemiological data from non-acromegaly populations, and longitudinal and cross-sectional cohorts of patients with acromegaly, a potential association between acromegaly and cancer has long been hypothesized, in particular colorectal cancer, and, to a lesser extent, breast, thyroid and prostate cancers. The exact mechanisms underlying this potential association have not been fully elucidated. Results from studies examining cancer incidence and mortality in acromegaly have been inconsistent, with some demonstrating increased risk, whereas others show no increase. This article reviews the existing data relating to cancer risk and mortality in acromegaly, exploring the limitations of study designs and the impact of changes in disease control and patient outcomes over time.
journal_name
Eur J Endocrinoljournal_title
European journal of endocrinologyauthors
Boguszewski CL,Ayuk Jdoi
10.1530/EJE-16-0178subject
Has Abstractpub_date
2016-10-01 00:00:00pages
R147-56issue
4eissn
0804-4643issn
1479-683Xpii
EJE-16-0178journal_volume
175pub_type
杂志文章,评审abstract：OBJECTIVE:Our purpose was to study the sex steroid-mediated changes in serum insulin and lipid concentrations in boys during puberty. DESIGN AND METHODS:We treated boys with constitutional delay of puberty either with testosterone plus placebo or with testosterone plus an aromatase inhibitor, letrozole, which inhibits...
journal_title：European journal of endocrinology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1530/eje.0.1460339
更新日期：2002-03-01 00:00:00
abstract：OBJECTIVE:In hyperthyroidism, tissue glucose disposal is increased to adapt to high energy demand. Our aim was to examine the regulation of glucose transporter (GLUT) isoforms by IGF-I in monocytes from patients with hyperthyroidism. DESIGN AND METHODS:Blood (20 ml) was drawn from 21 healthy and 10 hyperthyroid subjec...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-07-0532
更新日期：2008-03-01 00:00:00
abstract：BACKGROUND:Identification of pretreatment risk factors predicting relapse in patients with hyperthyroidism of Graves' disease after stopping anti-thyroid drugs (ATD) is decisive to guide therapeutic options. PURPOSE:We performed a systematic search and meta-analysis to study predictors for relapse after stopping ATD i...
journal_title：European journal of endocrinology
pub_type： 杂志文章,meta分析,评审
doi：10.1530/EJE-16-0725
更新日期：2017-01-01 00:00:00
abstract：:Glucose transporter-1 (GLUT1) has been found in high abundance in human placentas. The purpose of this study was to analyze the changes in the level of GLUT1 during pregnancy. We have analyzed the gestational changes in human placental GLUT1 by [3H]cytochalasin B binding assay, immunoblot analysis and Northern blot an...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1320206
更新日期：1995-02-01 00:00:00
abstract：OBJECTIVE:HRPT2 gene mutations are associated with parathyroid carcinomas, and absence of parafibromin immunoreactivity has been suggested as a diagnostic marker of malignancy. The aim of our study was to extend parafibromin studies in a series of benign and malignant parathyroid tumors and cross-validate the results o...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-06-0720
更新日期：2007-05-01 00:00:00
abstract：:We here investigate the potential rescue of the relative hyposomatotropism of aging and obesity by 3-day pulsatile GHRH infusions (i.v. bolus 0.33 microg/kg every 90 min) in 19 healthy men of varying ages (18 to 66 years) and body compositions (12 to 37% total body fat). Baseline (control) and GHRH-driven pulsatile GH...
journal_title：European journal of endocrinology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1530/eje.0.1390059
更新日期：1998-07-01 00:00:00
abstract：:Over the last 5 years, new actors involved in the pathogenesis of combined pituitary hormone deficiency in humans have been reported: they included a member of the immunoglobulin superfamily glycoprotein and ciliary G protein-coupled receptors, as well as new transcription factors and signalling molecules. New modes o...
journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1530/EJE-15-1095
更新日期：2016-06-01 00:00:00
abstract：OBJECTIVE:Makorin ring finger protein 3 (MKRN3) gene restrains the hypothalamic-pituitary-gonadal axis. In girls, peripheral levels of MKRN3 decline prior to the onset of puberty. We described longitudinal changes in serum MKRN3 levels in boys before and during puberty and assessed the effect of inhibition of estrogen ...
journal_title：European journal of endocrinology
pub_type： 杂志文章,随机对照试验
doi：10.1530/EJE-15-1193
更新日期：2016-06-01 00:00:00
abstract：:Pyridostigmine (PST), a cholinesterase inhibitor, induces a clear growth hormone (GH) release in man by suppression of hypothalamic somatostatin (SRIH). Somatostatin suppresses thyrotrophin (TSH) release in rats and men. Earlier studies showed that the thryotrophin-releasing hormone (TRH)-induced TSH response was not ...
journal_title：European journal of endocrinology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1530/eje.0.1330457
更新日期：1995-10-01 00:00:00
abstract：BACKGROUND:A limited number of mutations in the GH secretagogue receptor gene (GHSR) have been described in patients with short stature. Objective To analyze GHSR in idiopathic short stature (ISS) children including a subgroup of constitutional delay of growth and puberty (CDGP) patients. SUBJECTS AND METHODS:The GHSR...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-11-0168
更新日期：2011-08-01 00:00:00
abstract：:Recombinant human GH has been licensed for use in adult patients with GH deficiency (GHD) for over 15 years. Early weight- and surface area-based dosing regimens were effective but resulted in supraphysiological levels of IGF1 and increased incidence of side effects. Current practice has moved towards individualised r...
journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1530/EJE-12-0563
更新日期：2013-02-20 00:00:00
abstract：:In 1996, the German Registry of Pituitary Tumors was founded by the Pituitary Section of the German Society of Endocrinology as a reference center for collection and consultant pathohistological studies of pituitary tumors. The experiences of the first 10 years of this registry based on 4122 cases will herein be repor...
journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1530/eje.1.02326
更新日期：2007-02-01 00:00:00
abstract：:The two pituitary gonadotrophins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), and in particular LH-stimulated high intratesticular testosterone (ITT) concentration, are considered crucial for spermatogenesis. We have revisited these concepts in genetically modified mice, one being the LH receptor ...
journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1530/EJE-18-0396
更新日期：2018-09-01 00:00:00
abstract：OBJECTIVE:Free fatty acids (FFAs) deplete the intracellular insulin stores of pancreatic beta-cells. It has been suggested that this results from a lipotoxic dysregulation of both insulin secretion and insulin synthesis. In the present study, this hypothesis was tested within a 12-h time-course by directly relating the...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1480481
更新日期：2003-04-01 00:00:00
abstract：:Several lines of evidence suggest that tumor necrosis factor-alpha (TNFalpha) may contribute to the pathogenesis of autoimmune thyroid disease. It is not known, however, whether increased thyroidal TNFalpha levels are associated with changes in thyroid function. The purpose of the present study was to utilize in situ ...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1390539
更新日期：1998-11-01 00:00:00
abstract：OBJECTIVE:There are limited data on cardiometabolic risk factors and the prevalence of metabolic syndrome (MetS) across the different PCOS phenotypes in Caucasian population. Lipid accumulation product (LAP) is a clinical surrogate marker that could be used for evaluation of MetS in clinical practice. The aim of the st...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-16-0775
更新日期：2016-12-01 00:00:00
abstract：:The secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) is regulated by gonadotropin-releasing hormone (GnRH). As men age, mean serum concentrations of immunoreactive gonadotropic hormones tend to increase, while serum testosterone concentrations tend to decline. To evaluate age-related change...
journal_title：European journal of endocrinology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1530/eje.0.1350399
更新日期：1996-10-01 00:00:00
abstract：:Surgery is the treatment of choice for non-functioning pituitary macroadenomas (NFPAs). In cases of postoperative remnant growth or tumor recurrence, radiotherapy (RT) can be considered. The role of RT in the postoperative management of NFPAs is still debated. The main arguments against routine use of RT are the lack ...
journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1530/EJE-19-0058
更新日期：2019-07-01 00:00:00
abstract：:We report one patient with 21-hydroxylase deficiency and associated bilateral macro-orchidism caused by nodular hyperplasia of testicular adrenal rests (TAR). The boy, referred to us when 10 years old, was born with bilateral cryptorchidism that was treated unsuccessfully with i.m. injections of human chorionic gonado...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1410231
更新日期：1999-09-01 00:00:00
abstract：:There is increasing evidence that ovarian steroids inhibit vascular responsiveness to the neurohypophysial hormone vasopressin. The present study examined the recovery of the arterial blood pressure following a single (2 ml/100 g body weight) haemorrhage in ovariectomized (OVX) Brattleboro rats with hereditary hypotha...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1360330
更新日期：1997-03-01 00:00:00
abstract：OBJECTIVE:Only a few studies have investigated variations of different markers for inflammatory processes during the physiological menstrual cycle. The results are conflicting, particularly concerning the correlation between the marker leptin and steroid hormones. The aim of the study was to investigate the inflammator...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.1.02178
更新日期：2006-07-01 00:00:00
abstract：OBJECTIVE:In the field of fine-needle aspiration cytology, the category of suspicious for malignancy (SM) thyroid lesions, that bears 55-85% risk of malignant histology, is a challenging topic in which morphology alone is not always able to make a correct diagnosis. Recently, immunocytochemistry (ICC) has been referred...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-13-0023
更新日期：2013-05-02 00:00:00
abstract：:To study interactions between insulin-like growth factor-II (IGF-II) and growth hormone (GH) in vivo, we crossed hemizygous transgenic mice carrying phosphoenolpyruvate carboxykinase (PEPCK)-IGF-II fusion genes with hemizygous PEPCK-bovine GH (bGH) transgenic mice. Offspring harbouring both transgenes (IB), the IGF-II...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1370701
更新日期：1997-12-01 00:00:00
abstract：OBJECTIVE:11beta-Hydroxylase and aldosterone synthase are two highly homologous genes involved in different forms of human hypertension and in different animal models of hypertension. It has been shown that the conservative substitution D147E in the human CYP11B2 gene results in an increased production of corticosteron...
journal_title：European journal of endocrinology
pub_type： 临床试验,杂志文章
doi：10.1530/eje.0.1440397
更新日期：2001-04-01 00:00:00
abstract：OBJECTIVE:The malignancy of thyroid oncocytic tumours, or oncocytomas, is higher than that of follicular tumours. The aim of this study was to investigate the role of thyroid-specific genes in oncocytic tumours and papillary carcinomas. DESIGN AND METHODS:We compared 29 oncocytic tumours with 12 papillary carcinomas. ...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1500269
更新日期：2004-03-01 00:00:00
abstract：:Biosynthesis of iodothyronines in thyroglobulin occurs by oxidative coupling of two iodotyrosine residues catalyzed by thyroperoxidase. To study the mechanism of iodothyronine formation, iodine-free thyroglobulin was non-enzymatically iodinated and after removal of non-incorporated iodide, incubated with lactoperoxida...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1380227
更新日期：1998-02-01 00:00:00
abstract：:Maintenance of fluid homeostasis during periods of heightened physical stress can be best evaluated in humans using exercise as a model. Although it is well established that arginine vasopressin (AVP), aldosterone and atrial natriuretic peptide (ANP) are the principle hormones regulating fluid balance at rest, the pot...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-08-0064
更新日期：2008-12-01 00:00:00
abstract：OBJECTIVE:Various adjuvant therapies have been introduced along with intensive insulin therapy in patients with recent onset type 1 diabetes. Nicotinamide (NA), administered at diagnosis of the disease, can have beneficial effects on the clinical remission rate, improve metabolic control and preserve or slightly increa...
journal_title：European journal of endocrinology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1530/eje.0.1500719
更新日期：2004-05-01 00:00:00
abstract：BACKGROUND:Few published data link overweight and obesity with measures of quality of life (QoL) including sexual health in men. OBJECTIVE:To assess the association of overweight/obesity with impairment of physical and psychological QoL and sexual functions in men. DESIGN AND SETTING:Cross-sectional, multicentre surv...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-10-1129
更新日期：2011-06-01 00:00:00
abstract：:Tall stature is defined as a height of more than 2 standard deviations (s.d.) above average for same sex and age. Tall individuals are usually referred to endocrinologists so that hormonal disorders leading to abnormal growth are excluded. However, the majority of these patients have familial tall stature or constitut...
journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1530/EJE-16-1054
更新日期：2017-06-01 00:00:00
