当前位置： SCI文献检索 > EUROPEAN JOURNAL OF ENDOCRINOLOGY期刊下所有文献 > Graves' disease in children and adolescents. Late results of surgical treatment.

Graves' disease in children and adolescents. Late results of surgical treatment.

Abstract：

:All children and adolescents with Graves' disease in the county of Uppsala (catchment area population 250,000) treated between 1970 and 1994 were evaluated in a retrospective study. The material comprised 31 patients with a mean age of 11 years (range 4-16), 29 (94%) of whom were girls, and four (13%) of the patients had Down's syndrome. Treatment was primarily conservative and surgery was considered if prolonged medical treatment failed. Lasting remission after antithyroid drug therapy (median 6.5 years; range 4.5-8 years) was noted in 6/31 patients (19%), three (10%) of whom subsequently developed hypothyroidism. Twenty-four of the remaining patients (77%) ultimately underwent subtotal (N = 20) or total thyroidectomy (N = 4) after experiencing one or more episodes of recurrent hyperthyroidism during medical treatment (median 6 years; range 0.5-11 years). After surgery one patient developed permanent hypocalcemia requiring low-dose vitamin D supplementation. During a postoperative follow-up period of 12.2 years ( median; range 1-17 years), there were two cases of recurrent thyrotoxicosis, 1 and 10 years after surgery. The results underline that gender and Down's syndrome are risk factors of juvenile Graves' disease and that the disorder often is difficult to control by long-term medical therapy. In such cases thyroid surgery offers a safe and prompt reversal of the thyrotoxicosis. A proportion of the patients may ultimately develop hypothyroidism, substantiating a need for long-term follow-up of persons afflicted with Graves' disease early in life.

journal_name

Eur J Endocrinol

journal_title

European journal of endocrinology

authors

Rudberg C,Johansson H,Akerström G,Tuvemo T,Karlsson FA

doi

10.1530/eje.0.1340710

subject

Has Abstract

pub_date

1996-06-01 00:00:00

pages

710-5

issue

6

eissn

0804-4643

issn

1479-683X

journal_volume

134

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF ENDOCRINOLOGY文献大全
  • Long-term effects of cranial irradiation for childhood malignancy on sleep in adulthood.

    abstract：BACKGROUND:Cranial radiation therapy (CRT) is required for successful treatment of a variety of brain tumours in childhood. OBJECTIVE:To investigate whether childhood CRT leads to altered sleep-wakefulness organization in adulthood, and to identify the determinants of such alterations. SUBJECTS AND METHODS:Subjective...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1500503

    authors： Van Someren EJ,Swart-Heikens J,Endert E,Bisschop PH,Swaab DF,Bakker PJ,Romijn JA,Fliers E

    更新日期：2004-04-01 00:00:00

  • Serum concentrations of LH and FSH in the healthy newborn.

    abstract：OBJECTIVE:A sex difference in fetal and neonatal pituitary-gonadal function has been well documented. The aim of the following study was to determine sex differences and patterns of basal LH/FSH in the neonatal period. DESIGN:Peripheral venous blood was obtained from 164 healthy full term newborns (91 males, 73 female...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1430213

    authors： Schmidt H,Schwarz HP

    更新日期：2000-08-01 00:00:00

  • Genetic influence of an ACTH receptor promoter polymorphism on adrenal androgen secretion.

    abstract：OBJECTIVE:Adrenocorticotropic hormone (ACTH) is the primary secretagogue stimulating secretion of adrenal androgens (AA). Yet, genetic and environmental factors are assumed to play a determining role in the regulation of their biosynthesis and thus might explain the high variability of AA levels. Here we investigate th...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.1.02015

    authors： Reisch N,Slawik M,Zwermann O,Beuschlein F,Reincke M

    更新日期：2005-11-01 00:00:00

  • Cognitive functioning in children with Prader-Willi syndrome during 8 years of growth hormone treatment.

    abstract：Objective:Children with Prader-Willi syndrome (PWS) have mild to moderate cognitive impairment. Short-term studies showed positive effects of growth hormone (GH) on cognitive development. This study investigated the effects of 8 years of GH on cognitive development in children with PWS. We also investigated whether sta...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-19-0479

    authors： Donze SH,Damen L,Mahabier EF,Hokken-Koelega ACS

    更新日期：2020-04-01 00:00:00

  • Is surgery necessary for 'mild' or 'asymptomatic' hyperparathyroidism?

    abstract：:A large majority of the currently diagnosed patients with hyperparathyroidism (PHPT) are mild or asymptomatic, mainly women after menopause. Following the debate held at the 16th European Congress of Endocrinology in Wroclaw (Poland) from May 3-7, 2014, arguments are here presented by a surgeon and a medical practitio...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-15-0277

    authors： Niederle B,Wémeau JL

    更新日期：2015-09-01 00:00:00

  • Decreased lipin 1 beta expression in visceral adipose tissue is associated with insulin resistance in polycystic ovary syndrome.

    abstract：OBJECTIVE:In polycystic ovary syndrome (PCOS), insulin resistance (IR) appears with high prevalence and represents the major cause of cardiometabolic complications. Lipin 1beta regulates lipid metabolism and augments insulin sensitivity. The impact of lipin 1beta expression in visceral and subcutaneous adipose tissue o...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-08-0387

    authors： Mlinar B,Pfeifer M,Vrtacnik-Bokal E,Jensterle M,Marc J

    更新日期：2008-12-01 00:00:00

  • Absence of activating mutations in the GnRH receptor gene in human pituitary gonadotroph adenomas.

    abstract：:The monoclonal origin of gonadotropin-secreting pituitary adenomas has been well demonstrated but only few molecular abnormalities have so far been recognized in these tumors. For many years, several authors have suggested a role for GnRH and/or GnRH receptors (GnRH-R) in the development of these pituitary adenomas. T...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1390157

    authors： Chanson P,De Roux N,Young J,Bidart JM,Jacquet P,Misrahi M,Milgrom E,Schaison G

    更新日期：1998-08-01 00:00:00

  • Supplementation with cholecalciferol does not result in weight reduction in overweight and obese subjects.

    abstract：OBJECTIVE:Investigate whether cholecalciferol supplementation leads to weight loss in overweight and obese adults. DESIGN:Randomized double blind clinical trial with 20,000 IU cholecalciferol twice a week, or 20,000 IU once a week plus placebo, or placebo twice a week, for 12 months. All subjects were given 500 mg cal...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,随机对照试验

    doi：10.1530/EJE-08-0339

    authors： Sneve M,Figenschau Y,Jorde R

    更新日期：2008-12-01 00:00:00

  • The presence of thyroid peroxidase antibody of IgG2 subclass is a risk factor for thyroid dysfunction in chronic hepatitis C patients.

    abstract：OBJECTIVE:To investigate the prevalence of thyroid dysfunction (TD) and IgG subclasses of thyroid autoantibodies (TAs) and to determine the predictive factors of TD in chronic hepatitis C (CHC) patients. DESIGN:Three hundred and twelve untreated hepatitis C virus-infected patients without a history of TD or treatment ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-12-0775

    authors： Shao C,Huo N,Zhao L,Gao Y,Fan X,Zheng Y,Wang L,Lu H,Xu X,Guo X

    更新日期：2013-04-15 00:00:00

  • BclI glucocorticoid receptor polymorphism in relation to cardiovascular variables: the Hoorn and CODAM studies.

    abstract：OBJECTIVE:Excess glucocorticoids are known to cause hypertension and cardiovascular disease (CVD). The BclI glucocorticoid receptor (GR) polymorphism increases glucocorticoid sensitivity and is associated with adverse metabolic effects. Previous studies investigating cardiovascular implications have shown inconsistent ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-15-0381

    authors： van Moorsel D,van Greevenbroek MM,Schaper NC,Henry RM,Geelen CC,van Rossum EF,Nijpels G,'t Hart LM,Schalkwijk CG,van der Kallen CJ,Sauerwein HP,Dekker JM,Stehouwer CD,Havekes B

    更新日期：2015-10-01 00:00:00

  • MANAGEMENT OF ENDOCRINE DISEASE: Novel anabolic treatments for osteoporosis.

    abstract：:Skeletal anabolic agents enhance bone formation, which is determined by the number and function of osteoblasts. Signals that influence the differentiation and function of cells of the osteoblast lineage play a role in the mechanism of action of anabolic agents in the skeleton. Wnts induce the differentiation of mesenc...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-17-0920

    authors： Canalis E

    更新日期：2018-02-01 00:00:00

  • Absence of angiotensin II type 1 receptor gene mutations in human adrenal tumors.

    abstract：:Regulatory actions of angiotensin II (AngII), which is involved in the pathophysiology of hypertension and also participates in cell proliferation and cell differentiation, are mainly mediated by AngII type 1 (AT1) receptor. Recently, activating mutations of receptors causing hyperfunctioning endocrine diseases have b...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1370262

    authors： Sachse R,Shao XJ,Rico A,Finckh U,Rolfs A,Reincke M,Hensen J

    更新日期：1997-09-01 00:00:00

  • Effect of amiodarone and dronedarone administration in rats on thyroid hormone-dependent gene expression in different cardiac components.

    abstract：OBJECTIVE:In view of their different actions on thyroid hormone receptor (TR) isoforms we set out to investigate whether amiodarone (AM) and dronedarone (Dron) have different and/or component-specific effects on cardiac gene expression. DESIGN:Rats were treated with AM or Dron and the expression of TRalpha 1, TRalpha ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-07-0017

    authors： Stoykov I,van Beeren HC,Moorman AF,Christoffels VM,Wiersinga WM,Bakker O

    更新日期：2007-06-01 00:00:00

  • 17 beta-estradiol stimulates a rapid Ca2+ influx in LNCaP human prostate cancer cells.

    abstract：:Prostate growth is known to be controlled by steroids such as androgens and estradiol. For this reason steroids (estradiol, adrenal androgens) or steroid inhibitors are commonly used as palliative treatments for prostate carcinoma. In view of the pivotal role played by Ca2+ ions in cell proliferation, we decided to in...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1350367

    authors： Audy MC,Vacher P,Duly B

    更新日期：1996-09-01 00:00:00

  • Incidence and prevalence of nutritional and hereditary rickets in southern Denmark.

    abstract：OBJECTIVE:To estimate the incidence of nutritional rickets and the incidence and prevalence of hereditary rickets. DESIGN:Population-based retrospective cohort study based on a review of medical records. METHODS:Patients aged 0-14.9 years referred to or discharged from hospitals in southern Denmark from 1985 to 2005 ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-08-0818

    authors： Beck-Nielsen SS,Brock-Jacobsen B,Gram J,Brixen K,Jensen TK

    更新日期：2009-03-01 00:00:00

  • A perspective on stem cells by a clinician.

    abstract：:Stem cell terminology has entered the lexicon of medical practitioners even though the application of harvesting stem cells to treat diseases other than haematological disorders is not yet a reality in clinical practice. All branches of medicine will be affected by the new technology, more so those related to regenera...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.151u003

    authors： Hughes IA

    更新日期：2004-11-01 00:00:00

  • The genetic characteristics of congenital hypothyroidism in China by comprehensive screening of 21 candidate genes.

    abstract：OBJECTIVE:Congenital hypothyroidism (CH), the most common neonatal metabolic disorder, is characterized by impaired neurodevelopment. Although several candidate genes have been associated with CH, comprehensive screening of causative genes has been limited. DESIGN AND METHODS:One hundred ten patients with primary CH w...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-17-1017

    authors： Sun F,Zhang JX,Yang CY,Gao GQ,Zhu WB,Han B,Zhang LL,Wan YY,Ye XP,Ma YR,Zhang MM,Yang L,Zhang QY,Liu W,Guo CC,Chen G,Zhao SX,Song KY,Song HD

    更新日期：2018-06-01 00:00:00

  • Evaluation of health-related quality of life in patients with Cushing's syndrome with a new questionnaire.

    abstract：UNLABELLED:Chronic exposure to hypercortisolism has significant impact on patient's health and health-related quality of life (HRQoL), as demonstrated with generic questionnaires. We have developed a disease-generated questionnaire to evaluate HRQoL in patients with Cushing's syndrome (CS; CushingQoL). OBJECTIVE:Valid...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-07-0762

    authors： Webb SM,Badia X,Barahona MJ,Colao A,Strasburger CJ,Tabarin A,van Aken MO,Pivonello R,Stalla G,Lamberts SW,Glusman JE

    更新日期：2008-05-01 00:00:00

  • Effects of N-methyl-D-aspartate and kainic acid on prolactin secretion in prepubertal female rats.

    abstract：:The control of prolactin (PRL) secretion by N-methyl-D-aspartate (NMDA) and kainic acid (KA), agonists of NMDA and kainate receptors, and the interactions between NMDA and KA with nitric oxide (NO) were analysed in prepubertal female rats. For this purpose, serum PRL concentrations and hypothalamic and pituitary dopam...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1350464

    authors： Pinilla L,González D,Tena-Sempere M,Aguilar R,Aguilar E

    更新日期：1996-10-01 00:00:00

  • Serum free insulin-like growth factor-I in growth hormone-deficient adults before and after growth hormone replacement.

    abstract：:The objective of the present study was to compare fasting levels of free IGF-I in serum from patients with adult onset growth hormone deficiency (GHD) and from healthy volunteers, and to examine the effect of GH replacement therapy in GHD on serum free IGF-I. Free IGF-I was measured using separation of free IGF-I by u...

    journal_title：European journal of endocrinology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1530/eje.0.1370132

    authors： Skjaerbaek C,Vahl N,Frystyk J,Hansen TB,Jørgensen JO,Hagen C,Christiansen JS,Orskov H

    更新日期：1997-08-01 00:00:00

  • Skeletal muscle mitochondrial function in polycystic ovarian syndrome.

    abstract：OBJECTIVE:Polycystic ovarian syndrome (PCOS) is associated with skeletal muscle insulin resistance (IR), which has been linked to decreased mitochondrial function. We measured mitochondrial respiration in lean and obese women with and without PCOS using high-resolution respirometry. METHODS:Hyperinsulinemic-euglycemic...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-11-0419

    authors： Rabøl R,Svendsen PF,Skovbro M,Boushel R,Schjerling P,Nilas L,Madsbad S,Dela F

    更新日期：2011-10-01 00:00:00

  • Validation of a next-generation sequencing (NGS) panel to improve the diagnosis of X-linked hypophosphataemia (XLH) and other genetic disorders of renal phosphate wasting.

    abstract：Background:Hypophosphataemic rickets (HR) comprise a clinically and genetically heterogeneous group of conditions, defined by renal-tubular phosphate wasting and consecutive loss of bone mineralisation. X-linked hypophosphataemia (XLH) is the most common form, caused by inactivating dominant mutations in PHEX, a gene e...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-20-0275

    authors： Thiele S,Werner R,Stubbe A,Hiort O,Hoeppner W

    更新日期：2020-11-01 00:00:00

  • Reduced microvascular perfusion and reactivity in adult GH deficient patients is restored by GH replacement.

    abstract：BACKGROUND:An increased cardiovascular risk and mortality in hypopituitary patients receiving conventional hormonal treatment without GH replacement have been shown in several studies. Various atherogenic risk factors including endothelial dysfunction - an early event in the atherogenesis - are more expressed in adults...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1470333

    authors： Hána V,Prázný M,Marek J,Skrha J,Justová V

    更新日期：2002-09-01 00:00:00

  • Food intake regulating hormones in adult craniopharyngioma patients.

    abstract：INTRODUCTION:Patients with craniopharyngioma (CP) have disturbances of the hypothalamic-pituitary axis and serious comorbidities such as obesity. We hypothesized that the secretion of hormones regulating the nutritional status is altered in adult patients with CP compared with patients with non-functioning pituitary ad...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-13-0832

    authors： Roemmler-Zehrer J,Geigenberger V,Störmann S,Losa M,Crippa V,Otto B,Bidlingmaier M,Dimopoulou C,Stalla GK,Schopohl J

    更新日期：2014-03-13 00:00:00

  • A thyroxine absorption test followed by weekly thyroxine administration: a method to assess non-adherence to treatment.

    abstract：OBJECTIVE:For patients who remain hypothyroid despite the administration of what would seem adequate doses of levothyroxine (L-T4), the underlying cause can be difficult to determine. The possibility of a biological cause should first be explored; however, in the majority of cases, poor adherence to medication is likel...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-12-1035

    authors： Walker JN,Shillo P,Ibbotson V,Vincent A,Karavitaki N,Weetman AP,Wass JA,Allahabadia A

    更新日期：2013-05-10 00:00:00

  • Intracellular depletion of insulin: a comparative study with palmitate, oleate and elaidate in INS-1 cells.

    abstract：OBJECTIVE:Free fatty acids (FFAs) deplete the intracellular insulin stores of pancreatic beta-cells. It has been suggested that this results from a lipotoxic dysregulation of both insulin secretion and insulin synthesis. In the present study, this hypothesis was tested within a 12-h time-course by directly relating the...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1480481

    authors： Bollheimer LC,Kemptner DM,Kagerbauer SM,Kestler TM,Wrede CE,Buettner R

    更新日期：2003-04-01 00:00:00

  • Density of ghrelin-producing cells is higher in the gastric mucosa of morbidly obese patients.

    abstract：BACKGROUND:Ghrelin is a peptide mainly secreted by gastric mucosa and has been implicated in the regulation of eating behavior and weight balance. Obesity and Helicobacter pylori infection are associated with changes in plasma ghrelin levels. OBJECTIVE:This study was designed to evaluate the density of ghrelin-produci...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-11-0201

    authors： Maksud FA,Alves JS,Diniz MT,Barbosa AJ

    更新日期：2011-07-01 00:00:00

  • Extremely low values of serum leptin in children with congenital generalized lipoatrophy.

    abstract：:Congenital generalized lipoatrophy (CGL) is a syndrome with multiple clinical manifestations and complete atrophy of adipose tissue. The exact mechanism of this disease remains unknown. One hypothesis presupposes an abnormal development of adipocytes. Leptin, the adipocyte-specific product of the ob gene, acts as a re...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1400107

    authors： Jaquet D,Khallouf E,Lévy-Marchal C,Czernichow P

    更新日期：1999-01-01 00:00:00

  • Infrequent mutations of p16INK4A and p15INK4B genes in human pituitary adenomas.

    abstract：:The p16INK4A and p15INK4B genes on chromosome 9p21 encode the p16 and p15 inhibitors of cyclin D/cyclin-dependent kinase 4 complexes respectively. Mutations and deletions of the p16INK4A gene have been found in melanomas and many other types of tumors. To assess the role of the p16INK4A and p15NK4B genes in tumorigene...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1360074

    authors： Yoshimoto K,Tanaka C,Yamada S,Kimura T,Iwahana H,Sano T,Itakura M

    更新日期：1997-01-01 00:00:00

  • Effect of insulin and growth hormone on the synthesis of radiolabelled proteoglycans from cultured human arterial smooth-muscle cells.

    abstract：:The present study focuses on the pathogenesis of increased frequency of large-vessel disease in diabetes. The diabetic arterial wall displays characteristic alterations of the extracellular matrix secreted by arterial smooth-muscle cells. The effects of insulin and growth hormone on the synthesis of sulphate-labelled ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1340326

    authors： Thøgersen VB,Heickendorff L,Ledet T

    更新日期：1996-03-01 00:00:00