当前位置： SCI文献检索 > EUROPEAN JOURNAL OF ENDOCRINOLOGY期刊下所有文献 > Thyroglobulin measurement using highly sensitive assays in patients with differentiated thyroid cancer: a clinical position paper.

Thyroglobulin measurement using highly sensitive assays in patients with differentiated thyroid cancer: a clinical position paper.

Abstract：

:Differentiated thyroid cancer (DTC) is the most common endocrine cancer and its incidence has increased in recent decades. Initial treatment usually consists of total thyroidectomy followed by ablation of thyroid remnants by iodine-131. As thyroid cells are assumed to be the only source of thyroglobulin (Tg) in the human body, circulating Tg serves as a biochemical marker of persistent or recurrent disease in DTC follow-up. Currently, standard follow-up for DTC comprises Tg measurement and neck ultrasound combined, when indicated, with an additional radioiodine scan. Measurement of Tg after stimulation by endogenous or exogenous TSH is recommended by current clinical guidelines to detect occult disease with a maximum sensitivity due to the suboptimal sensitivity of older Tg assays. However, the development of new highly sensitive Tg assays with improved analytical sensitivity and precision at low concentrations now allows detection of very low Tg concentrations reflecting minimal amounts of thyroid tissue without the need for TSH stimulation. Use of these highly sensitive Tg assays has not yet been incorporated into clinical guidelines but they will, we believe, be used by physicians caring for patients with DTC. The aim of this clinical position paper is, therefore, to offer advice on the various aspects and implications of using these highly sensitive Tg assays in the clinical care of patients with DTC.

journal_name

Eur J Endocrinol

journal_title

European journal of endocrinology

authors

Giovanella L,Clark PM,Chiovato L,Duntas L,Elisei R,Feldt-Rasmussen U,Leenhardt L,Luster M,Schalin-Jäntti C,Schott M,Seregni E,Rimmele H,Smit J,Verburg FA

doi

10.1530/EJE-14-0148

subject

Has Abstract

pub_date

2014-08-01 00:00:00

pages

R33-46

issue

2

eissn

0804-4643

issn

1479-683X

pii

EJE-14-0148

journal_volume

171

pub_type

共识发展会议,杂志文章,评审

相关文献

EUROPEAN JOURNAL OF ENDOCRINOLOGY文献大全
  • BclI glucocorticoid receptor polymorphism in relation to cardiovascular variables: the Hoorn and CODAM studies.

    abstract：OBJECTIVE:Excess glucocorticoids are known to cause hypertension and cardiovascular disease (CVD). The BclI glucocorticoid receptor (GR) polymorphism increases glucocorticoid sensitivity and is associated with adverse metabolic effects. Previous studies investigating cardiovascular implications have shown inconsistent ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-15-0381

    authors： van Moorsel D,van Greevenbroek MM,Schaper NC,Henry RM,Geelen CC,van Rossum EF,Nijpels G,'t Hart LM,Schalkwijk CG,van der Kallen CJ,Sauerwein HP,Dekker JM,Stehouwer CD,Havekes B

    更新日期：2015-10-01 00:00:00

  • Serum GH response to pharmacological stimuli and physical exercise in two siblings with two new inactivating mutations in the GH-releasing hormone receptor gene.

    abstract：OBJECTIVE:Inactivating mutations of the GH-releasing hormone receptor (GHRHR) gene (GHRHR) cause familial isolated GH deficiency (IGHD) type IB. The GH response to physical exercise (PE) in patients lacking GHRHR has never been studied. We hypothesized that subjects lacking functional GHRHR may be a model to study GH r...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1470591

    authors： Salvatori R,Fan X,Veldhuis JD,Couch R

    更新日期：2002-11-01 00:00:00

  • Continuous s.c. infusion rather than twice-daily injections of IGF-I more effectively increases serum IGF binding protein-3 in female monkeys.

    abstract：OBJECTIVE:In order to better understand how the IGF-I axis is affected by exogenous IGF-I, this study compared the effects of a constant s.c. infusion of IGF-I with that of twice-daily injections of IGF-I in young adult female rhesus monkeys. Clinical studies suggest that circulating concentrations of insulin-like grow...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1410303

    authors： Wilson ME,Lackey SL

    更新日期：1999-09-01 00:00:00

  • Renal stones and calcifications in patients with primary hyperparathyroidism: associations with biochemical variables.

    abstract：OBJECTIVE:To study the prevalence of renal stones and nephrocalcinosis in patients with primary hyperparathyroidism (PHPT) and to appraise biochemical variables as risk factors for developing renal calcifications. DESIGN:Cross-sectional. MATERIALS AND METHODS:All patients (n=177) undergoing diagnostic evaluation and ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-12-0032

    authors： Starup-Linde J,Waldhauer E,Rolighed L,Mosekilde L,Vestergaard P

    更新日期：2012-06-01 00:00:00

  • MANAGEMENT OF ENDOCRINE DISEASE: Rituximab therapy for Graves' orbitopathy - lessons from randomized control trials.

    abstract：:Rituximab (RTX) use in open-label series has been associated with very encouraging responses in patients with active and moderate-to-severe Graves' orbitopathy (GO). Recently, randomized controlled trials of RTX have been performed in such patients to answer the question of clinical efficacy and the safety profile of ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-16-0552

    authors： Stan MN,Salvi M

    更新日期：2017-02-01 00:00:00

  • Increased prevalence of polycystic ovary syndrome in premenopausal women with nonalcoholic fatty liver disease.

    abstract：OBJECTIVE:Limited data exist concerning the presence of polycystic ovary syndrome (PCOS) in premenopausal women with nonalcoholic fatty liver disease (NAFLD). We aimed to investigate the prevalence of PCOS in overweight and obese premenopausal women with NAFLD. DESIGN:Prospective, observational, and cross-sectional st...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-15-0567

    authors： Vassilatou E,Vassiliadi DA,Salambasis K,Lazaridou H,Koutsomitopoulos N,Kelekis N,Kassanos D,Hadjidakis D,Dimitriadis G

    更新日期：2015-12-01 00:00:00

  • Negative correlation between thyroperoxidase and dual oxidase H2O2-generating activities in thyroid nodular lesions.

    abstract：:Iodine incorporation into thyroglobulin is dependent on the activities of both thyroperoxidase (TPO) and thyroid dual oxidase 2 (DuOx2). Although TPO expression is decreased in some thyroid nodular lesions, DuOx1 and 2 mRNA expressions are maintained, but DuOx H2O2-generating activity has never been evaluated in such ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-07-0602

    authors： Ginabreda MG,Cardoso LC,Nobrega FM,Ferreira AC,Gonçalves MD,Vaisman M,Carvalho DP

    更新日期：2008-02-01 00:00:00

  • Quality of life is decreased in female patients treated for microprolactinoma.

    abstract：OBJECTIVE:Most studies on treatment of microprolactinoma have focused on clinical and biochemical outcome rather than on functional and mental well-being. We evaluated this topic in female patients with microprolactinoma, because other pituitary adenomas are associated with decreased quality of life. DESIGN:We conduct...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-07-0259

    authors： Kars M,van der Klaauw AA,Onstein CS,Pereira AM,Romijn JA

    更新日期：2007-08-01 00:00:00

  • Interactions between the extracellular domain and the extracellular loops as well as the 6th transmembrane domain are necessary for TSH receptor activation.

    abstract：OBJECTIVE:The molecular mechanisms of TSH receptor (TSHR) activation and intramolecular signal transduction are largely unknown. Deletion of the extracellular domain (ECD) of the TSHR results in increased constitutive activity, which suggests a self-inhibitory interaction between the ECD and the extracellular loops (EC...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.1.01891

    authors： Neumann S,Claus M,Paschke R

    更新日期：2005-04-01 00:00:00

  • Relationship between parathyroid calcium-sensing receptor expression and potency of the calcimimetic, cinacalcet, in suppressing parathyroid hormone secretion in an in vivo murine model of primary hyperparathyroidism.

    abstract：:Cinacalcet HCl, an allosteric modulator of the calcium-sensing receptor (CaR), has recently been approved for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease on dialysis, due to its suppressive effect on parathyroid hormone (PTH) secretion. Although cinacalcet's effects in patien...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.1.02007

    authors： Kawata T,Imanishi Y,Kobayashi K,Kenko T,Wada M,Ishimura E,Miki T,Nagano N,Inaba M,Arnold A,Nishizawa Y

    更新日期：2005-10-01 00:00:00

  • Ipilimumab: a novel immunomodulating therapy causing autoimmune hypophysitis: a case report and review.

    abstract：:Ipilimumab (Yervoy; Medarex and Bristol-Myers Squibb) is a human MAB against cytotoxic T-lymphocyte antigen 4, which enhances co-stimulation of cytotoxic T-lymphocytes, resulting in their proliferation and an anti-tumour response. It is licensed for the treatment of unresectable or metastatic malignant melanoma, while...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-12-0167

    authors： Juszczak A,Gupta A,Karavitaki N,Middleton MR,Grossman AB

    更新日期：2012-07-01 00:00:00

  • The therapeutic outcome to intravenous steroid therapy for active Graves' orbitopathy is influenced by the time of response but not polymorphisms of the glucocorticoid receptor.

    abstract：BACKGROUND:Glucocorticoids are the mainstay of immunosuppression for active moderate-severe Graves' orbitopathy (GO). AIM:To analyze the response to therapy and the contribution of glucocorticoid receptor (GR) gene polymorphisms to the therapeutic outcome of intravenous glucocorticoids (IVGC) in active moderate-severe...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-13-0611

    authors： Vannucchi G,Covelli D,Campi I,Origo D,Currò N,Cirello V,Dazzi D,Beck-Peccoz P,Salvi M

    更新日期：2013-11-22 00:00:00

  • Calcium mobilization is a prerequisite for the expression of phorbol ester-stimulated luteinizing hormone secretion from pituitaries of male and acutely ovariectomized rats.

    abstract：:Ionomycin, which mobilizes Ca2+, and phorbol 12-myristate 13-acetate (PMA), which activates protein kinase C (PKC), were used to compare the effects/interactions of Ca2+ and PKC on luteinizing hormone (LH) secretion from pituitaries of intact male and acutely ovariectomized (72 h) rats. Quartered pituitaries from dono...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1300151

    authors： Das S,Fahmy NW,Bourne GA

    更新日期：1994-02-01 00:00:00

  • Growth hormone-releasing activity of growth hormone-releasing peptide-6 is maintained after short-term oral pretreatment with the hexapeptide in normal aging.

    abstract：:The reduced activity of the growth hormone (GH)-insulin-like growth factor I (IGF-I) axis in aging may contribute to changes in body composition. As this GH insufficiency is due to hypothalamic pathogenesis, the availability of GH-releasing peptides (GHRPs), such as GHRP-6 (His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) which is ac...

    journal_title：European journal of endocrinology

    pub_type： 临床试验,杂志文章

    doi：10.1530/eje.0.1310499

    authors： Ghigo E,Arvat E,Rizzi G,Goffi S,Grottoli S,Mucci M,Boghen MF,Camanni F

    更新日期：1994-11-01 00:00:00

  • Single nucleotide polymorphisms in the intergenic region between metformin transporter OCT2 and OCT3 coding genes are associated with short-term response to metformin monotherapy in type 2 diabetes mellitus patients.

    abstract：OBJECTIVES:High variability in clinical response to metformin is often observed in type 2 diabetes (T2D) patients, and it highlights the need for identification of genetic components affecting the efficiency of metformin therapy. Aim of this observational study is to evaluate the role of tagSNPs (tagging single nucleot...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-16-0347

    authors： Zaharenko L,Kalnina I,Geldnere K,Konrade I,Grinberga S,Židzik J,Javorský M,Lejnieks A,Nikitina-Zake L,Fridmanis D,Peculis R,Radovica-Spalvina I,Hartmane D,Pugovics O,Tkáč I,Klimčáková L,Pīrāgs V,Klovins J

    更新日期：2016-12-01 00:00:00

  • Serum leptin levels in children and adolescents with insulin-dependent diabetes mellitus in relation to metabolic control and body mass index.

    abstract：:The ob protein, termed leptin, is produced by adipocytes and is thought to act as an afferent satiety signal regulating weight through suppressing appetite and stimulating energy expenditure in humans and/or rodents. Insulin has been found to be a potent stimulator of leptin expression in rodents. It is unclear at pre...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1380501

    authors： Kiess W,Anil M,Blum WF,Englaro P,Juul A,Attanasio A,Dötsch J,Rascher W

    更新日期：1998-05-01 00:00:00

  • Autosomal dominant osteopetrosis revisited: lessons from recent studies.

    abstract：:Systematic studies of autosomal dominant osteopetrosis (ADO) were followed by the identification of underlying mutations giving unique possibilities to perform translational studies. What was previously designated ADO1 turned out to be a high bone mass phenotype caused by a missense mutation in the first propeller of ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-13-0136

    authors： Bollerslev J,Henriksen K,Nielsen MF,Brixen K,Van Hul W

    更新日期：2013-07-13 00:00:00

  • DNA methylation profiling in MEN1-related pancreatic neuroendocrine tumors reveals a potential epigenetic target for treatment.

    abstract：OBJECTIVE:Epigenetic changes contribute to pancreatic neuroendocrine tumor (PanNET) development. Hypermethylation of promoter DNA as a cause of tumor suppressor gene silencing is a well-established oncogenic mechanism that is potentially reversible and therefore an interesting therapeutic target. Multiple endocrine neo...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-18-0195

    authors： Conemans EB,Lodewijk L,Moelans CB,Offerhaus GJA,Pieterman CRC,Morsink FH,Dekkers OM,de Herder WW,Hermus AR,van der Horst-Schrivers AN,Drent ML,Bisschop PH,Havekes B,Brosens LAA,Dreijerink KMA,Borel Rinkes IHM,Timmers HTM

    更新日期：2018-09-01 00:00:00

  • Catecholamine production in patients with gastroenteropancreatic neuroendocrine tumors.

    abstract：OBJECTIVE:Amine precursor uptake and decarboxylation is a classical feature of gastroenteropancreatic (GEP) neuroendocrine tumors (NET). Production of catecholamines was studied in GEP NET and non-NET patients. DESIGN:A cross-sectional study was undertaken. METHODS:We studied catecholamine and metabolite secretion in...

    journal_title：European journal of endocrinology

    pub_type： 临床试验,杂志文章

    doi：10.1530/eje.0.1400434

    authors： Ciofu A,Baudin E,Chanson P,Cailleux AF,Comoy E,Sabourin JC,Ducreux M,Schaison G,Schlumberger M

    更新日期：1999-05-01 00:00:00

  • Thirst perception and arginine vasopressin production in a kindred with an activating mutation of the type 2 vasopressin receptor: the pathophysiology of nephrogenic syndrome of inappropriate antidiuresis.

    abstract：BACKGROUND:Activating mutations of the vasopressin receptor gene on the X chromosome cause the nephrogenic syndrome of inappropriate antidiuresis (NSIAD). We describe a male child who presented with persistent hyponatraemia and whose mother was also found to be hyponatraemic. She had learnt to avoid excess fluid consum...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-09-0246

    authors： Gupta S,Cheetham TD,Lambert HJ,Roberts C,Bourn D,Coulthard MG,Ball SG

    更新日期：2009-09-01 00:00:00

  • Low dose cabergoline for hyperprolactinaemia is not associated with clinically significant valvular heart disease.

    abstract：OBJECTIVE:Recent trials suggest that using ergot-derived dopamine agonists such as cabergoline in the treatment of Parkinson's disease is associated with an increased risk of valvular heart disease. However, the dose of cabergoline used to treat hyperprolactinaemia is considerably less than that used in Parkinson's dis...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-08-0365

    authors： Wakil A,Rigby AS,Clark AL,Kallvikbacka-Bennett A,Atkin SL

    更新日期：2008-10-01 00:00:00

  • Treatment of inoperable or metastatic paragangliomas and pheochromocytomas with peptide receptor radionuclide therapy using 177Lu-DOTATATE.

    abstract：Objectives:Inoperable or metastatic paragangliomas (PGLs) and malignant pheochromocytomas (PCCs) are rare tumours with limited options for systemic treatment. Aim of this study was to assess the safety and efficacy of the radiolabelled somatostatin analogue (177LutetiumDOTA0-Tyr3)octreotate (177Lu-DOTATATE) for the tre...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-18-0901

    authors： Zandee WT,Feelders RA,Smit Duijzentkunst DA,Hofland J,Metselaar RM,Oldenburg RA,van Linge A,Kam BLR,Teunissen JJM,Korpershoek E,Hendriks JM,Abusaris H,Slagter C,Franssen GJH,Brabander T,De Herder WW

    更新日期：2019-07-01 00:00:00

  • Low-dose GH improves exercise capacity in adults with GH deficiency: effects of a 22-month placebo-controlled, crossover trial.

    abstract：:Fifty-five patients with adult-onset GH deficiency (mean age, 49 years) were enrolled in a placebo-controlled, crossover study to investigate the effects of GH therapy on exercise capacity, body composition, and quality of life (QOL). GH and placebo were administered for 9 months each, separated by a 4-month washout p...

    journal_title：European journal of endocrinology

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1530/eje.1.01971

    authors： Bollerslev J,Hallén J,Fougner KJ,Jørgensen AP,Kristo C,Fagertun H,Gudmundsen O,Burman P,Schreiner T

    更新日期：2005-09-01 00:00:00

  • Predictors of access to pituitary tumor resection in the United States, 1988-2005.

    abstract：OBJECTIVE:Surgery remains a common form of treatment for sellar and parasellar tumors involving the pituitary gland and adjacent structures. Studies have suggested that pituitary surgery procedures performed at high-volume centers are associated with less adverse outcomes, yet it remains unclear which types of patients...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-09-0043

    authors： Mukherjee D,Zaidi HA,Kosztowski T,Chaichana KL,Salvatori R,Chang DC,Quiñones-Hinojosa A

    更新日期：2009-08-01 00:00:00

  • Osteoporosis and male age-related hypogonadism: role of sex steroids on bone (patho)physiology.

    abstract：:Male age-related bone loss is caused, at least in part, by hypogonadism that occurs with advancing age. The study of the effects of sex steroids on bone physiology in men has recently highlighted the central role of estrogens on bone pathophysiology. This review focuses on particular aspects of bone physiology and pat...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/eje.1.02088

    authors： Rochira V,Balestrieri A,Madeo B,Zirilli L,Granata AR,Carani C

    更新日期：2006-02-01 00:00:00

  • Decreased expression of thyrotropin receptor gene suggests a high-risk subgroup for oncocytic adenoma.

    abstract：OBJECTIVE:The malignancy of thyroid oncocytic tumours, or oncocytomas, is higher than that of follicular tumours. The aim of this study was to investigate the role of thyroid-specific genes in oncocytic tumours and papillary carcinomas. DESIGN AND METHODS:We compared 29 oncocytic tumours with 12 papillary carcinomas. ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1500269

    authors： Mirebeau-Prunier D,Guyétant S,Rodien P,Franc B,Baris O,Rohmer V,Reynier P,Tourmen Y,Malthièry Y,Savagner F

    更新日期：2004-03-01 00:00:00

  • ESE audit on management of Adult Growth Hormone Deficiency in clinical practice.

    abstract：:Guidelines recommend adults with pituitary disease in whom GH therapy is contemplated, to be tested for GH deficiency (AGHD); however, clinical practice is not uniform. AIMS:1) To record current practice of AGHD management throughout Europe and benchmark it against guidelines; 2) To evaluate educational status of hea...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-20-1180

    authors： Martel-Duguech LM,Jorgensen JOL,Korbonits M,Johannsson G,Webb SM,Amadidou F,Mintziori G,Arosio M,Giavoli C,Badiu C,Boschetti M,Ferone D,Ricci Bitti S,Brue T,Albarel F,Cannavò S,Cotta OR,Carvalho D,Salazar D,Christ E

    更新日期：2020-12-01 00:00:00

  • Impact of metformin and rosiglitazone treatment on glucose transporter 4 mRNA expression in women with polycystic ovary syndrome.

    abstract：OBJECTIVE:The insulin-resistant state of the polycystic ovary syndrome (PCOS) was found to be associated with a decreased glucose transporter GLUT4 expression in the insulin target tissues. This study was performed to explore whether the well-known clinical, hormonal and metabolic efficacy of metformin or rosiglitazone...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,随机对照试验

    doi：10.1530/EJE-07-0857

    authors： Jensterle M,Janez A,Mlinar B,Marc J,Prezelj J,Pfeifer M

    更新日期：2008-06-01 00:00:00

  • Plasma methoxytyramine: clinical utility with metanephrines for diagnosis of pheochromocytoma and paraganglioma.

    abstract：CONTEXT:Measurements of plasma methoxytyramine, the O-methylated dopamine metabolite, are useful for detecting rare dopamine-producing pheochromocytomas and paragangliomas (PPGLs) and head and neck paragangliomas (HNPGLs), but utility for screening beyond that achieved using standard measurements of normetanephrine and...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,多中心研究

    doi：10.1530/EJE-17-0077

    authors： Rao D,Peitzsch M,Prejbisz A,Hanus K,Fassnacht M,Beuschlein F,Brugger C,Fliedner S,Langton K,Pamporaki C,Gudziol V,Stell A,Januszewicz A,Timmers HJLM,Lenders JWM,Eisenhofer G

    更新日期：2017-08-01 00:00:00

  • In vitro and in vivo herpetic vector-mediated gene transfer in the pituitary gland: impact on hormone secretion.

    abstract：OBJECTIVE:Herpes simplex virus type 1 (HSV-1)-derived vectors are known to be effective tools to deliver transgenes into normal and neoplastic anterior pituitary (AP) cells in vitro. Our objective was to assess the in vitro and in vivo effects of tsK/beta-gal, a temperature-sensitive HSV-1-derived vector harbouring the...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1450497

    authors： Bolognani F,Albariño C,Romanowski V,Carri NG,Goya RG

    更新日期：2001-10-01 00:00:00