Management of osteoporosis in children.

abstract：:Glycoprotein hormone alpha-subunit (alpha SU) is a recognized product of clinically non-functioning, glycoprotein hormone-secreting and somatotroph adenomas but has not been studied systematically in corticotroph tumours. We have performed immunohistochemistry for alpha SU in a consecutive series of four corticotroph ...

journal_title：European journal of endocrinology

authors： Desai B,Burrin JM,Nott CA,Geddes JF,Lamb EJ,Aylwin SJ,Wood DF,Thakkar C,Monson JP

更新日期：1995-07-01 00:00:00

abstract：:Male age-related bone loss is caused, at least in part, by hypogonadism that occurs with advancing age. The study of the effects of sex steroids on bone physiology in men has recently highlighted the central role of estrogens on bone pathophysiology. This review focuses on particular aspects of bone physiology and pat...

journal_title：European journal of endocrinology

authors： Rochira V,Balestrieri A,Madeo B,Zirilli L,Granata AR,Carani C

更新日期：2006-02-01 00:00:00

abstract：OBJECTIVE:Primary hyperparathyroidism (pHPT) is characterized by excessive production of parathyroid hormone (PTH) due to parathyroid adenomas while uremic secondary HPT (sHPT) is caused by parathyroid hyperplasia in response to renal failure. Active vitamin D, 1,25-dihydroxyvitamin D(3) (1,25-(OH)(2)D(3)), with the vi...

journal_title：European journal of endocrinology

authors： Correa P,Akerstrom G,Westin G

更新日期：2002-11-01 00:00:00

abstract：OBJECTIVE:Amine precursor uptake and decarboxylation is a classical feature of gastroenteropancreatic (GEP) neuroendocrine tumors (NET). Production of catecholamines was studied in GEP NET and non-NET patients. DESIGN:A cross-sectional study was undertaken. METHODS:We studied catecholamine and metabolite secretion in...

journal_title：European journal of endocrinology

authors： Ciofu A,Baudin E,Chanson P,Cailleux AF,Comoy E,Sabourin JC,Ducreux M,Schaison G,Schlumberger M

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:Familial neurohypophyseal (central) diabetes insipidus (DI) is caused by mutations in the arginine vasopressin-neurophysin II (AVP-NPII) gene. The majority of cases is inherited in an autosomal dominant way. In this study, we present the clinical features of a mother and her son with autosomal dominant neuro...

journal_title：European journal of endocrinology

authors： de Fost M,van Trotsenburg AS,van Santen HM,Endert E,van den Elzen C,Kamsteeg EJ,Swaab DF,Fliers E

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVE:Vascular endothelial growth factor (VEGF) exists in three main splice variants, characterized by 121, 165 and 189 amino acids (VEGF 121, VEGF 165 and VEGF 189) and acts via two specific receptors: VEGF-R1 or Flt-1 and VEGF-R2 or KDR. VEGF plays an important role in the pathogenesis of diabetic retinopathy. Th...

journal_title：European journal of endocrinology

authors： Bortoloso E,Del Prete D,Dalla Vestra M,Gambaro G,Saller A,Antonucci F,Baggio B,Anglani F,Fioretto P

更新日期：2004-06-01 00:00:00

abstract：CONTEXT AND OBJECTIVE:Arterial stimulation and venous sampling (ASVS) is an important technique for localizing insulinoma. The principle behind ASVS is that insulin secretion is promoted from insulinoma cells by the injection of calcium into the insulinoma-feeding artery. However, the mechanism for ASVS-induced insulin...

journal_title：European journal of endocrinology

authors： Ono Y,Oda N,Ishihara S,Shimomura A,Hayakawa N,Suzuki A,Horiguchi A,Senda T,Miyakawa S,Itoh M

更新日期：2008-07-01 00:00:00

abstract：CONTEXT:Acromegaly is a rare disease associated with chronic multisystem complications. National registries have been created in several countries. DESIGN:The French Registry contains data on acromegaly epidemiology, management and comorbidities recorded over more than three decades, retrospectively until 1999 and pro...

journal_title：European journal of endocrinology

authors： Maione L,Brue T,Beckers A,Delemer B,Petrossians P,Borson-Chazot F,Chabre O,François P,Bertherat J,Cortet-Rudelli C,Chanson P,French Acromegaly Registry Group.

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVE:Disturbed renal function may play an important role in the clinico-pathological presentation of primary hyperparathyroidism (pHPT). We studied the influence of renal function on the clinico-pathological characteristics of 141 patients (123 women and 18 men) with surgically proven pHPT. METHODS:The 141 patien...

journal_title：European journal of endocrinology

authors： Yamashita H,Noguchi S,Uchino S,Watanabe S,Murakami T,Ogawa T,Masatsugu T,Takamatsu Y,Miyatake E,Yamashita H

更新日期：2003-06-01 00:00:00

abstract：OBJECTIVE:Mutations in HESX1 represent a rare cause of GH deficiency (GHD) associated with a broad spectrum of other anomalies. We searched for causative mutations in a cohort of 244 Italian patients affected by combined and isolated GHD (IGHD). METHODS:The HESX1 gene-coding region and exon-intron boundaries were scre...

journal_title：European journal of endocrinology

authors： Vivenza D,Godi M,Faienza MF,Mellone S,Moia S,Rapa A,Petri A,Bellone S,Riccomagno S,Cavallo L,Giordano M,Bona G

更新日期：2011-05-01 00:00:00

abstract：OBJECTIVE:Confirmatory testing of suspected primary aldosteronism (PA) requires an extensive medication switch that can be difficult for patients with severe complicated hypertension and/or refractory hypokalemia. For this reason, we investigated the effect of chronic antihypertensive medication on confirmatory testing...

journal_title：European journal of endocrinology

authors： Solar M,Malirova E,Ballon M,Pelouch R,Ceral J

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVE:The malignancy of thyroid oncocytic tumours, or oncocytomas, is higher than that of follicular tumours. The aim of this study was to investigate the role of thyroid-specific genes in oncocytic tumours and papillary carcinomas. DESIGN AND METHODS:We compared 29 oncocytic tumours with 12 papillary carcinomas. ...

journal_title：European journal of endocrinology

authors： Mirebeau-Prunier D,Guyétant S,Rodien P,Franc B,Baris O,Rohmer V,Reynier P,Tourmen Y,Malthièry Y,Savagner F

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:Differences in circulating steroid hormone levels have been hypothesized to explain ethnic differences in steroid-related diseases. The aim of this study was to determine the serum levels of a wide panel of steroid hormones, both androgens and estrogens, in healthy middle-aged African-Caribbean and European ...

journal_title：European journal of endocrinology

authors： Giton F,Fiet J,Cornu JN,Cussenot O,Bélanger A,Urien S,Oliva A,Blanchet P,Multigner L

更新日期：2011-12-01 00:00:00

abstract：CONTEXT:The TIMES2 (testosterone replacement in hypogonadal men with either metabolic syndrome or type 2 diabetes) study reported beneficial effects of testosterone replacement therapy (TRT) on insulin resistance and other variables in men with diabetes or metabolic syndrome. The androgen receptor CAG repeat polymorphi...

journal_title：European journal of endocrinology

authors： Stanworth RD,Akhtar S,Channer KS,Jones TH

更新日期：2013-12-21 00:00:00

abstract：:Glucocorticoids are potent osteopenic agents, producing negative calcium and bone balance via actions at many sites. The most significant adverse effects of glucocorticoid drugs on the skeleton are probably a direct inhibition of matrix synthesis by the osteoblast, reductions in calcium absorption in both the gut and ...

journal_title：European journal of endocrinology

authors： Reid IR

更新日期：1997-09-01 00:00:00

abstract：OBJECTIVE:In the field of fine-needle aspiration cytology, the category of suspicious for malignancy (SM) thyroid lesions, that bears 55-85% risk of malignant histology, is a challenging topic in which morphology alone is not always able to make a correct diagnosis. Recently, immunocytochemistry (ICC) has been referred...

journal_title：European journal of endocrinology

authors： Rossi ED,Martini M,Capodimonti S,Straccia P,Cenci T,Lombardi CP,Pontecorvi A,Larocca LM,Fadda G

更新日期：2013-05-02 00:00:00

abstract：:In the last few years, molecular studies on pituitary adenomas have yielded evidence supporting a primary pituitary origin of these tumors. Although the existence of genomic alterations in tumoral cells is strongly suggested by the fact that almost all pituitary adenomas are monoclonal in origin, structural genetic ab...

journal_title：European journal of endocrinology

authors： Spada A,Vallar L,Faglia G

更新日期：1994-01-01 00:00:00

abstract：OBJECTIVE:Muscle mass plays an important role in determining cardiovascular and metabolic risks in polycystic ovary syndrome (PCOS). In addition, whether lean mass influences carotid intima-media thickness (IMT) in PCOS has not been assessed. DESIGN:Prospective investigation. METHODS:Ninety-five women with PCOS were ...

journal_title：European journal of endocrinology

authors： Carmina E,Guastella E,Longo RA,Rini GB,Lobo RA

更新日期：2009-10-01 00:00:00

abstract：OBJECTIVE:GHRH is secreted by the hypothalamus and, upon binding to specific GHRH receptors in the pituitary, stimulates growth hormone (GH) production and release from the pituitary. In addition to this neuroendocrine action, accumulated evidence implies additional roles for GHRH in carcinogenesis in non-pituitary tis...

journal_title：European journal of endocrinology

authors： Chatzistamou I,Schally AV,Kiaris H,Politi E,Varga J,Kanellis G,Kalofoutis A,Pafiti A,Koutselini H

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVE:Pretibial myxedema (PM) is a manifestation of Graves' disease (GD). Currently, its diagnosis depends on physicians' observation and biopsy. No satisfactory, objective, and non-invasive tool is available to record and investigate lesions. Digital infrared thermal imaging (DITI) detects surface temperature, and...

journal_title：European journal of endocrinology

authors： Shih SR,Lin MS,Li HY,Yang HY,Hsiao YL,Chang MT,Chen CM,Chang TC

更新日期：2011-04-01 00:00:00

abstract：:We investigated the ontogeny of melatonin synthesis during fetal maturation by measuring the melatonin (MLT) and 6-hydroxymelatonin sulfate (MLTS) excretion in the urine of male infants aged 2-7 days and gestational age 26-42 weeks. We found a negative correlation between advancing gestational age and the MLT and MLTS...

journal_title：European journal of endocrinology

authors： Commentz JC,Henke A,Dammann O,Hellwege HH,Willig RP

更新日期：1996-08-01 00:00:00

abstract：OBJECTIVE:Short stature caused by point mutations or deletions of the short stature homeobox (SHOX) gene (SHOX haploinsufficiency (SHI)) is a registered indication for GH treatment. Patients with a SHOX enhancer deletion (SED) have a similar phenotype, but their response to GH is unknown. It is uncertain if duplication...

journal_title：European journal of endocrinology

authors： Donze SH,Meijer CR,Kant SG,Zandwijken GR,van der Hout AH,van Spaendonk RM,van den Ouweland AM,Wit JM,Losekoot M,Oostdijk W

更新日期：2015-11-01 00:00:00

abstract：DESIGN:The aim of this study was to determine the association between aging and adiponectin level from the aspect of the influence of renal function and sex hormones in humans. METHODS:Serum adiponectin and blood urea nitrogen (BUN) levels were measured in 964 subjects (372 males) aged 60.3+/-12.5 years. Testosterone ...

journal_title：European journal of endocrinology

authors： Isobe T,Saitoh S,Takagi S,Takeuchi H,Chiba Y,Katoh N,Shimamoto K

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVE AND DESIGN:Patients with type 2 diabetes mellitus (T2D) have an increased fracture risk despite a normal or elevated bone mineral density (BMD). The aim of this cross-sectional in vivo study was to assess parameters of peripheral bone microarchitecture, estimated bone strength and bone remodeling in T2D patie...

journal_title：European journal of endocrinology

authors： Shanbhogue VV,Hansen S,Frost M,Jørgensen NR,Hermann AP,Henriksen JE,Brixen K

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVE:Familial isolated primary hyperparathyroidism (FIHP) is defined as hereditary primary hyperparathyroidism without the association of other diseases or tumors. Linkage analyses suggest that different genotypes can lead to the same phenotype of primary hyperparathyroidism. Hereditary syndromes associated with p...

journal_title：European journal of endocrinology

authors： Miedlich S,Lohmann T,Schneyer U,Lamesch P,Paschke R

更新日期：2001-08-01 00:00:00

abstract：:Endocrine complications are frequently observed in childhood cancer survivors (CCS). One of two CCS will experience at least one endocrine complication during the course of his/her lifespan, most commonly as a late-effect of cancer treatments, especially radiotherapy and alkylating agent chemotherapy. Endocrine late-e...

journal_title：European journal of endocrinology

authors： Chemaitilly W,Cohen LE

更新日期：2017-04-01 00:00:00

abstract：:The strategy for diagnosis of primary aldosteronism (PA) in the hypertensive population includes firstly a screening step, based on the measurement of plasma aldosterone-to-renin ratio (ARR), a test which must have high sensitivity, and secondly a confirmatory step based on the demonstration of excessive aldosterone p...

journal_title：European journal of endocrinology

authors： Morera J,Reznik Y

更新日期：2019-02-01 00:00:00

abstract：:This is a brief review of the normal changes in adolescent behaviour and the interplay between biology and social factors that occur at and around puberty, in an attempt to explain when this transition may become problematic The onset of puberty is a biological marker for an individual's transition from a non-reproduc...

journal_title：European journal of endocrinology

authors： Waylen A,Wolke D

更新日期：2004-11-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to evaluate the effect of intraoperative high-field (1.5 Tesla) magnetic resonance imaging (MRI) on the results of transsphenoidal surgery of GH-secreting pituitary macroadenomas. METHODS:Twenty-three acromegalic patients (mean tumor size, 25 +/- 12 mm; untreated preoperative GH, 4.2...

journal_title：European journal of endocrinology

authors： Fahlbusch R,Keller Bv,Ganslandt O,Kreutzer J,Nimsky C

更新日期：2005-08-01 00:00:00

abstract：OBJECTIVE:Untreated hypothyroidism is common in iodine-replete areas. Frequent thyroid function testing and use of levothyroxine treatment for subclinical hypothyroidism suggest that the prevalence may have decreased. Therefore, in this study, we examined changes in the prevalence of hypothyroidism in a Norwegian count...

journal_title：European journal of endocrinology

authors： Asvold BO,Vatten LJ,Bjøro T

更新日期：2013-10-01 00:00:00