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Urinary gonadotropin peptide as acute phase reactant: transient elevation after operation for digestive diseases.

Abstract：

OBJECTIVE:In order to characterize urinary gonadotropin peptide (UGP) as an acute phase reactant, we focused on the UGP levels after surgical operation. DESIGN:Fifty cases of gastrointestinal cancer, 4 cases of cancers of other organs and 13 cases of benign digestive diseases were enrolled into this study. METHODS:UGP levels were measured using an enzyme immunoassay before and after surgery. RESULTS:Fifty-four (80.6%) of the 67 cases studied showed transient elevations of UGP. Both urinary interleukin (IL)-6 and LH levels were also increased transiently in 49 cases (73.1%). All of these three factors were increased in 38 cases (56.7%), and in 32 (84.2%) of these 38 cases, the order of peak appearance was as follows: IL-6, LH, and UGP. The UGP levels in the group of total gastrectomy were significantly higher than those in the group of partial gastrectomy. CONCLUSIONS:These results suggest that UGP shows a transient peak after surgery, correlating with levels of cytokines such as IL-6. UGP may be an acute phase reactant, and its levels are correlated with the grade of surgical stress.

journal_name

Eur J Endocrinol

journal_title

European journal of endocrinology

authors

Motoo Y,Watanabe H,Okai T,Sawabu N

doi

10.1530/eje.0.1400555

subject

Has Abstract

pub_date

1999-06-01 00:00:00

pages

555-60

issue

6

eissn

0804-4643

issn

1479-683X

pii

1400555

journal_volume

140

pub_type

临床试验,杂志文章

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