Abstract：
:A pheochromocytoma in a pregnant patient is one of the most threatening medical conditions for mother, fetus, and physician. Although extraordinarily rare with a frequency of 0.002% of all pregnancies, this tumor is notorious for its devastating consequences. As in non-pregnant patients, the signs and symptoms are quite variable but not specific, with hypertension being one of the most prominent signs. Confusion with the much more prevalent forms of pregnancy-related hypertension is the main cause of overlooking the diagnosis. If undiagnosed, maternal and fetal mortality is around 50%. Conversely, early detection and proper treatment during pregnancy decrease the maternal and fetal mortality to <5 and 15% respectively. For the biochemical diagnosis, plasma or urinary metanephrines are the tests of first choice since they have a nearly maximal negative predictive value. For reliable localization, only magnetic resonance imaging is suitable, with a sensitivity of more than 90%. When the tumor is diagnosed in the first 24 weeks of gestation, it should be removed by laparoscopic adrenalectomy after 10-14 days of medical preparation with the same drugs as in non-pregnant patients. If the tumor is diagnosed in the third trimester, the patient should be managed until the fetus is viable using the same drug regimen as for regular surgical preparation. Cesarean section with tumor removal in the same session or at a later stage is then preferred since vaginal delivery is possibly associated with higher mortality. Despite all technical diagnostic and therapeutic progress over the last decades, the key factor for further reduction of maternal and fetal mortality is early awareness and recognition of the potential presence of a pheochromocytoma in a pregnant patient with hypertension.
journal_name
Eur J Endocrinoljournal_title
European journal of endocrinologyauthors
Lenders JWdoi
10.1530/EJE-11-0528subject
Has Abstractpub_date
2012-02-01 00:00:00pages
143-50issue
2eissn
0804-4643issn
1479-683Xpii
EJE-11-0528journal_volume
166pub_type
杂志文章,评审abstract：OBJECTIVE:To i) compare incretin responses to oral glucose and mixed meal of diabetic patients with the normoglycaemic population and ii) to investigate whether incretin responses are associated with hypertriglyceridaemia and alanine aminotransferase (ALT) as liver fat marker. DESIGN:A population-based study. METHODS...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-13-0487
更新日期：2013-09-12 00:00:00
abstract：:Glucocorticoids are potent osteopenic agents, producing negative calcium and bone balance via actions at many sites. The most significant adverse effects of glucocorticoid drugs on the skeleton are probably a direct inhibition of matrix synthesis by the osteoblast, reductions in calcium absorption in both the gut and ...
journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1530/eje.0.1370209
更新日期：1997-09-01 00:00:00
abstract：Background:If biochemical control of acromegaly is not achieved by operation and medication, radiotherapy may be indicated. Objective:To describe fractionated radiotherapy (FRT) and stereotactic radiosurgery (SRS) regarding excess of IGF-1 and pituitary function. Design and methods:A retrospective analysis of 352 pat...
journal_title：European journal of endocrinology
pub_type： 杂志文章
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journal_title：European journal of endocrinology
pub_type： 杂志文章
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更新日期：2012-08-01 00:00:00
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journal_title：European journal of endocrinology
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doi：10.1530/EJE-15-0185
更新日期：2015-07-01 00:00:00
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journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1460209
更新日期：2002-02-01 00:00:00
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journal_title：European journal of endocrinology
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doi：10.1530/eje.0.1460067
更新日期：2002-01-01 00:00:00
abstract：OBJECTIVE:A significant decrease in vitamin D receptor (VDR) and calcium-sensing receptor (CaSR) protein expression has been demonstrated recently in parathyroid (PT) adenomas. In this study, we investigated the relationships between the proliferative activity of parathyroid glands (PTGs) and the expression of VDR as w...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1480403
更新日期：2003-04-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2001-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1530/EJE-07-0502
更新日期：2008-03-01 00:00:00
abstract：:Activating mutations of G proteins, which are membrane signal transducers, have been associated recently with the development of various endocrine neoplasms. Mutations of two highly conserved codons, Arg201 and Gln227, in the alpha-subunit of the Gs protein, the adenylyl cyclase-stimulating protein, were first describ...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1330166
更新日期：1995-08-01 00:00:00
abstract：:Iodine incorporation into thyroglobulin is dependent on the activities of both thyroperoxidase (TPO) and thyroid dual oxidase 2 (DuOx2). Although TPO expression is decreased in some thyroid nodular lesions, DuOx1 and 2 mRNA expressions are maintained, but DuOx H2O2-generating activity has never been evaluated in such ...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-07-0602
更新日期：2008-02-01 00:00:00
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journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
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更新日期：2002-01-01 00:00:00
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journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1370040
更新日期：1997-07-01 00:00:00
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journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-13-0306
更新日期：2013-09-12 00:00:00
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journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1320771
更新日期：1995-06-01 00:00:00
abstract：OBJECTIVE:The acute decrease in iodide organification in the thyroid in response to excess iodide is termed the acute Wolff-Chaikoff effect and normal organification resumes in spite of continued high plasma iodide concentrations (escape from the acute Wolff-Chaikoff effect). We have recently reported that large doses ...
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pub_type： 杂志文章
doi：10.1530/eje.0.1440139
更新日期：2001-02-01 00:00:00
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doi：10.1530/eje.0.1420263
更新日期：2000-03-01 00:00:00
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doi：10.1530/eje.0.1410231
更新日期：1999-09-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2019-06-01 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：2003-08-01 00:00:00
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journal_title：European journal of endocrinology
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更新日期：2014-03-08 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2008-12-01 00:00:00
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journal_title：European journal of endocrinology
pub_type： 临床试验,杂志文章
doi：10.1530/eje.0.1430657
更新日期：2000-11-01 00:00:00
abstract：:We report our experience in treating growth delay in boys with isolated growth hormone deficiency (IGHD) receiving biosynthetic human growth hormone. The study was performed in 15 boys with IGHD receiving GH. At the chronological age of 13.1 (1.1) years (SD), 13 were prepubertal, two were in early puberty and there wa...
journal_title：European journal of endocrinology
pub_type： 杂志文章
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更新日期：1994-01-01 00:00:00
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journal_title：European journal of endocrinology
pub_type： 杂志文章
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更新日期：1997-11-01 00:00:00
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更新日期：2016-02-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1530/eje.0.1350238
更新日期：1996-08-01 00:00:00
abstract：INTRODUCTION:Activating mutations of the BRAF oncogene are frequently detected in papillary thyroid carcinoma (PTC) and have been associated with a worse prognosis. The amino acid substitution V600E accounts for 90% of all oncogenic BRAF mutations and is typically detected in classic PTCs, whereas other less frequent B...
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pub_type： 杂志文章
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更新日期：2008-07-01 00:00:00
abstract：:To study the involvement of gonadotropin-releasing hormone (GnRH) in glycosylation of circulating gonadotropin isoforms in anorexia nervosa (AN), 14 amenorrhoic patients with AN, 14 age-matched volunteers in early follicular phase, and five normal-weight re-fed patients with AN were investigated under baseline conditi...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1380076
更新日期：1998-01-01 00:00:00
