Vitamin D levels and liver histological alterations in children with nonalcoholic fatty liver disease.

abstract：CONTEXT:The diagnosis of central hypothyroidism (CH) is often difficult to establish as serum TSH levels may be low, normal, or slightly increased. OBJECTIVE:To explore the use of recombinant human TSH (rhTSH) in the diagnosis of CH. DESIGN:Randomized single-blind clinical trial. SETTING:Outpatient clinic of a terti...

journal_title：European journal of endocrinology

authors： Filipsson H,Nyström E,Johannsson G

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVE:Platinum-based chemotherapy (PBC) is the most effective cytotoxic treatment for advanced adrenocortical carcinoma (ACC). Excision repair cross complementing group 1 (ERCC1) plays a critical role in the repair of platinum-induced DNA damage. Two studies investigating the role of ERCC1 immunostaining as a predi...

journal_title：European journal of endocrinology

authors： Laufs V,Altieri B,Sbiera S,Kircher S,Steinhauer S,Beuschlein F,Quinkler M,Willenberg HS,Rosenwald A,Fassnacht M,Ronchi CL

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Nateglinide restores early-phase insulin secretion to feeding and reduces postprandial hyperglycaemia in type 2 diabetes. This study evaluated the effects of nateglinide on dipeptidyl peptidase-IV (DPP-IV) activity and glucose-dependent insulinotropic polypeptide (GIP) degradation. Research design and method...

journal_title：European journal of endocrinology

authors： McKillop AM,Duffy NA,Lindsay JR,Green BD,Patterson S,O'Harte FP,Bell PM,Flatt PR

更新日期：2009-12-01 00:00:00

abstract：:Regulatory actions of angiotensin II (AngII), which is involved in the pathophysiology of hypertension and also participates in cell proliferation and cell differentiation, are mainly mediated by AngII type 1 (AT1) receptor. Recently, activating mutations of receptors causing hyperfunctioning endocrine diseases have b...

journal_title：European journal of endocrinology

authors： Sachse R,Shao XJ,Rico A,Finckh U,Rolfs A,Reincke M,Hensen J

更新日期：1997-09-01 00:00:00

abstract：:Glucocorticoids (GC) such as cortisol regulate multiple physiological functions, notably those involved in development, metabolism, inflammatory processes and stress, and exert their effects upon binding to the glucocorticoid receptor (GR, encoded by NR3C1 gene in humans). GC signaling follows several consecutive step...

journal_title：European journal of endocrinology

authors： Vitellius G,Lombes M

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:In men, the feedback of gonadotropins is regulated by estrogens that come from the aromatization of testosterone, but the relative contribution to the inhibition of LH and FSH secretion by the amount of locally produced estrogens within the hypothalamus and/or the pituitary, and the amount of circulating est...

journal_title：European journal of endocrinology

authors： Rochira V,Zirilli L,Genazzani AD,Balestrieri A,Aranda C,Fabre B,Antunez P,Diazzi C,Carani C,Maffei L

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:The aim was to evaluate changes of bone mineral density (BMD) and markers of bone turnover in healthy adolescents, and in adolescent users of combined oral contraceptives (COCs) with different ethinylestradiol (EE) contents. METHODS:In this prospective crossover study, 56 healthy females (15-19.5 years) wit...

journal_title：European journal of endocrinology

authors： Cibula D,Skrenkova J,Hill M,Stepan JJ

更新日期：2012-06-01 00:00:00

abstract：:Genetic predictors of outcome are reviewed in the context of a disease--cancer--that can be (too) simplistically described as a 'successful, invasive clone of our own tissues'. Context has many faces that determine a thyroid cancer patient's outcome beyond the influence of genetic markers. There is also plenty of evid...

journal_title：European journal of endocrinology

authors： Tavares C,Melo M,Cameselle-Teijeiro JM,Soares P,Sobrinho-Simões M

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVE:Short stature caused by point mutations or deletions of the short stature homeobox (SHOX) gene (SHOX haploinsufficiency (SHI)) is a registered indication for GH treatment. Patients with a SHOX enhancer deletion (SED) have a similar phenotype, but their response to GH is unknown. It is uncertain if duplication...

journal_title：European journal of endocrinology

authors： Donze SH,Meijer CR,Kant SG,Zandwijken GR,van der Hout AH,van Spaendonk RM,van den Ouweland AM,Wit JM,Losekoot M,Oostdijk W

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVE:Thyroid function parameters have been associated with obesity, but associations with the type of adiposity have not been examined. We used ultrasound (US) to assess regional adiposity and investigated associations of thyroid function with parameters of central obesity. DESIGN:Cross-sectional study. METHODS:...

journal_title：European journal of endocrinology

authors： Alevizaki M,Saltiki K,Voidonikola P,Mantzou E,Papamichael C,Stamatelopoulos K

更新日期：2009-09-01 00:00:00

abstract：OBJECTIVE:While anti-pituitary antibodies (APAs) were detected in some patients with Sheehan's syndrome (SS) suggesting an autoimmune pituitary involvement in the development of their hypopituitarism, hypothalamic cell anti-hypothalamus antibodies (AHAs) have not been investigated so far. DESIGN:The aim of this study ...

journal_title：European journal of endocrinology

authors： De Bellis A,Kelestimur F,Sinisi AA,Ruocco G,Tirelli G,Battaglia M,Bellastella G,Conzo G,Tanriverdi F,Unluhizarci K,Bizzarro A,Bellastella A

更新日期：2008-02-01 00:00:00

abstract：:A comparative study of high-dose (HD, carbimazole 60 mg plus thyroxine 100-150 micrograms daily) and titration-dose (TD) regimens of carbimazole was carried out in 70 patients with Graves' disease, the patients being assigned randomly to one or other regimen. The treatment was given for 1 year and follow-up was for 2 ...

journal_title：European journal of endocrinology

authors： Edmonds CJ,Tellez M

更新日期：1994-08-01 00:00:00

abstract：OBJECTIVE:It has been suggested that adiponectin regulates plasma free fatty acid (FFA) clearance by stimulating FFA uptake and/or oxidation in muscle. We aimed to determine changes in plasma adiponectin concentration and adiponectin receptor 1 and 2 mRNA expression in skeletal muscle during and after prolonged exercis...

journal_title：European journal of endocrinology

authors： Punyadeera C,Zorenc AH,Koopman R,McAinch AJ,Smit E,Manders R,Keizer HA,Cameron-Smith D,van Loon LJ

更新日期：2005-03-01 00:00:00

abstract：:X-linked adrenoleucodystrophy (ALD) has been shown to be one of the most frequent causes of Addison's disease in men. It is characterized by an impaired peroxisomal beta-oxidation of very long chain fatty acids and is associated with mutations of the ALD gene resulting in a defective peroxisomal membrane transport pro...

journal_title：European journal of endocrinology

authors： Korenke GC,Roth C,Krasemann E,Hüfner M,Hunneman DH,Hanefeld F

更新日期：1997-07-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to evaluate the effect of intraoperative high-field (1.5 Tesla) magnetic resonance imaging (MRI) on the results of transsphenoidal surgery of GH-secreting pituitary macroadenomas. METHODS:Twenty-three acromegalic patients (mean tumor size, 25 +/- 12 mm; untreated preoperative GH, 4.2...

journal_title：European journal of endocrinology

authors： Fahlbusch R,Keller Bv,Ganslandt O,Kreutzer J,Nimsky C

更新日期：2005-08-01 00:00:00

abstract：AIM:It is widely known that inflammation is related to type 2 diabetes (T2D), but few studies have shown a direct relationship between the immune system and T2D using a reliable biomarker. Neutrophil:lymphocyte ratio (NLR) is an easy-to-analyze inflammation biomarker, but few studies have assessed the relationship betw...

journal_title：European journal of endocrinology

authors： Guo X,Zhang S,Zhang Q,Liu L,Wu H,Du H,Shi H,Wang C,Xia Y,Liu X,Li C,Sun S,Wang X,Zhou M,Huang G,Jia Q,Zhao H,Song K,Niu K

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVE:The relationship between sex hormones and hepatocellular adenoma development is well established. On the contrary, their contribution to liver adenomatosis (LA) development is still a debatable issue. Recently, inactivating mutations of hepatocyte nuclear factor-1alpha (HNF-1alpha) transcription factor gene o...

journal_title：European journal of endocrinology

authors： Svrcek M,Jeannot E,Arrivé L,Poupon R,Fromont G,Fléjou JF,Zucman-Rossi J,Bouchard P,Wendum D

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVE:To evaluate the impact of long-term, non-suppressive levothyroxine (L-T(4)) treatment on quantitative ultrasonometry in women. DESIGN:This was a case-control study. SUBJECTS AND METHODS:Altogether 667 women (mean age+/-s.d., 49.5+/-13.1 years) were studied. Of these, 156 (23%) had non-toxic goitre or hypoth...

journal_title：European journal of endocrinology

authors： Hadji P,Hars O,Sturm G,Bauer T,Emons G,Schulz KD

更新日期：2000-05-01 00:00:00

abstract：Background:Hypophosphataemic rickets (HR) comprise a clinically and genetically heterogeneous group of conditions, defined by renal-tubular phosphate wasting and consecutive loss of bone mineralisation. X-linked hypophosphataemia (XLH) is the most common form, caused by inactivating dominant mutations in PHEX, a gene e...

journal_title：European journal of endocrinology

authors： Thiele S,Werner R,Stubbe A,Hiort O,Hoeppner W

更新日期：2020-11-01 00:00:00

abstract：:In 2006, two major society-sponsored guidelines and one major consensus statement for thyroid diagnosis and management were published by: the American Association of Clinical Endocrinologists/Associazione Medici Endocrinologi (AACE/AME); the American Thyroid Association (ATA); and the European Thyroid Association (ETA...

journal_title：European journal of endocrinology

authors： Gharib H,Papini E,Paschke R

更新日期：2008-11-01 00:00:00

abstract：:Serum thyroid parameters show substantial inter-individual variability, in which genetic variation is a major factor. Findings in patients with subclinical hyper- and hypothyroidism illustrate that even minor alterations in serum thyroid function tests can have important consequences for a variety of thyroid hormone-r...

journal_title：European journal of endocrinology

authors： Peeters RP,van der Deure WM,Visser TJ

更新日期：2006-11-01 00:00:00

abstract：:Papillary craniopharyngioma (PCP) is an intracranial tumor that results in high levels of morbidity. We recently demonstrated that the vast majority of these tumors harbor the oncogenic BRAF V600E mutation. The pathologic diagnosis of PCP can now be confirmed using mutation specific immunohistochemistry and targeted g...

journal_title：European journal of endocrinology

authors： Brastianos PK,Santagata S

更新日期：2016-04-01 00:00:00

abstract：CONTEXT AND OBJECTIVE:Arterial stimulation and venous sampling (ASVS) is an important technique for localizing insulinoma. The principle behind ASVS is that insulin secretion is promoted from insulinoma cells by the injection of calcium into the insulinoma-feeding artery. However, the mechanism for ASVS-induced insulin...

journal_title：European journal of endocrinology

authors： Ono Y,Oda N,Ishihara S,Shimomura A,Hayakawa N,Suzuki A,Horiguchi A,Senda T,Miyakawa S,Itoh M

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVE:This study aimed to analyze the autonomic control of heart rate variability (HRV) in subjects receiving chronic l-thyroxine (l-T4) treatment after total thyroidectomy and (131)I therapy for differentiated thyroid carcinoma. METHODS:Blood pressure (BP) and sympatho-vagal activity (evaluated by power spectral ...

journal_title：European journal of endocrinology

authors： Casu M,Cappi C,Patrone V,Repetto E,Giusti M,Minuto F,Murialdo G

更新日期：2005-06-01 00:00:00

abstract：:All children and adolescents with Graves' disease in the county of Uppsala (catchment area population 250,000) treated between 1970 and 1994 were evaluated in a retrospective study. The material comprised 31 patients with a mean age of 11 years (range 4-16), 29 (94%) of whom were girls, and four (13%) of the patients ...

journal_title：European journal of endocrinology

authors： Rudberg C,Johansson H,Akerström G,Tuvemo T,Karlsson FA

更新日期：1996-06-01 00:00:00

abstract：:Several bone matrix protein constituents, including the major component collagen type I and the hydroxyapatite binding protein, osteocalcin, have been implicated in the regulation of bone turnover. Cortical bone osteocalcin, collagen and mineral content were studied in autosomal dominant osteopetrosis type I (ADO), a ...

journal_title：European journal of endocrinology

authors： Bollerslev J,Marks SC Jr,Mosekilde L,Lian JB,Stein GS,Mosekilde L

更新日期：1994-06-01 00:00:00

abstract：:The aim of this study was to investigate the frequencies of clinical diabetes and humoral markers of anti-pancreatic autoimmunity in a homogeneous population of 600 Caucasian patients with recently diagnosed Graves' disease (GD), in order to characterize the specific features of this group of endocrine patients among ...

journal_title：European journal of endocrinology

authors： Maugendre D,Vérité F,Guilhem I,Genetet B,Allannic H,Delamaire M

更新日期：1997-11-01 00:00:00

abstract：:The aim of this review was to examine the evidence for age-related changes of the hypothalamic-pituitary-adrenal (HPA) axis in both physiological and pathological aging, on the basis of the many data in the literature, as well as of our personal findings. A statistically significant circadian rhythmicity of serum cort...

journal_title：European journal of endocrinology

authors： Ferrari E,Cravello L,Muzzoni B,Casarotti D,Paltro M,Solerte SB,Fioravanti M,Cuzzoni G,Pontiggia B,Magri F

更新日期：2001-04-01 00:00:00

abstract：OBJECTIVE:Mutations in HESX1 represent a rare cause of GH deficiency (GHD) associated with a broad spectrum of other anomalies. We searched for causative mutations in a cohort of 244 Italian patients affected by combined and isolated GHD (IGHD). METHODS:The HESX1 gene-coding region and exon-intron boundaries were scre...

journal_title：European journal of endocrinology

authors： Vivenza D,Godi M,Faienza MF,Mellone S,Moia S,Rapa A,Petri A,Bellone S,Riccomagno S,Cavallo L,Giordano M,Bona G

更新日期：2011-05-01 00:00:00

abstract：:Congenital generalized lipoatrophy (CGL) is a syndrome with multiple clinical manifestations and complete atrophy of adipose tissue. The exact mechanism of this disease remains unknown. One hypothesis presupposes an abnormal development of adipocytes. Leptin, the adipocyte-specific product of the ob gene, acts as a re...

journal_title：European journal of endocrinology

authors： Jaquet D,Khallouf E,Lévy-Marchal C,Czernichow P

更新日期：1999-01-01 00:00:00