当前位置： SCI文献检索 > EUROPEAN JOURNAL OF ENDOCRINOLOGY期刊下所有文献 > Treatment of Graves' disease by carbimazole: high dose with thyroxine compared to titration dose.

Treatment of Graves' disease by carbimazole: high dose with thyroxine compared to titration dose.

Abstract：

:A comparative study of high-dose (HD, carbimazole 60 mg plus thyroxine 100-150 micrograms daily) and titration-dose (TD) regimens of carbimazole was carried out in 70 patients with Graves' disease, the patients being assigned randomly to one or other regimen. The treatment was given for 1 year and follow-up was for 2 years after stopping treatment. In both groups, recurrence of hyperthyroidism occurred, most commonly during the first 6 months (35% of HD and 44% of TD). By 2 years after stopping treatment, recurrence had occurred in 50% of the HD and 66% of the TD group. The differences were not significant. Thyroid antibodies, serum thyroglobulin and pertechnetate uptake fell similarly in both groups during treatment. Cigarette smoking was similar in both the groups and did not influence the frequency of relapse. In both HD and TD groups, when relapsing patients were examined according to whether they relapsed early (within 6 months or less) or late it was found that those who relapsed late were, in respect of goitre size, pertechnetate uptake and presence of detectable plasma TSH, similar to the patients who did not relapse at all. In conclusion, the changes in the measured variables and the progress of the patients was similar whether treated by the HD or TD regimen.

journal_name

Eur J Endocrinol

journal_title

European journal of endocrinology

authors

Edmonds CJ,Tellez M

doi

10.1530/eje.0.1310120

subject

Has Abstract

pub_date

1994-08-01 00:00:00

pages

120-4

issue

2

eissn

0804-4643

issn

1479-683X

journal_volume

131

pub_type

临床试验,杂志文章,随机对照试验

相关文献

EUROPEAN JOURNAL OF ENDOCRINOLOGY文献大全
  • Impact of subclinical hypothyroidism on the coronary artery disease in apparently healthy subjects.

    abstract：OBJECTIVE:Cardiovascular disease (CVD) occurs frequently and may progress more rapidly in overt hypothyroidism (OVH). However, the role of mild thyroid failure as a risk factor for CVD is not clear. This study is aimed at exploring the association between subclinical hypothyroidism (SCH) and coronary artery disease (CA...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-11-0014

    authors： Park YJ,Lee YJ,Choi SI,Chun EJ,Jang HC,Chang HJ

    更新日期：2011-07-01 00:00:00

  • Exploring the use of recombinant human TSH in the diagnosis of central hypothyroidism.

    abstract：CONTEXT:The diagnosis of central hypothyroidism (CH) is often difficult to establish as serum TSH levels may be low, normal, or slightly increased. OBJECTIVE:To explore the use of recombinant human TSH (rhTSH) in the diagnosis of CH. DESIGN:Randomized single-blind clinical trial. SETTING:Outpatient clinic of a terti...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,随机对照试验

    doi：10.1530/EJE-08-0151

    authors： Filipsson H,Nyström E,Johannsson G

    更新日期：2008-08-01 00:00:00

  • Peculiarities of Graves' disease in children and adolescents with Down's syndrome.

    abstract：OBJECTIVE:To compare the presentation and clinical course of Graves' disease (GD) in two pediatric populations consisting of 28 patients with Down's syndrome (DS) and 109 controls without DS respectively. DESIGN AND METHODS:The evolution over time of GD was determined in both groups according to the clinical changes a...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-09-0751

    authors： De Luca F,Corrias A,Salerno M,Wasniewska M,Gastaldi R,Cassio A,Mussa A,Aversa T,Radetti G,Arrigo T

    更新日期：2010-03-01 00:00:00

  • Association of HDL-C and apolipoprotein A-I with the risk of type 2 diabetes in subjects with impaired fasting glucose.

    abstract：OBJECTIVES:HDLs have many diverse functions. The goal of this study was to determine the association of HDL cholesterol (HDL-C) and apolipoprotein A-I (apoA-I) with the development of type 2 diabetes (T2D). In particular, this study determined the association between the ratio of HDL-C to apoA-I (HA) and incident T2D. ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-14-0195

    authors： Hwang YC,Ahn HY,Park SW,Park CY

    更新日期：2014-07-01 00:00:00

  • Parallel downregulation of retinol-binding protein-4 and adiponectin expression in subcutaneous adipose tissue of non-morbidly obese subjects.

    abstract：CONTEXT AND OBJECTIVE:Adipokines are involved in the etiopathology of obesity-related disorders. Since the role of adipokine retinol-binding protein-4 (RBP4) in obesity remains uncertain and its relationship with other adipokines and inflammatory markers has not been examined in detail, we investigated the relationship...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-08-0866

    authors： Broch M,Auguet MT,Ramírez R,Olona M,Aguilar C,Megia A,Alcaide MJ,Pastor R,Martínez S,Caubet E,Garcia-España A,Richart C

    更新日期：2009-07-01 00:00:00

  • Hyperprolactinaemia is associated with a higher prevalence of pituitary-adrenal dysfunction in non-functioning pituitary macroadenoma.

    abstract：:In non-functioning pituitary macroadenoma (NFMA), hyperprolactinaemia (hyperPRL) is considered to be a sign of hypothalamic-pituitary dysregulation, but it is unknown whether hyperPRL is associated with an increased frequency of pituitary hormone deficiencies. Forty consecutive patients with histology-proven NFMA were...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1350299

    authors： Tjeerdsma G,Sluiter WJ,Hew JM,Molenaar WM,de Lange WE,Dullaart RP

    更新日期：1996-09-01 00:00:00

  • Growth hormone treatment before the age of 4 years prevents short stature in young girls with Turner syndrome.

    abstract：OBJECTIVE:Adult height deficit seen in Turner syndrome (TS) originates, in part, from growth retardation in utero and throughout the first 3 years of life. Earlier diagnosis enables earlier therapeutic intervention, such as with recombinant human GH (r-hGH), which may help to prevent growth retardation. In this open-la...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,多中心研究

    doi：10.1530/EJE-10-1048

    authors： Linglart A,Cabrol S,Berlier P,Stuckens C,Wagner K,de Kerdanet M,Limoni C,Carel JC,Chaussain JL,French Collaborative Young Turner Study Group.

    更新日期：2011-06-01 00:00:00

  • Exclusive underexpression of vitamin D receptor exon 1f transcripts in tumors of primary hyperparathyroidism.

    abstract：OBJECTIVE:Primary hyperparathyroidism (pHPT) is characterized by excessive production of parathyroid hormone (PTH) due to parathyroid adenomas while uremic secondary HPT (sHPT) is caused by parathyroid hyperplasia in response to renal failure. Active vitamin D, 1,25-dihydroxyvitamin D(3) (1,25-(OH)(2)D(3)), with the vi...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1470671

    authors： Correa P,Akerstrom G,Westin G

    更新日期：2002-11-01 00:00:00

  • Selective parathyroid venous sampling in patients with complicated hyperparathyroidism.

    abstract：OBJECTIVE:The role of preoperative localisation of abnormal parathyroid glands remains controversial but is particularly relevant to the management of patients with recurrent or persistent hyperparathyroidism and familial syndromes. We report our experience of the use of selective parathyroid venous sampling (PVS) in t...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.1.02304

    authors： Ogilvie CM,Brown PL,Matson M,Dacie J,Reznek RH,Britton K,Carpenter R,Berney D,Drake WM,Jenkins PJ,Chew SL,Monson JP

    更新日期：2006-12-01 00:00:00

  • Thyroglobulin measurement using highly sensitive assays in patients with differentiated thyroid cancer: a clinical position paper.

    abstract：:Differentiated thyroid cancer (DTC) is the most common endocrine cancer and its incidence has increased in recent decades. Initial treatment usually consists of total thyroidectomy followed by ablation of thyroid remnants by iodine-131. As thyroid cells are assumed to be the only source of thyroglobulin (Tg) in the hu...

    journal_title：European journal of endocrinology

    pub_type： 共识发展会议,杂志文章,评审

    doi：10.1530/EJE-14-0148

    authors： Giovanella L,Clark PM,Chiovato L,Duntas L,Elisei R,Feldt-Rasmussen U,Leenhardt L,Luster M,Schalin-Jäntti C,Schott M,Seregni E,Rimmele H,Smit J,Verburg FA

    更新日期：2014-08-01 00:00:00

  • Cold exposure inhibits leptin secretion in vitro by a direct and non-specific action on adipose tissue.

    abstract：OBJECTIVE:Leptin secretion is reduced by low temperatures in experimental animals, and this effect has been explained as an adaptive mechanism to cold environments. This study investigated the in vitro effects of cold exposure on human white adipose tissue. DESIGN:To understand whether the low temperature action is a ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1420195

    authors： Peinó R,Piñeiro V,Gualillo O,Menéndez C,Brenlla J,Casabiell X,Diéguez C,Casanueva FF

    更新日期：2000-02-01 00:00:00

  • Long-term treatment of acromegaly with the slow-release somatostatin analogue lanreotide.

    abstract：:Thirteen patients with active acromegaly despite previous surgery were treated with 30 mg lanreotide im twice a month for 9 months. In 10 subjects the treatment continued to 19 months. GH serum levels of all patients decreased significantly from an initial value of 32.0 (29.4) micrograms/l [median (standard error of m...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1310020

    authors： Marek J,Hána V,Krsek M,Justová V,Catus F,Thomas F

    更新日期：1994-07-01 00:00:00

  • Anionic iodotyrosine residues are required for iodothyronine synthesis.

    abstract：:Biosynthesis of iodothyronines in thyroglobulin occurs by oxidative coupling of two iodotyrosine residues catalyzed by thyroperoxidase. To study the mechanism of iodothyronine formation, iodine-free thyroglobulin was non-enzymatically iodinated and after removal of non-incorporated iodide, incubated with lactoperoxida...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1380227

    authors： de Vijlder JJ,den Hartog MT

    更新日期：1998-02-01 00:00:00

  • Retarded bone growth in thyroid hormone resistance. A clinical study of a large family with a novel thyroid hormone receptor mutation.

    abstract：OBJECTIVE:Thyroid hormone resistance (RTH) is characterised by variable tissue hyporesponsiveness to thyroid hormone. The disorder is usually caused by mutations in the thyroid hormone receptor beta (TR beta). We describe a large family with this disorder. SUBJECTS AND MEASUREMENT: We identified 36 family members with ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1500425

    authors： Kvistad PH,Løvås K,Boman H,Myking OL

    更新日期：2004-04-01 00:00:00

  • Impact of fetal growth restriction on body composition and hormonal status at birth in infants of small and appropriate weight for gestational age.

    abstract：BACKGROUND:Fetal growth restriction (FGR) has been related to several health risks, which have been generally identified in small-for-gestational age (SGA) individuals. OBJECTIVE:To evaluate the impact of FGR on body composition and hormonal status in infants born either small- or appropriate-for-gestational age (AGA)...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-07-0286

    authors： Verkauskiene R,Beltrand J,Claris O,Chevenne D,Deghmoun S,Dorgeret S,Alison M,Gaucherand P,Sibony O,Lévy-Marchal C

    更新日期：2007-11-01 00:00:00

  • Four years' treatment of resistant acromegaly with octreotide.

    abstract：:This study was designed to ascertain the long-term safety and efficacy profile of the somatostatin analogue octreotide as treatment of refractory acromegaly. Eight patients (aged 21-62 years) with persistent growth hormone (GH) elevation (duration 1-15 years) despite previous therapy were studied. Octreotide was given...

    journal_title：European journal of endocrinology

    pub_type： 临床试验,杂志文章

    doi：10.1530/eje.0.1320429

    authors： McKnight JA,McCance DR,Sheridan B,Atkinson AB

    更新日期：1995-04-01 00:00:00

  • Isolated GH deficiency (IGHD) type II: imaging of the pituitary gland by magnetic resonance reveals characteristic differences in comparison with severe IGHD of unknown origin.

    abstract：OBJECTIVE:To determine the specific morphology of the pituitary gland in children with severe isolated GH deficiency due to GH-1 gene mutations (IGHD type II). DESIGN:The pituitary gland morphology in magnetic resonance imaging (MRI) of children with IGHD type II was analyzed and compared with the findings in a group ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1470755

    authors： Binder G,Nagel BH,Ranke MB,Mullis PE

    更新日期：2002-12-01 00:00:00

  • A luteinizing hormone-, alpha-subunit- and prolactin-secreting pituitary adenoma responsive to somatostatin analogs: in vivo and in vitro studies.

    abstract：OBJECTIVE:Evaluation of the efficiency of somatostatin analogues in the treatment of a mixed luteinizing hormone (LH)-, alpha-subunit-, prolactin (PRL)-secreting pituitary adenoma. DESIGN:A 30-year-old woman, with amenorrhaea-galactorrhaea, presented with a pituitary macroadenoma. The endocrine evaluation showed high ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1450035

    authors： Saveanu A,Morange-Ramos I,Gunz G,Dufour H,Enjalbert A,Jaquet P

    更新日期：2001-07-01 00:00:00

  • Multi-center study on the characteristics and treatment strategies of patients with Graves' orbitopathy: the first European Group on Graves' Orbitopathy experience.

    abstract：UNLABELLED:To improve management of patients with Graves' orbitopathy, a multi-center collaborative approach is necessary in order to have large enough sample sizes for meaningful randomized clinical trials. This is hampered by a lack of consensus on how to investigate the eye condition. The European Group on Graves' O...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,多中心研究

    doi：10.1530/eje.0.1480491

    authors： Prummel MF,Bakker A,Wiersinga WM,Baldeschi L,Mourits MP,Kendall-Taylor P,Perros P,Neoh C,Dickinson AJ,Lazarus JH,Lane CM,Heufelder AE,Kahaly GJ,Pitz S,Orgiazzi J,Hullo A,Pinchera A,Marcocci C,Sartini MS,Rocchi R,N

    更新日期：2003-05-01 00:00:00

  • An alternative spliced variant of circulating soluble tumor necrosis factor-alpha receptor-2 is paradoxically associated with insulin action.

    abstract：OBJECTIVE:Serum concentrations of soluble tumor necrosis factor-alpha (TNF-alpha) receptor 2 (sTNFR2) are associated with insulin resistance. In a recent study, we provided evidence for the existence of a biologically active form of sTNFR2 produced by alternative splicing (DS-TNFR2). We aimed to evaluate whether this c...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.1.02145

    authors： Fernández-Real JM,Straczkowski M,Lainez B,Chacón MR,Kowalska I,López-Bermejo A,García-España A,Nikolajuk A,Kinalska I,Ricart W

    更新日期：2006-05-01 00:00:00

  • Diabetes care in pediatric refugees from Africa or Middle East: experiences from Germany and Austria based on real-world data from the DPV registry.

    abstract：Objective:With increasing migration to Europe, diabetes diagnosis and treatment of refugees became challenging. To describe the current experience with pediatric refugees in Germany and Austria. Design and Methods:43,137 patients (<21 years) with type 1 diabetes from the diabetes patient follow-up registry (DPV) were ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-18-0898

    authors： Prinz N,Konrad K,Brack C,Hahn E,Herbst A,Icks A,Grulich-Henn J,Jorch N,Kastendieck C,Mönkemöller K,Razum O,Steigleder-Schweiger C,Witsch M,Holl RW

    更新日期：2019-07-01 00:00:00

  • Multiple endocrine neoplasia type 1 in Northern Finland; clinical features and genotype phenotype correlation.

    abstract：OBJECTIVE:The existence of genotype-phenotype correlation in multiple endocrine neoplasia type 1 (MEN1) is controversial. Two founder mutations of the MEN1 gene in Northern Finland gave us an opportunity to compare clinical features among heterozygotes of different mutations. DESIGN AND METHODS:Study cohort included 8...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-07-0195

    authors： Vierimaa O,Ebeling TM,Kytölä S,Bloigu R,Eloranta E,Salmi J,Korpi-Hyövälti E,Niskanen L,Orvola A,Elovaara E,Gynther A,Sane T,Välimäki M,Ignatius J,Leisti J,Salmela PI

    更新日期：2007-09-01 00:00:00

  • Should anterior pituitary function be tested during follow-up of all patients presenting at the emergency department because of traumatic brain injury?

    abstract：CONTEXT:A wide range (15-56%) of prevalences of anterior pituitary insufficiency are reported in patients after traumatic brain injury (TBI). However, different study populations, study designs, and diagnostic procedures were used. No data are available on emergency-department-based cohorts of TBI patients. OBJECTIVE:...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-09-0436

    authors： van der Eerden AW,Twickler MT,Sweep FC,Beems T,Hendricks HT,Hermus AR,Vos PE

    更新日期：2010-01-01 00:00:00

  • GEP-NETS update: functional localisation and scintigraphy in neuroendocrine tumours of the gastrointestinal tract and pancreas (GEP-NETs).

    abstract：:For patients with neuroendocrine tumours (NETs) of the gastrointestinal tract and pancreas (GEP) (GEP-NETs), excellent care should ideally be provided by a multidisciplinary team of skilled health care professionals. In these patients, a combination of nuclear medicine imaging and conventional radiological imaging tec...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-14-0077

    authors： de Herder WW

    更新日期：2014-04-10 00:00:00

  • Relationship between calcitrophic hormones and blood pressure in elderly subjects.

    abstract：:The relationship between calcitrophic hormones and blood pressure has been investigated in 583 elderly subjects who were untreated for hypertension. Univariate analysis demonstrated that serum parathyroid hormone, calcitriol, albumin and calcium were correlated significantly with mean blood pressure (r = +0.15, +0.10,...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1300446

    authors： St John A,Dick I,Hoad K,Retallack R,Welborn T,Prince R

    更新日期：1994-05-01 00:00:00

  • Dose-dependent effects of recombinant human growth hormone on biochemical markers of bone and collagen metabolism in adult growth hormone deficiency.

    abstract：:Administration of growth hormone (GH) to patients with growth hormone deficiency (GHD) has beneficial effects, but so far has been employed only empirically. We have, therefore, investigated the dose-dependent effect of GH on target tissue by studying biochemical markers of bone and collagen turnover in GHD. Then pati...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1350666

    authors： Bollerslev J,Møller J,Thomas S,Djøseland O,Christiansen JS

    更新日期：1996-12-01 00:00:00

  • Effect of cosyntropin during adrenal venous sampling on subtype of primary aldosteronism: analysis of surgical outcome.

    abstract：Objectives:We investigated the clinical significance of ACTH stimulation during adrenal venous sampling (AVS) by surgical outcome of primary aldosteronism (PA). Design:Multicenter retrospective study by Japan PA study. Method:We allocated 314 patients with both basal and ACTH-stimulated AVS data who underwent adrenal...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,多中心研究

    doi：10.1530/EJE-19-0860

    authors： Kobayashi H,Nakamura Y,Abe M,Kurihara I,Itoh H,Ichijo T,Takeda Y,Yoneda T,Katabami T,Tsuiki M,Wada N,Ogawa Y,Sakamoto R,Kawashima J,Sone M,Inagaki N,Yoshimoto T,Yamada T,Okamoto R,Matsuda Y,Fujita M,Watanabe M,

    更新日期：2020-03-01 00:00:00

  • Endocrinology in the time of COVID-19: Management of pituitary tumours.

    abstract：:Patients with pituitary tumours, ensuing hormonal abnormalities and mass effects are usually followed in multidisciplinary pituitary clinics and can represent a management challenge even during the times of non-pandemic. The COVID-19 pandemic has put on hold routine medical care for hundreds of millions of patients ar...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-20-0473

    authors： Fleseriu M,Dekkers OM,Karavitaki N

    更新日期：2020-07-01 00:00:00

  • Expression of nitric oxide synthase III in human thyroid follicular cells: evidence for increased expression in hyperthyroidism.

    abstract：:Nitric oxide mediates a wide array of cellular functions in many tissues. It is generated by three known isoforms of nitric oxide synthases (NOS). Recently, the endothelial isoform, NOSIII, was shown to be abundantly expressed in the rat thyroid gland and its expression increased in goitrous glands. In this study, we ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1360649

    authors： Colin IM,Kopp P,Zbären J,Häberli A,Grizzle WE,Jameson JL

    更新日期：1997-06-01 00:00:00

  • Metabolic and endocrine effects of treatment with peroral or transdermal oestrogens in conjunction with peroral cyproterone acetate in women with polycystic ovary syndrome.

    abstract：OBJECTIVE:To compare the influence of transdermal and peroral oestrogen treatments in conjunction with cyproterone acetate (CPA) on metabolic and hormonal parameters in women with polycystic ovary syndrome (PCOS). PATIENTS AND METHODS:Twenty-four women with PCOS, aged 25.4+/-4.3 (mean+/-s.d.) years, body mass index 24...

    journal_title：European journal of endocrinology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1530/eje.0.1500215

    authors： Vrbíková J,Stanická S,Dvoráková K,Hill M,Vondra K,Bendlová B,Stárka L

    更新日期：2004-02-01 00:00:00