Abstract:
CONTEXT:There is evidence to suggest that IGF-I plays a role in regulating bone turnover. OBJECTIVE:To evaluate the relationships between serum concentrations of IGF-I and IGF-binding protein-3 (IGFBP-3), and bone metabolism markers in healthy children. DESIGN AND SETTING:Prospective cross-sectional study. SUBJECTS AND METHODS:A cohort of 579 boys and 540 girls, all healthy Caucasian, were included in this study. Serum IGF-I and IGFBP-3 concentrations, bone alkaline phosphatase (BAP) and CrossLaps (markers of bone formation and bone resorption respectively) levels were evaluated as a function of age, gender, pubertal stage and body mass index. RESULTS:Serum IGF-I SDS levels were positively correlated with BAP and CrossLaps SDS levels before and after puberty, and also with CrossLaps during puberty (weak correlation). Serum IGFBP-3 SDS levels were positively correlated with BAP and CrossLaps levels before, during (weak correlation) and after puberty (for BAP levels only). CONCLUSIONS:This study demonstrated the independent association between serum IGF-I and IGFBP-3 concentrations with both serum bone formation and resorption markers in healthy children. Physiological differences before, during and after puberty in the association of serum IGF-I and IGFBP-3 levels with the serum bone metabolism markers were found. These differences may be related to differences in interactions between sex steroid hormones and the GH/IGF-I system, bone metabolism and growth during the pubertal transition. Improvements in our understanding of life course determinants of the IGF-I system and bone metabolism are required to shed further light on the role of the GH/IGF-I axis in bone remodelling.
journal_name
Eur J Endocrinoljournal_title
European journal of endocrinologyauthors
Léger J,Mercat I,Alberti C,Chevenne D,Armoogum P,Tichet J,Czernichow Pdoi
10.1530/EJE-07-0402subject
Has Abstractpub_date
2007-11-01 00:00:00pages
685-92issue
5eissn
0804-4643issn
1479-683Xpii
157/5/685journal_volume
157pub_type
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journal_title:European journal of endocrinology
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更新日期:2017-04-01 00:00:00
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更新日期:1999-10-01 00:00:00
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更新日期:2004-08-01 00:00:00
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更新日期:2016-06-01 00:00:00
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更新日期:2003-10-01 00:00:00
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更新日期:1997-09-01 00:00:00