Abstract:
:We studied the roles played by the renin-angiotensin system in inducing hypertension in nine patients with Cushing's syndrome (CS) resulting from adrenocortical adenoma, and compared them with those in patients with primary aldosteronism (PA), renovascular hypertension (RVH) and essential hypertension (EH). In the CS group, each parameter, including serum potassium, plasma renin activity, plasma aldosterone, deoxycorticosterone and corticosterone concentrations, is within the normal range. However, plasma renin activity in the CS group was lower than that in the RVH group but higher than that in the PA group, and plasma aldosterone concentration was lower than that in each RVH or PA group. These findings indicated that the CS group had a different type of hypertension from that in either RVH or PA, in which the renin angiotensin system or mineralocorticoids play an important role in hypertension. Meanwhile, captopril (50 mg) administration either with or without indomethacin pretreatment decreased the mean blood pressure in the CS group, although captopril failed to change it in the PA group or in normal subjects. Furthermore, the pressor response to exogenous angiotensin II in the CS group was higher than that in the RVH or EH group, but was not different from that in the PA group. Thus, the hypertension in patients with CS due to adrenocortical adenoma appears to be mediated through a change in the renin-angiotensin system in the form of exaggerated pressor responses to angiotensin II.
journal_name
Eur J Endocrinoljournal_title
European journal of endocrinologyauthors
Yasuda G,Shionoiri H,Umemura S,Takasaki I,Ishii Mdoi
10.1530/eje.0.1310582subject
Has Abstractpub_date
1994-12-01 00:00:00pages
582-8issue
6eissn
0804-4643issn
1479-683Xjournal_volume
131pub_type
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journal_title:European journal of endocrinology
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journal_title:European journal of endocrinology
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pub_type: 杂志文章,随机对照试验
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更新日期:1994-09-01 00:00:00
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更新日期:2004-12-01 00:00:00
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更新日期:2002-10-01 00:00:00
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更新日期:2001-10-01 00:00:00
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更新日期:2016-04-01 00:00:00
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更新日期:2012-03-01 00:00:00
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更新日期:2004-10-01 00:00:00
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更新日期:1996-10-01 00:00:00
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