当前位置： SCI文献检索 > EUROPEAN JOURNAL OF ENDOCRINOLOGY期刊下所有文献 > The metabolic syndrome and its components in 178 patients treated for craniopharyngioma after 16 years of follow-up.

The metabolic syndrome and its components in 178 patients treated for craniopharyngioma after 16 years of follow-up.

Abstract：

OBJECTIVE:Patients with craniopharyngioma are at an increased risk for cardio- and cerebrovascular mortality. The metabolic syndrome (MetS) is an important cardiometabolic risk factor, but barely studied in patients with craniopharyngioma. We aimed to investigate the prevalence of and risk factors for the MetS and its components in patients with craniopharyngioma. DESIGN:Cross-sectional study with retrospective data. METHODS:We studied the prevalence of and risk factors for the MetS and its components in 110 Dutch (median age 47 years, range 18-92) and 68 Swedish (median age 50 years, range 20-81) patients with craniopharyngioma with ≥3 years of follow-up (90 females (51%); 83 patients with childhood-onset craniopharyngioma (47%); median follow-up after craniopharyngioma diagnosis 16 years (range 3-62)). In Dutch patients aged 30-70 years and Swedish patients aged 45-69 years, we examined the prevalence of the MetS and its components relative to the general population. RESULTS:Sixty-nine (46%) of 149 patients with complete data demonstrated the MetS. Prevalence of the MetS was significantly higher in patients with craniopharyngioma compared with the general population (40% vs 26% (P < 0.05) for Dutch patients; 52% vs 15% (P < 0.05) for Swedish patients). Multivariable logistic regression analysis identified visual impairment as a borderline significant predictor of the MetS (OR 2.54, 95% CI 0.95-6.81; P = 0.06) after adjustment for glucocorticoid replacement therapy and follow-up duration. Age, female sex, tumor location, radiological hypothalamic damage, 90Yttrium brachytherapy, glucocorticoid replacement therapy and follow-up duration significantly predicted components of the MetS. CONCLUSIONS:Patients with craniopharyngioma are at an increased risk for the MetS, especially patients with visual impairment.

journal_name

Eur J Endocrinol

journal_title

European journal of endocrinology

authors

Wijnen M,Olsson DS,van den Heuvel-Eibrink MM,Hammarstrand C,Janssen JAMJL,van der Lely AJ,Johannsson G,Neggers SJCMM

doi

10.1530/EJE-17-0387

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

11-22

issue

1

eissn

0804-4643

issn

1479-683X

pii

EJE-17-0387

journal_volume

178

pub_type

杂志文章

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