Testosterone prevents protein loss via the hepatic urea cycle in human.


CONTEXT:The urea cycle is a rate-limiting step for amino acid nitrogen elimination. The rate of urea synthesis is a true indicator of whole-body protein catabolism. Testosterone reduces protein and nitrogen loss. The effect of testosterone on hepatic urea synthesis in humans has not been studied. OBJECTIVE:To determine whether testosterone reduces hepatic urea production. DESIGN:An open-label study. PATIENTS AND INTERVENTION:Eight hypogonadal men were studied at baseline, and after two weeks of transdermal testosterone replacement (Testogel, 100 mg/day). MAIN OUTCOMES MEASURES:The rate of hepatic urea synthesis was measured by the urea turnover technique using stable isotope methodology, with 15N2-urea as tracer. Whole-body leucine turnover was measured, from which leucine rate of appearance (LRa), an index of protein breakdown and leucine oxidation (Lox), a measure of irreversible protein loss, were calculated. RESULTS:Testosterone administration significantly reduced the rate of hepatic urea production (from 544.4 ± 71.8 to 431.7 ± 68.3 µmol/min; P < 0.01), which was paralleled by a significant reduction in serum urea concentration. Testosterone treatment significantly reduced net protein loss, as measured by percent Lox/LRa, by 19.3 ± 5.8% (P < 0.05). There was a positive association between Lox and hepatic urea production at baseline (r2 = 0.60, P < 0.05) and after testosterone administration (r2 = 0.59, P < 0.05). CONCLUSION:Testosterone replacement reduces protein loss and hepatic urea synthesis. We conclude that testosterone regulates whole-body protein metabolism by suppressing the urea cycle.


Eur J Endocrinol


Lam T,Poljak A,McLean M,Bahl N,Ho KKY,Birzniece V




Has Abstract


2017-04-01 00:00:00














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    abstract:OBJECTIVE AND DESIGN:Patients with type 2 diabetes mellitus (T2D) have an increased fracture risk despite a normal or elevated bone mineral density (BMD). The aim of this cross-sectional in vivo study was to assess parameters of peripheral bone microarchitecture, estimated bone strength and bone remodeling in T2D patie...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Shanbhogue VV,Hansen S,Frost M,Jørgensen NR,Hermann AP,Henriksen JE,Brixen K

    更新日期:2016-02-01 00:00:00

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    abstract:OBJECTIVES:High variability in clinical response to metformin is often observed in type 2 diabetes (T2D) patients, and it highlights the need for identification of genetic components affecting the efficiency of metformin therapy. Aim of this observational study is to evaluate the role of tagSNPs (tagging single nucleot...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Zaharenko L,Kalnina I,Geldnere K,Konrade I,Grinberga S,Židzik J,Javorský M,Lejnieks A,Nikitina-Zake L,Fridmanis D,Peculis R,Radovica-Spalvina I,Hartmane D,Pugovics O,Tkáč I,Klimčáková L,Pīrāgs V,Klovins J

    更新日期:2016-12-01 00:00:00

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    更新日期:2005-11-01 00:00:00

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    authors: Pickering L,Jennum P,Gammeltoft S,Poulsgaard L,Feldt-Rasmussen U,Klose M

    更新日期:2014-06-01 00:00:00

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    abstract::The expression of GnRH and its receptor as a part of an autocrine regulatory system of cell proliferation has been demonstrated in a number of human malignant tumors, including cancers of the breast, ovary and endometrium. Dose-dependent antiproliferative effects of GnRH agonists in cell lines derived from these cance...

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    pub_type: 杂志文章,评审


    authors: Gründker C,Günthert AR,Westphalen S,Emons G

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    abstract:OBJECTIVE:Although the beneficial effects of estrogen on bone are well known, the roles of estrogen receptors (ERs) in mediating these effects are not fully understood. METHODS:To study the effects of long-term ER alpha deficiency, bone phenotype was studied in aged ER alpha knockout (ERKO) mice. In addition, ERKO ost...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Parikka V,Peng Z,Hentunen T,Risteli J,Elo T,Väänänen HK,Härkönen P

    更新日期:2005-02-01 00:00:00

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    journal_title:European journal of endocrinology

    pub_type: 杂志文章,评审


    authors: Dunkel L,Quinton R

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    journal_title:European journal of endocrinology

    pub_type: 杂志文章,多中心研究


    authors: Lake JE,Debroy P,Ng D,Erlandson KM,Kingsley LA,Palella FJ,Budoff MJ,Post WS,Brown TT

    更新日期:2019-10-01 00:00:00

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    journal_title:European journal of endocrinology

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    authors: Wilson ME,Lackey SL

    更新日期:1999-09-01 00:00:00

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    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Maghnie M,Genovese E,Sommaruga MG,Aricò M,Locatelli D,Arbustini E,Pezzotta S,Severi F

    更新日期:1998-12-01 00:00:00

  • Efficacy and tolerability of lanreotide Autogel therapy in acromegalic patients previously treated with octreotide LAR.

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    pub_type: 临床试验,杂志文章,多中心研究


    authors: Alexopoulou O,Abrams P,Verhelst J,Poppe K,Velkeniers B,Abs R,Maiter D

    更新日期:2004-09-01 00:00:00

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    journal_title:European journal of endocrinology

    pub_type: 杂志文章,评审


    authors: Grossman A,Johannsson G,Quinkler M,Zelissen P

    更新日期:2013-10-21 00:00:00

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    authors: Benvenga S,Smedile G,Lo Giudice F,Trimarchi F

    更新日期:1999-09-01 00:00:00

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    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Deutschbein T,Bidlingmaier M,Schopohl J,Strasburger CJ,Petersenn S

    更新日期:2017-03-01 00:00:00

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    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: de Vijlder JJ,den Hartog MT

    更新日期:1998-02-01 00:00:00

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    journal_title:European journal of endocrinology

    pub_type: 临床试验,杂志文章


    authors: Fahlbusch R,Keller Bv,Ganslandt O,Kreutzer J,Nimsky C

    更新日期:2005-08-01 00:00:00

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    journal_title:European journal of endocrinology

    pub_type: 杂志文章,评审


    authors: Ferrari E,Cravello L,Muzzoni B,Casarotti D,Paltro M,Solerte SB,Fioravanti M,Cuzzoni G,Pontiggia B,Magri F

    更新日期:2001-04-01 00:00:00

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    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Grolmusz VK,Kövesdi A,Borks K,Igaz P,Patócs A

    更新日期:2018-10-01 00:00:00

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    journal_title:European journal of endocrinology

    pub_type: 杂志文章


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    更新日期:1998-01-01 00:00:00

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    authors: de Vries L,Horev G,Schwartz M,Phillip M

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    authors: Sproul K,Jones MR,Azziz R,Goodarzi MO

    更新日期:2009-09-01 00:00:00

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    abstract::There are close interactions between the adipocyte-derived hormone, leptin, and the anterior pituitary, especially the hypothalamic-pituitary-adrenal (HPA) axis. We investigated the relationship between the sympathetic adrenergic system and serum leptin levels, dependent on the function of anterior pituitary hormone a...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Schafroth U,Godang K,Ueland T,Bollerslev J

    更新日期:2001-09-01 00:00:00

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    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Deloof S,De Seze C,Montel V,Chatelain A

    更新日期:1999-08-01 00:00:00

  • Long-acting somatostatin analogues are an effective treatment for type 1 gastric carcinoid tumours.

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    pub_type: 临床试验,杂志文章,多中心研究


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    更新日期:2008-10-01 00:00:00

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    journal_title:European journal of endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Edmonds CJ,Tellez M

    更新日期:1994-08-01 00:00:00

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    journal_title:European journal of endocrinology

    pub_type: 杂志文章,评审


    authors: Boguszewski CL,Ayuk J

    更新日期:2016-10-01 00:00:00

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    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Kvistad PH,Løvås K,Boman H,Myking OL

    更新日期:2004-04-01 00:00:00

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    journal_title:European journal of endocrinology

    pub_type: 杂志文章,随机对照试验


    authors: Dalal M,Sun K,Cappola AR,Ferrucci L,Crasto C,Fried LP,Semba RD

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    journal_title:European journal of endocrinology

    pub_type: 杂志文章,评审


    authors: Effraimidis G

    更新日期:2019-09-01 00:00:00