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Testosterone prevents protein loss via the hepatic urea cycle in human.

Abstract：

CONTEXT:The urea cycle is a rate-limiting step for amino acid nitrogen elimination. The rate of urea synthesis is a true indicator of whole-body protein catabolism. Testosterone reduces protein and nitrogen loss. The effect of testosterone on hepatic urea synthesis in humans has not been studied. OBJECTIVE:To determine whether testosterone reduces hepatic urea production. DESIGN:An open-label study. PATIENTS AND INTERVENTION:Eight hypogonadal men were studied at baseline, and after two weeks of transdermal testosterone replacement (Testogel, 100 mg/day). MAIN OUTCOMES MEASURES:The rate of hepatic urea synthesis was measured by the urea turnover technique using stable isotope methodology, with 15N2-urea as tracer. Whole-body leucine turnover was measured, from which leucine rate of appearance (LRa), an index of protein breakdown and leucine oxidation (Lox), a measure of irreversible protein loss, were calculated. RESULTS:Testosterone administration significantly reduced the rate of hepatic urea production (from 544.4 ± 71.8 to 431.7 ± 68.3 µmol/min; P < 0.01), which was paralleled by a significant reduction in serum urea concentration. Testosterone treatment significantly reduced net protein loss, as measured by percent Lox/LRa, by 19.3 ± 5.8% (P < 0.05). There was a positive association between Lox and hepatic urea production at baseline (r2 = 0.60, P < 0.05) and after testosterone administration (r2 = 0.59, P < 0.05). CONCLUSION:Testosterone replacement reduces protein loss and hepatic urea synthesis. We conclude that testosterone regulates whole-body protein metabolism by suppressing the urea cycle.

journal_name

Eur J Endocrinol

journal_title

European journal of endocrinology

authors

Lam T,Poljak A,McLean M,Bahl N,Ho KKY,Birzniece V

doi

10.1530/EJE-16-0868

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

489-496

issue

4

eissn

0804-4643

issn

1479-683X

pii

EJE160868

journal_volume

176

pub_type

杂志文章

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