当前位置： SCI文献检索 > EUROPEAN JOURNAL OF ENDOCRINOLOGY期刊下所有文献 > Testosterone prevents protein loss via the hepatic urea cycle in human.

Testosterone prevents protein loss via the hepatic urea cycle in human.

Abstract：

CONTEXT:The urea cycle is a rate-limiting step for amino acid nitrogen elimination. The rate of urea synthesis is a true indicator of whole-body protein catabolism. Testosterone reduces protein and nitrogen loss. The effect of testosterone on hepatic urea synthesis in humans has not been studied. OBJECTIVE:To determine whether testosterone reduces hepatic urea production. DESIGN:An open-label study. PATIENTS AND INTERVENTION:Eight hypogonadal men were studied at baseline, and after two weeks of transdermal testosterone replacement (Testogel, 100 mg/day). MAIN OUTCOMES MEASURES:The rate of hepatic urea synthesis was measured by the urea turnover technique using stable isotope methodology, with 15N2-urea as tracer. Whole-body leucine turnover was measured, from which leucine rate of appearance (LRa), an index of protein breakdown and leucine oxidation (Lox), a measure of irreversible protein loss, were calculated. RESULTS:Testosterone administration significantly reduced the rate of hepatic urea production (from 544.4 ± 71.8 to 431.7 ± 68.3 µmol/min; P < 0.01), which was paralleled by a significant reduction in serum urea concentration. Testosterone treatment significantly reduced net protein loss, as measured by percent Lox/LRa, by 19.3 ± 5.8% (P < 0.05). There was a positive association between Lox and hepatic urea production at baseline (r2 = 0.60, P < 0.05) and after testosterone administration (r2 = 0.59, P < 0.05). CONCLUSION:Testosterone replacement reduces protein loss and hepatic urea synthesis. We conclude that testosterone regulates whole-body protein metabolism by suppressing the urea cycle.

journal_name

Eur J Endocrinol

journal_title

European journal of endocrinology

authors

Lam T,Poljak A,McLean M,Bahl N,Ho KKY,Birzniece V

doi

10.1530/EJE-16-0868

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

489-496

issue

4

eissn

0804-4643

issn

1479-683X

pii

EJE160868

journal_volume

176

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF ENDOCRINOLOGY文献大全
  • Compromised cortical bone compartment in type 2 diabetes mellitus patients with microvascular disease.

    abstract：OBJECTIVE AND DESIGN:Patients with type 2 diabetes mellitus (T2D) have an increased fracture risk despite a normal or elevated bone mineral density (BMD). The aim of this cross-sectional in vivo study was to assess parameters of peripheral bone microarchitecture, estimated bone strength and bone remodeling in T2D patie...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-15-0860

    authors： Shanbhogue VV,Hansen S,Frost M,Jørgensen NR,Hermann AP,Henriksen JE,Brixen K

    更新日期：2016-02-01 00:00:00

  • Single nucleotide polymorphisms in the intergenic region between metformin transporter OCT2 and OCT3 coding genes are associated with short-term response to metformin monotherapy in type 2 diabetes mellitus patients.

    abstract：OBJECTIVES:High variability in clinical response to metformin is often observed in type 2 diabetes (T2D) patients, and it highlights the need for identification of genetic components affecting the efficiency of metformin therapy. Aim of this observational study is to evaluate the role of tagSNPs (tagging single nucleot...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-16-0347

    authors： Zaharenko L,Kalnina I,Geldnere K,Konrade I,Grinberga S,Židzik J,Javorský M,Lejnieks A,Nikitina-Zake L,Fridmanis D,Peculis R,Radovica-Spalvina I,Hartmane D,Pugovics O,Tkáč I,Klimčáková L,Pīrāgs V,Klovins J

    更新日期：2016-12-01 00:00:00

  • Shift from Conn's syndrome to Cushing's syndrome in a recurrent adrenocortical carcinoma.

    abstract：OBJECTIVE:Adrenocortical tumors may originate from the zona glomerulosa, zona fasciculata, or zona reticularis and be associated with syndromes due to overproduction of mineralocorticoids, glucocorticoids, or androgens respectively. We report an unusual case of recurrent adrenocortical carcinoma (ACC), which seems to c...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.1.02011

    authors： Barzon L,Masi G,Fincati K,Pacenti M,Pezzi V,Altavilla G,Fallo F,Palù G

    更新日期：2005-11-01 00:00:00

  • Sleep-wake and melatonin pattern in craniopharyngioma patients.

    abstract：OBJECTIVE:To assess the influence of craniopharyngioma or consequent surgery on melatonin secretion, and the association with fatigue, sleepiness, sleep pattern and sleep quality. DESIGN:Cross-sectional study. METHODS:A total of 15 craniopharyngioma patients were individually matched to healthy controls. In this stud...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-13-1025

    authors： Pickering L,Jennum P,Gammeltoft S,Poulsgaard L,Feldt-Rasmussen U,Klose M

    更新日期：2014-06-01 00:00:00

  • Biology of the gonadotropin-releasing hormone system in gynecological cancers.

    abstract：:The expression of GnRH and its receptor as a part of an autocrine regulatory system of cell proliferation has been demonstrated in a number of human malignant tumors, including cancers of the breast, ovary and endometrium. Dose-dependent antiproliferative effects of GnRH agonists in cell lines derived from these cance...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/eje.0.1460001

    authors： Gründker C,Günthert AR,Westphalen S,Emons G

    更新日期：2002-01-01 00:00:00

  • Estrogen responsiveness of bone formation in vitro and altered bone phenotype in aged estrogen receptor-alpha-deficient male and female mice.

    abstract：OBJECTIVE:Although the beneficial effects of estrogen on bone are well known, the roles of estrogen receptors (ERs) in mediating these effects are not fully understood. METHODS:To study the effects of long-term ER alpha deficiency, bone phenotype was studied in aged ER alpha knockout (ERKO) mice. In addition, ERKO ost...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.1.01832

    authors： Parikka V,Peng Z,Hentunen T,Risteli J,Elo T,Väänänen HK,Härkönen P

    更新日期：2005-02-01 00:00:00

  • Transition in endocrinology: induction of puberty.

    abstract：:Puberty is the period during which we attain adult secondary sexual characteristics and reproductive capability. Its onset depends upon reactivation of pulsative GNRH, secretion from its relative quiescence during childhood, on the background of intact potential for pituitary-gonadal function. This review is intended:...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-13-0894

    authors： Dunkel L,Quinton R

    更新日期：2014-06-01 00:00:00

  • Associations between subcutaneous fat density and systemic inflammation differ by HIV serostatus and are independent of fat quantity.

    abstract：Objectives:Adipose tissue (AT) density measurement may provide information about AT quality among people living with HIV. We assessed AT density and evaluated relationships between AT density and immunometabolic biomarker concentrations in men with HIV. Design:Cross-sectional analysis of men enrolled in the Multicente...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,多中心研究

    doi：10.1530/EJE-19-0296

    authors： Lake JE,Debroy P,Ng D,Erlandson KM,Kingsley LA,Palella FJ,Budoff MJ,Post WS,Brown TT

    更新日期：2019-10-01 00:00:00

  • Continuous s.c. infusion rather than twice-daily injections of IGF-I more effectively increases serum IGF binding protein-3 in female monkeys.

    abstract：OBJECTIVE:In order to better understand how the IGF-I axis is affected by exogenous IGF-I, this study compared the effects of a constant s.c. infusion of IGF-I with that of twice-daily injections of IGF-I in young adult female rhesus monkeys. Clinical studies suggest that circulating concentrations of insulin-like grow...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1410303

    authors： Wilson ME,Lackey SL

    更新日期：1999-09-01 00:00:00

  • Evolution of childhood central diabetes insipidus into panhypopituitarism with a large hypothalamic mass: is 'lymphocytic infundibuloneurohypophysitis' in children a different entity?

    abstract：:We report on a 15-year-old girl who had presented with acute onset central diabetes insipidus at the age of 8 years; this was followed by growth failure due to acquired growth hormone deficiency. Initial magnetic resonance imaging showed a uniformly enlarged pituitary stalk and absence of posterior pituitary hyperinte...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1390635

    authors： Maghnie M,Genovese E,Sommaruga MG,Aricò M,Locatelli D,Arbustini E,Pezzotta S,Severi F

    更新日期：1998-12-01 00:00:00

  • Efficacy and tolerability of lanreotide Autogel therapy in acromegalic patients previously treated with octreotide LAR.

    abstract：OBJECTIVE:This open label, multicentre study was designed to evaluate the efficacy and tolerability of lanreotide Autogel (L-Autogel) in acromegalic patients over a 24-week period. The outcome of treatment with this new, long-acting, aqueous formulation of lanreotide was also compared with the patients' previous treatm...

    journal_title：European journal of endocrinology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1530/eje.0.1510317

    authors： Alexopoulou O,Abrams P,Verhelst J,Poppe K,Velkeniers B,Abs R,Maiter D

    更新日期：2004-09-01 00:00:00

  • Therapy of endocrine disease: Perspectives on the management of adrenal insufficiency: clinical insights from across Europe.

    abstract：BACKGROUND:Conventional glucocorticoid (GC) replacement for patients with adrenal insufficiency (AI) is inadequate. Patients with AI continue to have increased mortality and morbidity and compromised quality of life despite treatment and monitoring. OBJECTIVES:i) To review current management of AI and the unmet medica...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-13-0450

    authors： Grossman A,Johannsson G,Quinkler M,Zelissen P

    更新日期：2013-10-21 00:00:00

  • Testicular adrenal rests: evidence for luteinizing hormone receptors and for distinct types of testicular nodules differing for their autonomization.

    abstract：:We report one patient with 21-hydroxylase deficiency and associated bilateral macro-orchidism caused by nodular hyperplasia of testicular adrenal rests (TAR). The boy, referred to us when 10 years old, was born with bilateral cryptorchidism that was treated unsuccessfully with i.m. injections of human chorionic gonado...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1410231

    authors： Benvenga S,Smedile G,Lo Giudice F,Trimarchi F

    更新日期：1999-09-01 00:00:00

  • Anthropometric factors have significant influence on the outcome of the GHRH-arginine test: establishment of normative data for an automated immunoassay specifically measuring 22 kDa human growth hormone.

    abstract：CONTEXT:Adult growth hormone (GH) deficiency (GHD) is diagnosed by provocative testing of GH secretion. OBJECTIVE:To improve the diagnostic accuracy of GH-releasing hormone (GHRH) plus arginine (GARG) testing, we evaluated the influence of age, BMI and sex and established normative data for an automatic immunoassay sp...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-16-0668

    authors： Deutschbein T,Bidlingmaier M,Schopohl J,Strasburger CJ,Petersenn S

    更新日期：2017-03-01 00:00:00

  • Anionic iodotyrosine residues are required for iodothyronine synthesis.

    abstract：:Biosynthesis of iodothyronines in thyroglobulin occurs by oxidative coupling of two iodotyrosine residues catalyzed by thyroperoxidase. To study the mechanism of iodothyronine formation, iodine-free thyroglobulin was non-enzymatically iodinated and after removal of non-incorporated iodide, incubated with lactoperoxida...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1380227

    authors： de Vijlder JJ,den Hartog MT

    更新日期：1998-02-01 00:00:00

  • Transsphenoidal surgery in acromegaly investigated by intraoperative high-field magnetic resonance imaging.

    abstract：OBJECTIVE:The aim of the study was to evaluate the effect of intraoperative high-field (1.5 Tesla) magnetic resonance imaging (MRI) on the results of transsphenoidal surgery of GH-secreting pituitary macroadenomas. METHODS:Twenty-three acromegalic patients (mean tumor size, 25 +/- 12 mm; untreated preoperative GH, 4.2...

    journal_title：European journal of endocrinology

    pub_type： 临床试验,杂志文章

    doi：10.1530/eje.1.01970

    authors： Fahlbusch R,Keller Bv,Ganslandt O,Kreutzer J,Nimsky C

    更新日期：2005-08-01 00:00:00

  • Age-related changes of the hypothalamic-pituitary-adrenal axis: pathophysiological correlates.

    abstract：:The aim of this review was to examine the evidence for age-related changes of the hypothalamic-pituitary-adrenal (HPA) axis in both physiological and pathological aging, on the basis of the many data in the literature, as well as of our personal findings. A statistically significant circadian rhythmicity of serum cort...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/eje.0.1440319

    authors： Ferrari E,Cravello L,Muzzoni B,Casarotti D,Paltro M,Solerte SB,Fioravanti M,Cuzzoni G,Pontiggia B,Magri F

    更新日期：2001-04-01 00:00:00

  • Prognostic relevance of proliferation-related miRNAs in pancreatic neuroendocrine neoplasms

    abstract：Objective:Pancreatic neuroendocrine neoplasms (PanNENs) are rare tumors arising from the endocrine pancreas; however, their prognosis differs significantly upon their proliferative state, which is characterized by histopathological grading. MiRNAs are small, noncoding RNAs posttranscriptionally regulating gene expressi...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-18-0305

    authors： Grolmusz VK,Kövesdi A,Borks K,Igaz P,Patócs A

    更新日期：2018-10-01 00:00:00

  • Changes in the glycosylation pattern of circulating gonadotropins after acute administration of gonadotropin-releasing hormone in patients with anorexia nervosa.

    abstract：:To study the involvement of gonadotropin-releasing hormone (GnRH) in glycosylation of circulating gonadotropin isoforms in anorexia nervosa (AN), 14 amenorrhoic patients with AN, 14 age-matched volunteers in early follicular phase, and five normal-weight re-fed patients with AN were investigated under baseline conditi...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1380076

    authors： Savastano S,Tommaselli AP,Valentino R,Luciano A,Gigante M,Randazzo G,Contaldo F,Scalfi L,Lombardi G

    更新日期：1998-01-01 00:00:00

  • Ultrasonographic and clinical parameters for early differentiation between precocious puberty and premature thelarche.

    abstract：OBJECTIVE:To determine if uterine and ovarian measurements can significantly distinguish between precocious puberty (PP) and premature thelarche (PT) and whether ultrasound has any advantage over the gonadotropin-releasing hormone (GnRH) stimulation test. DESIGN:Prospective. METHODS:One hundred and three girls referr...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.1.02151

    authors： de Vries L,Horev G,Schwartz M,Phillip M

    更新日期：2006-06-01 00:00:00

  • Association study of AMP-activated protein kinase subunit genes in polycystic ovary syndrome.

    abstract：OBJECTIVE:To examine the genes for AMP-activated protein kinase (AMPK) subunits alpha2 (PRKAA2) and gamma3 (PRKAG3) as candidates for polycystic ovary syndrome (PCOS) and its component traits. DESIGN AND METHODS:A total of 287 white PCOS women were recruited from the reproductive endocrinology clinic at the University...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-09-0245

    authors： Sproul K,Jones MR,Azziz R,Goodarzi MO

    更新日期：2009-09-01 00:00:00

  • A unique exonic splicing mutation in the CYP17A1 gene as the cause for steroid 17{alpha}-hydroxylase deficiency.

    abstract：BACKGROUND:17α-Hydroxylase/17,20-lyase deficiency (17OHD) caused by a mutation in the CYP17A1 gene is characterized by hypertension, hypokalemia, and abnormal development of the genitalia. The majority of CYP17A1 mutations are located in the coding sequence, and several intronic splicing site mutations have been report...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-10-0933

    authors： Qiao J,Han B,Liu BL,Liu W,Wu JJ,Pan CM,Jiang H,Gu T,Jiang BR,Zhu H,Lu YL,Wu WL,Chen MD,Song HD

    更新日期：2011-04-01 00:00:00

  • Leptin response to endogenous acute stress is independent of pituitary function.

    abstract：:There are close interactions between the adipocyte-derived hormone, leptin, and the anterior pituitary, especially the hypothalamic-pituitary-adrenal (HPA) axis. We investigated the relationship between the sympathetic adrenergic system and serum leptin levels, dependent on the function of anterior pituitary hormone a...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1450295

    authors： Schafroth U,Godang K,Ueland T,Bollerslev J

    更新日期：2001-09-01 00:00:00

  • Effects of water deprivation on atrial natriuretic peptide secretion and density of binding sites in adrenal glands and kidneys of maternal and fetal rats in late gestation.

    abstract：:The effects of water deprivation for 3 days were studied in pregnant rats and their fetuses on day 21 of gestation. Maternal water deprivation induced a significant decrease of the body weight in both maternal and fetal rats. This weight loss was accompanied by significant increases in plasma osmolality and haematocri...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1410160

    authors： Deloof S,De Seze C,Montel V,Chatelain A

    更新日期：1999-08-01 00:00:00

  • Long-acting somatostatin analogues are an effective treatment for type 1 gastric carcinoid tumours.

    abstract：BACKGROUND:Gastric carcinoid tumours type 1 (GCA1) originate from hyperplastic enterochromaffin-like (ECL) cells secondary to hypergastrinaemia. Treatment with somatostatin analogues (SSA) might impede ECL-cell hyperplasia by suppressing gastrin secretion and/or by a direct anti-proliferative effect on ECL cells. We co...

    journal_title：European journal of endocrinology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1530/EJE-08-0420

    authors： Grozinsky-Glasberg S,Kaltsas G,Gur C,Gal E,Thomas D,Fichman S,Alexandraki K,Barak D,Glaser B,Shimon I,Gross DJ

    更新日期：2008-10-01 00:00:00

  • Treatment of Graves' disease by carbimazole: high dose with thyroxine compared to titration dose.

    abstract：:A comparative study of high-dose (HD, carbimazole 60 mg plus thyroxine 100-150 micrograms daily) and titration-dose (TD) regimens of carbimazole was carried out in 70 patients with Graves' disease, the patients being assigned randomly to one or other regimen. The treatment was given for 1 year and follow-up was for 2 ...

    journal_title：European journal of endocrinology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1530/eje.0.1310120

    authors： Edmonds CJ,Tellez M

    更新日期：1994-08-01 00:00:00

  • MANAGEMENT OF ENDOCRINE DISEASE: Acromegaly and cancer: an old debate revisited.

    abstract：:Based on experimental and animal models, epidemiological data from non-acromegaly populations, and longitudinal and cross-sectional cohorts of patients with acromegaly, a potential association between acromegaly and cancer has long been hypothesized, in particular colorectal cancer, and, to a lesser extent, breast, th...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-16-0178

    authors： Boguszewski CL,Ayuk J

    更新日期：2016-10-01 00:00:00

  • Retarded bone growth in thyroid hormone resistance. A clinical study of a large family with a novel thyroid hormone receptor mutation.

    abstract：OBJECTIVE:Thyroid hormone resistance (RTH) is characterised by variable tissue hyporesponsiveness to thyroid hormone. The disorder is usually caused by mutations in the thyroid hormone receptor beta (TR beta). We describe a large family with this disorder. SUBJECTS AND MEASUREMENT: We identified 36 family members with ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1500425

    authors： Kvistad PH,Løvås K,Boman H,Myking OL

    更新日期：2004-04-01 00:00:00

  • Relationship of serum fibroblast growth factor 23 with cardiovascular disease in older community-dwelling women.

    abstract：OBJECTIVE:Although fibroblast growth factor 23 (FGF23) has been implicated in the pathogenesis of cardiovascular disease, the relationship between FGF23 and cardiovascular disease has not been well characterized in the general population. The aim of this study was to determine whether serum FGF23 is independently assoc...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,随机对照试验

    doi：10.1530/EJE-11-0577

    authors： Dalal M,Sun K,Cappola AR,Ferrucci L,Crasto C,Fried LP,Semba RD

    更新日期：2011-11-01 00:00:00

  • MANAGEMENT OF ENDOCRINE DISEASE: Predictive scores in autoimmune thyroid disease: are they useful?

    abstract：:Prediction models are of a great assistance for predicting the development of a disease, detecting or screening undiagnosed patients, predicting the effectiveness of a treatment and helping toward better decision-making. Recently, three predictive scores in the field of autoimmune thyroid disease (AITD) have been intr...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-19-0234

    authors： Effraimidis G

    更新日期：2019-09-01 00:00:00