abstract：:DNA replication checkpoint is a cell signaling pathway that is activated in response to perturbed replication. Although it is crucial for maintaining genomic integrity and cell survival, the exact mechanism of the checkpoint signaling remains to be understood. Emerging evidence has shown that RecQ helicases, a large f...

journal_title：Current genetics

authors： Ahamad N,Khan S,Mahdi ATA,Xu YJ

更新日期：2021-01-11 00:00:00

abstract：:Cohesin is essential for sister chromatid cohesion, which ensures equal segregation of the chromatids to daughter cells. However, the molecular mechanism by which cohesin mediates this function is elusive. Scc3, one of the four core subunits of cohesin, is vital to cohesin activity. However, the mechanism by which Scc...

journal_title：Current genetics

authors： Pathania A,Liu W,Matityahu A,Irudayaraj J,Onn I

更新日期：2021-01-06 00:00:00

abstract：:RNA/DNA hybrids are processed by RNases H1 and H2, while single ribonucleoside-monophosphates (rNMPs) embedded in genomic DNA are removed by the error-free, RNase H2-dependent ribonucleotide excision repair (RER) pathway. In the absence of RER, however, topoisomerase 1 (Top1) can cleave single genomic rNMPs in a mutag...

journal_title：Current genetics

authors： Cerritelli SM,El Hage A

更新日期：2020-12-01 00:00:00

abstract：:Cell aging is the result of deteriorating competence in maintaining cellular homeostasis and quality control. Certain cell types are able to rejuvenate through asymmetric cell division by excluding aging factors, including damaged cellular compartments and extrachromosomal rDNA circles, from entering the daughter cell...

journal_title：Current genetics

authors： Koch-Bojalad BA,Carson L,Yu HG

更新日期：2020-11-27 00:00:00

abstract：:Cells divide with appropriate frequency by coupling division to growth-that is, cells divide only when they have grown sufficiently large. This process is poorly understood, but has been studied using cell size mutants. In principle, mutations affecting cell size could affect the mean size ("set-point" mutants), or th...

journal_title：Current genetics

authors： Chen Y,Futcher B

更新日期：2020-11-05 00:00:00

abstract：:Phyto-pathogenic fungi can cause huge damage to crop production. During millions of years of coexistence, fungi have evolved diverse life-style to obtain nutrients from the host and to colonize upon them. They deploy various proteinaceous as well as non-proteinaceous secreted molecules commonly referred as effectors t...

journal_title：Current genetics

authors： Pradhan A,Ghosh S,Sahoo D,Jha G

更新日期：2020-11-04 00:00:00

abstract：:Replication-coupled (RC) nucleosome assembly is an essential process in eukaryotic cells to maintain chromatin structure during DNA replication. The deposition of newly-synthesized H3/H4 histones during DNA replication is facilitated by specialized histone chaperones. CAF-1 is an important histone chaperone complex an...

journal_title：Current genetics

authors： Tsirkas I,Dovrat D,Lei Y,Kalyva A,Lotysh D,Li Q,Aharoni A

更新日期：2020-10-06 00:00:00

abstract：:Saccharomyces cerevisiae adapts to oxidative, osmotic stress and nutrient deprivation through transcriptional changes, decreased proliferation, and entry into other developmental pathways such as pseudohyphal formation and sporulation. Inositol pyrophosphates are necessary for these cellular responses. Inositol pyroph...

journal_title：Current genetics

authors： Morrissette VA,Rolfes RJ

更新日期：2020-10-01 00:00:00

abstract：:Gene expression using alternative transcription start sites (TSSs) is an important transcriptional regulatory mechanism for environmental responses in eukaryotes. Here, we identify two alternative TSSs in the enolase-encoding gene (enoA) in Aspergillus oryzae, an industrially important filamentous fungus. TSS use in e...

journal_title：Current genetics

authors： Inoue T,Toji H,Tanaka M,Takama M,Hasegawa-Shiro S,Yamaki Y,Shintani T,Gomi K

更新日期：2020-08-01 00:00:00

abstract：:Although cell division is usually portrayed as an equitable process by which a progenitor cell originates two identical daughter cells, there are multiple examples of asymmetric divisions that generate two cells that differ in their content, morphology and/or proliferative potential. The capacity of the cells to gener...

journal_title：Current genetics

authors： Manzano-López J,Monje-Casas F

更新日期：2020-08-01 00:00:00

abstract：:It is now established that base-pairing regulatory RNAs are key players in post-transcriptional regulatory networks where they affect the translation and/or stability of their target RNAs. In many cases, the base-pairing between two RNAs is facilitated by an RNA-binding protein (RBP) that serves as an RNA chaperone. R...

journal_title：Current genetics

authors： Melamed S

更新日期：2020-08-01 00:00:00

abstract：:Many species are able to hybridize, but the sterility of these hybrids effectively prevents gene flow between the species, reproductively isolating them and allowing them to evolve independently. Yeast hybrids formed by Saccharomyces cerevisiae and Saccharomyces paradoxus parents are viable and able to grow by mitosis...

journal_title：Current genetics

authors： Ono J,Greig D

更新日期：2020-06-01 00:00:00

abstract：:Forces generated by molecular motors and the cytoskeleton move the nucleus and genome during many cellular processes, including cell migration and division. How these forces impact the genome, and whether cells regulate cytoskeletal forces to preserve genome integrity is unclear. We recently demonstrated that, in budd...

journal_title：Current genetics

authors： Estrem C,Moore JK

更新日期：2020-04-01 00:00:00

abstract：:Most organisms prefer to utilize glucose as a carbon source. Accordingly, the expression of genes involved in the catabolism of other carbon sources is repressed by the presence of glucose in a process known as (carbon) catabolite repression. However, much less is known about the relationships between "poor" carbon so...

journal_title：Current genetics

authors： Simpson-Lavy K,Kupiec M

更新日期：2019-12-01 00:00:00

abstract：:Single-strand breaks (SSB) are discontinuities in one strand of the DNA double helix and are the most common type of damages that arise in cells. SSBs arise mainly from direct attack by intracellular metabolites, however, also essential nuclear processes generate SSBs as intermediates. During the catalytic cycle of DN...

journal_title：Current genetics

authors： Jakobsen KP,Andersen AH,Bjergbæk L

更新日期：2019-10-01 00:00:00

abstract：:In fungi, sexual reproduction primarily depends on the interaction between peptide pheromones and their receptors. Most ascomycete fungi produce two classes of peptide mating pheromones, a simple peptide and a modified peptide. These peptides are recognized by their corresponding receptors on the surface of cells of t...

journal_title：Current genetics

authors： Seike T

更新日期：2019-10-01 00:00:00

abstract：:Sister chromatid cohesion is essential for chromosome segregation both in mitosis and meiosis. Cohesion between two chromatids is mediated by a protein complex called cohesin. The loading and unloading of the cohesin are tightly regulated during the cell cycle. In vertebrate cells, cohesin is released from chromosomes...

journal_title：Current genetics

authors： Challa K,Shinohara M,Shinohara A

更新日期：2019-08-01 00:00:00

abstract：:To supply abundant ribosomes, multiple copies of ribosomal RNA genes (rDNA) are conserved from bacterial to human cells. In eukaryotic genomes, clusters of tandemly repeated rDNA units are present, and their number is stably maintained. Due to high level of transcription of rRNA genes, the repetitive structure is pron...

journal_title：Current genetics

authors： Iida T,Kobayashi T

更新日期：2019-08-01 00:00:00

abstract：:The bacterial hexameric helicase known as Rho is an archetypal sequence-specific transcription terminator that typically halts the synthesis of a defined set of transcripts, particularly those bearing cytosine-rich 3'-untranslated regions. However, under conditions of translational stress, Rho can also terminate trans...

journal_title：Current genetics

authors： Lawson MR,Berger JM

更新日期：2019-06-01 00:00:00

abstract：:The soil-borne, asexual fungus Fusarium oxysporum f.sp. lycopersici (Fol) is a causal agent of tomato wilt disease. The infection process of Fol comprises root recognition, adhesion, penetration, colonization of the root cortex and hyphal proliferation within the xylem vessels, which are under the regulation of virule...

journal_title：Current genetics

authors： Yun Y,Zhou X,Yang S,Wen Y,You H,Zheng Y,Norvienyeku J,Shim WB,Wang Z

更新日期：2019-06-01 00:00:00

abstract：:DNA polymerases are evolved to extend the 3'-OH of a growing primer annealed to a template DNA substrate. Since replicative DNA polymerases have a limited role while replicating structurally distorted template, translesion DNA polymerases mostly from Y-family come to the rescue of stalled replication fork and maintain...

journal_title：Current genetics

authors： Acharya N,Manohar K,Peroumal D,Khandagale P,Patel SK,Sahu SR,Kumari P

更新日期：2019-06-01 00:00:00

abstract：:In eukaryotes, genomic DNA is packaged into the nucleus together with histone proteins, forming chromatin. The fundamental repeating unit of chromatin is the nucleosome, a naturally symmetric structure that wraps DNA and is the substrate for numerous regulatory post-translational modifications. However, the biological...

journal_title：Current genetics

authors： Ichikawa Y,Kaufman PD

更新日期：2019-04-01 00:00:00

abstract：:Loss of heterozygosity (LOH) in a vegetatively growing diploid cell signals irregularity of mitosis. Therefore, assays of LOH serve to discover pathways critical for proper replication and segregation of chromosomes. We screened for enhanced LOH in a whole-genome collection of diploid yeast strains in which a single g...

journal_title：Current genetics

authors： Tutaj H,Pogoda E,Tomala K,Korona R

更新日期：2019-04-01 00:00:00

abstract：:The zinc finger transcription factor Crz1 is an important downstream regulator of calcium-dependent signal transduction pathways in many organisms. The function of Crz1 in the wheat-head blight pathogen Fusarium graminearum remains unclear. In this study, we identified and functionally characterised FgCrz1A, a potenti...

journal_title：Current genetics

authors： Chen L,Tong Q,Zhang C,Ding K

更新日期：2019-02-01 00:00:00

abstract：:Cellular heterogeneity is a widespread phenomenon, existing across organisms and serving a crucial role in evolution and cell survival. Genetically identical cells may as a result present in a variety of forms with different gene and protein expressions, as well as oxidation level. As a result, a wide range of methodo...

journal_title：Current genetics

authors： Radzinski M,Reichmann D

更新日期：2019-02-01 00:00:00

abstract：:The mother-bud neck is defined as the boundary between the mother cell and bud in budding microorganisms, wherein sequential morphological events occur throughout the cell cycle. This study was designed to quantitatively investigate the morphology of the mother-bud neck in budding yeast Saccharomyces cerevisiae. Obser...

journal_title：Current genetics

authors： Kubo K,Okada H,Shimamoto T,Kimori Y,Mizunuma M,Bi E,Ohnuki S,Ohya Y

更新日期：2019-02-01 00:00:00

abstract：:The Cys6Zn2 DNA-binding domain transcription factor Pdr1 is a central regulator of drug resistance in the pathogenic yeast Candida glabrata. In this review, I discuss the multiple control mechanisms modulating the function of this positive transcriptional regulator. Available data suggest that Pdr1 activity is restrai...

journal_title：Current genetics

authors： Moye-Rowley WS

更新日期：2019-02-01 00:00:00

abstract：:Arenicin-1, a 21-mer antimicrobial peptide exerts significant broad-spectrum antimicrobial activity with membrane-active mechanisms. However, owing to multiple mechanisms of cell death, the antibacterial mechanism of arenicin-1 requires detailed analysis. In the present study, arenicin-1-treated bacteria underwent an ...

journal_title：Current genetics

authors： Lee H,Lee DG

更新日期：2019-02-01 00:00:00

abstract：:Cellular reverse transcriptase-related (rvt) genes represent a novel class of reverse transcriptases (RTs), which are only distantly related to RTs of retrotransposons and retroviruses, but, similarly to telomerase RTs, are immobilized in the genome as single-copy genes. They have been preserved by natural selection t...

journal_title：Current genetics

authors： Yushenova IA,Arkhipova IR

更新日期：2018-12-01 00:00:00

abstract：:In eukaryotes, the ubiquitin-like (UBL) protein-activating enzymes play a crucial role in autophagy process, however, it is poorly characterized in filamentous fungi. Here, we investigated the functions of two UBL activating enzymes, BcAtg3 (E2) and BcAtg7 (E1) in the plant pathogenic fungus Botrytis cinerea. The phys...

journal_title：Current genetics

authors： Ren W,Sang C,Shi D,Song X,Zhou M,Chen C

更新日期：2018-08-01 00:00:00

abstract：:Mono-ubiquitinated histone H2B (H2B-Ub) is important for chromatin regulation of transcription, chromatin assembly, and also influences heterochromatin. In this review, we discuss the effects of H2B-Ub from nucleosome to higher-order chromatin structure. We then assess what is currently known of the role of H2B-Ub in ...

journal_title：Current genetics

authors： Zukowski A,Johnson AM

更新日期：2018-08-01 00:00:00

abstract：:Telomere maintenance mechanism is poorly studied in quiescence, a reversible non-proliferative state. We previously described in fission yeast a new mode of repair of telomeres named STEEx, that specifically operates in post-mitotic cells harboring eroded telomeres. This mechanism, promoted by transcription-induced te...

journal_title：Current genetics

authors： Maestroni L,Géli V,Coulon S

更新日期：2018-08-01 00:00:00

abstract：:Microorganisms have the ability to adapt and respond to different environmental conditions, whether they are stressful or not. Although the detection and/or responding mechanisms are often unknown, a large number of proteins may participate in signal transduction pathways involved in environmental stimulus to induce p...

journal_title：Current genetics

authors： Virgilio S,Bertolini MC

更新日期：2018-06-01 00:00:00

abstract：:Full genome recoding, or rewriting codon meaning, through chemical synthesis of entire bacterial chromosomes has become feasible in the past several years. Recoding an organism can impart new properties including non-natural amino acid incorporation, virus resistance, and biocontainment. The estimated cost of construc...

journal_title：Current genetics

authors： Kuo J,Stirling F,Lau YH,Shulgina Y,Way JC,Silver PA

更新日期：2018-04-01 00:00:00

abstract：:DNA-damage tolerance (DDT) is employed by eukaryotes to deal with replication blocks on the template strand, and is divided into two parallel pathways that are activated by sequential ubiquitination of proliferating cell nuclear antigen (PCNA) at the Lys164 residue. Rad6-Rad18-mediated PCNA monoubiquitination promotes...

journal_title：Current genetics

authors： Li F,Ball LG,Fan L,Hanna M,Xiao W

更新日期：2018-04-01 00:00:00

abstract：:The search for novel pathological and functional amyloids represents one of the most important tasks of contemporary biomedicine. Formation of pathological amyloid fibrils in the aging brain causes incurable neurodegenerative disorders such as Alzheimer's, Parkinson's Huntington's diseases. At the same time, a set of ...

journal_title：Current genetics

authors： Ryzhova TA,Sopova JV,Zadorsky SP,Siniukova VA,Sergeeva AV,Galkina SA,Nizhnikov AA,Shenfeld AA,Volkov KV,Galkin AP

更新日期：2018-04-01 00:00:00

abstract：:Timely progression of living cells through the cell cycle is precisely regulated. This involves a series of phosphorylation events which are regulated by various cyclins, activated in coordination with the cell cycle progression. Phosphorylated proteins govern cell growth, division as well as duplication of the geneti...

journal_title：Current genetics

authors： Dmowski M,Fijałkowska IJ

更新日期：2017-12-01 00:00:00

abstract：:Studies on replicative and chronological aging in Saccharomyces cerevisiae have greatly advanced our understanding of how longevity is regulated in all eukaryotes. Chronological lifespan (CLS) of yeast is defined as the age-dependent viability of non-dividing cell populations. A number of nutrient sensing and signal t...

journal_title：Current genetics

authors： Zhang N,Cao L

更新日期：2017-10-01 00:00:00

abstract：:Cohesin is one of three multi-protein structural maintenance of chromosome (SMC) complexes that regulate eukaryotic chromosome dynamics. It forms a ring-shaped structure that embraces sister chromatids through interphase to promote their pairing. In preparation for mitosis, most cohesin is stripped from the chromosome...

journal_title：Current genetics

authors： Lin SJ,O'Connell MJ

更新日期：2017-10-01 00:00:00

abstract：:In Aspergillus nidulans, carbon catabolite repression (CCR) is mediated by the global repressor protein CreA. The deubiquitinating enzyme CreB is a component of the CCR network. Genetic interaction was confirmed using a strain containing complete loss-of-function alleles of both creA and creB. No direct physical inter...

journal_title：Current genetics

authors： Alam MA,Kelly JM

更新日期：2017-08-01 00:00:00