Abstract:
:Telomere maintenance mechanism is poorly studied in quiescence, a reversible non-proliferative state. We previously described in fission yeast a new mode of repair of telomeres named STEEx, that specifically operates in post-mitotic cells harboring eroded telomeres. This mechanism, promoted by transcription-induced telomeric recombination, prevents cells to exit properly from quiescence, suggesting that STEEx act as an anti-proliferative barrier. Here, we further showed that STEEx are genetically controlled by the Tel1ATM- and Rad3ATR- dependent DDR pathways. We discussed the possibility that STEEx represent a boundary between quiescence and vegetative cycle.
journal_name
Curr Genetjournal_title
Current geneticsauthors
Maestroni L,Géli V,Coulon Sdoi
10.1007/s00294-018-0808-xsubject
Has Abstractpub_date
2018-08-01 00:00:00pages
901-905issue
4eissn
0172-8083issn
1432-0983pii
10.1007/s00294-018-0808-xjournal_volume
64pub_type
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