Abstract:
:Microorganisms have the ability to adapt and respond to different environmental conditions, whether they are stressful or not. Although the detection and/or responding mechanisms are often unknown, a large number of proteins may participate in signal transduction pathways involved in environmental stimulus to induce physiological and cellular events. Here, we examine the important role in cell homeostasis that extracellular pH plays in different fungi, and summarize the recent data reported in distinct organisms, by comparing them to the well-characterized mechanisms firstly described in Aspergillus and yeast. While most of the knowledge regarding the cellular processes triggered by the pH signaling pathway is based on the work in these two organisms, new data have been emerging in a diverse group of filamentous fungi, namely the involvement of this signaling pathway in metabolism and fungal pathogenicity. In this review, we present the major aspects of the pH signaling pathway in different model organisms, focusing on the protein components and the biological processes influenced by this pathway. In particular, we discuss novel cellular processes regulated by this pathway in the fungus Neurospora crassa. The diversity of functional processes that are affected under pH stress highlights how broadly this condition impacts on basic cellular processes in fungi and reveals how divergent fungal species are.
journal_name
Curr Genetjournal_title
Current geneticsauthors
Virgilio S,Bertolini MCdoi
10.1007/s00294-017-0772-xsubject
Has Abstractpub_date
2018-06-01 00:00:00pages
529-534issue
3eissn
0172-8083issn
1432-0983pii
10.1007/s00294-017-0772-xjournal_volume
64pub_type
杂志文章,评审相关文献
CURRENT GENETICS文献大全abstract::Yeast ornithine transaminase is known to be induced by arginine and ornithine, through the action of regulatory elements common to arginase induction. We show here that it is subject to a second induction circuit, that which is responsible for urea amidolyase and urea permease induction by allophanate and defined by t...
journal_title:Current genetics
pub_type: 杂志文章
doi:10.1007/BF00376788
更新日期:1981-09-01 00:00:00
abstract::Although 29 tRNA genes have been deduced from the complete nucleotide sequence of the mitochondrial genome from the liverwort Marchantia polymorpha, a tRNAIle gene decoding AUU and AUC codons is conspicuously absent. In order to address the question of the possible involvement of nuclear-encoded tRNA, we isolated and ...
journal_title:Current genetics
pub_type: 杂志文章
doi:10.1007/s002940050118
更新日期:1996-07-31 00:00:00
abstract::A double-stranded (ds)RNA, designated as M2, is associated with hypovirulence, conversion of the quinic acid pathway from inducible to constitutive and downregulation of the shikimic acid pathway in the Rhizoctonia solani culture Rhs 1A1. In this study, we report that in the virulent, M2-lacking isolate Rhs 1AP, which...
journal_title:Current genetics
pub_type: 杂志文章
doi:10.1007/s00294-003-0375-6
更新日期:2003-05-01 00:00:00
abstract::The wild diastatic yeast Saccharomyces cerevisiae NCYC 625 has been shown to be homozygous for the glucoamylase-specifying gene STA2. spoII-1-mapping has positioned STA2 on chromosome II. Expression of STA2 is suppressed in some but not all diploids capable of sporulation, and is also inhibited by unlinked nuclear sup...
journal_title:Current genetics
pub_type: 杂志文章
doi:10.1007/BF00314873
更新日期:1990-04-01 00:00:00
abstract::A PCR approach, employing the use of degenerate oligonucleotide mixtures, was used to isolate pph-1, a type-2A protein phosphatase (catalytic subunit)-encoding gene, from Neurospora crassa. The isolated single copy gene is 1327 nucleotides in length, contains four putative introns and encodes a 310 amino-acid polypept...
journal_title:Current genetics
pub_type: 杂志文章
doi:10.1007/BF00310816
更新日期:1995-10-01 00:00:00
abstract::Spindle pole body (SPB; the microtubule organizing center in yeast) duplication is essential to form a bipolar spindle. The duplicated SPBs must then separate and migrate to opposite sides of the nucleus. We identified a novel functional relationship in SPB separation between the microtubule stabilizing protein Bik1p/...
journal_title:Current genetics
pub_type: 杂志文章
doi:10.1007/s00294-006-0098-6
更新日期:2006-12-01 00:00:00
abstract::Cyclosporin A is a potent and clinically-important immunosuppressive drug (SandimmunR). It is produced by the fungus Tolypocladium niveum. A transformation system for T. niveum ATCC34921 based on hygromycin selection was established. In order to obtain a T. niveum promoter, the cyclophilin gene was isolated using the ...
journal_title:Current genetics
pub_type: 杂志文章
doi:10.1007/BF00309935
更新日期:1994-11-01 00:00:00
abstract::The soil-borne, asexual fungus Fusarium oxysporum f.sp. lycopersici (Fol) is a causal agent of tomato wilt disease. The infection process of Fol comprises root recognition, adhesion, penetration, colonization of the root cortex and hyphal proliferation within the xylem vessels, which are under the regulation of virule...
journal_title:Current genetics
pub_type: 杂志文章
doi:10.1007/s00294-019-00931-9
更新日期:2019-06-01 00:00:00
abstract::Although the mitochondrial genomes of the Chinese Spring and Aquila varieties of wheat are normally similar in organization, this is not so in tissue cultures initiated from their immature embryos where the mitochondrial genomes of both are rearranged and in different, characteristic, ways. However, the mitochondrial ...
journal_title:Current genetics
pub_type: 杂志文章
doi:10.1007/BF00351662
更新日期:1992-05-01 00:00:00
abstract::Mitochondrial DNA from etiolated seedling of male-fertile (F) and male-sterile (S) sunflower (Helianthus annuus L.) has been investigated for the first time in an isogenic couple HA89. 1. The mt-DNAs isolated from the S and F cytoplasms give a sharp and symmetrical band at 1.706 g/ml in an analytical CsCI gradient ult...
journal_title:Current genetics
pub_type: 杂志文章
doi:10.1007/BF00420319
更新日期:1985-03-01 00:00:00
abstract::Ubiquitination/deubiquitination pathways are now recognized as key components of gene regulatory mechanisms in eukaryotes. The major transcriptional repressor for carbon catabolite repression in Aspergillus nidulans is CreA, and mutational analysis led to the suggestion that a regulatory ubiquitination/deubiquitinatio...
journal_title:Current genetics
pub_type: 杂志文章
doi:10.1007/s00294-016-0643-x
更新日期:2016-09-02 00:00:00
abstract::In this work, we explore the use of the unbiased cDNA-AFLP strategy to identify genes involved in Mn(2+) homeostasis in Ceriporiopsis subvermispora. In this ligninolytic white-rot fungus, whose genome has not yet been sequenced, three Mn peroxidase genes responding to Mn(2+) have been characterized. Using cDNA-AFLP to...
journal_title:Current genetics
pub_type: 杂志文章
doi:10.1007/s00294-008-0209-7
更新日期:2008-10-01 00:00:00
abstract::Retrotransposons are activated as organisms age, based on work from several model systems. Since these mobile DNA elements can promote genome instability, this has raised the possibility that they can contribute to loss of cellular function with age. Many questions remain to be addressed about the relationship between...
journal_title:Current genetics
pub_type: 杂志文章,评审
doi:10.1007/s00294-015-0538-2
更新日期:2016-05-01 00:00:00
abstract::A gene which confers resistance to the systemic fungicide carboxin (Cbx) has been isolated from the maize pathogen, Ustilago maydis, by transferring a plasmid gene library from a Cbx-resistant mutant strain into a sensitive strain and selecting for expression of the resistance gene. Five plasmids, rescued from transfo...
journal_title:Current genetics
pub_type: 杂志文章
doi:10.1007/BF00312739
更新日期:1991-06-01 00:00:00
abstract::Extracellular proteins of filamentous fungi are important for biomedical and biotechnological applications. Aspergillus terreus not only comprises an important class of organisms that have significant commercial relevance to the biotechnology industry, but also is an emerging fungal pathogen. However, no information i...
journal_title:Current genetics
pub_type: 杂志文章
doi:10.1007/s00294-010-0308-0
更新日期:2010-08-01 00:00:00
abstract::Transforming DNAs form cointegrates in Aspergillus nidulans by homologous and non-homologous recombination as well as by end-to-end ligation of linear fragments. This process has been studied by means of a model in which the linkage of a marker gene to the origin of autonomous replication AMA1 was selected for. Recomb...
journal_title:Current genetics
pub_type: 杂志文章
doi:10.1007/BF00310500
更新日期:1994-10-01 00:00:00
abstract::Most eukaryotes require molecular oxygen for growth. In general, oxygen is the terminal electron acceptor of the respiratory chain and represents an important substrate for the biosynthesis of cellular compounds. However, in their natural environment, such as soil, and also during the infection, filamentous fungi are ...
journal_title:Current genetics
pub_type: 杂志文章,评审
doi:10.1007/s00294-015-0487-9
更新日期:2015-08-01 00:00:00
abstract::An Agrocybe aegerita cDNA library, constructed from fruit body primordia poly(A)+ RNAs, was screened by differential colony hybridization. Clones which preferentially hybridized to poly(A)+ RNA sequences from fruit body primordia, versus poly(A)+ RNAs from mycelium, were isolated. Eight of these clones (EMAa-1 to EMAa...
journal_title:Current genetics
pub_type: 杂志文章
doi:10.1007/BF00326234
更新日期:1991-08-01 00:00:00
abstract::Mycorrhizal ascomycetes are ecologically and commercially important fungi that have proved impervious to genetic transformation so far. We report here on the successful transient transformation of Tuber borchii, an ectomycorrhizal ascomycete that colonizes a variety of trees and produces highly prized hypogeous fruitb...
journal_title:Current genetics
pub_type: 杂志文章
doi:10.1007/s00294-005-0579-z
更新日期:2005-07-01 00:00:00
abstract::Two types of DNA sequence polymorphisms were found among different geographic isolates of the basidiomycete fungus Coprinus einereus. These strains showed gains and losses of restriction enzyme recognition sites as well as extensive insertion/ deletion variation within DNA sequences present in a single copy per haploi...
journal_title:Current genetics
pub_type: 杂志文章
doi:10.1007/BF00445879
更新日期:1983-09-01 00:00:00
abstract::Homologous recombination repairs discontinuities in DNA including single-strand gaps (SSGs) and double-strand breaks (DSBs). This commentary describes how the RecBCD and RecF pathways might be exchangeable for the repair of their respective DSB and SSG canonical substrates. In particular, I will discuss how the RecBCD...
journal_title:Current genetics
pub_type: 杂志文章,评审
doi:10.1007/s00294-016-0575-5
更新日期:2016-08-01 00:00:00
abstract::Five haploid monokaryons of the basidiomycete Coprinus cinereus were already known to be unable to form sclerotia (asexual resting structures) on the vegetative monokaryotic mycelium. Genetic analyses had shown that four distinct genes (symbolised scl were represented, all being "recessive" to their sclerotium-produci...
journal_title:Current genetics
pub_type: 杂志文章
doi:10.1007/BF00365718
更新日期:1981-05-01 00:00:00
abstract::Timely progression of living cells through the cell cycle is precisely regulated. This involves a series of phosphorylation events which are regulated by various cyclins, activated in coordination with the cell cycle progression. Phosphorylated proteins govern cell growth, division as well as duplication of the geneti...
journal_title:Current genetics
pub_type: 杂志文章,评审
doi:10.1007/s00294-017-0706-7
更新日期:2017-12-01 00:00:00
abstract::Chemoreceptor-based signaling is a major bacterial signal transduction mechanism. Escherichia coli, the traditional model, has five chemoreceptors. Recent genome analyses have shown that many bacteria have a much higher number of chemoreceptors. Pseudomonas putida KT2440 is an alternative model that has 27 chemorecept...
journal_title:Current genetics
pub_type: 杂志文章
doi:10.1007/s00294-016-0646-7
更新日期:2017-06-01 00:00:00
abstract::Degenerative processes in the filamentous fungus Podospora anserina are strongly correlated with the instability of the mitochondrial genome. Among the sources of instability is the mobile group-II intron COX1-i1, also called intron alpha, which encodes a protein with a reverse transcriptase activity. In this paper we...
journal_title:Current genetics
pub_type: 杂志文章
doi:10.1007/s002940050003
更新日期:2000-01-01 00:00:00
abstract::Over the last decade, mutation studies have grown in popularity due to the affordability and accessibility of whole genome sequencing. As the number of species in which spontaneous mutation has been directly estimated approaches 20 across two domains of life, questions arise over the repeatability of results in such e...
journal_title:Current genetics
pub_type: 杂志文章,评审
doi:10.1007/s00294-016-0573-7
更新日期:2016-08-01 00:00:00
abstract::DNA replication checkpoint is a cell signaling pathway that is activated in response to perturbed replication. Although it is crucial for maintaining genomic integrity and cell survival, the exact mechanism of the checkpoint signaling remains to be understood. Emerging evidence has shown that RecQ helicases, a large f...
journal_title:Current genetics
pub_type: 杂志文章,评审
doi:10.1007/s00294-020-01147-y
更新日期:2021-01-11 00:00:00
abstract::Arenicin-1, a 21-mer antimicrobial peptide exerts significant broad-spectrum antimicrobial activity with membrane-active mechanisms. However, owing to multiple mechanisms of cell death, the antibacterial mechanism of arenicin-1 requires detailed analysis. In the present study, arenicin-1-treated bacteria underwent an ...
journal_title:Current genetics
pub_type: 杂志文章
doi:10.1007/s00294-018-0855-3
更新日期:2019-02-01 00:00:00
abstract::Deletion mutants for the yeast transketolase gene TKL1 were constructed by gene replacement. Transketolase activity was below the level of detection in mutant crude extracts. Transketolase protein could be detected as a single protein band of the expected size by Western-blot analysis in wild-type strains but not in t...
journal_title:Current genetics
pub_type: 杂志文章
doi:10.1007/BF00351843
更新日期:1993-11-01 00:00:00
abstract::Nucleic acid extracted from killer strains of Saccharomyces cerevisiae and run on agarose gels under sub-optimal conditions for M dsRNA yielded two species of L dsRNA (L1 and L2) which migrated at slightly different rates. L2 dsRNA was shown to be dependent upon MAK3, MAK10 and PES1 but not MAK1 nuclear genes for its ...
journal_title:Current genetics
pub_type: 杂志文章
doi:10.1007/BF00365682
更新日期:1983-03-01 00:00:00