Checkpoint functions of RecQ helicases at perturbed DNA replication fork.

Abstract:

:DNA replication checkpoint is a cell signaling pathway that is activated in response to perturbed replication. Although it is crucial for maintaining genomic integrity and cell survival, the exact mechanism of the checkpoint signaling remains to be understood. Emerging evidence has shown that RecQ helicases, a large family of helicases that are conserved from bacteria to yeasts and humans, contribute to the replication checkpoint as sensors, adaptors, or regulation targets. Here, we highlight the multiple functions of RecQ helicases in the replication checkpoint in four model organisms and present additional evidence that fission yeast RecQ helicase Rqh1 may participate in the replication checkpoint as a sensor.

journal_name

Curr Genet

journal_title

Current genetics

authors

Ahamad N,Khan S,Mahdi ATA,Xu YJ

doi

10.1007/s00294-020-01147-y

subject

Has Abstract

pub_date

2021-01-11 00:00:00

eissn

0172-8083

issn

1432-0983

pii

10.1007/s00294-020-01147-y

pub_type

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