Abstract:
:DNA replication checkpoint is a cell signaling pathway that is activated in response to perturbed replication. Although it is crucial for maintaining genomic integrity and cell survival, the exact mechanism of the checkpoint signaling remains to be understood. Emerging evidence has shown that RecQ helicases, a large family of helicases that are conserved from bacteria to yeasts and humans, contribute to the replication checkpoint as sensors, adaptors, or regulation targets. Here, we highlight the multiple functions of RecQ helicases in the replication checkpoint in four model organisms and present additional evidence that fission yeast RecQ helicase Rqh1 may participate in the replication checkpoint as a sensor.
journal_name
Curr Genetjournal_title
Current geneticsauthors
Ahamad N,Khan S,Mahdi ATA,Xu YJdoi
10.1007/s00294-020-01147-ysubject
Has Abstractpub_date
2021-01-11 00:00:00eissn
0172-8083issn
1432-0983pii
10.1007/s00294-020-01147-ypub_type
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