Abstract:
:The Cys6Zn2 DNA-binding domain transcription factor Pdr1 is a central regulator of drug resistance in the pathogenic yeast Candida glabrata. In this review, I discuss the multiple control mechanisms modulating the function of this positive transcriptional regulator. Available data suggest that Pdr1 activity is restrained by multiple negative inputs that can be lost by either mutagenesis of the protein or loss of trans-acting factors. Although extensive data are available on the C. glabrata transactivator as well as its cognate proteins in Saccharomyces cerevisiae, the physiological rationale underlying the regulation of these factors remains to be understood.
journal_name
Curr Genetjournal_title
Current geneticsauthors
Moye-Rowley WSdoi
10.1007/s00294-018-0870-4subject
Has Abstractpub_date
2019-02-01 00:00:00pages
103-108issue
1eissn
0172-8083issn
1432-0983pii
10.1007/s00294-018-0870-4journal_volume
65pub_type
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