Abstract:
:DNA polymerases are evolved to extend the 3'-OH of a growing primer annealed to a template DNA substrate. Since replicative DNA polymerases have a limited role while replicating structurally distorted template, translesion DNA polymerases mostly from Y-family come to the rescue of stalled replication fork and maintain genome stability. DNA polymerase eta is one such specialized enzyme whose function is directly associated with casual development of certain skin cancers and chemo-resistance. More than 20 years of extensive studies are available to support TLS activities of Polη in bypassing various DNA lesions, in addition, limited but crucial growing evidence also exist to suggest Polη possessing TLS-independent cellular functions. In this review, we have mostly focused on non-TLS activities of Polη from different organisms including our recent findings from pathogenic yeast Candida albicans.
journal_name
Curr Genetjournal_title
Current geneticsauthors
Acharya N,Manohar K,Peroumal D,Khandagale P,Patel SK,Sahu SR,Kumari Pdoi
10.1007/s00294-018-0918-5subject
Has Abstractpub_date
2019-06-01 00:00:00pages
649-656issue
3eissn
0172-8083issn
1432-0983pii
10.1007/s00294-018-0918-5journal_volume
65pub_type
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