Multifaceted activities of DNA polymerase η: beyond translesion DNA synthesis.

Abstract:

:DNA polymerases are evolved to extend the 3'-OH of a growing primer annealed to a template DNA substrate. Since replicative DNA polymerases have a limited role while replicating structurally distorted template, translesion DNA polymerases mostly from Y-family come to the rescue of stalled replication fork and maintain genome stability. DNA polymerase eta is one such specialized enzyme whose function is directly associated with casual development of certain skin cancers and chemo-resistance. More than 20 years of extensive studies are available to support TLS activities of Polη in bypassing various DNA lesions, in addition, limited but crucial growing evidence also exist to suggest Polη possessing TLS-independent cellular functions. In this review, we have mostly focused on non-TLS activities of Polη from different organisms including our recent findings from pathogenic yeast Candida albicans.

journal_name

Curr Genet

journal_title

Current genetics

authors

Acharya N,Manohar K,Peroumal D,Khandagale P,Patel SK,Sahu SR,Kumari P

doi

10.1007/s00294-018-0918-5

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

649-656

issue

3

eissn

0172-8083

issn

1432-0983

pii

10.1007/s00294-018-0918-5

journal_volume

65

pub_type

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