Abstract：
:Saccharomyces cerevisiae adapts to oxidative, osmotic stress and nutrient deprivation through transcriptional changes, decreased proliferation, and entry into other developmental pathways such as pseudohyphal formation and sporulation. Inositol pyrophosphates are necessary for these cellular responses. Inositol pyrophosphates are molecules composed of the phosphorylated myo-inositol ring that carries one or more diphosphates. Mutations in the enzymes that metabolize these molecules lead to altered patterns of stress resistance, altered morphology, and defective sporulation. Mechanisms to alter the synthesis of inositol pyrophosphates have been recently described, including inhibition of enzyme activity by oxidation and by phosphorylation. Cells with increased levels of 5-diphosphoinositol pentakisphosphate have increased nuclear localization of Msn2 and Gln3. The altered localization of these factors is consistent with the partially induced environmental stress response and increased expression of genes under the control of Msn2/4 and Gln3. Other transcription factors may also exhibit increased nuclear localization based on increased expression of their target genes. These transcription factors are each regulated by TORC1, suggesting that TORC1 may be inhibited by inositol pyrophosphates. Inositol pyrophosphates affect stress responses in other fungi (Aspergillus nidulans, Ustilago maydis, Schizosaccharomyces pombe, and Cryptococcus neoformans), in human and mouse, and in plants, suggesting common mechanisms and possible novel drug development targets.
journal_name
Curr Genetjournal_title
Current geneticsauthors
Morrissette VA,Rolfes RJdoi
10.1007/s00294-020-01078-8subject
Has Abstractpub_date
2020-10-01 00:00:00pages
901-910issue
5eissn
0172-8083issn
1432-0983pii
10.1007/s00294-020-01078-8journal_volume
66pub_type
杂志文章,评审相关文献
CURRENT GENETICS文献大全abstract：:A screening of haploid yeast strains for enhanced resistance to nitrogen mustard (HN2) yielded a recessive mutant allele, hnm1, that conferred hyper-resistance (HYR) to HN2. Diploids, homo- or heterozygous for the HNM1 locus, exhibit normal wild-type like resistance while homozygosity for hnm1 leads to the phenotype H...
journal_title：Current genetics
pub_type： 杂志文章
doi：10.1007/BF00318378
更新日期：1990-10-01 00:00:00
abstract：:Mutations in the RecA-like genes RAD51 and RAD57 reduce the frequency of gene conversion/reciprocal exchange between inverted repeats 7-fold. However, they enhance the frequency of deletions between direct repeats 5-12-fold. These induced deletions are RAD1- and RAD52-dependent. On the basis of these results it is pro...
journal_title：Current genetics
pub_type： 杂志文章
doi：10.1007/BF00352096
更新日期：1995-03-01 00:00:00
abstract：:The mitochondrial genomes are one of the most information-rich markers in phylogenetics. The relationships within superorder Dictyoptera have been debated in the literature. However, the closely related termites (Isoptera) are retained as unranked taxon within the order Blattaria (cockroaches). In this work, we sequen...
journal_title：Current genetics
pub_type： 杂志文章
doi：10.1007/s00294-012-0365-7
更新日期：2012-04-01 00:00:00
abstract：:Inorganic phosphate is an essential nutrient because it is required for the biosynthesis of nucleotides, phospholipids and metabolites in energy metabolism. During phosphate starvation, phosphatases play a major role in phosphate acquisition by hydrolyzing phosphorylated macromolecules. In Saccharomyces cerevisiae, PH...
journal_title：Current genetics
pub_type： 杂志文章,评审
doi：10.1007/s00294-015-0544-4
更新日期：2016-05-01 00:00:00
abstract：:To gain a deeper insight into the evolution of mating-type genes from filamentous ascomycetes, a comprehensive sequence analysis of PCR-amplified sequences corresponding to A- and a-specific mating-type sequences was undertaken. The study included nine homothallic (compatible) and eight heterothallic (incompatible) me...
journal_title：Current genetics
pub_type： 杂志文章
doi：10.1007/s002940050494
更新日期：1999-10-01 00:00:00
abstract：:URA4, the gene coding for orotidine monophosphate decarboxylase (OMPdecase), has been cloned from the fission yeast by homologous complementation and restricted in an Escherichia coli-Schizosaccharomyces pombe (E. coli-S. pombe) replicative plasmid to a 1.76 kb HindIII fragment. This plasmid is maintained at a high co...
journal_title：Current genetics
pub_type： 杂志文章
doi：10.1007/BF00419562
更新日期：1987-01-01 00:00:00
abstract：:Tuplp is a general corepressor in Saccharomyces cerevisiae. We performed a split-ubiquitin screen with Tup1p as bait, in order to understand how Tuplp mediates repression. Cdc73p was the only component of a holoenzyme of transcription isolated as a Tuplp-interacting protein in this screen. Expression analysis of a str...
journal_title：Current genetics
pub_type： 杂志文章
doi：10.1007/s002940100229
更新日期：2001-07-01 00:00:00
abstract：:Deletion mutants for the yeast transketolase gene TKL1 were constructed by gene replacement. Transketolase activity was below the level of detection in mutant crude extracts. Transketolase protein could be detected as a single protein band of the expected size by Western-blot analysis in wild-type strains but not in t...
journal_title：Current genetics
pub_type： 杂志文章
doi：10.1007/BF00351843
更新日期：1993-11-01 00:00:00
abstract：:Microorganisms have the ability to adapt and respond to different environmental conditions, whether they are stressful or not. Although the detection and/or responding mechanisms are often unknown, a large number of proteins may participate in signal transduction pathways involved in environmental stimulus to induce p...
journal_title：Current genetics
pub_type： 杂志文章,评审
doi：10.1007/s00294-017-0772-x
更新日期：2018-06-01 00:00:00
abstract：:We recently discovered the novel non-chromosomal determinant in Saccharomyces cerevisiae [NSI(+)] (nonsense suppression inducer), which causes omnipotent nonsense suppression in strains where the Sup35 N-terminal domain is deleted. [NSI(+)] possesses yeast prion features and does not correspond to previously identifie...
journal_title：Current genetics
pub_type： 杂志文章
doi：10.1007/s00294-011-0363-1
更新日期：2012-02-01 00:00:00
abstract：:Arenicin-1, a 21-mer antimicrobial peptide exerts significant broad-spectrum antimicrobial activity with membrane-active mechanisms. However, owing to multiple mechanisms of cell death, the antibacterial mechanism of arenicin-1 requires detailed analysis. In the present study, arenicin-1-treated bacteria underwent an ...
journal_title：Current genetics
pub_type： 杂志文章
doi：10.1007/s00294-018-0855-3
更新日期：2019-02-01 00:00:00
abstract：:DNA-hybridisation studies showed a close relationship between Phanerochaete chrysosporium ME446, most used in lignin degradation studies, and Sporotrichum pulverulentum Novobranova, the other standard lignin degrading strain. Two other strains of P. chrysosporium were both less related. We show that P. chrysosporium M...
journal_title：Current genetics
pub_type： 杂志文章
doi：10.1007/BF00410436
更新日期：1984-09-01 00:00:00
abstract：:Broad bean (Vicia faba) mitochondrial DNA (mtDNA) includes three circular plasmids: mt-plasmid 1 (1,704 ntp), mt-plasmid 2 (1,695 ntp) and mt-plasmid 3 (1,476 ntp). Partially replicated circular forms of these mt-plasmids have been observed in electron microscope preparations. Restriction enzymes that cleave either mt...
journal_title：Current genetics
pub_type： 杂志文章
doi：10.1007/BF00569340
更新日期：1988-08-01 00:00:00
abstract：:The nucleotide sequences of the plastidal psbD genes of Bumilleriopsis filiformis and Porphyridium purpureum (encoding the D2 protein of photosystem II) are reported in this paper. The Bumilleriopsis sequence clusters together with Porphyridium when a most parsimonious protein tree of D2 sequences is constructed. A co...
journal_title：Current genetics
pub_type： 杂志文章
doi：10.1007/BF00351854
更新日期：1993-11-01 00:00:00
abstract：:A double-stranded (ds)RNA, designated as M2, is associated with hypovirulence, conversion of the quinic acid pathway from inducible to constitutive and downregulation of the shikimic acid pathway in the Rhizoctonia solani culture Rhs 1A1. In this study, we report that in the virulent, M2-lacking isolate Rhs 1AP, which...
journal_title：Current genetics
pub_type： 杂志文章
doi：10.1007/s00294-003-0375-6
更新日期：2003-05-01 00:00:00
abstract：:Zearalenone (ZEA) is a secondary metabolite produced by various Fusarium species and causes estrogenic disorders in humans and animals. Recent studies have identified the ZEA biosynthesis gene cluster in F. graminearum, but other genes such as transporters responsible for ZEA export have not been identified in the clu...
journal_title：Current genetics
pub_type： 杂志文章
doi：10.1007/s00294-011-0352-4
更新日期：2011-10-01 00:00:00
abstract：:Yeast ornithine transaminase is known to be induced by arginine and ornithine, through the action of regulatory elements common to arginase induction. We show here that it is subject to a second induction circuit, that which is responsible for urea amidolyase and urea permease induction by allophanate and defined by t...
journal_title：Current genetics
pub_type： 杂志文章
doi：10.1007/BF00376788
更新日期：1981-09-01 00:00:00
abstract：:La France disease of the cultivated mushroom, Agaricus bisporus, is known to be associated with the presence of a number of dsRNA segments. The nucleotide sequences of the dsRNAs M2 (1.3 kb), M1 (1.55 kb) and L3 (2.8 kb), invariably associated with the disease, were determined. Putative coding sequences for proteins w...
journal_title：Current genetics
pub_type： 杂志文章
doi：10.1007/BF00312776
更新日期：1991-07-01 00:00:00
abstract：:Small insertions are reported from the SSU rDNA of the genera Cladonia, Cladina, Stereocaulon, Pertusaria and Physcia (lichen-forming Lecanorales, Ascomycetes). The insertions range in length from 56 to 81 nucleotides, and occur at a shared position, 330 (relative to Escherichia coli), in a semi-conserved region of th...
journal_title：Current genetics
pub_type： 杂志文章
doi：10.1007/s002940050317
更新日期：1998-02-01 00:00:00
abstract：:The wild diastatic yeast Saccharomyces cerevisiae NCYC 625 has been shown to be homozygous for the glucoamylase-specifying gene STA2. spoII-1-mapping has positioned STA2 on chromosome II. Expression of STA2 is suppressed in some but not all diploids capable of sporulation, and is also inhibited by unlinked nuclear sup...
journal_title：Current genetics
pub_type： 杂志文章
doi：10.1007/BF00314873
更新日期：1990-04-01 00:00:00
abstract：:A hybrid selectable marker for transformation was constructed by placing the promoter (TEF1p) from the gene encoding the Aureobasidium pullulans translation elongation factor 1-alpha (TEF1) adjacent to the 5' end of the Escherichia coli hygromycin B phosphotransferase gene (HPT). Plasmids containing this hybrid gene (...
journal_title：Current genetics
pub_type： 杂志文章
doi：10.1007/BF00313195
更新日期：1995-12-01 00:00:00
abstract：:The wheat mitochondrial (mt) cox3 has been localized and sequenced. The gene exists as a single copy in the wheat mt master chromosome and is transcribed into a single 1.2 kb RNA, whose extremities have been mapped. Comparison of the wheat and Oenothera cox3 sequences gives ambiguous indications concerning the amino a...
journal_title：Current genetics
pub_type： 杂志文章
doi：10.1007/BF00313247
更新日期：1990-01-01 00:00:00
abstract：:Efficient mating-type (MT) switching in homothallic strains of Schizosaccharomyces pombe is significantly reduced if they have a mutation in any of the eleven known swi genes. The swi4 mutation causes heterothallic as well as homothallic segregants, both of which have duplications in the MT region. In contrast to homo...
journal_title：Current genetics
pub_type： 杂志文章
doi：10.1007/BF00327020
更新日期：1990-12-01 00:00:00
abstract：:Full genome recoding, or rewriting codon meaning, through chemical synthesis of entire bacterial chromosomes has become feasible in the past several years. Recoding an organism can impart new properties including non-natural amino acid incorporation, virus resistance, and biocontainment. The estimated cost of construc...
journal_title：Current genetics
pub_type： 杂志文章,评审
doi：10.1007/s00294-017-0754-z
更新日期：2018-04-01 00:00:00
abstract：:The occupancy of nucleosomes governs access to the eukaryotic genomes and results from a combination of biophysical features and the effect of ATP-dependent remodelling complexes. Most promoter regions show a conserved pattern characterized by a nucleosome-depleted region (NDR) flanked by nucleosomal arrays. The conse...
journal_title：Current genetics
pub_type： 杂志文章,评审
doi：10.1007/s00294-016-0642-y
更新日期：2017-05-01 00:00:00
abstract：:Over the last decade, mutation studies have grown in popularity due to the affordability and accessibility of whole genome sequencing. As the number of species in which spontaneous mutation has been directly estimated approaches 20 across two domains of life, questions arise over the repeatability of results in such e...
journal_title：Current genetics
pub_type： 杂志文章,评审
doi：10.1007/s00294-016-0573-7
更新日期：2016-08-01 00:00:00
abstract：:Expression of pho1-encoded acid phosphatase of Schizosaccharomyces pombe has been reported to be regulated by phosphate. In this communication we show that it is also regulated by adenine. Starving adenine auxotrophic strains for adenine leads to a drastic increase of the enzymatic activity while adenine represses thi...
journal_title：Current genetics
pub_type： 杂志文章
doi：10.1007/BF00317923
更新日期：1992-10-01 00:00:00
abstract：:Phylum Euglenozoa comprises three groups of eukaryotic microbes (kinetoplastids, diplonemids, and euglenids), the mitochondrial (mt) genomes of which exhibit radically different modes of organization and expression. Gene fragmentation is a striking feature of both euglenid and diplonemid mtDNAs. To rationalize the eme...
journal_title：Current genetics
pub_type： 杂志文章,评审
doi：10.1007/s00294-011-0340-8
更新日期：2011-08-01 00:00:00
abstract：:Sister chromatid cohesion is essential for chromosome segregation both in mitosis and meiosis. Cohesion between two chromatids is mediated by a protein complex called cohesin. The loading and unloading of the cohesin are tightly regulated during the cell cycle. In vertebrate cells, cohesin is released from chromosomes...
journal_title：Current genetics
pub_type： 杂志文章,评审
doi：10.1007/s00294-019-00959-x
更新日期：2019-08-01 00:00:00
abstract：:The Cercospora nicotianae SOR1 gene is required for resistance to singlet oxygen-generating photosensitizers. SOR1 was characterized in the wild-type and in five photosensitizer-sensitive mutant strains which are complemented to photosensitizer resistance by transformation with SOR1. Sequence analysis determined that ...
journal_title：Current genetics
pub_type： 杂志文章
doi：10.1007/s002940050423
更新日期：1999-01-01 00:00:00
