The interplay of histone H2B ubiquitination with budding and fission yeast heterochromatin.

Abstract:

:Mono-ubiquitinated histone H2B (H2B-Ub) is important for chromatin regulation of transcription, chromatin assembly, and also influences heterochromatin. In this review, we discuss the effects of H2B-Ub from nucleosome to higher-order chromatin structure. We then assess what is currently known of the role of H2B-Ub in heterochromatic silencing in budding and fission yeasts (S. cerevisiae and S. pombe), which have distinct silencing mechanisms. In budding yeast, the SIR complex initiates heterochromatin assembly with the aid of a H2B-Ub deubiquitinase, Ubp10. In fission yeast, the RNAi-dependent pathway initiates heterochromatin in the context of low H2B-Ub. We examine how the different silencing machineries overcome the challenge of H2B-Ub chromatin and highlight the importance of using these microorganisms to further our understanding of H2B-Ub in heterochromatic silencing pathways.

journal_name

Curr Genet

journal_title

Current genetics

authors

Zukowski A,Johnson AM

doi

10.1007/s00294-018-0812-1

subject

Has Abstract

pub_date

2018-08-01 00:00:00

pages

799-806

issue

4

eissn

0172-8083

issn

1432-0983

pii

10.1007/s00294-018-0812-1

journal_volume

64

pub_type

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