Abstract:
:Cell aging is the result of deteriorating competence in maintaining cellular homeostasis and quality control. Certain cell types are able to rejuvenate through asymmetric cell division by excluding aging factors, including damaged cellular compartments and extrachromosomal rDNA circles, from entering the daughter cell. Recent findings from the budding yeast S. cerevisiae have shown that gametogenesis represents another type of cellular rejuvenation. Gametes, whether produced by an old or a young mother cell, are granted a renewed replicative lifespan through the formation of a fifth nuclear compartment that sequesters the harmful senescence factors accumulated by the mother. Here, we describe the importance and mechanism of cellular remodeling at the nuclear envelope mediated by ESCRT-III and the LEM-domain proteins, with a focus on nuclear pore biogenesis and chromatin interaction during gamete rejuvenation.
journal_name
Curr Genetjournal_title
Current geneticsauthors
Koch-Bojalad BA,Carson L,Yu HGdoi
10.1007/s00294-020-01133-4subject
Has Abstractpub_date
2020-11-27 00:00:00eissn
0172-8083issn
1432-0983pii
10.1007/s00294-020-01133-4pub_type
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