Forever young: the key to rejuvenation during gametogenesis.

Abstract:

:Cell aging is the result of deteriorating competence in maintaining cellular homeostasis and quality control. Certain cell types are able to rejuvenate through asymmetric cell division by excluding aging factors, including damaged cellular compartments and extrachromosomal rDNA circles, from entering the daughter cell. Recent findings from the budding yeast S. cerevisiae have shown that gametogenesis represents another type of cellular rejuvenation. Gametes, whether produced by an old or a young mother cell, are granted a renewed replicative lifespan through the formation of a fifth nuclear compartment that sequesters the harmful senescence factors accumulated by the mother. Here, we describe the importance and mechanism of cellular remodeling at the nuclear envelope mediated by ESCRT-III and the LEM-domain proteins, with a focus on nuclear pore biogenesis and chromatin interaction during gamete rejuvenation.

journal_name

Curr Genet

journal_title

Current genetics

authors

Koch-Bojalad BA,Carson L,Yu HG

doi

10.1007/s00294-020-01133-4

subject

Has Abstract

pub_date

2020-11-27 00:00:00

eissn

0172-8083

issn

1432-0983

pii

10.1007/s00294-020-01133-4

pub_type

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