Nucleotide sequence of the ERG12 gene of Saccharomyces cerevisiae encoding mevalonate kinase.

Abstract:

:The nucleotide sequence of the ERG12 gene, encoding mevalonate kinase, from Saccharomyces cerevisiae is presented. The longest open reading frame may code for a protein containing 443 amino acids with a deduced relative molecular mass of 48,500. The analysis of the nucleotide sequence reveals a complete identity with the yeast gene RAR1, isolated elsewhere by complementation of a rar1 mutation involved in the stability of plasmids with weak ARS. In addition, we show that mevalonate kinase is not a rate-limiting enzyme; however its sensitivity to FFP could be a key regulatory mechanism in the sterol pathway of yeast.

journal_name

Curr Genet

journal_title

Current genetics

authors

Oulmouden A,Karst F

doi

10.1007/BF00362081

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

9-14

issue

1

eissn

0172-8083

issn

1432-0983

journal_volume

19

pub_type

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