Abstract:
:The nucleotide sequence of the ERG12 gene, encoding mevalonate kinase, from Saccharomyces cerevisiae is presented. The longest open reading frame may code for a protein containing 443 amino acids with a deduced relative molecular mass of 48,500. The analysis of the nucleotide sequence reveals a complete identity with the yeast gene RAR1, isolated elsewhere by complementation of a rar1 mutation involved in the stability of plasmids with weak ARS. In addition, we show that mevalonate kinase is not a rate-limiting enzyme; however its sensitivity to FFP could be a key regulatory mechanism in the sterol pathway of yeast.
journal_name
Curr Genetjournal_title
Current geneticsauthors
Oulmouden A,Karst Fdoi
10.1007/BF00362081subject
Has Abstractpub_date
1991-01-01 00:00:00pages
9-14issue
1eissn
0172-8083issn
1432-0983journal_volume
19pub_type
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