Abstract：
:Timely progression of living cells through the cell cycle is precisely regulated. This involves a series of phosphorylation events which are regulated by various cyclins, activated in coordination with the cell cycle progression. Phosphorylated proteins govern cell growth, division as well as duplication of the genetic material and transcriptional activation of genes involved in these processes. A subset of these tightly regulated genes, which depend on the MBF transcription factor and are mainly involved in DNA replication and cell division, is transiently activated at the transition from G1 to S phase. A Saccharomyces cerevisiae mutant in the Dpb2 non-catalytic subunit of DNA polymerase ε (Polε) demonstrates abnormalities in transcription of MBF-dependent genes even in normal growth conditions. It is, therefore, tempting to speculate that Dpb2 which, as described previously, participates in the early stages of DNA replication initiation, has an impact on the regulation of replication-related genes expression with possible implications for genomic stability.
journal_name
Curr Genetjournal_title
Current geneticsauthors
Dmowski M,Fijałkowska IJdoi
10.1007/s00294-017-0706-7subject
Has Abstractpub_date
2017-12-01 00:00:00pages
983-987issue
6eissn
0172-8083issn
1432-0983pii
10.1007/s00294-017-0706-7journal_volume
63pub_type
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