abstract：:Accurate relative gene expression analysis by reverse transcription-quantitative polymerase chain reaction relies on the usage of suitable reference genes for data normalization. The RNA content of small extracellular vesicles including exosomes is growingly considered as cancer biomarkers. So, reliable relative quant...

journal_title：Cell biology international

authors： Gorji-Bahri G,Moradtabrizi N,Vakhshiteh F,Hashemi A

更新日期：2021-01-27 00:00:00

abstract：:Bisphosphonates (BPs), especially zoledronic acid (ZOL), are clinically used to treat osteolytic bone lesions. However, serious side-effects may be also induced during the therapeutic process. To improve the BPs drugs, here, we investigated the effects of a series of ZOL derivatives with increasing number of methylene...

journal_title：Cell biology international

authors： Peng Y,Liu Q,Xu D,Li K,Li H,Qiu L,Lin J

更新日期：2021-01-06 00:00:00

abstract：:Inflammatory cytokines exert different effects on hematopoietic stem cells (HSCs), lead to the development of various cell lineages in bone marrow (BM) and are thus a differentiation axis for HSCs. The content used in this article has been obtained by searching PubMed database and Google Scholar search engine of Engli...

journal_title：Cell biology international

authors： Najafi S,Ghanavat M,Shahrabi S,Gatavizadeh Z,Saki N

更新日期：2021-01-02 00:00:00

abstract：:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) gains access to host cells by attaching to angiotensin-converting enzyme 2 (ACE2). Vitamin D (VitD) can upregulate ACE2 and has an antagonistic effect on Renin, which exerts a vasodilatation and anti-inflammatory effect against coronavirus disease (COVID-19)...

journal_title：Cell biology international

authors： Shojaeefar E,Malih N,Rezaei N

更新日期：2021-01-01 00:00:00

abstract：:Imbalance of sexual steroids milieu and oxidative stress are often observed during aging and correlated to prostate disorders. Likewise, high-fat intake has been related to prostate damage and tumor development. Melatonin (MLT) is an antioxidant whose secretion decreases in elderly and is also suggested to protect the...

journal_title：Cell biology international

authors： Tamarindo GH,Gobbo MG,Taboga SR,Almeida EA,Góes RM

更新日期：2021-01-01 00:00:00

abstract：:microRNAs (miRNAs) have recently been recognized as playing an important role in bone-associated diseases. This study investigated whether the reduced miR-155-5p in steroid-associated osteonecrosis of the femoral head (ONFH) attenuated osteogenic differentiation and cell proliferation by targeting GSK3B. Bone marrow w...

journal_title：Cell biology international

authors： Wu F,Huang W,Yang Y,Liu F,Chen J,Wang G,Sun Z

更新日期：2021-01-01 00:00:00

abstract：:Emerging evidence suggests that miR-143 plays an important role in the regulation of tumor sensitivity to chemotherapeutic agents. The study explores the underlying mechanism of miR-143 in reversing cisplatin resistance in ovarian cancer. The cisplatin-resistant ovarian cancer cell line A2780/CDDP was induced and esta...

journal_title：Cell biology international

authors： Han X,Liu D,Zhou Y,Wang L,Hou H,Chen H,Zhang L,Chen W,Li X,Zhao L

更新日期：2021-01-01 00:00:00

abstract：:Prostate cancer is a life-threatening condition worldwide. As the tumor progresses, smooth muscle cells (SMCs) become atrophic/dedifferentiated, within a series of stromal changes named stromal reaction. Here, we tested whether a laminin 111-rich extracellular matrix (Lr-ECM) could affect SMCs phenotype and differenti...

journal_title：Cell biology international

authors： Osório DA,Consonni SR,Dos Santos AM,Carvalho HF

更新日期：2020-12-30 00:00:00

abstract：:Endothelial progenitor cells (EPCs) are precursor cells of vascular endothelial cells, which are widely involved in the pathological process of cardiovascular diseases. EPCs apoptosis could accelerate the process of cardiovascular diseases. 14-3-3-η protein has been proved to be a potent antiapoptosis molecule. Howeve...

journal_title：Cell biology international

authors： Li Y,Sun X,Zhang X,Zhou H,Wang D,Xia Y,Li X

更新日期：2020-12-15 00:00:00

abstract：:Although clinical data suggest remarkable promise for targeting programmed cell death protein-1 (PD-1) and ligand (PD-L1) signaling in non-small-cell lung cancer (NSCLC), it is still largely undetermined which subtype of patients will be responsive to checkpoint blockade. In the present study, we explored whether PD-L...

journal_title：Cell biology international

authors： Pan LN,Ma YF,Li Z,Hu JA,Xu ZH

更新日期：2020-12-15 00:00:00

abstract：:Resistance to radiotherapy and chemotherapy has been a major problem of conventional cancer therapies, which consequently leads to cancer relapse and cancer-related death. It is known that cancer stem cells (CSCs) play a key role in therapy resistance and CSC-based targeted therapies have been considered as a powerful...

journal_title：Cell biology international

authors： Johari B,Rahmati M,Nasehi L,Mortazavi Y,Faghfoori MH,Rezaeejam H

更新日期：2020-12-01 00:00:00

abstract：:Periodontitis is a chronic inflammatory disease that results in the destruction of periodontal soft tissue and the resorption of alveolar bone. Evidence indicates that in diabetic patients, hyperglycemia suppresses periodontal ligament stem cell (PDLSC) functions and leads to difficulties in periodontal repair. The pr...

journal_title：Cell biology international

authors： Luo H,Zhu W,Mo W,Liang M

更新日期：2020-12-01 00:00:00

abstract：:Epilepsy was characterized by the occurrence of spontaneous recurrent epileptiform discharges (SREDs) in neurons. Previous studies suggested that microRNA (miR)-139-5p and the Notch pathway were implicated in Epilepsy; however, their interaction remained vague. Rat primary hippocampal neurons were isolated and identif...

journal_title：Cell biology international

authors： Zhao C,Yang F,Wei X,Zhang J

更新日期：2020-11-28 00:00:00

abstract：:Breast cancer is one of the most common cancers in the female population worldwide, and its development is thought to be associated with genetic mutations that lead to uncontrolled and accelerated growth of breast cells. This abnormal behavior requires extra energy, and indeed, tumor cells display a rewired energy met...

journal_title：Cell biology international

authors： Lacerda-Abreu MA,Russo-Abrahão T,Leite Tenório Aguiar R,Monteiro RQ,Rumjanek FD,Meyer-Fernandes JR

更新日期：2020-11-03 00:00:00

abstract：:Transforming growth factor β1 (TGFβ1) is a negative regulator of hematopoiesis, and yet, it is frequently found at the active sites of hematopoiesis. Here, we show for the first time that bone marrow-derived mononuclear cells (BM MNCs) secrete TGFβ1 in response to erythropoietin (EPO). We further show that human bone ...

journal_title：Cell biology international

authors： Kale VP

更新日期：2020-11-01 00:00:00

abstract：:The aim of this study was to determine the polarization of macrophages in the tumor microenvironment, as well as the effect of soluble factors secreted from these polarized macrophages on etoposide-induced cancer cell apoptosis. We investigated the effect of soluble factors secreted from the supernatant of PC3 cells t...

journal_title：Cell biology international

authors： Malekghasemi S,Majidi J,Baradaran B,Aghebati-Maleki L

更新日期：2020-10-01 00:00:00

abstract：:Reactive oxygen species (ROS) act as signaling molecules to regulate various cell functions. Numerous studies have demonstrated ROS to be essential for the differentiation of adipocytes. Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant enzymes in mammalian cells. Prx2 is present in the cytoplasm and cell m...

journal_title：Cell biology international

authors： Kim MH,Kim JY,Kim JH,Lee HS,Huh JW,Lee DS

更新日期：2020-10-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is a highly heterogeneous disease. The aim of this study is to identify the diagnostic and poor prognostic signatures in TNBC by exploring the aberrant DNA methylation and gene expression. Differential expression and methylation analysis of the TNBC and paracancer samples from The ...

journal_title：Cell biology international

authors： Zhang X,Kang X,Jin L,Bai J,Zhang H,Liu W,Wang Z

更新日期：2020-10-01 00:00:00

abstract：:Osteosarcoma (OS) is the most common type of primary bone tumor that exhibits invasive growth and long-distance organ metastasis. Thus, investigating the specifically targeted therapeutic agents against metastatic osteosarcoma depends on understanding the molecular mechanisms. The long noncoding RNAs (lncRNA) XIST (X-...

journal_title：Cell biology international

authors： Wen JF,Jiang YQ,Li C,Dai XK,Wu T,Yin WZ

更新日期：2020-10-01 00:00:00

abstract：:To better treat patients with non-small cell lung cancer (NSCLC), the investigations on novel molecules affecting NSCLC progression are of vital importance. Long noncoding RNAs (lncRNAs) are identified as pivotal regulators that can affect the cellular activities of carcinomas. Long intergenic non-protein coding RNA 6...

journal_title：Cell biology international

authors： Yang H,Yang W,Dai W,Ma Y,Zhang G

更新日期：2020-08-01 00:00:00

abstract：:Ghrelin-O-acyltransferase (GOAT) is a membrane-bound enzyme that attaches eight-carbon octanoate to a serine residue in ghrelin and thereby acylates inactive ghrelin to produce active ghrelin. In this study, we investigated the function of GOAT in the intestinal mucosal barrier. The intestinal mucosal barrier prevents...

journal_title：Cell biology international

authors： Tian P,Lu X,Jin N,Shi J

更新日期：2020-08-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) play important roles in diverse cellular processes and carcinogenesis. Homeobox A cluster antisense RNA 2 (HOXA-AS2) is a 1,048-basepairs lncRNA located between human HOXA3 and HOXA4 genes, whose overactivation was previously found to promote the proliferation and invasion of solid tumors...

journal_title：Cell biology international

authors： Qu Y,Wang Y,Wang P,Lin N,Yan X,Li Y

更新日期：2020-08-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) belongs to one of the most common malignant tumors worldwide and possesses high mortality. Long non-coding RNAs (lncRNAs) have been demonstrated to be essential biological participants in the progression of ESCC. On the basis of bio-informatics prediction, forkhead box P4 anti...

journal_title：Cell biology international

authors： Li Y,Li T,Yang Y,Kang W,Dong S,Cheng S

更新日期：2020-07-01 00:00:00

abstract：:Tripartite motif protein 25 (TRIM25) expression was altered in various human cancers. Herein, we found that the expression of TRIM25 was elevated in hepatocellular carcinoma (HCC) tissues and cell lines. Knockdown of TRIM25 increased the sensitivity of HCC HepG2 cells to epirubicin (EPI), as indicated by reduced cell ...

journal_title：Cell biology international

authors： Yuan P,Zheng A,Tang Q

更新日期：2020-07-01 00:00:00

abstract：:Fibrillin-1 is the major component of extracellular matrix microfibrils. Microfibrils dysfunction is responsible for the onset of various connective tissue diseases, including Marfan syndrome. Although ADAMTSL (a disintegrin and metalloproteinase with thrombospondin motifs-like) 6β is one of the fibrillin-1 binding pr...

journal_title：Cell biology international

authors： Orimoto A,Fukuda T

更新日期：2020-07-01 00:00:00

abstract：:Hypoxia is a condition in which the whole body or a region of the body is deprived of oxygen supply. The brain is very sensitive to the lack of oxygen and cerebral hypoxia can rapidly cause severe brain damage. Astrocytes are essential for the survival and function of neurons. Therefore, protecting astrocytes against ...

journal_title：Cell biology international

authors： Kang YW,Kim YS,Park JY,Chu GE,Yang YC,Choi BY,Cho WG

更新日期：2020-06-01 00:00:00

abstract：:We review Don Gilbert's pioneering seminal contributions that both detailed the mathematical principles and the experimental demonstration of several of the key dynamic characteristics of life. Long before it became evident to the wider biochemical community, Gilbert proposed that cellular growth and replication neces...

journal_title：Cell biology international

authors： Gilbert K,Hammond KD,Brodsky VY,Lloyd D

更新日期：2020-06-01 00:00:00

abstract：:Conditioned medium (CM) (cell secretome) is a cocktail of growth factors, cytokines, and other soluble mediators secreted by cells into a culture medium. These growth factors are fundamental in many cellular processes such as cell growth, differentiation, and others and the composition of these factors is individual f...

journal_title：Cell biology international

authors： Mambelli-Lisboa NC,Frare EO,da Costa-Neves A,Prieto da Silva ÁRB,Kerkis I

更新日期：2020-05-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) exists low efficiency to trans-differentiate into other germinal layer cell types. One key issue is to discover the effect of important factor on MSCs differentiation abiltiy. In this study, we investigated the role and mechanism of epiregulin (EREG) on the osteogenic differentiation and ...

journal_title：Cell biology international

authors： Cao Y,Shi R,Yang H,Zhang J,Ge L,Gao R,Fan Z

更新日期：2020-04-01 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is a common cancer with poor prognosis and high mortality. The role of CCN5 has attracted a great focus on the regulation of cancer progression. However, the biological function and mechanism of CCN5 in OSCC are still not well elucidated. The current study was designed to determine ...

journal_title：Cell biology international

authors： Sun S,Cui Z,Yan T,Wu J,Liu Z

更新日期：2020-04-01 00:00:00

abstract：:A line of evidences have validated that multiple microRNAs (including miR-16, miR-483 and miR-324-3p) were abnormally expressed in granulosa cells, which may be closely related with the pathogenesis of polycystic ovary syndrome (PCOS). Long-chain non-coding RNA (lncRNA) nuclear paraspeckle assembly transcript 1 (NEAT1...

journal_title：Cell biology international

authors： Sang X,Zhang Y

更新日期：2020-03-28 00:00:00

abstract：:Receptor-interacting serine/threonine kinase 4 (RIPK4) and transforming growth factor-β 1 (TGF-β1) play critical roles in the development and maintenance of the epidermis. A negative correlation between the expression patterns of RIPK4 and TGF-β signaling during epidermal homeostasis-related events and suppression of ...

journal_title：Cell biology international

authors： Dinçer T,Boz Er AB,Er İ,Toraman B,Yildiz G,Kalay E

更新日期：2020-03-01 00:00:00

abstract：:Peroxisomicine A1 (PA1) is a potential antineoplastic agent with high and selective toxicity toward peroxisomes of tumor cells. Pexophagy is a selective autophagy process that degrades damaged peroxisomes; this process has been studied mainly in methylotrophic yeasts. There are two main modes of pexophagy in yeast: ma...

journal_title：Cell biology international

authors： Ortega-Martínez M,Gutiérrez-Dávila V,Niderhauser-García A,Salazar-Aranda R,Solís-Soto JM,Montes-de-Oca-Luna R,Jaramillo-Rangel G

更新日期：2020-03-01 00:00:00

abstract：:We investigated the effect of triptolide (TP) on spinal cord injury (SCI), and its underlying mechanism. Following the establishment of the SCI model using YFP H-line transgenic mice, TP was intraperitoneally injected at a dose of 0.2 mg/kg once daily for 7 days. Behavioral tests, Nissl staining, and hematoxylin-eosin...

journal_title：Cell biology international

authors： Zhu N,Ruan J,Yang X,Huang Y,Jiang Y,Wang Y,Cai D,Geng Y,Fang M

更新日期：2020-03-01 00:00:00

abstract：:We previously reported that mechanical vibration-induced proinflammatory cytokines, interleukin-6 (IL-6) and IL-8, expression in human periodontal ligament (hPDL) cells, however, the underlying mechanism remained unclear. Mechanical stimuli are able to activate cellular responses by inducing the activation of several ...

journal_title：Cell biology international

authors： Phusuntornsakul P,Jitpukdeebodintra S,Pavasant P,Leethanakul C

更新日期：2020-02-01 00:00:00

abstract：:Genistein is an isoflavone that has estrogen (E2 )-like activity and is beneficial for follicular development, but little is known regarding its function in oxidative stress (OS)-mediated granulosa cell (GC) injury. Here, we found that after exposure to H2 O2 , Genistein weakened the elevated levels of intracellular r...

journal_title：Cell biology international

authors： Luo M,Yang ZQ,Huang JC,Wang YS,Guo B,Yue ZP

更新日期：2020-02-01 00:00:00

abstract：:Ischemic stroke is a major common cause of death and long-term disability worldwide. Several pathophysiological events including excitotoxicity, oxidative/nitrative stress, inflammation, and apoptosis are involved in ischemic injuries. Recently, the molecular mechanisms involved in cerebral ischemia through a focus on...

journal_title：Cell biology international

authors： Behdarvandy M,Karimian M,Atlasi MA,Azami Tameh A

更新日期：2020-02-01 00:00:00

abstract：:Genetic analysis has strongly implicated human FHIT (Fragile Histidine Triad) as a tumor suppressor gene, being mutated in a large proportion of early-stage cancers. The functions of the FHIT protein have, however, remained elusive. Here, we investigated aph1+ , the fission yeast homolog of FHIT, for functions related...

journal_title：Cell biology international

authors： Sjölander JJ,Sunnerhagen P

更新日期：2020-02-01 00:00:00

abstract：:In this study, we determined whether multilineage-differentiating stress-enduring (Muse) cells exist in rat bone marrow and elucidated their effects on protection against the injury of intestinal epithelial cells associated with inflammation. Rat Muse cells were separated from bone marrow mesenchymal stem cells (BMMSC...

journal_title：Cell biology international

authors： Sun D,Yang L,Cao H,Shen ZY,Song HL

更新日期：2020-02-01 00:00:00

abstract：:Neuroinflammatory disorders such as Alzheimer's and Parkinson's diseases are characterised by chronic inflammation and loss of vascular integrity. Bradykinin 1 receptor (B1R) activation has been implicated in many neuroinflammatory diseases, but the contribution of B1R to inflammation and vascular breakdown is yet to ...

journal_title：Cell biology international

authors： Mugisho OO,Robilliard LD,Nicholson LFB,Graham ES,O'Carroll SJ

更新日期：2019-09-09 00:00:00