Transforming growth factor-β boosts the functionality of human bone marrow-derived mesenchymal stromal cells.

Abstract:

:Transforming growth factor β1 (TGFβ1) is a negative regulator of hematopoiesis, and yet, it is frequently found at the active sites of hematopoiesis. Here, we show for the first time that bone marrow-derived mononuclear cells (BM MNCs) secrete TGFβ1 in response to erythropoietin (EPO). We further show that human bone marrow-derived mesenchymal stromal cells (BMSCs) briefly exposed to the conditioned medium of EPO-primed MNCs, or purified TGFβ1, gain significantly increased hematopoiesis-supportive ability. Mechanistically, we show that this phenomenon involves TGFβ1-mediated activation of nitric oxide (NO) signalling pathway in the BMSCs. The data suggest that EPO-MNC-TGFβ1 could be one of the regulatory axes operative in the bone marrow microenvironment involved in maintaining the functionality of the resident BMSCs.

journal_name

Cell Biol Int

authors

Kale VP

doi

10.1002/cbin.11437

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

2293-2306

issue

11

eissn

1065-6995

issn

1095-8355

journal_volume

44

pub_type

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