Abstract:
:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) gains access to host cells by attaching to angiotensin-converting enzyme 2 (ACE2). Vitamin D (VitD) can upregulate ACE2 and has an antagonistic effect on Renin, which exerts a vasodilatation and anti-inflammatory effect against coronavirus disease (COVID-19). However, it may also facilitate viral entry by increasing ACE2 as the main SARS-CoV-2 receptor and mediates ROS production through NADPH oxidase, as a double-edged sword effect. Lung function and the immune system are also influenced by VitD through several mechanisms, including increased natural antibiotics (Defensin and Cathelicidin) and upregulated transforming growth factor-β. A higher IgA, Th2/Th1 ratio, and T-regulatory cells are attributable to VitD effects on the immune cells, while these changes may also be a double-edged sword in COVID-19. Although VitD supplementation might be highly recommended in COVID-19, the administration's dosage and route could be challenging. Furthermore, this issue has not been mentioned in various studies so far. So, the report aimed to explain the current challenges with the application of VitD in COVID-19.
journal_name
Cell Biol Intjournal_title
Cell biology internationalauthors
Shojaeefar E,Malih N,Rezaei Ndoi
10.1002/cbin.11469subject
Has Abstractpub_date
2021-01-01 00:00:00pages
54-57issue
1eissn
1065-6995issn
1095-8355journal_volume
45pub_type
杂志文章,评审abstract::Whether fructose (FRU), as the sole energy source, confers a metabolic advantage on cancer cells against noxious stimuli is unknown. The aim of this study was to evaluate the effects of low (11 mM), moderate (25 mM), and high (55 mM) FRU concentrations alone or in combination with rotenone (ROT) or doxorubicin (DOX) i...
journal_title:Cell biology international
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journal_title:Cell biology international
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journal_title:Cell biology international
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journal_title:Cell biology international
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journal_title:Cell biology international
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journal_title:Cell biology international
pub_type: 杂志文章
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journal_title:Cell biology international
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journal_title:Cell biology international
pub_type: 杂志文章
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journal_title:Cell biology international
pub_type: 杂志文章
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journal_title:Cell biology international
pub_type: 杂志文章
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journal_title:Cell biology international
pub_type: 杂志文章
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journal_title:Cell biology international
pub_type: 杂志文章
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journal_title:Cell biology international
pub_type: 杂志文章
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journal_title:Cell biology international
pub_type: 杂志文章
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journal_title:Cell biology international
pub_type: 杂志文章
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journal_title:Cell biology international
pub_type: 杂志文章
doi:10.1016/j.cellbi.2007.08.014
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journal_title:Cell biology international
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journal_title:Cell biology international
pub_type: 杂志文章
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journal_title:Cell biology international
pub_type: 杂志文章
doi:10.1016/j.cellbi.2007.05.007
更新日期:2007-10-01 00:00:00
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journal_title:Cell biology international
pub_type: 杂志文章
doi:10.1006/cbir.1993.1077
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journal_title:Cell biology international
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journal_title:Cell biology international
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journal_title:Cell biology international
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journal_title:Cell biology international
pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.1016/j.cellbi.2008.04.005
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journal_title:Cell biology international
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journal_title:Cell biology international
pub_type: 杂志文章
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abstract::Tripartite motif protein 25 (TRIM25) expression was altered in various human cancers. Herein, we found that the expression of TRIM25 was elevated in hepatocellular carcinoma (HCC) tissues and cell lines. Knockdown of TRIM25 increased the sensitivity of HCC HepG2 cells to epirubicin (EPI), as indicated by reduced cell ...
journal_title:Cell biology international
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journal_title:Cell biology international
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journal_title:Cell biology international
pub_type: 杂志文章
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