当前位置： SCI文献检索 > CELL BIOLOGY INTERNATIONAL期刊下所有文献 > Vibration activates the actin/NF-κB axis and upregulates IL-6 and IL-8 expression in human periodontal ligament cells.

Vibration activates the actin/NF-κB axis and upregulates IL-6 and IL-8 expression in human periodontal ligament cells.

Abstract：

:We previously reported that mechanical vibration-induced proinflammatory cytokines, interleukin-6 (IL-6) and IL-8, expression in human periodontal ligament (hPDL) cells, however, the underlying mechanism remained unclear. Mechanical stimuli are able to activate cellular responses by inducing the activation of several signaling pathways including cytoskeletal changes and inflammation. The actin cytoskeleton is a highly dynamic network and plays many important roles in intracellular events. Here, we aimed to investigate the involvement of a pivotal mediator of inflammatory responses, nuclear factor-κB (NF-κB), and actin polymerization in vibration-induced upregulation of IL-6 and IL-8 expression in hPDL cells. hPDL cells were pretreated with the NF-κB inhibitor BAY 11-7082 or cytochalasin D, respectively, before exposure to vibration. IL-6 and IL-8 messenger RNA (mRNA) and protein expression were quantified by quantitative polymerase chain reaction and enzyme-linked immunosorbent assays, respectively. Subcellular localization of the NF-κB p65 subunit was visualized by immunofluorescent staining. We found an increase in NF-κB nuclear translocation in vibrated cells compared with control cells. Pretreatment with BAY 11-7082 significantly inhibited vibration-induced IL-6 and IL-8 mRNA and protein expression in hPDL cells. Moreover, pretreatment with cytochalasin D inhibited NF-κB nuclear translocation and attenuated upregulation of IL-6 and IL-8 mRNA and protein in vibrated cells. Therefore, modulation of actin cytoskeletal polymerization in response to vibration may activate the NF-κB signaling pathway and subsequently upregulate IL-6 and IL-8 expression in hPDL cells.

journal_name

Cell Biol Int

journal_title

Cell biology international

authors

Phusuntornsakul P,Jitpukdeebodintra S,Pavasant P,Leethanakul C

doi

10.1002/cbin.11267

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

661-670

issue

2

eissn

1065-6995

issn

1095-8355

journal_volume

44

pub_type

杂志文章

相关文献

CELL BIOLOGY INTERNATIONAL文献大全
  • The role of reactive oxygen metabolites in the transcriptional regulation of IFN-gamma gene expression by histamine in NK cells following IL-2 stimulation.

    abstract：:The secretion of interferon-gamma (IFN-gamma) by natural killer (NK) cells following in vitro stimulation with interleukin-2 (IL-2) is inhibited by co-incubation with autologous monocytes at a transcriptional level by more than sixty-fold. In this study, we investigate the nature of the inhibitory signal and particula...

    journal_title：Cell biology international

    pub_type： 杂志文章

    doi：10.1006/cbir.1996.0077

    authors： Houze TA,Larsson PA,Hellstrand K,Gustavsson B

    更新日期：1996-09-01 00:00:00

  • Runx2 alleviates high glucose-suppressed osteogenic differentiation via PI3K/AKT/GSK3β/β-catenin pathway.

    abstract：:Hyperglycemia is one of the most important pathogenesis of diabetic osteopathy. Several lines of studies indicate Runx2 plays a critical role in the process of osteogenic differentiation. However, little studies have analyzed the effect of Runx2 on osteoblast differentiation of rat bone mesenchymal stem cells (rBMSCs)...

    journal_title：Cell biology international

    pub_type： 杂志文章

    doi：10.1002/cbin.10779

    authors： Chen Y,Hu Y,Yang L,Zhou J,Tang Y,Zheng L,Qin P

    更新日期：2017-08-01 00:00:00

  • Sterol glucosyltransferases have different functional roles in Pichia pastoris and Yarrowia lipolytica.

    abstract：:Mutants of the methanol-utilizing yeast Pichia pastoris and the alkane-utilizing yeast Yarrowia lipolytica defective in the orthologue of UGT51 (encoding sterol glucosyltransferase) were isolated and compared. These mutants do not contain the specific ergosterol derivate, ergosterol glucoside. We observed that the P. ...

    journal_title：Cell biology international

    pub_type： 杂志文章

    doi：10.1016/j.cellbi.2003.08.004

    authors： Stasyk OV,Nazarko TY,Stasyk OG,Krasovska OS,Warnecke D,Nicaud JM,Cregg JM,Sibirny AA

    更新日期：2003-01-01 00:00:00

  • Genetic networks in nonpermissive temperature-induced cell differentiation of Sertoli TTE3 cells harboring temperature-sensitive SV40 large T-antigen.

    abstract：:To identify the molecular basis by which nonpermissive temperature (NPT) induces cell differentiation in Sertoli TTE3 cells harboring temperature-sensitive SV40 large T-antigen, we performed global scale microarray and computational gene network analyses. In TTE3 cells, inactivation of the large T-antigen by a NPT at ...

    journal_title：Cell biology international

    pub_type： 杂志文章

    doi：10.1016/j.cellbi.2007.04.007

    authors： Tabuchi Y,Takasaki I,Suto A,Kondo T,Suzuki Y,Obinata M

    更新日期：2007-10-01 00:00:00

  • Verification of epigenetic inheritance in a unicellular model system: multigenerational effects of hormonal imprinting.

    abstract：:The unicellular Tetrahymena has receptors for hormones of higher vertebrates, produces these hormones, and their signal pathways are similar. The first encounter with a hormone in higher dose provokes the phenomenon of hormonal imprinting, by which the reaction of the cell is quantitatively modified. This modification...

    journal_title：Cell biology international

    pub_type： 杂志文章

    doi：10.1042/CBI20110677

    authors： Kőhidai L,Lajkó E,Pállinger E,Csaba G

    更新日期：2012-10-01 00:00:00

  • RNAi-mediated MMP-9 silencing inhibits mouse melanoma cell invasion and migration in vitro and in vivo.

    abstract：:MMP-9 participates in tumour growth, invasion, metastasis and vascularisation. Thus, inhibition of MMP-9 may be involved in the process of tumourigenesis. We have investigated the effect of RNAi-mediated MMP-9 silencing on inhibiting invasion and migration of mouse melanoma cell B16. A specific and optimised siRNA vec...

    journal_title：Cell biology international

    pub_type： 杂志文章

    doi：10.1002/cbin.10107

    authors： Tang ZY,Liu Y,Liu LX,Ding XY,Zhang H,Fang LQ

    更新日期：2013-08-01 00:00:00

  • Effect of monochromatic visible light on intracellular superoxide anion production and mitochondrial membrane potential of B16F1 and B16F10 murine melanoma cells.

    abstract：:We have investigated the effect of visible light on animal cells using light-emitting diodes to emit monochromatic visible light (red, yellow, green and blue light). To explore the relevant mechanism of apoptosis, we assessed the intracellular superoxide anion production and mitochondrial membrane potential (ΔΨm) of B...

    journal_title：Cell biology international

    pub_type： 杂志文章

    doi：10.1002/cbin.10069

    authors： Sato K,Minai Y,Watanabe H

    更新日期：2013-06-01 00:00:00

  • Morphometry of nuclear and nucleolar structures in a CaCo-2 cell line.

    abstract：:The number of the nucleoli in a CaCo-2 cell nucleus does not generally depend on the quantity of DNA in the nucleus, but nucleolar DNA content is directly proportional to total nuclear DNA. However, in multinucleolar cells (three or more nucleoli), the nucleolar DNA content increases after 96 h incubation in culture w...

    journal_title：Cell biology international

    pub_type： 杂志文章

    doi：10.1016/j.cellbi.2004.01.004

    authors： Karalyan ZA,Djaghatspanyan NG,Gasparyan MH,Hakobyan LA,Abroyan LO,Magakyan YH,Ter-Pogossyan ZR,Kamalyan LA,Karalova EM

    更新日期：2004-01-01 00:00:00

  • Stem cells conditioned medium: a new approach to skin wound healing management.

    abstract：:Stem cell biology has gained remarkable interest in recent years, driven by the hope of finding cures for numerous diseases including skin wound healing through transplantation medicine. Initially upon transplantation, these cells home to and differentiate within the injured tissue into specialised cells. Contrariwise...

    journal_title：Cell biology international

    pub_type： 杂志文章

    doi：10.1002/cbin.10138

    authors： Jayaraman P,Nathan P,Vasanthan P,Musa S,Govindasamy V

    更新日期：2013-10-01 00:00:00

  • Synaptic modulation of neuronal coupling.

    abstract：:Electrotonic coupling among neurons in the vertebrate, and more specifically the mammalian, brain has now been demonstrated to exist in all major brain subdivisions and in the spinal cord. For many of these brain areas, recent studies have investigated the possibilities of modulation of that coupling by synaptically r...

    journal_title：Cell biology international

    pub_type： 杂志文章,评审

    doi：10.1006/cbir.1998.0386

    authors： Hatton GI

    更新日期：1998-11-01 00:00:00

  • Quantification of annexin I in subcellular fractions of human neutrophils reveals an exclusive cytosolic localisation.

    abstract：:Annexin I is an abundant cytosolic protein in human neutrophils. Besides its intracellular location, annexin I is found as an extracellular protein and the pathway for secretion has been of interest since the protein lacks a signal sequence for secretion. It was recently shown that annexin I is stored in the secretory...

    journal_title：Cell biology international

    pub_type： 杂志文章

    doi：10.1006/cbir.2001.0760

    authors： Movitz C,Dahlgren C

    更新日期：2001-01-01 00:00:00

  • Serpin A1 and the modulation of type I collagen turnover: Effect of the C-terminal peptide 409-418 (SA1-III) in human dermal fibroblasts.

    abstract：:The pharmacological modulation of collagen turnover is a strategy potentially useful in different skin conditions. The serine protease inhibitor Serpin A1 and portions of its C-terminal region have been investigated as collagen modulators. To clarify the mechanisms by which the C-terminal 409-418 peptide SA1-III incre...

    journal_title：Cell biology international

    pub_type： 杂志文章

    doi：10.1002/cbin.11018

    authors： Cipriani C,Pascarella S,Errante F,Menicacci B,Magnelli L,Mocali A,Rovero P,Giovannelli L

    更新日期：2018-09-01 00:00:00

  • Mycobacterial growth in human macrophages: variation according to donor, inoculum and bacterial strain.

    abstract：:The microbicidal capacity of the macrophage is frequently evaded by mycobacteria, leading to tuberculosis (TB). We investigated a number of parameters affecting the rate of growth of mycobacteria in human monocyte-derived macrophages (MDM). The results show a great deal of variation in the growth of both Mycobacterium...

    journal_title：Cell biology international

    pub_type： 杂志文章

    doi：10.1006/cbir.2000.0679

    authors： Hoal-van Helden EG,Hon D,Lewis LA,Beyers N,van Helden PD

    更新日期：2001-01-01 00:00:00

  • Quantity and proliferation rate of mesenchymal stem cells in human cord blood during gestation.

    abstract：:UCB (umbilical cord blood) as a resource of MSCs (mesenchymal stem cells) is widely accepted, but the quantity and characteristics of UCB-MSCs from different gestational ages have not been well studied. We have quantified the number of MSCs in UCB at different gestational ages using a multi-colour flowcytometer and co...

    journal_title：Cell biology international

    pub_type： 杂志文章

    doi：10.1042/CBI20110173

    authors： Ma LL,Meng FB,Shi P,Li G,Pang XN

    更新日期：2012-04-01 00:00:00

  • A novel estrogen receptor GPER mediates proliferation induced by 17β-estradiol and selective GPER agonist G-1 in estrogen receptor α (ERα)-negative ovarian cancer cells.

    abstract：:G protein-coupled estrogen receptor (GPER) is recently identified as a membrane-associated estrogen receptor that mediates non-genomic effects of estrogen. Our previous immunohistochemistry study found an association between GPER and the proliferation of epithelial ovarian cancer. However, the contributions and mechan...

    journal_title：Cell biology international

    pub_type： 杂志文章

    doi：10.1002/cbin.10243

    authors： Liu H,Yan Y,Wen H,Jiang X,Cao X,Zhang G,Liu G

    更新日期：2014-05-01 00:00:00

  • Inability of 50 Hz magnetic fields to regulate PKC- and Ca(2+)-dependent gene expression in Jurkat cells.

    abstract：:We have previously reported that the T cell line Jurkat registers the exposure of a sinusoidal extremely low frequency magnetic field at the level of the plasma membrane, resulting in activation of the tyrosine kinase p56(lck), increase in inositol-3-phosphate levels and increase in intracellular calcium concentration...

    journal_title：Cell biology international

    pub_type： 杂志文章

    doi：10.1006/cbir.2001.0837

    authors： Still M,Lindström E,Ekstrand AJ,Mild KH,Mattsson MO,Lundgren E

    更新日期：2002-01-01 00:00:00

  • Role of 14-3-3σ in resistance to cisplatin in non-small cell lung cancer cells.

    abstract：:The efficacies of chemotherapeutic agents are often limited by side effects and acquired drug resistance. We have investigated whether the differential expression pattern of 14-3-3σ affects cisplatin response in non-small cell lung cancer cell lines. Two pairs of parental/cisplatin resistant cell lines (A549/CRA549 an...

    journal_title：Cell biology international

    pub_type： 杂志文章

    doi：10.1002/cbin.10006

    authors： Cetintas VB,Tetik A,Cok G,Kucukaslan AS,Kosova B,Gunduz C,Veral A,Eroglu Z

    更新日期：2013-01-01 00:00:00

  • Ectophosphatase activity in the triple-negative breast cancer cell line MDA-MB-231.

    abstract：:Breast cancer is one of the most common cancers in the female population worldwide, and its development is thought to be associated with genetic mutations that lead to uncontrolled and accelerated growth of breast cells. This abnormal behavior requires extra energy, and indeed, tumor cells display a rewired energy met...

    journal_title：Cell biology international

    pub_type： 杂志文章

    doi：10.1002/cbin.11497

    authors： Lacerda-Abreu MA,Russo-Abrahão T,Leite Tenório Aguiar R,Monteiro RQ,Rumjanek FD,Meyer-Fernandes JR

    更新日期：2020-11-03 00:00:00

  • Studies on nitric oxide free radicals generated from polymorphonuclear leukocytes (PMN) stimulated by phorbol myristate acetate (PMA).

    abstract：:The interaction of NO and O2- free radicals generated from PMA (phorbol myristate acetate)-stimulated PMN (polymorphonuclear leukocytes) was studied by a nitroxide spin trap, DMPO (5,5-dimethyl-1-pyrroline-1-oxide). It was found that addition of L-arginine to the system would significantly decrease the trapped O2- by ...

    journal_title：Cell biology international

    pub_type： 杂志文章

    doi：10.1006/cbir.1996.0039

    authors： Zhao BL,Wang JC,Hou JW,Xin WJ

    更新日期：1996-05-01 00:00:00

  • Validation of common reference genes stability in exosomal mRNA-isolated from liver and breast cancer cell lines.

    abstract：:Accurate relative gene expression analysis by reverse transcription-quantitative polymerase chain reaction relies on the usage of suitable reference genes for data normalization. The RNA content of small extracellular vesicles including exosomes is growingly considered as cancer biomarkers. So, reliable relative quant...

    journal_title：Cell biology international

    pub_type： 杂志文章

    doi：10.1002/cbin.11556

    authors： Gorji-Bahri G,Moradtabrizi N,Vakhshiteh F,Hashemi A

    更新日期：2021-01-27 00:00:00

  • Transcription factor XBP-1 is expressed during osteoblast differentiation and is transcriptionally regulated by parathyroid hormone (PTH).

    abstract：:X-box-binding protein 1 (XBP-1) is a basic-region leucine zipper protein in the cyclic AMP response element binding protein/activating transcription factor (CREB/ATF) family of transcription factors involved in different cell-differentiation processes. We have investigated the expression of XBP-1 in differentiating MC...

    journal_title：Cell biology international

    pub_type： 杂志文章

    doi：10.1016/j.cellbi.2005.03.018

    authors： Zambelli A,Mongiardini E,Villegas SN,Carri NG,Boot-Handford RP,Wallis GA

    更新日期：2005-08-01 00:00:00

  • Vascular endothelial cells and smooth muscle cells mediate carbachol-induced hepatocyte proliferation via muscarinic receptors and IP3/PKC signaling cascades.

    abstract：:An acetylcholine (ACh) agonist, carbachol (Cch), causes hepatocytes to proliferate in the presence of hepatic nonparenchymal cells (HNPCs). To identify the HNPCs and ACh receptor subtypes involved in carbachol-induced hepatocyte proliferation (CIHP), we examined two types of vascular cells as candidates for HNPCs medi...

    journal_title：Cell biology international

    pub_type： 杂志文章

    doi：10.1016/j.cellbi.2009.01.018

    authors： Yoshimura R,Arai J,Endo Y

    更新日期：2009-04-01 00:00:00

  • Molecular identification of PpHDAC1, the first histone deacetylase fron the slime mold Physarum polycephalum.

    abstract：:The dynamic state of post-translational acetylation of eukaryotic histones is maintained by histone acetyltransferases (HATs) and histone deacetylases (HDACs). HATs and HDACs have been shown to be components of various regulatory protein complexes in the cell. Their enzymatic activities, intracellular localization and...

    journal_title：Cell biology international

    pub_type： 杂志文章

    doi：10.1016/s1065-6995(02)90933-9

    authors： Brandtner EM,Lechner T,Loidl P,Lusser A

    更新日期：2002-01-01 00:00:00

  • A GFP trap study uncovers the functions of Gilgamesh protein kinase in Drosophila melanogaster spermatogenesis.

    abstract：:The function of the gene gilgamesh (89B9-12) encoding a casein kinase in Drosophila spermatogenesis was studied. The chimeric Gilgamesh-GFP protein in spermatocytes is cortically located. In the polar and apolar spermatocytes, it concentrates at the terminal ends of the fusome, the organelle that passes through the sy...

    journal_title：Cell biology international

    pub_type： 杂志文章

    doi：10.1016/j.cellbi.2009.02.009

    authors： Nerusheva OO,Dorogova NV,Gubanova NV,Yudina OS,Omelyanchuk LV

    更新日期：2009-05-01 00:00:00

  • Automated detection of morphological alterations during apoptosis.

    abstract：:A convenient means of measuring apoptosis is described using an automated analyzer (MF-1; Sysmex), which normally provides rapid measurement of malarial parasites. By means of this MF-1 procedure, apoptotic cells exhibited characteristic changes of light scatter (size) and fluorescence (DNA content) relating to cell s...

    journal_title：Cell biology international

    pub_type： 杂志文章

    doi：10.1006/cbir.2000.0560

    authors： Lertworasirikul T,Bunyaratvej A,Kubota F

    更新日期：2000-01-01 00:00:00

  • Tripartite motif protein 25 is associated with epirubicin resistance in hepatocellular carcinoma cells via regulating PTEN/AKT pathway.

    abstract：:Tripartite motif protein 25 (TRIM25) expression was altered in various human cancers. Herein, we found that the expression of TRIM25 was elevated in hepatocellular carcinoma (HCC) tissues and cell lines. Knockdown of TRIM25 increased the sensitivity of HCC HepG2 cells to epirubicin (EPI), as indicated by reduced cell ...

    journal_title：Cell biology international

    pub_type： 杂志文章

    doi：10.1002/cbin.11346

    authors： Yuan P,Zheng A,Tang Q

    更新日期：2020-07-01 00:00:00

  • Tissues formed during distraction osteogenesis in the rabbit are determined by the distraction rate: localization of the cells that express the mRNAs and the distribution of types I and II collagens.

    abstract：:An experimental model of leg lengthening was used to study the morphology of, the collagenous proteins present, and the collagen genes expressed in the regenerating tissue following 20% lengthening at four different distraction rates. At a distraction rate of 0.3 mm/day (8 weeks distraction), the regenerate consists o...

    journal_title：Cell biology international

    pub_type： 杂志文章

    doi：10.1006/cbir.1999.0449

    authors： Li G,Virdi AS,Ashhurst DE,Simpson AH,Triffitt JT

    更新日期：2000-01-01 00:00:00

  • Loganin prevents BV-2 microglia cells from Aβ1-42 -induced inflammation via regulating TLR4/TRAF6/NF-κB axis.

    abstract：:Neuroinflammation is closely related with the pathogenesis and progress of neurodegenerative diseases including Alzheimer's disease (AD). Loganin, an iridoid glycoside obtained from traditional Chinese medicine Cornus officinalis, has properties of inhibiting inflammation and improving memory. The present study was ai...

    journal_title：Cell biology international

    pub_type： 杂志文章

    doi：10.1002/cbin.11060

    authors： Cui Y,Wang Y,Zhao D,Feng X,Zhang L,Liu C

    更新日期：2018-12-01 00:00:00

  • Rosbin, a synthetic small molecule, induces A549 cells apoptosis through a ROS-mediated pathway.

    abstract：:Rosbin (Thieno [2, 3-c] piperidine-3-carboxamide-2-[(3-methoxy-naphtha-lene-2-carbonyl)-amino]-6-(benzyl)-, hydrochloride), a synthetic piperidinothieno derivative compound obtained from chemical genetics screenings, significantly suppresses the viability of non-small cell lung cancer A549 cells with an IC50 of 2.05 ±...

    journal_title：Cell biology international

    pub_type： 杂志文章

    doi：10.1002/cbin.10714

    authors： Zhao T,Jin W,Pan H,Li H,Zhao Y,Feng Y

    更新日期：2017-02-01 00:00:00

  • Evaluation of STAT3 decoy oligodeoxynucleotides' synergistic effects on radiation and/or chemotherapy in metastatic breast cancer cell line.

    abstract：:Resistance to radiotherapy and chemotherapy has been a major problem of conventional cancer therapies, which consequently leads to cancer relapse and cancer-related death. It is known that cancer stem cells (CSCs) play a key role in therapy resistance and CSC-based targeted therapies have been considered as a powerful...

    journal_title：Cell biology international

    pub_type： 杂志文章

    doi：10.1002/cbin.11456

    authors： Johari B,Rahmati M,Nasehi L,Mortazavi Y,Faghfoori MH,Rezaeejam H

    更新日期：2020-12-01 00:00:00