Abstract:
:We have investigated the effect of visible light on animal cells using light-emitting diodes to emit monochromatic visible light (red, yellow, green and blue light). To explore the relevant mechanism of apoptosis, we assessed the intracellular superoxide anion production and mitochondrial membrane potential (ΔΨm) of B16F1 and B16F10 murine melanoma cells after monochromatic light irradiation. Blue light caused ΔΨm depolarization subsequent to elevation of intracellular superoxide production. However, red and yellow light had no affect on both cell lines. Green light induced ΔΨm collapse only in B16F1 melanoma cells. ΔΨm is a key indicator of mitochondrial function, therefore its disruption causes mitochondria-dependent apoptosis. Thus, blue light causes mitochondrial dysfunction and subsequent cell death.
journal_name
Cell Biol Intjournal_title
Cell biology internationalauthors
Sato K,Minai Y,Watanabe Hdoi
10.1002/cbin.10069subject
Has Abstractpub_date
2013-06-01 00:00:00pages
633-7issue
6eissn
1065-6995issn
1095-8355journal_volume
37pub_type
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