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Molecular identification of PpHDAC1, the first histone deacetylase fron the slime mold Physarum polycephalum.

Abstract：

:The dynamic state of post-translational acetylation of eukaryotic histones is maintained by histone acetyltransferases (HATs) and histone deacetylases (HDACs). HATs and HDACs have been shown to be components of various regulatory protein complexes in the cell. Their enzymatic activities, intracellular localization and substrate specificities are regulated in a complex, cell cycle related manner. In the myxomycete Physarum polycephalum multiple HATs and HDACs can be distinguished in biochemical terms and they exhibit dynamic activity patterns depending on the cell cycle stage. Here we report on the cloning of the first P. polycephalum HDAC (PpHDAC1) related to the S. cerevisiae Rpd3 protein. The expression pattern of PpHDAC1 mRNA was analysed at different time points of the cell cycle and found to be largely constant. Treatment of macroplasmodia with the HDAC inhibitor trichostatin A at several cell cycle stages resulted in a significant delay in entry into mitosis of treated versus untreated plasmodia. No effect of TSA treatment could be observed on PpHDAC1 expression itself.

journal_name

Cell Biol Int

journal_title

Cell biology international

authors

Brandtner EM,Lechner T,Loidl P,Lusser A

doi

10.1016/s1065-6995(02)90933-9

keywords:

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

783-9

issue

9

eissn

1065-6995

issn

1095-8355

pii

S1065699502909339

journal_volume

26

pub_type

杂志文章

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