Human insulin receptor juxtamembrane domain independent insulin signaling.

abstract：:It has been proposed that cyclical gene expression occurs at a large number of different times during the cell cycle. The existence of a large number of cycle-specific variations in mRNA and protein during the eukaryotic cell cycle raises the problem of how cell-cycle variations are regulated. This is the "infinite re...

journal_title：Cell biology international

authors： Cooper S,Shedden K,Vu-Phan D

更新日期：2009-01-01 00:00:00

abstract：:Neuroinflammatory disorders such as Alzheimer's and Parkinson's diseases are characterised by chronic inflammation and loss of vascular integrity. Bradykinin 1 receptor (B1R) activation has been implicated in many neuroinflammatory diseases, but the contribution of B1R to inflammation and vascular breakdown is yet to ...

journal_title：Cell biology international

authors： Mugisho OO,Robilliard LD,Nicholson LFB,Graham ES,O'Carroll SJ

更新日期：2019-09-09 00:00:00

abstract：:CO25 cells, a mouse myoblast line, contain multiple centrioles and primary cilia. A most unusual feature has been the finding of large numbers of separate structures in single cells-up to a maximum of nine centrioles, six primary cilia, and 12 of both organelles together. Aberrant multipolar spindles were occasionally...

journal_title：Cell biology international

authors： Zeytinoglu M,Ritter J,Wheatley DN,Warn RM

更新日期：1996-12-01 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is a common cancer with poor prognosis and high mortality. The role of CCN5 has attracted a great focus on the regulation of cancer progression. However, the biological function and mechanism of CCN5 in OSCC are still not well elucidated. The current study was designed to determine ...

journal_title：Cell biology international

authors： Sun S,Cui Z,Yan T,Wu J,Liu Z

更新日期：2020-04-01 00:00:00

abstract：:The purpose of the study was to examine mechanisms controlling cell cycle progression/arrest and differentiation of mouse C2C12 myoblasts exposed to long-chain saturated fatty acid salt, palmitate. Treatment of proliferating myoblasts with palmitate (0.1 mmol/l) markedly decreased myoblast number. Cyclin A and cyclin ...

journal_title：Cell biology international

authors： Grabiec K,Milewska M,Błaszczyk M,Gajewska M,Grzelkowska-Kowalczyk K

更新日期：2015-09-01 00:00:00

abstract：:The efficacies of chemotherapeutic agents are often limited by side effects and acquired drug resistance. We have investigated whether the differential expression pattern of 14-3-3σ affects cisplatin response in non-small cell lung cancer cell lines. Two pairs of parental/cisplatin resistant cell lines (A549/CRA549 an...

journal_title：Cell biology international

authors： Cetintas VB,Tetik A,Cok G,Kucukaslan AS,Kosova B,Gunduz C,Veral A,Eroglu Z

更新日期：2013-01-01 00:00:00

abstract：:The action of theophylline on the uptake of alpha-aminoisobutyric acid (AIB; an indicator of anti-inflammatory potency) stimulated by the glucocorticoid, dexamethasone, in cultured rat fibroblast monolayers was evaluated. Theophylline alone (0.1 m m) did not show significant activity (3314+/-27 cpm) compared with the ...

journal_title：Cell biology international

authors： Xenos K,Kalogeromitros D,Markantonis SL,Katsambas A,Katsarou A

更新日期：1998-01-01 00:00:00

abstract：:A structural link between cell's nucleus and centrosome was proposed years ago. Such a link was suggested to maintain nucleus-centrosome axis, determine polarity of interphase cells and ensure spindle assembly in mitotic cells. The idea of structural link is supported by the facts that centrosomes are usually located ...

journal_title：Cell biology international

authors： Burakov AV,Nadezhdina ES

更新日期：2013-02-01 00:00:00

abstract：:The epidermal keratinocytes express two major pairs of keratin polypeptides. One pair (K5/K14) expressed specifically in basal generative compartment and the other (K1/K10) expressed specifically in the differentiating suprabasal compartment. The switch in the expression of the keratins from proliferating to different...

journal_title：Cell biology international

authors： Rao KS,Babu KK,Gupta PD

更新日期：1996-04-01 00:00:00

abstract：:Fibrinogen participates in important cellular physiological processes, such as cell adhesion and blood clotting. Although the primary and secondary structures of fibrinogen are known, its tertiary structure is yet to be determined. In attempts to understand the tertiary structure of this important hydrated cellular an...

journal_title：Cell biology international

authors： Taatjes DJ,Quinn AS,Jenny RJ,Hale P,Bovill EG,McDonagh J

更新日期：1997-11-01 00:00:00

abstract：:Neuroinflammation is closely related with the pathogenesis and progress of neurodegenerative diseases including Alzheimer's disease (AD). Loganin, an iridoid glycoside obtained from traditional Chinese medicine Cornus officinalis, has properties of inhibiting inflammation and improving memory. The present study was ai...

journal_title：Cell biology international

authors： Cui Y,Wang Y,Zhao D,Feng X,Zhang L,Liu C

更新日期：2018-12-01 00:00:00

abstract：:Local anesthetic of bupivacaine may inhibit neurite outgrowth and induce apoptosis in mouse dorsal root ganglia (DRG) neurons. In this work, we intended to investigate the functional role of microRNA 26a (miR-26a) in regulating bupivacaine-induced nerve injury in DRG neurons. DRG neurons were extracted from C57BL/6 mi...

journal_title：Cell biology international

authors： Cui C,Xu G,Qiu J,Fan X

更新日期：2015-08-01 00:00:00

abstract：:Propofol is one of the extensively commonly used intravenous anaesthetic agents. The effects of Propofol on hepatocellular carcinoma (HCC) growth inhibition and apoptosis have been examined. The techniques used were the MTT assay, flow cytometry, real-time PCR to assess miR-199a expression, as also caspase-8 and caspa...

journal_title：Cell biology international

authors： Zhang J,Wu GQ,Zhang Y,Feng ZY,Zhu SM

更新日期：2013-03-01 00:00:00

abstract：:Whether fructose (FRU), as the sole energy source, confers a metabolic advantage on cancer cells against noxious stimuli is unknown. The aim of this study was to evaluate the effects of low (11 mM), moderate (25 mM), and high (55 mM) FRU concentrations alone or in combination with rotenone (ROT) or doxorubicin (DOX) i...

journal_title：Cell biology international

authors： Diaz-Aguirre V,Velez-Pardo C,Jimenez-Del-Rio M

更新日期：2016-11-01 00:00:00

abstract：:ES (embryonic stem)-derived cells have been investigated in many animal models of severe injury and degenerative disease. However, few studies have examined the ability of ES-derived cells to improve functional outcome following partially damaged breast and also the modification of mammary tissue to produce costly pro...

journal_title：Cell biology international

authors： Huang HJ,Gao QS,Qian YG,Zhang YD,Tao BF,Xiang M,Peng J,Jiang SW,Hause B

更新日期：2010-10-01 00:00:00

abstract：:Rosbin (Thieno [2, 3-c] piperidine-3-carboxamide-2-[(3-methoxy-naphtha-lene-2-carbonyl)-amino]-6-(benzyl)-, hydrochloride), a synthetic piperidinothieno derivative compound obtained from chemical genetics screenings, significantly suppresses the viability of non-small cell lung cancer A549 cells with an IC50 of 2.05 ±...

journal_title：Cell biology international

authors： Zhao T,Jin W,Pan H,Li H,Zhao Y,Feng Y

更新日期：2017-02-01 00:00:00

abstract：:Photodynamic therapy (PDT) for cancer is a therapeutic modality in the treatment of tumors in which visible light is used to activate a photosensitizer. Cell membranes have been identified as an important intracellular target for singlet oxygen produced during the photochemical pathway. This study analyzed the cytotox...

journal_title：Cell biology international

authors： Maftoum-Costa M,Naves KT,Oliveira AL,Tedesco AC,da Silva NS,Pacheco-Soares C

更新日期：2008-08-01 00:00:00

abstract：:Restriction Endonucleases (REs) may recognize, cleave and remove DNA from fixed chromatin producing specific chromosome banding patterns. However, the modifications produced in the chromatin fibre are not easy to evaluate and compare. The aim of the present investigation was to visualize differences resulting in the t...

journal_title：Cell biology international

authors： Gosálvez J,López-Fernández C,Fernández JL,Goyanes VJ,Buño I

更新日期：1996-03-01 00:00:00

abstract：:The purpose of this study was three fold: (1) to reveal the implications of Wnt5A for cytokine and chemokine production by human ovarian cancer cell line SKOV-3 cells, (2) to determine the influence of Wnt5A on chemotactic SKOV-3 cell migration, and (3) to assess the effect of inflammatory mediators on Wnt5A expressio...

journal_title：Cell biology international

authors： Arabzadeh S,Hossein G,Zarnani AH

更新日期：2016-02-01 00:00:00

abstract：:Heparin-binding epidermal growth factor (HB-EGF) is a member of highly conserved superfamily of proteins that has potential mitogenic activity and stimulates differentiation and migration of various cell types. Since HB-EGF has three intra-molecular disulfide bonds, a high expression pattern of active HB-EGF in an E. ...

journal_title：Cell biology international

authors： Khalili M,Soleyman MR,Baazm M,Beyer C

更新日期：2015-07-01 00:00:00

abstract：:The advent of scanning probe microscopy has introduced a powerful new method of probing the structural features of biological specimens. In this study, high resolution atomic force microscopy micrographs of single, isolated, cardiac myocytes are presented. Significantly, our images show not only the features to be exp...

journal_title：Cell biology international

authors： Davis JJ,Hill HA,Powell T

更新日期：2001-01-01 00:00:00

abstract：:The function of the gene gilgamesh (89B9-12) encoding a casein kinase in Drosophila spermatogenesis was studied. The chimeric Gilgamesh-GFP protein in spermatocytes is cortically located. In the polar and apolar spermatocytes, it concentrates at the terminal ends of the fusome, the organelle that passes through the sy...

journal_title：Cell biology international

authors： Nerusheva OO,Dorogova NV,Gubanova NV,Yudina OS,Omelyanchuk LV

更新日期：2009-05-01 00:00:00

abstract：:Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a key enzyme of the glycolytic pathway. Recent studies have demonstrated an additional role in apoptosis: GAPDH is targeted to the nucleus during apoptotic signalling. This nuclear transport has also been observed in serum-depleted cells, but it is reversible in fibr...

journal_title：Cell biology international

authors： Schmitz HD,Dutiné C,Bereiter-Hahn J

更新日期：2003-01-01 00:00:00

abstract：:Mitomycin C (MMC) treatment has been used to arrest cell proliferation but not much is known about the effect of MMC on human foreskin fibroblasts (HFF) used as feeders for human embryonic stem cells (hESC). We tested the ability of MMC to stop the proliferation of HFF and to induce apoptosis. MMC inhibited the prolif...

journal_title：Cell biology international

authors： Nieto A,Cabrera CM,Catalina P,Cobo F,Barnie A,Cortés JL,Barroso del Jesus A,Montes R,Concha A

更新日期：2007-03-01 00:00:00

abstract：:In this paper the radioresistance of human erythrocytes to radiation-induced haemolysis was studied by means of the split-dose technique. Human erythrocytes suspended in an isotonic Na-phosphatase buffer, pH 7.4 were exposed under air to gamma radiation. Erythrocytes were irradiated with a single dose of 2.7 kGy and w...

journal_title：Cell biology international

authors： Zaborowski A,Szweda-Lewandowska Z

更新日期：1997-09-01 00:00:00

abstract：:To identify the molecular basis by which nonpermissive temperature (NPT) induces cell differentiation in Sertoli TTE3 cells harboring temperature-sensitive SV40 large T-antigen, we performed global scale microarray and computational gene network analyses. In TTE3 cells, inactivation of the large T-antigen by a NPT at ...

journal_title：Cell biology international

authors： Tabuchi Y,Takasaki I,Suto A,Kondo T,Suzuki Y,Obinata M

更新日期：2007-10-01 00:00:00

abstract：:We have characterised, using both in vivo and in vitro methods, the effects of the metabotropic glutamate receptor subtype 3 (mGlu3) antagonist (LY341495) and agonist (LY379268) on the proliferation and differentiation of glioma stem cells (GSC). For in vitro studies, a CCK-8 assay was used to determine the cell proli...

journal_title：Cell biology international

authors： Zhou K,Song Y,Zhou W,Zhang C,Shu H,Yang H,Wang B

更新日期：2014-04-01 00:00:00

abstract：:Ricin is internalized after binding at the cell surface via lectin activity of the B-chain recognizing terminal galactose residues. Ricin-A chain is then translocated to the cytosol from various endocytic structures. Cell death is the result of catalytic inactivation of protein synthesis. Using (125)I-ricin overlays, ...

journal_title：Cell biology international

authors： Alami M,Taupiac MP,Beaumelle B

更新日期：1997-03-01 00:00:00

abstract：:The effect of hypoxia on the differentiation of chronic myeloid leukaemic K562 cells were studied, as was the role of the NHE1 (Na+/H+ exchanger 1). Hypoxia induced differentiation of K562 cells as seen by modifications in their morphological features, up-regulation of C/EBPα (CCAAT/enhancer-binding protein α), and ma...

journal_title：Cell biology international

authors： Jin W,Li Q,Wang J,Chang G,Lin Y,Li H,Wang L,Gao W,Pang T

更新日期：2012-08-01 00:00:00

abstract：:A subcellular fractionation procedure was developed to isolate the different endosomal compartments present during reticulocyte maturation. After reticulocyte lysis and removal of excess haemoglobin by gel chromatography, membrane vesicles were separated over a discontinuous sucrose gradient (10-40%). Two fractions we...

journal_title：Cell biology international

authors： Dardalhon V,Géminard C,Reggio H,Vidal M,Sainte-Marie J

更新日期：2002-01-01 00:00:00