Abstract：
:It has been proposed that cyclical gene expression occurs at a large number of different times during the cell cycle. The existence of a large number of cycle-specific variations in mRNA and protein during the eukaryotic cell cycle raises the problem of how cell-cycle variations are regulated. This is the "infinite regression" or Russian Doll problem where postulating a cell-cycle specific control element pushes the explanation of cell-cycle variation back one step to the problem of how that control element varies during the cell cycle. PCR studies on unperturbed cells indicate Cyclin mRNA content is invariant during the cell cycle. Furthermore, calculations reveal that variations in mRNA content do not account for observed protein variations. Continuous and constant gene expression during the cell cycle, continuous protein accumulation, and protein breakdown only within the mitotic window solves the Russian Doll problem or infinite regression problem. These results, and theoretical ideas support an alternative view of the cell cycle where many of the proposed control systems do not exist.
journal_name
Cell Biol Intjournal_title
Cell biology internationalauthors
Cooper S,Shedden K,Vu-Phan Ddoi
10.1016/j.cellbi.2008.10.004subject
Has Abstractpub_date
2009-01-01 00:00:00pages
10-8issue
1eissn
1065-6995issn
1095-8355pii
S1065-6995(08)00598-2journal_volume
33pub_type
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