Abstract:
:Wnt signalling regulates cell proliferation and cell fate determination during embryogenesis. However, little is known about the developmental role of one Wnt family member, Wnt-3, during avian development. To investigate the possible functions of Wnt-3, its expression pattern was determined using whole-mount in situ hybridization. Wnt-3 is expressed in important signalling centres, including the dorsal neural tube, Hensen's node and the AER (apical ectodermal ridge). Most interestingly, Wnt-3 is expressed in the dorsal neural tube as a gradient, with the strongest expression anterior in the trunk. Furthermore, this study showed that Wnt-3 and Wnt-3a play a different role in neural crest lineages derived from different axial level of neural tube. Wnt-3 might be involved in proliferation of neural crest lineages, whereas Wnt-3a plays an important role in melanogenesis in vagal. However, both Wnt-3 and Wnt-3a cause a significant increase in melanogenesis in the trunk neural crest lineage.
journal_name
Cell Biol Intjournal_title
Cell biology internationalauthors
Dongkyun K,Jinsoo S,Jin EJdoi
10.1042/CBI20090133subject
Has Abstractpub_date
2010-07-01 00:00:00pages
763-8issue
7eissn
1065-6995issn
1095-8355pii
CBI20090133journal_volume
34pub_type
杂志文章abstract::Zebularine is a cytidine analogue incorporated into DNA during replication, inhibiting DNA methyltransferase 1 (DNMT1), resulting in demethylation and changes in gene expression. Such modification may improve radiosensitivity in resistant lymphoma cells. The hypothesis of this study was that zebularine and radiation w...
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