Abstract:
:Most traditional cytotoxic chemotherapeutic agents have poor aqueous solubility and significant toxicity. Hence, there is a need to develop molecule-targeted drugs. Programmed death-ligand 1 (PD-L1) is associated with the prognosis of several cancer types, and blockade of PD-1/PD-L1 signaling increases the amplitude of anti-tumor immunity. In the present study, we investigated the effects of JQ1, a bromodomain and extraterminal-bromodomain inhibitor, on cell growth, and messenger RNA (mRNA) and protein levels of PD-L1 in renal cell carcinoma primary culture cells, and prostate, liver, and lung cancer cell lines. The results of the cell counting kit-8 assay suggested that JQ1 inhibits cell growth in a dose-dependent manner. The mRNA and protein levels of PD-L1 decreased in the primary culture of JQ1-treated renal carcinoma, prostate cancer, liver cancer, and lung cancer cell lines. In addition, the mRNA level of PD-L2 also decreased in the JQ1-treated cells. Overall, JQ1 might be a potential anti-tumor agent.
journal_name
Cell Biol Intjournal_title
Cell biology internationalauthors
Liu K,Zhou Z,Gao H,Yang F,Qian Y,Jin H,Guo Y,Liu Y,Li H,Zhang C,Guo J,Wan Y,Chen Rdoi
10.1002/cbin.11139subject
Has Abstractpub_date
2019-06-01 00:00:00pages
642-650issue
6eissn
1065-6995issn
1095-8355journal_volume
43pub_type
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