Mechanical aspects of cell shape regulation and signaling.

Abstract:

:Physical forces play a critical role in cell integrity and development, but little is known how cells convert mechanical signals into biochemical responses. This mini-review examines potential molecular mediators like integrins, focal adhesion proteins, and the cytoskeleton in the context of a complex cell structure. These molecules-when activated by cell binding to the extracellular matrix-associate with the skeletal scaffold via the focal adhesion complex. Vinculin is presented as a mechanical coupling protein that contributes to the integrity of the cytoskeleton and cell shape control, and examples are given of how mechanical signals converge into biochemical responses through force-dependent changes in cell geometry and molecular mechanics.

journal_name

Cell Biol Int

authors

Goldmann WH

doi

10.1006/cbir.2002.0857

keywords:

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

313-7

issue

4

eissn

1065-6995

issn

1095-8355

pii

S1065699502908577

journal_volume

26

pub_type

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