Abstract:
:Physical forces play a critical role in cell integrity and development, but little is known how cells convert mechanical signals into biochemical responses. This mini-review examines potential molecular mediators like integrins, focal adhesion proteins, and the cytoskeleton in the context of a complex cell structure. These molecules-when activated by cell binding to the extracellular matrix-associate with the skeletal scaffold via the focal adhesion complex. Vinculin is presented as a mechanical coupling protein that contributes to the integrity of the cytoskeleton and cell shape control, and examples are given of how mechanical signals converge into biochemical responses through force-dependent changes in cell geometry and molecular mechanics.
journal_name
Cell Biol Intjournal_title
Cell biology internationalauthors
Goldmann WHdoi
10.1006/cbir.2002.0857keywords:
subject
Has Abstractpub_date
2002-01-01 00:00:00pages
313-7issue
4eissn
1065-6995issn
1095-8355pii
S1065699502908577journal_volume
26pub_type
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