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Genetic networks in nonpermissive temperature-induced cell differentiation of Sertoli TTE3 cells harboring temperature-sensitive SV40 large T-antigen.

Abstract：

:To identify the molecular basis by which nonpermissive temperature (NPT) induces cell differentiation in Sertoli TTE3 cells harboring temperature-sensitive SV40 large T-antigen, we performed global scale microarray and computational gene network analyses. In TTE3 cells, inactivation of the large T-antigen by a NPT at 39 degrees C led to cell differentiation accompanying elevation of transferrin, a marker for differentiation of Sertoli cells, and CDKN1A, a cyclin-dependent kinase inhibitor. Of the 22,690 probe sets analyzed, NPT down-regulated 498 probe sets and up-regulated 432 probe sets by >2.0-fold. Hierarchical clustering analysis showed six gene clusters. In the down-regulated cluster I, a significant genetic network including fibronectin 1 was associated with cellular growth and proliferation. In up-regulated cluster IV, a significant genetic network including CDKN1A was associated with cellular differentiation. The present results provide additional novel insights into the molecular basis of cell differentiation induced by NPT in cells.

journal_name

Cell Biol Int

journal_title

Cell biology international

authors

Tabuchi Y,Takasaki I,Suto A,Kondo T,Suzuki Y,Obinata M

doi

10.1016/j.cellbi.2007.04.007

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

1231-6

issue

10

eissn

1065-6995

issn

1095-8355

pii

S1065-6995(07)00129-1

journal_volume

31

pub_type

杂志文章

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