Quantity and proliferation rate of mesenchymal stem cells in human cord blood during gestation.

Abstract:

:UCB (umbilical cord blood) as a resource of MSCs (mesenchymal stem cells) is widely accepted, but the quantity and characteristics of UCB-MSCs from different gestational ages have not been well studied. We have quantified the number of MSCs in UCB at different gestational ages using a multi-colour flowcytometer and compared the cell proliferation rates of these UCB-MSCs. Defining MSCs as CD44+/CD105+/CD34-/CD45 population, their numbers declined in the UCB at the gestational age. Proliferation rates were significantly higher in UCB before term than at full term. Non-full term UCB samples may be a better source of MSCs.

journal_name

Cell Biol Int

authors

Ma LL,Meng FB,Shi P,Li G,Pang XN

doi

10.1042/CBI20110173

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

415-8

issue

4

eissn

1065-6995

issn

1095-8355

pii

CBI20110173

journal_volume

36

pub_type

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