Molecular interactions between vinculin and phospholipids.

Abstract:

:The focal adhesion protein vinculin has been implicated in associating with soluble and membranous phospholipids. Detailed investigations over the past ten years describe the intermolecular interactions of the vinculin tail domain with soluble and membrane phospholipids. Previous studies have implied that the tail's unstructured C-terminal region affects the mechanical behavior of cells and that the same region, at the molecular level, has bi-stable behavior sensitive to different protonation states. The aim of this short communication is to discuss whether the C-terminal vinculin tail (Vt) domain interacts favorably with membrane-embedded phospholipids such as PIP2 and that the region is also an anchor for lipid membranes.

journal_name

Cell Biol Int

authors

Goldmann WH

doi

10.1002/cbin.10978

subject

Has Abstract

pub_date

2018-08-01 00:00:00

pages

1076-1078

issue

8

eissn

1065-6995

issn

1095-8355

journal_volume

42

pub_type

杂志文章
  • Insulin-dependent cytoplasmic distribution of Rab4a in mouse adipocytes is inhibited by interleukin-6, -8, and -15.

    abstract::The purpose of the study was to examine the effect of interleukins, IL-6, IL-8, and IL-15, on insulin-mediated redistribution of Rab4a, an early endosome marker, in mouse 3T3-L1 adipocytes. The interleukins did not affect cell viability; however, cell number was slightly but significantly higher in cultures exposed to...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1002/cbin.10743

    authors: Błaszczyk M,Gajewska M,Milewska M,Grzelkowska-Kowalczyk K

    更新日期:2017-04-01 00:00:00

  • Dendritic cell uptake of iron-based magnetic nanoparticles.

    abstract::We have investigated the internalization of magnetic nanoparticles (NPs) into dendritic cells (DCs) in order to assess both the final location of the particles and the viability of the cultured cells. The particles, consisting of a metallic iron core covered with carbon, showed no toxic effects on the DCs and had no e...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1016/j.cellbi.2008.04.001

    authors: Goya GF,Marcos-Campos I,Fernández-Pacheco R,Sáez B,Godino J,Asín L,Lambea J,Tabuenca P,Mayordomo JI,Larrad L,Ibarra MR,Tres A

    更新日期:2008-08-01 00:00:00

  • ADAMTSL6β promotes fibrillin-1 microfibril assembly, which is possibly mediated via binding through the third thrombospondin type I domain to fibrillin-1.

    abstract::Fibrillin-1 is the major component of extracellular matrix microfibrils. Microfibrils dysfunction is responsible for the onset of various connective tissue diseases, including Marfan syndrome. Although ADAMTSL (a disintegrin and metalloproteinase with thrombospondin motifs-like) 6β is one of the fibrillin-1 binding pr...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1002/cbin.11337

    authors: Orimoto A,Fukuda T

    更新日期:2020-07-01 00:00:00

  • FAM107B is regulated by S100A4 and mediates the effect of S100A4 on the proliferation and migration of MGC803 gastric cancer cells.

    abstract::FAM107B expression was decreased in stomach cancer and many other kinds of cancer. The forced expression of FAM107B in HeLa cells diminished proliferation in response to growth factors, suggesting that FAM107B might play important roles in many types of cancers. But the mechanisms underlying the decreased expression o...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1002/cbin.10816

    authors: Guo J,Bian Y,Wang Y,Chen L,Yu A,Sun X

    更新日期:2017-10-01 00:00:00

  • Wnt5A exerts immunomodulatory activity in the human ovarian cancer cell line SKOV-3.

    abstract::The purpose of this study was three fold: (1) to reveal the implications of Wnt5A for cytokine and chemokine production by human ovarian cancer cell line SKOV-3 cells, (2) to determine the influence of Wnt5A on chemotactic SKOV-3 cell migration, and (3) to assess the effect of inflammatory mediators on Wnt5A expressio...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1002/cbin.10551

    authors: Arabzadeh S,Hossein G,Zarnani AH

    更新日期:2016-02-01 00:00:00

  • Magnesium regulates neural stem cell proliferation in the mouse hippocampus by altering mitochondrial function.

    abstract::In the adult brain, neural stem cells from the subgranular zone (SGZ) of the hippocampus and the subventricular zone (SVZ) of the cortex progress through the following five developmental stages: radial glia-like cells, neural progenitor cells, neuroblasts, immature neurons, and mature neurons. These developmental stag...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1002/cbin.10569

    authors: Jia S,Mou C,Ma Y,Han R,Li X

    更新日期:2016-04-01 00:00:00

  • Inhibition of Ca2+/calmodulin-dependent protein kinase or epidermal growth factor receptor tyrosine kinase abolishes lysophosphatidic acid-mediated DNA-synthesis in human myometrial smooth muscle cells.

    abstract::Human myometrial smooth muscle cells (SMCs) were used to evaluate the proliferative activity of lysophosphatidic acid (LPA). This study specifically focuses on the role of Ca(2+)/calmodulin-dependent protein (CaM) kinase and epidermal growth factor (EGF) receptor tyrosine kinase. Myometrial SMCs were cultured from bio...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1016/s1065-6995(02)00352-9

    authors: Nilsson UK,Svensson SP

    更新日期:2003-01-01 00:00:00

  • Invariant mRNA and mitotic protein breakdown solves the Russian Doll problem of the cell cycle.

    abstract::It has been proposed that cyclical gene expression occurs at a large number of different times during the cell cycle. The existence of a large number of cycle-specific variations in mRNA and protein during the eukaryotic cell cycle raises the problem of how cell-cycle variations are regulated. This is the "infinite re...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1016/j.cellbi.2008.10.004

    authors: Cooper S,Shedden K,Vu-Phan D

    更新日期:2009-01-01 00:00:00

  • Tyrosine phosphorylation is involved in Ca(2+)entry in human gingival fibroblasts.

    abstract::Bradykinin (1 microM) and histamine (100 microM) evoked an initial transient increase and a subsequent sustained increase in intracellular Ca(2+) concentration ([Ca(2+)](i)) in fura-2-loaded human gingival fibroblasts, which may be attributed to Ca(2+) release from intracellular stores and Ca(2+) entry from extracellu...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1016/s1065-6995(03)00125-2

    authors: Ogata Y,Nakao S,Shimizu E,Matsuda-Honjyo Y,Yamazaki M,Furuyama S,Sugiya H

    更新日期:2003-01-01 00:00:00

  • Heat shock protein 27 expression in the human testis showing normal and abnormal spermatogenesis.

    abstract::Heat shock proteins (HSPs) are molecular chaperones involved in protein folding, assembly and transport, and which play critical roles in the regulation of cell growth, survival and differentiation. We set out to test the hypothesis that HSP27 protein is expressed in the human testes and its expression varies with the...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1016/j.cellbi.2008.07.009

    authors: Adly MA,Assaf HA,Hussein MR

    更新日期:2008-10-01 00:00:00

  • Long non-coding RNAs with low expression levels in cells are enriched in secreted exosomes.

    abstract::Long non-coding RNAs (lncRNAs) are involved in regulating chromatin modifications, gene transcription, mRNA translation, and protein function. We recently reported a high variation in the basal expression levels of a panel of lncRNAs in HeLa and MCF-7 cells and their differential response to DNA damage induction. Here...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1002/cbin.10301

    authors: Gezer U,Özgür E,Cetinkaya M,Isin M,Dalay N

    更新日期:2014-09-01 00:00:00

  • Erythrocyte sodium/hydrogen exchange inhibition by (-) epicatechin.

    abstract::Epicatechin, a flavonoid belonging to the group of compounds collectively called catechins, have been reported to possess insulin-like properties. Besides their anti-diabetic properties, catechins also show growth inhibition. Since cytosolic pH (pHi) plays a role in cell proliferation and the Na/H exchanger (NHE) is t...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1006/cbir.2000.0719

    authors: Matteucci E,Rizvi SI,Giampietro O

    更新日期:2001-01-01 00:00:00

  • Peroxynitrite activates K+-Cl- cotransport in human erythrocytes.

    abstract::Peroxynitrite was found to induce the release of K+ via the Na+/Cl- cotransport system, as do other oxidants. Since peroxynitrite is formed in vivo, its presence could contribute to a pathological dehydration of red blood cells. ...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1006/cbir.2001.0778

    authors: Grzelak A,Mazur J,Bartosz G

    更新日期:2001-01-01 00:00:00

  • The negative feedback between miR-143 and DNMT3A regulates cisplatin resistance in ovarian cancer.

    abstract::Emerging evidence suggests that miR-143 plays an important role in the regulation of tumor sensitivity to chemotherapeutic agents. The study explores the underlying mechanism of miR-143 in reversing cisplatin resistance in ovarian cancer. The cisplatin-resistant ovarian cancer cell line A2780/CDDP was induced and esta...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1002/cbin.11486

    authors: Han X,Liu D,Zhou Y,Wang L,Hou H,Chen H,Zhang L,Chen W,Li X,Zhao L

    更新日期:2021-01-01 00:00:00

  • Mitochondrial localization of non-histone protein HMGB1 during human endothelial cell-Toxoplasma gondii infection.

    abstract::Toxoplasma gondii is an obligate intracellular pathogen, replicating only within a specialized membrane-bounded cytoplasmic vacuole, the parasitophorous vacuole (PV), which interacts with host cell mitochondria. High mobility group box 1 (HMGB1), a known nuclear transcription factor, also may be involved in pathologic...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1016/j.cellbi.2007.08.031

    authors: Stumbo AC,Cortez E,Rodrigues CA,Henriques Md,Porto LC,Barbosa HS,Carvalho L

    更新日期:2008-02-01 00:00:00

  • VEGF expression is regulated by HIF-1α and ARNT in 3D KYSE-70, esophageal cancer cell spheroids.

    abstract::In 3D cultured cell systems, the cells form 3D spheroids that mimic cancer cell spheroids in vivo. Cancer cells form cell spheroids as they grow. The in vivo spheroids do not contain a vascular network; therefore, oxygen and nutrition supplies are insufficient. Specifically, the cells in the core region of the cluster...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1002/cbin.10656

    authors: Terashima J,Sampei S,Iidzuka M,Ohsakama A,Tachikawa C,Satoh J,Kudo K,Habano W,Ozawa S

    更新日期:2016-11-01 00:00:00

  • Uptake of cadmium ions in white-rot fungus Trametes versicolor: effect of cd (II) ions on the activity of laccase.

    abstract::The effects of cadmium Cd (II) ions on the physiology and biological activity of Trametes versicolor, a strain belonging to white-rotting Basidiomycetes, were examined. Cd (II) ions were added to 10-day-old cultures grown on a liquid medium, or at the time of inoculation. Our experiments showed that T. versicolor is a...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1006/cbir.2002.0887

    authors: Jarosz-Wilkolazka A,Malarczyk E,Pirszel J,Skowroński T,Leonowicz A

    更新日期:2002-01-01 00:00:00

  • Cytotoxicity of daunorubicin in trisomic (+21) human fibroblasts: relation to drug uptake and cell membrane fluidity.

    abstract::The influence of daunorubicin (DNR) on survival of human normal (S-126) and trisomic, with respect to chromosome 21 (T-164; S-240), skin fibroblasts and some parameters related to it, such as intracellular drug accumulation, distribution and interaction with cell membrane, were studied. The in vitro growth-inhibition ...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1006/cbir.2000.0583

    authors: Przybylska M,Koceva-Chyla A,Rózga B,Józwiak Z

    更新日期:2001-01-01 00:00:00

  • Upregulated osterix expression elicited by Runx2 and Dlx5 is required for the accelerated osteoblast differentiation in PP2A Cα-knockdown cells.

    abstract::Serine/threonine protein phosphatase 2A (PP2A) is involved in regulating various physiological processes including cell cycle, growth, apoptosis, and signal transduction. Osteoblast differentiation is controlled by main bone specific transcription factors including Osterix, distal-less homeobox 5 (Dlx5), and Runt-rela...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1002/cbin.10902

    authors: Yang D,Okamura H,Qiu L

    更新日期:2018-04-01 00:00:00

  • Retinoic acid can induce mouse embryonic stem cell R1/E to differentiate toward female germ cells while oleanolic acid can induce R1/E to differentiate toward both types of germ cells.

    abstract::Retinoic acid (RA) and oleanolic acid (OA) were studied about their potential to induce mouse embryonic stem cell R1/E (MESC-R1/E) to differentiate toward germ cells. Embryoid bodies (EBs) first formed from MESC-R1/E and EBs were allowed to attach to the bottoms of normal cell-culturing plate and grow. Then, different...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1002/cbin.10380

    authors: Wan Q,Lu H,Wu LT,Liu X,Xiang JB

    更新日期:2014-12-01 00:00:00

  • Microfilament-dependent modulation of cytoplasmic protein binding to TNFalpha mRNA AU-rich instability element in human lymphoid cells.

    abstract::Cytoplasmic proteins with binding capability to AU-rich instability determinant sequences (ARE) of tumour necrosis factor alpha (TNFalpha) mRNA 3' untranslated region (3'UTR) were assessed in human lymphoid cells. In vitro label transfer experiments using wild type as well as mutant sequences in which the 70 nucleotid...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1006/cbir.1999.0418

    authors: Henics T

    更新日期:1999-01-01 00:00:00

  • Rosbin, a synthetic small molecule, induces A549 cells apoptosis through a ROS-mediated pathway.

    abstract::Rosbin (Thieno [2, 3-c] piperidine-3-carboxamide-2-[(3-methoxy-naphtha-lene-2-carbonyl)-amino]-6-(benzyl)-, hydrochloride), a synthetic piperidinothieno derivative compound obtained from chemical genetics screenings, significantly suppresses the viability of non-small cell lung cancer A549 cells with an IC50 of 2.05 ±...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1002/cbin.10714

    authors: Zhao T,Jin W,Pan H,Li H,Zhao Y,Feng Y

    更新日期:2017-02-01 00:00:00

  • Gelatinases and metalloproteinase inhibitor secreted by murine colonic carcinoma cells with differing metastatic potential.

    abstract::Gelatinase activity and inhibitory activity against collagenase were measured in serum-free medium conditioned by murine colonic carcinoma cells with different spontaneous metastatic potentials to the lung. The medium conditioned with poorly metastatic NM11 cells gave higher inhibitory activity than that conditioned w...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1006/cbir.1994.1057

    authors: Kishi J,Tanaka R,Koiwai O,Yamagata S,Numata Y,Hayakawa T,Shimizu S

    更新日期:1994-03-01 00:00:00

  • Mitotic catastrophe and endomitosis in tumour cells: an evolutionary key to a molecular solution.

    abstract::Following genotoxic insult, p53 mutated tumour cells undergo mitotic catastrophe. This is characterised by a switch from mitosis to the endocycle. The essential difference between mitosis and the endocycle is that in the latter, DNA synthesis is uncoupled from cell division, which leads to the formation of endopolyplo...

    journal_title:Cell biology international

    pub_type: 杂志文章,评审

    doi:10.1016/j.cellbi.2005.10.005

    authors: Erenpreisa J,Kalejs M,Cragg MS

    更新日期:2005-12-01 00:00:00

  • Triptolide improves spinal cord injury by promoting autophagy and inhibiting apoptosis.

    abstract::We investigated the effect of triptolide (TP) on spinal cord injury (SCI), and its underlying mechanism. Following the establishment of the SCI model using YFP H-line transgenic mice, TP was intraperitoneally injected at a dose of 0.2 mg/kg once daily for 7 days. Behavioral tests, Nissl staining, and hematoxylin-eosin...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1002/cbin.11273

    authors: Zhu N,Ruan J,Yang X,Huang Y,Jiang Y,Wang Y,Cai D,Geng Y,Fang M

    更新日期:2020-03-01 00:00:00

  • Expression of glutamyl aminopeptidase by osteogenic induction in rat bone marrow stromal cells.

    abstract::Glutamyl aminopeptidase (GluAP, EC 3.4.11.7, ENPEP) is a 130-kDa homodimeric zinc metallopeptidase which specifically cleaves the N-terminal glutamate or aspartate residue of peptidic substrates such as cholecystokinin-8 or angiotensin (Ang) II, in vitro. We used a DNA microarray hybridization (Genechip Rat Expression...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1016/j.cellbi.2008.02.006

    authors: Wu Y,Xiao J,Wu L,Tian W,Liu L

    更新日期:2008-07-01 00:00:00

  • Trolox-induced cardiac differentiation is mediated by the inhibition of Wnt/β-catenin signaling in human embryonic stem cells.

    abstract::Cardiac differentiation of human pluripotent stem cells may be induced under chemically defined conditions, wherein the regulation of Wnt/β-catenin pathway is often desirable. Here, we examined the effect of trolox, a vitamin E analog, on the cardiac differentiation of human embryonic stem cells (hESCs). 6-Hydroxy-2,5...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1002/cbin.11200

    authors: Choe MS,Yeo HC,Bae CM,Han HJ,Baek KM,Kim JS,Lim KS,Shin IS,Chang W,Yun SP,Lee HJ,Lee MY

    更新日期:2019-07-10 00:00:00

  • The perilipin-2 (adipophilin) coat of cytosolic lipid droplets is regulated by an Arf1-dependent mechanism in HC11 mouse mammary epithelial cells.

    abstract::The cytosolic lipid droplets (cLDs) store excess intracellular lipids, and perilipin-2 is believed to protect cLDs from degradation. Here, we investigated the role of the small G-protein Arf1 and the proteasome in the fates of perilipin-2 and cLDs. In oleate-loaded cells, upon brefeldin A (BFA) treatment, perilipin-2 ...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1002/cbin.10547

    authors: Pauloin A,Adenot P,Hue-Beauvais C,Chanat E

    更新日期:2016-02-01 00:00:00

  • Differentiation of embryonic stem cells towards pancreatic progenitor cells and their transplantation into streptozotocin-induced diabetic mice.

    abstract::Type I diabetes is characterized by the deficiency of endocrine beta cells in the pancreatic islets of Langerhans and transplantation of islet cells can be an effective therapeutic approach. Embryonic stem cells can be differentiated into any cell type, and therefore represent an unlimited source of islet cells for th...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1016/j.cellbi.2007.12.017

    authors: Chen C,Zhang Y,Sheng X,Huang C,Zang YQ

    更新日期:2008-04-01 00:00:00

  • Cytostatic effect of inostamycin, an inhibitor of cytidine 5'-diphosphate 1,2-diacyl-sn-glycerol (CDP-DG): inositol transferase, on oral squamous cell carcinoma cell lines.

    abstract::Inostamycin, which was recently isolated from Streptomyces sp. MH816-AF15 as an inhibitor of cytidine 5'-diphosphate 1,2-diacyl-sn-glycerol (CDP-DG): inositol transferase, caused a G1-phase accumulation in the cell cycle of small cell lung carcinomas. To investigate whether the cytostatic effect of inostamycin is rest...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1006/cbir.2000.0706

    authors: Baba Y,Tsukuda M,Mochimatsu I,Furukawa S,Kagata H,Nagashima Y,Koshika S,Imoto M,Kato Y

    更新日期:2001-01-01 00:00:00