δ-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.

Abstract:

:δ-Catenin and β-catenin belong to different subfamilies of armadillo proteins but share some common binding partners, such as E-cadherin. This is the first study that demonstrated a novel common binding partner for δ-catenin and β-catenin, lymphoid enhancer factor-1 (LEF-1). We found that the N-terminus of δ-catenin (amino acids 85-325) bound to the middle region of LEF-1 unlike β-catenin. Overexpressed δ-catenin entered the nucleus and inhibited LEF-1-mediated transcriptional activity in Bosc23 and DLD-1 cell lines. The current study provided novel insights that will provide a better understanding of the effects of δ-catenin on Wnt/LEF-1-mediated transcriptional activity.

journal_name

Cell Biol Int

authors

He Y,Ki H,Kim H,Kim K

doi

10.1002/cbin.10465

subject

Has Abstract

pub_date

2015-08-01 00:00:00

pages

954-61

issue

8

eissn

1065-6995

issn

1095-8355

journal_volume

39

pub_type

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