Abstract:
:δ-Catenin and β-catenin belong to different subfamilies of armadillo proteins but share some common binding partners, such as E-cadherin. This is the first study that demonstrated a novel common binding partner for δ-catenin and β-catenin, lymphoid enhancer factor-1 (LEF-1). We found that the N-terminus of δ-catenin (amino acids 85-325) bound to the middle region of LEF-1 unlike β-catenin. Overexpressed δ-catenin entered the nucleus and inhibited LEF-1-mediated transcriptional activity in Bosc23 and DLD-1 cell lines. The current study provided novel insights that will provide a better understanding of the effects of δ-catenin on Wnt/LEF-1-mediated transcriptional activity.
journal_name
Cell Biol Intjournal_title
Cell biology internationalauthors
He Y,Ki H,Kim H,Kim Kdoi
10.1002/cbin.10465subject
Has Abstractpub_date
2015-08-01 00:00:00pages
954-61issue
8eissn
1065-6995issn
1095-8355journal_volume
39pub_type
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