解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::α-Pharmacological conotoxins are among the most selective ligands of nicotinic acetylcholine receptors with typical cysteine frameworks. They are characterized by the intercysteine loop and classified into various subfamilies, such as α3/5 and α4/7 conotoxins. A novel α-conotoxin, Pu14a (DCPPHPVPGMHKCVCLKTC), with a d...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-011-1093-x
更新日期:2012-07-01 00:00:00
abstract::The dipeptide carnosine is found in high concentrations in human skeletal muscle and shows large inter-individual differences. Sex and age are determining factors, however, systematic studies investigating the sex effects on muscle carnosine content throughout the human lifespan are lacking. Despite the large inter-in...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-011-1197-3
更新日期:2012-07-01 00:00:00
abstract::The streptococcal enzyme that catalyzes the last step in proline biosynthesis was heterologously expressed and the recombinant protein was purified to electrophoretic homogeneity and characterized thoroughly. As for δ1-pyrroline-5-carboxylate reductases from other sources, it was able to use either NADH or NADPH as th...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-011-1077-x
更新日期:2012-07-01 00:00:00
abstract::Oral β-alanine (βA) doses larger than 800 mg commonly result in unpleasant sensory symptoms (paresthesia). However, the association of form (pure vs. slow-release) with side-effects has not been fully described. The aim of this single-blinded, randomized three-arm clinical trial was to compare plasma kinetics and symp...
journal_title:Amino acids
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00726-011-1169-7
更新日期:2012-07-01 00:00:00
abstract::Molecular imaging of human epidermal growth factor receptor type 2 (HER2) expression has drawn significant attention because of the unique role of the HER2 gene in diagnosis, therapy and prognosis of human breast cancer. In our previous research, a novel cyclic 2-helix small protein, MUT-DS, was discovered as an anti-...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-011-1096-7
更新日期:2012-07-01 00:00:00
abstract::Carnosine is present in high concentrations in skeletal muscle where it contributes to acid buffering and functions also as a natural protector against oxidative and carbonyl stress. Animal studies have shown an anti-diabetic effect of carnosine supplementation. High carnosinase activity, the carnosine degrading enzym...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-011-1165-y
更新日期:2012-07-01 00:00:00
abstract::Skin collagen metabolism abnormalities induced by ultraviolet (UV) radiation are the major causes of skin photoaging. It has been shown that the one-time exposure of UV irradiation decreases procollagen mRNA expression in dermis and that chronic UV irradiation decreases collagen amounts and induces wrinkle formation. ...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-011-1059-z
更新日期:2012-06-01 00:00:00
abstract::The tailor made amino acid β-N-methyl-amino-L-alanine (BMAA) is a neurotoxin produced by cyanobacteria. It has been associated with certain forms of progressive neurodegenerative disease, including sporadic Amyotrophic Lateral Sclerosis and Alzheimer's disease. Some different reports of BMAA in cyanobacterial blooms f...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-011-1057-1
更新日期:2012-06-01 00:00:00
abstract::The specific function of putative cut2 protein (or CFP25), encoded by the Rv2301 gene from Mycobacterium tuberculosis H37Rv, has not been identified yet. The aim of this study was to assess some of CFP25 characteristics and its possible biological role in Mycobacterium tuberculosis H37Rv invasion process to target cel...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-011-0938-7
更新日期:2012-06-01 00:00:00
abstract::The cyclization of N-Boc-α-alkylserines to corresponding β-lactones under Mitsunobu reaction conditions and the ring opening with heterocyclic amines (pyrrolidine, piperidine, morpholine and thiomorpholine) produced N-Boc-α-alkyl-β-(sec-amino)alanines. The removal of the Boc group gives di-hydrochlorides of non-protei...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-011-1055-3
更新日期:2012-06-01 00:00:00
abstract::Placental vascular formation and blood flow are crucial for fetal survival, growth and development, and arginine regulates vascular development and function. This study determined the effects of dietary arginine or N-carbamylglutamate (NCG) supplementation during late gestation of sows on the microRNAs, vascular endot...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-011-0948-5
更新日期:2012-06-01 00:00:00
abstract::The TES ether of the C6-hydroxy derivative of naturally occurring epi-jasmonic acid (epi-JA) was designed as epimerization-free equivalent of epi-JA. The TES ether was synthesized from (1R,4S)-4-hydroxycyclopent-2-enyl acetate in 13 steps. The acid part of the ether was activated with ClCO2Bui and subjected to condens...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-011-0925-z
更新日期:2012-05-01 00:00:00
abstract::Among many actions assigned to taurine (Tau), the most abundant amino acid in numerous mammalian tissues, it prevents high-fat diet-induced obesity with increasing resting energy expenditure. To sustain this Tau action, the goal of the present study was to explore the acute effects of Tau on baseline and on adrenaline...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-011-0919-x
更新日期:2012-05-01 00:00:00
abstract::We have developed the first operationally simple and environmentally benign protocol for the aqueous asymmetric Michael addition reaction of chiral nickel(II) glycinate with nitroalkenes. The reactions proceeded smoothly in the presence of TBAB (tetrabutyl ammonium bromide) in neat water at room temperature and provid...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-011-0870-x
更新日期:2012-05-01 00:00:00
abstract::This investigation sought to examine the contributions of exercise and nutrient replenishment on in vivo regulation of the insulin-like growth factor-I (IGF-I) axis components. Eight college-aged males completed three high-intensity interval training (HIIT) protocols followed by three post-exercise nutritional protoco...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-011-0837-y
更新日期:2012-04-01 00:00:00
abstract::The kidney plays a key role in arginine metabolism. Arginine production is controlled by argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL) which metabolize citrulline and aspartate to arginine and fumarate whereas arginine consumption is dependent on arginine:glycine amidinotransferase (GAT), which ...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-011-0897-z
更新日期:2012-04-01 00:00:00
abstract::Vascular smooth muscle cells (SMC) are able to proliferate when cultured on plates, but become differentiated when maintained in three-dimensional type I collagen matrices (honeycombs). SMC grown in honeycombs contained a low level of polyamines due to the presence of antizyme 1 (AZ1), a negative regulator of ornithin...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-011-1034-8
更新日期:2012-02-01 00:00:00
abstract::eIF5A is highly conserved from archaea to mammals, essential for cell viability and the only protein known to contain the essential amino acid residue hypusine, generated by a unique posttranslational modification. eIF5A was originally identified as a translation initiation factor due to its ability to stimulate the f...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-011-0985-0
更新日期:2012-02-01 00:00:00
abstract::Spermine oxidase (SMO) was discovered much more recently than other enzymes involved in polyamine metabolism; this review summarizes 10 years of researches on this enzyme. Spermine oxidase (SMO) is a FAD-dependent enzyme that specifically oxidizes spermine (Spm) and plays a dominant role in the highly regulated mammal...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-011-1014-z
更新日期:2012-02-01 00:00:00
abstract::BE-3-3-3-3 (1,15-(ethylamino)4,8,12-triazapentadecane) is a bis(ethyl)polyamine analogue under investigation as a therapeutic agent for breast cancer. Since estradiol (E(2)) is a critical regulatory molecule in the growth of breast cancer, we examined the effect of BE-3-3-3-3 on estrogen receptor α (ERα) positive MCF-...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-011-1005-0
更新日期:2012-02-01 00:00:00
abstract::Epithelial-to-mesenchymal transition and mesenchymal-to-epithelial transition are biologic processes responsible for conversion of epithelial cells into a mesenchymal phenotype or viceversa, respectively. They occur during embryo- and foetal-development and, in adult organisms, are involved in wound healing, in the ge...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-011-0995-y
更新日期:2012-02-01 00:00:00
abstract::Ornithine decarboxylase antizyme 1 (AZ1) is a major regulatory protein responsible for the regulation and degradation of ornithine decarboxylase (ODC). To better understand the role of AZ1 in polyamine metabolism and in modulating the response to anticancer polyamine analogues, a small interfering RNA strategy was use...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-011-1030-z
更新日期:2012-02-01 00:00:00
abstract::Transglutaminases (TGs) are a large family of related and ubiquitous enzymes that catalyze the cross-linking of a glutaminyl residue of a protein/peptide substrate to a lysyl residue of a protein/peptide co-substrate. Considerable and intense progress has been made in the understanding of the chemistry, molecular biol...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-011-1011-2
更新日期:2012-02-01 00:00:00
abstract::Glutamate is stored in synaptic vesicles in presynaptic neurons. It is released into the synaptic cleft to provide signalling to postsynaptic neurons. Normally, the astroglial glutamate transporters GLT-1 and GLAST take up glutamate to mediate a high signal-to-noise ratio in the synaptic signalling, and also to preven...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-011-0865-7
更新日期:2012-01-01 00:00:00
abstract::D: -Amino acid oxidase (DAAO) in mammal kidney regulates the renal reactive oxygen species (ROS) levels directly and plays a leading role in the development of ROS-mediated renal pathologic damages based on its crucial role in the oxidative deamination of D: -amino acids and the consequent generation of H(2)O(2). Quan...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0811-0
更新日期:2012-01-01 00:00:00
abstract::In previous studies we characterized arginine transporter genes from Trypanosoma cruzi and Leishmania donovani, the etiological agents of chagas disease and kala azar, respectively, both fatal diseases in humans. Unlike arginine transporters in higher eukaryotes that transport also lysine, these parasite transporters ...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0812-z
更新日期:2012-01-01 00:00:00
abstract::The glutamate/cystine antiporter system x(c)(-) transports cystine into cells in exchange for glutamate at a ratio of 1:1. It is composed of a specific light chain, xCT, and a heavy chain, 4F2, linked by a disulfide bridge. Intracellularly, cystine is reduced into cysteine, the rate-limiting precursor of glutathione (...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-011-0862-x
更新日期:2012-01-01 00:00:00
abstract::Early evaluation of cancer response to a therapeutic regimen can help increase the effectiveness of treatment schemes and, by enabling early termination of ineffective treatments, minimize toxicity, and reduce expenses. Biomarkers that provide early indication of tumor therapy response are urgently needed. Solid tumor...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0548-9
更新日期:2011-11-01 00:00:00
abstract::Non-invasive detection of prostate cancer or metastases still remains a challenge in the field of molecular imaging. In our recent work of screening arginine- or lysine-rich peptides for intracellular delivery of a therapeutic agent into prostate cancer cells, an arginine-rich cell permeable peptide (NH(2)GR(11)) was ...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0515-5
更新日期:2011-11-01 00:00:00
abstract::Lung cancer is still difficult to treat by current chemotherapeutic procedures. We recently found that MVL, an anti-HIV lectin from blue-green algae Microcystis viridis, also has antitumor activity. The objective of this study was to investigate apoptosis-inducing activity of recombinant MVL (R-MVL) and proteomic chan...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0791-0
更新日期:2011-10-01 00:00:00
abstract::In this work, we describe the asymmetric synthesis of a series of fluorinated and non-fluorinated quaternary α-amino acid derivatives. This methodology involves the diastereoselective addition of chiral 2-p-tolylsulfinyl benzylcarbanions to either imines containing a 2-furyl moiety or trifluoromethyl α-imino esters. S...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-011-0881-7
更新日期:2011-08-01 00:00:00
abstract::Interplay between proteins, nucleic acids, carbohydrates and/or lipids is involved in almost every process in life on earth. As a consequence, a wide range of diseases results from abnormal interactions of such biomolecules. The main motivation of foldamer science is the development of scaffolds that are capable of ad...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-011-0894-2
更新日期:2011-08-01 00:00:00
abstract::The synthesis of enantiomerically pure 2-aminocyclobutanecarboxylic acids has been refined to improve both the efficiency and the simplicity. These improvements provide a shorter and easier access to the racemic cis-cyclobutane β-amino acid core. Derivatization of this material with a chiral non-racemic oxazolidin-2-o...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-011-0918-y
更新日期:2011-08-01 00:00:00
abstract::Regulated proteolysis plays important roles in cell biology and pathological conditions. A crosstalk exists between apoptosis and the ubiquitin-proteasome system, two pathways responsible for regulated proteolysis executed by different proteases. To investigate whether the apoptotic process also affects the 20S protea...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0575-6
更新日期:2011-07-01 00:00:00
abstract::In living cells, the N-terminal tails of core histones, the proteinaceous component of nucleosomes, are subjected to a range of covalent post-translational modifications (PTMs), which have specific roles in modulating chromatin structure and function. A growing body of evidence suggests that deregulation of histone mo...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0668-2
更新日期:2011-07-01 00:00:00
abstract::Arginine adenosine-5'-diphosphoribosylation (ADP-ribosylation) is an enzyme-catalyzed, potentially reversible posttranslational modification, in which the ADP-ribose moiety is transferred from NAD(+) to the guanidino moiety of arginine. At 540 Da, ADP-ribose has the size of approximately five amino acid residues. In c...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-010-0676-2
更新日期:2011-07-01 00:00:00
abstract::D-Aspartate (D-Asp) is an endogenous substance in mammals. Degradation of D-Asp is carried out only by D-aspartate oxidase (DDO). We measured DDO activity in porcine tissues, and produced an anti-porcine DDO antibody to examine the cellular localization of DDO. All the tissues examined showed DDO activities, whereas t...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0785-y
更新日期:2011-07-01 00:00:00
abstract::Vigabatrin is a GABA derivative (gamma-vinyl GABA) which inhibits irreversibly the enzyme activity of GABA transaminase and thus increased indirectly brain GABA concentrations. We have used body temperature assay to examine the effects of Vigabatrin on thermoregulation in intact rats. In order to understand the mechan...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0754-5
更新日期:2011-05-01 00:00:00
abstract::The supplementation of creatine has shown a marked neuroprotective effect in mouse models of neurodegenerative diseases (Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis). This has been assigned to the known bioenergetic, anti-apoptotic, anti-excitotoxic and anti-oxidant properties of creatine....
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-011-0850-1
更新日期:2011-05-01 00:00:00
abstract::The aim of this study was to determine the contribution of dietary amino acids (AA) to energy metabolism under high protein (HP) diets, using a double tracer method to follow simultaneously the metabolic fate of α-amino groups and carbon skeletons. Sixty-seven male Wistar rats were fed a normal (NP) or HP diet for 14 ...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0756-3
更新日期:2011-05-01 00:00:00