解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The effects of the addition of short-term lithium to long-term administration of antidepressants (clomipramine or citalopram) on the levels of 5-HT and 5-HIAA and serotonergic receptors were studied in the rat cortex. The addition of short-term Li to long-term antidepressant treatment potentiated an increase in 5-HIAA...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119243
更新日期:1996-01-01 00:00:00
abstract::We examined the chronic effects of desipramine and mianserin on increases of intracellular Ca2+ concentration ([Ca2+]i) induced by noradrenaline (NA), acetylcholine (ACh), or high K+ in cultured neurons of rat frontal cortex, using fluoromicroscopic analysis with Ca(2+)-sensitive dye fura-2. NA- and ACh-induced [Ca2+]...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119251
更新日期:1996-01-01 00:00:00
abstract::Behavioral abnormalities, jumping reaction, increase in spontaneous activity abnormal violence, and lethargy were observed in long-term ultraviolet A (UVA)-irradiated hairy male Crj:CD-1 mice. The learning ability of 6- and 12-months UVA-irradiated mice was significantly reduced compared to un-irradiated age-matched m...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119274
更新日期:1996-01-01 00:00:00
abstract::The early research on an animal (cat) model and biological marker (visual evoked potential augmenting and reducing) of sensation seeking behavior is briefly described. Recent findings with selectively bred lines of rats show that (1) the relationship between sensation seeking behavior and augmenting vs. reducing is al...
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000119304
更新日期:1996-01-01 00:00:00
abstract::Schizophrenia is a heterogeneous and multidimensional disorder. The different syndromes or dimensions of this disorder represent distinct pathophysiological processes. Evidence is growing that each of the composite syndromes or dimensions of this disorder is associated with specific validators. This article reviewed n...
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000119310
更新日期:1996-01-01 00:00:00
abstract::Symptoms of anxiety suggest autonomic dysfunction and most of the psychotropic agents used to treat anxiety and affective disorders have strong autonomic effects. This article describes the utility and importance of analysis of heart rate and blood pressure time series to study cardiac autonomic function in psychiatri...
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000119234
更新日期:1995-01-01 00:00:00
abstract::Past epidemiological and clinical research has identified depression as the most common psychiatric disorder associated with headache. The present study carried out in a neurology headache clinic showed that the major associations were with current anxiety disorders, especially panic and related conditions. These find...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119182
更新日期:1995-01-01 00:00:00
abstract::In contrast to the single-channel dimensional complexity, the global dimensional complexity is calculated from a multichannel EEG. The intention with the method is to measure the spatial distribution of information processing in the brain. The method seems to be of interest in psychopharmacological research, but the i...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119171
更新日期:1995-01-01 00:00:00
abstract::Carnitine is essential for mitochondrial energy production. Disturbance in mitochondrial function may contribute to or cause the fatigue seen in chronic fatigue syndrome (CFS) patients. One previous investigation has reported decreased acylcarnitine levels in 38 CFS patients. We investigated 35 CFS patients (27 female...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119226
更新日期:1995-01-01 00:00:00
abstract::Twenty-two female patients with anorexia nervosa, restricted type, 14-35 years old, were treated with a 4-month course of combined cognitive-behavioral therapy, nutritional counselling and antidepressant drugs (nortriptyline for 7, fluoxetine for 15). Patients were monitored for body mass index (BMI), for eating disor...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000119213
更新日期:1995-01-01 00:00:00
abstract::We agree with the conclusions of a recent article in this journal [James, Neuropsychobiology 1994;30:124-125] that studies on the psychoactive effects of caffeine need to take into account the possibility that the results obtained might represent merely the reversal of deleterious effects of caffeine deprivation rathe...
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000119192
更新日期:1995-01-01 00:00:00
abstract::There is evidence that serotonin and norepinephrine are in some way involved in the pathophysiology of anxiety disorders. Urinary levels of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) and the norepinephrine metabolite vanillylmandelic acid (VMA) were measured in 46 patients with generalized anxiety di...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119165
更新日期:1995-01-01 00:00:00
abstract::Recent findings indicate that the memory-impairing effects of benzodiazepines may preferentially involve the basolateral nucleus of the amygdala. To test this hypothesis we examined the effects on pretrial injection of diazepam into the central as compared to the lateral/basolateral amygdaloid nuclei on memory for a c...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119209
更新日期:1995-01-01 00:00:00
abstract::The relation between EEG spectral power and alterations of the visual evoked potential (VEP) during different behavioral states and after intraperitoneal application of neuroactive drugs have been investigated in Long-Evans rats. FFT power and field potential maps were made in five behavioral states of the unrestraine...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119178
更新日期:1995-01-01 00:00:00
abstract::During interictal periods in 9 patients with partial epilepsy we examined whether there were correlations between the relative power of background EEG (power spectral analysis) and the absolute values of regional cerebral blood flow (rCBF) measured by 99mTc hexamethylpropylene amine oxime (HMPAO) SPECT in each cerebra...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119135
更新日期:1994-01-01 00:00:00
abstract::Urinary 3-methoxy-4-hydroxyphenylglycol (MHPG) levels in 53 depressed women were compared to current suicidal thoughts or activity. Comparisons were also made between MHPG and past suicide attempts, number of past attempts, and seriousness of the worst attempt. There was a weak trend for current but not past suicidali...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119072
更新日期:1994-01-01 00:00:00
abstract::The possible involvement of anxiety and learning/memory processes in escape-directed (struggling) behavior in a two-trial swimming test was investigated in mice, as well as the differential effects that low doses of flumazenil (a benzodiazepine receptor antagonist) could display depending on the animals' anxiety level...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119058
更新日期:1994-01-01 00:00:00
abstract::Quantitative pharmaco-EEG has become a useful technique for determining pharmacodynamic parameters after CNS-active drug administration. Nevertheless, one of the most important problems faced by practitioners of pharmaco-EEG is the difficulty in evaluating drug-specific effects. In this article, a methodology for comp...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119068
更新日期:1994-01-01 00:00:00
abstract::Little is known about the effects of cocaine on cognitive tasks. Event-related potentials (ERP) were recorded in 7 cocaine abusers during the performance of the auditory oddball task before and after the intravenous injections of saline and cocaine (60-80 mg). The P3B and slow wave components of the ERP were significa...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000119148
更新日期:1994-01-01 00:00:00
abstract::Cardiovascular measurements were used as indicators of autonomic arousal during an orthostatic challenge test without medication and after a test dose of 150 mg perazine in 20 acute schizophrenic patients. Unmedicated schizophrenics showed elevated heart rates and elevated systolic and diastolic blood pressure in comp...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000119144
更新日期:1994-01-01 00:00:00
abstract::Besides their regulation of the pituitary-adrenal and pituitary-thyroidal axis, respectively, the neurohormones CRH and TRH act within the central nervous system to evoke and modulate a number of behavioral and physiological processes. In particular, an increase in the sympathetic nervous system and respiratory activi...
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000119000
更新日期:1993-01-01 00:00:00
abstract::In humans and several other mammals, a quantitative EEG analysis has been used to study the regulation of sleep-wake behavior. In all mammalian species studied, cortical EEG recorded during non-REM sleep (NREMS) is characterized by the occurrence of spindles and high voltage, slow waves (0.5-4.0 Hz). Furthermore, slow...
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000119017
更新日期:1993-01-01 00:00:00
abstract::The search for specific predepressive personality factors has a long tradition in psychiatry. Studies in which assessments were made prospectively, before the onset of a first-ever episode of the illness, are, however, rare. In the present report from the Lundby Study we have investigated premorbid, mainly personality...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118956
更新日期:1993-01-01 00:00:00
abstract::The responses of cortisol to acute administration of saline and of clonidine (2.5 micrograms/kg B.W.) were examined in 10 children and adolescents with major depressive disorder and in 10 age- and sex-matched controls. Clonidine administration did not inhibit cortisol secretion in controls or in patients, contrary to ...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000119022
更新日期:1993-01-01 00:00:00
abstract::Evidence from preclinical studies, preliminary clinical reports, pharmacologic challenge studies and a small number of controlled trials suggests that several antiepileptic agents--valproate, carbamazepine, and clonazepam--may have therapeutic effects in the treatment of patients with panic disorder. We review the the...
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000118971
更新日期:1993-01-01 00:00:00
abstract::Quantitative assessment of regional cerebral blood flow (rCBF) was performed in a 22-year-old man with intractable temporal lobe epilepsy on long-term high-dose phenytoin (PHT) therapy, using single photon emission computed tomography (SPECT) with N-isopropyl-(iodine-123)-p-iodoamphetamine. In all the SPECT scans repe...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118982
更新日期:1993-01-01 00:00:00
abstract::Performance on temporal discrimination of time intervals in the range of milliseconds is interpreted by the assumption of an internal clock; the higher the clock rate the better the temporal resolution of the internal clock will be, which is equivalent to more accuracy in timing of brief intervals. Although there is s...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000118899
更新日期:1992-01-01 00:00:00
abstract::This report presents the results of a retrospective analysis of pooled efficacy data from eight studies in which buspirone was compared to placebo in 520 patients with generalized anxiety disorder (GAD). In addition to evaluating overall efficacy in the composite patient data base, four criteria were used to identify ...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,meta分析,随机对照试验
doi:10.1159/000118837
更新日期:1992-01-01 00:00:00
abstract::In 63 depressed patients, the associations between severity of depression, psychomotor retardation, assessed by the Bech-Rafaelsen Melancholia Scale, and EEG spectral analysis were examined. Slow EEG activity (theta 2/alpha 1 bands) was positively and fast activity (alpha 3/beta bands) negatively correlated with the o...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118804
更新日期:1992-01-01 00:00:00
abstract::No consensus has been obtained about blood electrolyte status, especially about magnesium, in affective disorders. This is mainly due to the lack of information about the distribution of the patients in clinical subgroups, sex, type of treatment and about the severity of their illnesses. Most of these studies concerne...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118914
更新日期:1992-01-01 00:00:00
abstract::Gamma-aminobutyric acid-B (GABAB) binding sites labelled with [3H]GABA were determined in postmortem frontal cortex samples of 20 control subjects and 16 suicides. The suicide group was further subdivided according to the method of suicide and the existence of depressive symptoms prior to death. No significant differe...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118893
更新日期:1992-01-01 00:00:00
abstract::Plasma noradrenaline (NA), adrenaline (Ad), dopamine (DA), platelet serotonin (p5HT), free serotonin (f5HT), glucose, heart rate (HR) and blood pressure (BP) were measured before and after an oral load of glucose (OGTT) in 100 normal humans. One sham-feeding test was performed in every subject 2-3 weeks before OGTT. A...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118889
更新日期:1992-01-01 00:00:00
abstract::To clarify the role of the serotonergic system in limbic and thalamic epileptic activity, we examined the effects of 5-hydroxytryptophan (5-HTP, 20 and 40 mg/kg) on fully kindled seizures from the hippocampus and lateral geniculate nucleus. The intraperitoneal administration of 20 mg/kg 5-HTP exerted no anticonvulsant...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118813
更新日期:1992-01-01 00:00:00
abstract::1,927 outpatients were included by 392 general practitioners in an open study in order to evaluate the safety of tianeptine in the ambulatory treatment of depression. The results of 1,858 depressed patients without melancholia and psychotic features, fulfilling DSM III criteria of Major Depressive Episode or Dysthymic...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118824
更新日期:1992-01-01 00:00:00
abstract::Clinical observations have suggested that lithium may exert adverse effects on memory. The difficulty in achieving empirical consensus regarding this issue has reflected several methodological problems: diversity of research designs, heterogeneous samples, lack of control groups and the possible confounding of memory ...
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000118904
更新日期:1992-01-01 00:00:00
abstract::Twelve healthy male volunteers received pyritinol 600 or 1,200 mg or placebo for 3 days according to a randomised, double-blind crossover design. On the 1st and 3rd days of each of the three treatment periods subjects completed a battery of psychological tests including Critical Flicker Fusion (CFFT), Choice Reaction ...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000119478
更新日期:1990-01-01 00:00:00
abstract::Fifteen general practitioners treated 21 newly diagnosed insomniac patients with benzodiazepines. In 15 cases, a short-acting benzodiazepine was prescribed without regard to the type, severity, duration and probable cause of insomnia. Sleep-wake ambulatory recordings were made at the respective homes of the patients b...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119461
更新日期:1990-01-01 00:00:00
abstract::We have previously shown that the tilt aftereffect (TAE) appears to respond to changes in central dopaminergic function. In this study, the TAE was investigated during the preovulatory and the premenstrual phases of the menstrual cycle. Results in the preovulatory phase mimicked those previously found associated with ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119484
更新日期:1990-01-01 00:00:00
abstract::Supine and standing heart rate (HR) and blood pressure measures were compared among 19 nonsmoking normal controls, 29 smoking patients and 36 nonsmoking patients with panic disorder. The smoking patients had a significantly higher supine HR, standing diastolic blood pressure, standing mean blood pressure and supine an...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119440
更新日期:1990-01-01 00:00:00
abstract::Single, 50- and 100-mg oral doses of phenobarbital and a matching placebo were administered double-blind to 8 young, healthy male subjects. Multilead electroencephalographic (EEG) samples were recorded prior to, and at regular intervals within the 2 h following administration. The EEG signal was processed by power spe...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000119453
更新日期:1990-01-01 00:00:00