Serotonergic inhibition of limbic and thalamic seizures in cats.

Abstract:

:To clarify the role of the serotonergic system in limbic and thalamic epileptic activity, we examined the effects of 5-hydroxytryptophan (5-HTP, 20 and 40 mg/kg) on fully kindled seizures from the hippocampus and lateral geniculate nucleus. The intraperitoneal administration of 20 mg/kg 5-HTP exerted no anticonvulsant effect on hippocampal kindled seizures, and a higher dose (40 mg/kg) produced a significant reduction in the behavioral seizure stage. 5-HTP at 20 mg/kg displayed no suppressive effect on lateral geniculate seizures, and 5-HTP at 40 mg/kg significantly reduced both the seizure stage and afterdischarge duration. Our data suggest that serotonergic mechanisms play an inhibitory role in seizures kindled from these brain regions.

journal_name

Neuropsychobiology

journal_title

Neuropsychobiology

authors

Wada Y,Hasegawa H,Nakamura M,Yamaguchi N

doi

10.1159/000118813

keywords:

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

87-90

issue

2

eissn

0302-282X

issn

1423-0224

pii

118813

journal_volume

25

pub_type

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