Abstract:
:The responses of cortisol to acute administration of saline and of clonidine (2.5 micrograms/kg B.W.) were examined in 10 children and adolescents with major depressive disorder and in 10 age- and sex-matched controls. Clonidine administration did not inhibit cortisol secretion in controls or in patients, contrary to what has been observed in depressed adults. In controls, but not in patients, clonidine administration induced a transitory increase of the steroid.
journal_name
Neuropsychobiologyjournal_title
Neuropsychobiologyauthors
Brambilla F,Guareschi-Cazzullo A,Musetti C,Nobile P,Tacchini Cdoi
10.1159/000119022subject
Has Abstractpub_date
1993-01-01 00:00:00pages
187-91issue
4eissn
0302-282Xissn
1423-0224pii
119022journal_volume
28pub_type
临床试验,杂志文章abstract::Failure to gain weight during withdrawal from chronic regimens of dependence-producing drugs is observed in laboratory rats. Withdrawal from the benzodiazepine anxiolytic agent diazepam, whether induced by cessation of treatment or precipitated by administration of the specific benzodiazepine antagonist Ro-15,1788, is...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118291
更新日期:1986-01-01 00:00:00
abstract::Human personality traits, which are substantially heritable, may be modulated by monoamine neurotransmitters. It has been demonstrated that the catechol-O-methyltransferase (COMT) Val158Met genetic polymorphism, a functional polymorphism that may affect monoamine metabolism, is possibly associated with specific person...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000079107
更新日期:2004-01-01 00:00:00
abstract::Diabetes mellitus can induce impairment in learning and memory. Cognitive and memory deficits are common in older adults and especially in those with diabetes. This is mainly because of hyperglycemia, oxidative stress, and vascular abnormalities. Coenzyme Q10 (CoQ10) can decrease oxidative stress, hyperglycemia, and i...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000495520
更新日期:2019-01-01 00:00:00
abstract::10 long-term schizophrenic patients with tardive dyskinesia were studied over 14 weeks and maintained on their usual neuroleptic medications while anticholinergic antiparkinson drugs were employed and then discontinued, and the cycle then repeated. Discontinuation of anticholinergic medications resulted in improvement...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117742
更新日期:1980-01-01 00:00:00
abstract:INTRODUCTION:Butyrate is a short-chain fatty acid metabolite produced by microbiota in the colon. With its antioxidant properties, butyrate has also been shown to alter the neurological functions in affective disorder models, suggesting it as a key mediator in gut-brain interactions. OBJECTIVE:Here, we evaluated the n...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000510886
更新日期:2020-10-19 00:00:00
abstract::Gamma oscillations (>30 Hz) in the brain are involved in attention, perception and memory. They are altered in various pathological states, as well as by neuropharmaceuticals, so that they are of interest in drug and clinical investigations. However, when the human electroencephalogram is recorded on the scalp, this n...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000382023
更新日期:2015-01-01 00:00:00
abstract::Plasma levels of free and conjugated 3,4-dihydroxyphenylethyleneglycol (DOPEG), the main deaminated metabolite of norepinephrine, were assayed in 48 depressed patients before initiating a treatment with either maprotiline, an inhibitor of norepinephrine reuptake, or indalpine, a specific inhibitor of serotonin reuptak...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118243
更新日期:1986-01-01 00:00:00
abstract::The purpose of this study was to investigate the relationship between postoperative confusion and the plasma norepinephrine (NE), adrenocorticotropin (ACTH) or cortisol response to surgery in schizophrenic patients. We studied 50 schizophrenic patients and 35 control patients who underwent orthopedic surgery and perio...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000063569
更新日期:2002-01-01 00:00:00
abstract::A common polymorphism in the alpha1-antichymotrypsin (ACT) gene is associated with Alzheimer's disease. ACT is also a trophic factor in the hippocampal neurons. In order to examine if the ACT gene plays a role in the pathogenesis of schizophrenic disorders, patients (n = 175) and control subjects (n = 114) were genoty...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000026600
更新日期:1999-01-01 00:00:00
abstract::The search for specific predepressive personality factors has a long tradition in psychiatry. Studies in which assessments were made prospectively, before the onset of a first-ever episode of the illness, are, however, rare. In the present report from the Lundby Study we have investigated premorbid, mainly personality...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118956
更新日期:1993-01-01 00:00:00
abstract::The effects of febarbamat and pipamperon on agitational and aggressive states of patients with diffuse psycho-organic syndrome were compared in a double-blind study on patients over 60 years of age requiring nursing care. Such disorders, particularly in the field of psychiatric gerontology, represent an increasing pro...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000118075
更新日期:1984-01-01 00:00:00
abstract::Using event-related potentials (ERPs), a reduction in the auditory N100, N200 and P300 amplitude has been found in schizophrenic patients and may represent some pathophysiological deficit. Therefore, we investigated whether the genetic variant of the serotonin-2A receptor is associated with ERP change after clozapine ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000054871
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Abnormalities in different parameters of the norepinephrine system have been widely described in major depression. The presence of alpha(2)-adrenoreceptors in blood platelets, similar to those in the brain, prompted us to evaluate them in depressed patients, as compared with healthy controls. METHODS:Fiftee...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000054930
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND/AIMS:Recent findings suggest an involvement of insulin-like growth factor-1 (IGF-1) in the pathogenesis of many psychiatric disorders; however, there is a lack of data regarding IGF-1 in patients with obsessive-compulsive disorder (OCD). The aims of the present study were (1) to analyze putative alterations ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000446918
更新日期:2016-01-01 00:00:00
abstract::Changes of field potentials electrically evoked from the mesencephalon were studied in two dopaminergic target areas. The modulation of the responses in prefrontal cortex and striatum induced by intravenous injection of various compounds influencing central dopaminergic transmission is followed. In general, drugs with...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118200
更新日期:1985-01-01 00:00:00
abstract::Dysfunctional mechanisms in the serotonergic system have been implicated in suicidal behavior among patients with schizophrenia. However, previous association analyses of major serotonin genes have provided inconsistent findings regarding their role in suicidal behavior. The goal of the current study was to identify s...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000441191
更新日期:2016-01-01 00:00:00
abstract::Male Wistar rats were able to drink water and different percentages of ethyl alcohol in a free-choice paradigm. Our results showed a clear-cut preference for 2 and 3% ethanol concentration. Addition of quinine in both drinking bottles increased preference for alcohol, while dilution of saccharin in both bottles totall...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118113
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:There is evidence that the nicotinic alpha7-acetylcholine receptor (alpha7-AChR) is involved in the pathophysiology of schizophrenia. Several neurotransmitter receptors, including alpha7-AChR, have been demonstrated on peripheral blood lymphocytes (PBL) and it has been suggested that these peripheral recepto...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000091725
更新日期:2006-01-01 00:00:00
abstract::Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in the degradation of dopamine, serotonin and norepinephrine and these neurotransmitters are hypothesized to be involved in the cognitive function of humans. This study of a cohort of 191 healthy young Chinese females attempts to utilize the intelligence qu...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000086609
更新日期:2005-01-01 00:00:00
abstract::Personality traits were assessed in a series of 148 patients classified according to Winokur into depression pure disease (DPD), depression spectrum disease (DSD) and sporadic depression (SD) with the addition of a fourth group: family history positive-others (FH + .O) comprised of patients with psychiatric disorders ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117945
更新日期:1983-01-01 00:00:00
abstract::7 women and 3 men with anorexia nervosa were tested with thyrotropin-releasing hormone (TRH) and luteinizing hormone-follicle stimulating hormone-releasing hormone (LH-RH) and the growth hormone (GH), prolactin (PRL), gonadotropin (FSH-LH) and thyrotropin (TSH) responsiveness of their anterior pituitaries (AP) to the ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117854
更新日期:1981-01-01 00:00:00
abstract::Platelet 5-HT and plasma cortisol concentrations were determined in 59 schizophrenic patients with different time course of illness before and after dexamethasone suppression test (DST). An abnormal DST (nonsuppression) was observed in 51% of patients. In these patients basal cortisol and platelet 5-HT concentrations ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000026493
更新日期:1998-01-01 00:00:00
abstract::The popular recreational drug, (+/-)3, 4-methylenedioxymethamphetamine (MDMA; 'Ecstasy') is a potent and selective brain serotonin (5-HT) neurotoxin in animals. MDMA-induced 5-HT neurotoxicity can be demonstrated using a variety of neurochemical, neuroanatomical and, more recently, functional measures of 5-HT neurons....
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000026664
更新日期:2000-01-01 00:00:00
abstract::Two independent samples of psychiatric outpatients (n = 52 and 60) with blood type A or O completed the Brief Symptom Inventory, an abbreviated version of the SCL-90. In both samples patients with blood type A scored significantly higher than those with type O on the 'Obsessive-Compulsive' and 'Psychoticism' factors. ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118295
更新日期:1986-01-01 00:00:00
abstract::Motor impairments of psychiatric patients can be assessed with digital recordings of handwriting tasks. The investigation of patients with bipolar affective disorders differentiates intraindividual changes related to the patient's fluctuating affective states. An unmedicated 67-year-old male with 48-hour bipolar ultra...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000054851
更新日期:2000-01-01 00:00:00
abstract::The possible involvement of anxiety and learning/memory processes in escape-directed (struggling) behavior in a two-trial swimming test was investigated in mice, as well as the differential effects that low doses of flumazenil (a benzodiazepine receptor antagonist) could display depending on the animals' anxiety level...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119058
更新日期:1994-01-01 00:00:00
abstract:INTRODUCTION:REM sleep behavior disorder (RBD) is considered a prodromal phase of α-synucleinopathy like Parkinson disease (PD). PD is characterized by a progressive decline of dopamine (DA) in the striatum. Here we report the surprising increase in DA transporter density over successive years in an RBD patient treated...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000488893
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Rasagiline and selegiline are classified as monoamine oxidase B (MAO-B) inhibitors. The present investigation deals with time-dependent electrical frequency changes (electropharmacograms) induced by these, as well as by aminoindan, the major metabolite of rasagiline. METHOD:Adult rats (day-night converted, ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000319947
更新日期:2010-01-01 00:00:00
abstract::An association between negative symptoms and frontal cortex abnormalities has been suggested in schizophrenic patients. We tested whether this association can be found when patients' task performance is good and while controlling for possible cortical atrophy. We investigated regional cerebral blood flow with the xeno...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119262
更新日期:1996-01-01 00:00:00
abstract::We present a randomized double-blind study on the efficacy of caroverine in the treatment of alcohol withdrawal symptoms. The group B Ca2+ channel blocking agent caroverine was tested against meprobamate in inpatient treatment of alcohol withdrawal. Patients of both groups were similar in age, weight, duration of drin...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000118340
更新日期:1987-01-01 00:00:00