Drug-induced field potential changes in dopaminergic target areas after electrical stimulation of the rat mesencephalon.

Abstract:

:Changes of field potentials electrically evoked from the mesencephalon were studied in two dopaminergic target areas. The modulation of the responses in prefrontal cortex and striatum induced by intravenous injection of various compounds influencing central dopaminergic transmission is followed. In general, drugs with a down-regulating effect on dopaminergic impulse activity produced a significant diminution of the response, whereas compounds enhancing dopaminergic impulse flow produced an increase of the signal amplitude. The results are discussed in terms of the usefulness of the evoked potential as a screening procedure for monitoring dopaminergic impulse flow during the evaluation of new drugs against schizophrenia.

journal_name

Neuropsychobiology

journal_title

Neuropsychobiology

authors

Dimpfel W

doi

10.1159/000118200

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

42-52

issue

1

eissn

0302-282X

issn

1423-0224

pii

118200

journal_volume

14

pub_type

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