Association analysis for serotonin transporter promoter polymorphism and auditory evoked potentials for major depression.

Abstract:

:The serotonergic system has been implicated in the production of the N1 and P2 components of auditory evoked potentials (AEPs). Moreover, studies have indicated the influence of heritability in the genesis of these AEP components. The serotonin transporter is the major site of serotonin reuptake into the presynaptic neuron, and it has been determined that variants in the serotonin transporter gene-linked polymorphic region (5-HTTLPR) may affect gene transcription activity. The present study tested the hypothesis that the 5-HTTLPR genetic polymorphism is associated with the N1 and P2 components of AEPs in a sample of 127 Chinese patients (mean age: 41.6 years; male/female ratio: 58/69) diagnosed with major depression. Analysis of the results revealed a significantly shorter P2 latency for patients bearing the s/s genotype in comparison with l allele carriers, especially for the female patients (p = 0.004). The 5-HTTLPR polymorphism accounted for 3.4% of the variance in P2 latency. Our findings suggest a relationship between the 5-HTTLPR polymorphism and AEP P2 latency, and further studies of other genetic polymorphisms in the serotonergic system may help to predict this latency.

journal_name

Neuropsychobiology

journal_title

Neuropsychobiology

authors

Chen TJ,Yu YW,Chen MC,Tsai SJ,Hong CJ

doi

10.1159/000065412

keywords:

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

57-60

issue

2

eissn

0302-282X

issn

1423-0224

pii

65412

journal_volume

46

pub_type

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