Long-term outcome after lithium augmentation in unipolar depression: focus on HPA system activity.

abstract：:Recent studies have suggested that synaptic abnormalities may be part of the pathophysiology of schizophrenia. SNAP-25 (synaptosomal-associated protein of 25 kD) is one of the synaptic proteins responsible for presynaptic neurotransmission, axonal elongation and synaptogenesis. Genetic variation in the 5'-upstream reg...

journal_title：Neuropsychobiology

authors： Tachikawa H,Harada S,Kawanishi Y,Okubo T,Suzuki T

更新日期：2001-01-01 00:00:00

abstract：:Behavioral abnormalities, jumping reaction, increase in spontaneous activity abnormal violence, and lethargy were observed in long-term ultraviolet A (UVA)-irradiated hairy male Crj:CD-1 mice. The learning ability of 6- and 12-months UVA-irradiated mice was significantly reduced compared to un-irradiated age-matched m...

journal_title：Neuropsychobiology

authors： Hiramoto K,Okada T,Ito M

更新日期：1996-01-01 00:00:00

abstract：:Acute quantitative electroencephalographic effects of cigarette smoking were examined in 15 smokers within a repeated-measures design which assessed changes in power-spectral estimates following acute pre-treatment with placebo, a dose (20 mg) of mecamylamine, a dose (0.6 mg) of scopolamine and a combined dose of meca...

journal_title：Neuropsychobiology

authors： Knott VJ,Harr A,Ilivitsky V,Mahoney C

更新日期：1998-01-01 00:00:00

abstract：:An association between negative symptoms and frontal cortex abnormalities has been suggested in schizophrenic patients. We tested whether this association can be found when patients' task performance is good and while controlling for possible cortical atrophy. We investigated regional cerebral blood flow with the xeno...

journal_title：Neuropsychobiology

authors： Zemishlany Z,Alexander GE,Prohovnik I,Goldman RG,Mukherjee S,Sackeim H

更新日期：1996-01-01 00:00:00

abstract：:The relation between fasting, a.m. plasma prolactin and plasma/homovanillic acid (HVA) was studied in 9 healthy males on one occasion and in 9 healthy females on two occasions (in the follicular and luteal phase of the menstrual cycle). There was a significant inverse correlation between plasma HVA and plasma prolacti...

journal_title：Neuropsychobiology

authors： Roy-Byrne PP,Rubinow DR,Linnoila M

更新日期：1986-01-01 00:00:00

abstract：:To clarify the circadian aspects of delayed sleep phase syndrome (DSPS) in 4 patients with DSPS, we recorded polysomnograms and rectal temperature before and after chronotherapy. The time interval (2.7 h) between sleep onset and rectal temperature minimum before chronotherapy was shorter than the time interval after c...

journal_title：Neuropsychobiology

authors： Ozaki N,Iwata T,Itoh A,Kogawa S,Ohta T,Okada T,Kasahara Y

更新日期：1988-01-01 00:00:00

abstract：:Eight healthy paid male volunteers (age: 21-28 years, mean: 24.5 +/- 1.7 years; weight 62-79 kg) were administered via intravenous infusion (3 min) acute 25-, 50-, and 75-mg doses of phosphatidylserine, or matching placebo in a latin-square design. Multichannel EEG recordings were performed in baseline conditions, dur...

journal_title：Neuropsychobiology

authors： Rosadini G,Sannita WG,Nobili F,Cenacchi T

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVE:Schizophrenia, a common neurological disorder appearing in the late teens or early adulthood, is characterized by disorganized thinking, behaviour, and perception of emotions. Aberrant N-methyl-D-aspartate (NMDA) receptor-mediated synaptic plasticity is a major pathological event here due to dysfunction of do...

journal_title：Neuropsychobiology

authors： Janardhanan A,Sadanand A,Vanisree AJ

更新日期：2016-01-01 00:00:00

abstract：:Plasma levels of free and conjugated 3,4-dihydroxyphenylethyleneglycol (DOPEG), the main deaminated metabolite of norepinephrine, were assayed in 48 depressed patients before initiating a treatment with either maprotiline, an inhibitor of norepinephrine reuptake, or indalpine, a specific inhibitor of serotonin reuptak...

journal_title：Neuropsychobiology

authors： Lôo H,Benkelfat C,Poirier MF,Vanelle JM,Olié JP,Dennis T,Scatton B

更新日期：1986-01-01 00:00:00

abstract：:The relationship between clinical effect of imipramine (IP) in 39 depressed patients and biochemical distinction, serum drug levels, and diagnostic classification was investigated retrospectively. Based on pretreatment plasma ratios of tryptophan and tyrosine to competing amino acids, which reflect the availability of...

journal_title：Neuropsychobiology

authors： Møller SE,Reisby N,Elley J,Krautwald O,Ortmann J,Larsen OB

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Abnormalities in different parameters of the norepinephrine system have been widely described in major depression. The presence of alpha(2)-adrenoreceptors in blood platelets, similar to those in the brain, prompted us to evaluate them in depressed patients, as compared with healthy controls. METHODS:Fiftee...

journal_title：Neuropsychobiology

authors： Marazziti D,Baroni S,Masala I,Di Nasso E,Giannaccini G,Betti L,Lucacchini A,Cassano GB

更新日期：2001-01-01 00:00:00

abstract：:Carnitine is essential for mitochondrial energy production. Disturbance in mitochondrial function may contribute to or cause the fatigue seen in chronic fatigue syndrome (CFS) patients. One previous investigation has reported decreased acylcarnitine levels in 38 CFS patients. We investigated 35 CFS patients (27 female...

journal_title：Neuropsychobiology

authors： Plioplys AV,Plioplys S

更新日期：1995-01-01 00:00:00

abstract：:The soporific effect of the neuroactive steroid pregnanolone, a metabolite of progesterone, and its relationship with plasma concentrations was assessed in 18 young, healthy, male volunteers for 2 h after administration of a single dose of pregnanolone prepared in two different formulations. Sedation was measured as s...

journal_title：Neuropsychobiology

authors： Schulz H,Jobert M,Gee KW,Ashbrook DW

更新日期：1996-01-01 00:00:00

abstract：:Isolation causes important changes in the behavioral reactivity of rats to environmental stimuli. These changes include deficit in sensorimotor gating and altered fear-like responses to aversive stimuli. Measures of ultrasound vocalizations at 20-22 kHz when rats are exposed to threatening conditions, such as novelty,...

journal_title：Neuropsychobiology

authors： Nunes Mamede Rosa ML,Nobre MJ,Ribeiro Oliveira A,Brandão ML

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:There is evidence that the nicotinic alpha7-acetylcholine receptor (alpha7-AChR) is involved in the pathophysiology of schizophrenia. Several neurotransmitter receptors, including alpha7-AChR, have been demonstrated on peripheral blood lymphocytes (PBL) and it has been suggested that these peripheral recepto...

journal_title：Neuropsychobiology

authors： Perl O,Strous RD,Dranikov A,Chen R,Fuchs S

更新日期：2006-01-01 00:00:00

abstract：:Dysfunctional mechanisms in the serotonergic system have been implicated in suicidal behavior among patients with schizophrenia. However, previous association analyses of major serotonin genes have provided inconsistent findings regarding their role in suicidal behavior. The goal of the current study was to identify s...

journal_title：Neuropsychobiology

authors： Bani-Fatemi A,Howe AS,Matmari M,Koga A,Zai C,Strauss J,De Luca V

更新日期：2016-01-01 00:00:00

abstract：:The serotonergic system has been implicated in the production of the N1 and P2 components of auditory evoked potentials (AEPs). Moreover, studies have indicated the influence of heritability in the genesis of these AEP components. The serotonin transporter is the major site of serotonin reuptake into the presynaptic n...

journal_title：Neuropsychobiology

authors： Chen TJ,Yu YW,Chen MC,Tsai SJ,Hong CJ

更新日期：2002-01-01 00:00:00

abstract：:Urinary 3-methoxy-4-hydroxyphenylglycol (MHPG) levels in 53 depressed women were compared to current suicidal thoughts or activity. Comparisons were also made between MHPG and past suicide attempts, number of past attempts, and seriousness of the worst attempt. There was a weak trend for current but not past suicidali...

journal_title：Neuropsychobiology

authors： Garvey MJ,Hollon SD,Tuason VB

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Cytokines do not only mediate responses to infection, but are also involved in behavioral and physiological responses to psychological stressors. IL-6 has received special attention in relation to the development of posttraumatic stress disorders and depression. OBJECTIVE:We tested effects of prior injectio...

journal_title：Neuropsychobiology

authors： Matsumoto T,Komori T,Yamamoto M,Shimada Y,Nakagawa M,Shiroyama T,Inui K,Okazaki Y

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND/AIMS:Recent findings suggest an involvement of insulin-like growth factor-1 (IGF-1) in the pathogenesis of many psychiatric disorders; however, there is a lack of data regarding IGF-1 in patients with obsessive-compulsive disorder (OCD). The aims of the present study were (1) to analyze putative alterations ...

journal_title：Neuropsychobiology

authors： Rosso G,Zanardini R,Chiodelli DF,Ferrari C,Gennarelli M,Bocchio-Chiavetto L

更新日期：2016-01-01 00:00:00

abstract：:Plasma noradrenaline (NA), adrenaline (Ad), dopamine (DA), platelet serotonin (p5HT), free serotonin (f5HT), glucose, heart rate (HR) and blood pressure (BP) were measured before and after an oral load of glucose (OGTT) in 100 normal humans. One sham-feeding test was performed in every subject 2-3 weeks before OGTT. A...

journal_title：Neuropsychobiology

authors： Lechin F,van der Dijs B,Lechin M,Báez S,Jara H,Lechin A,Orozco B,Rada I,Cabrera A,Jiménez V

更新日期：1992-01-01 00:00:00

abstract：:Individuals differ in hypnotizability. Information on hypnotizability-related EEG characteristics is controversial and incomplete, particularly on intracerebral source localization and EEG dimensionality. 19-channel, eyes-closed resting EEGs from right-handed, healthy, 8 high- and 4 low-hynotizable subjects (age: 26.7...

journal_title：Neuropsychobiology

authors： Isotani T,Lehmann D,Pascual-Marqui RD,Kochi K,Wackermann J,Saito N,Yagyu T,Kinoshita T,Sasada K

更新日期：2001-01-01 00:00:00

abstract：:The somnopolygraphs of 26 sober chronic alcoholics were compared with those of an age-matched control group, after approximately 25 days of sobriety. The sleep efficiency index and latency to sleep onset were significantly disturbed in alcoholic subjects. There was a decrease in the number of REM episodes. Slow-wave s...

journal_title：Neuropsychobiology

authors： Snyder S,Karacan I

更新日期：1985-01-01 00:00:00

abstract：:Spontaneous and drug-induced locomotor behavior was investigated in rats subjected to lesions of the ventral striatum, using the neurotoxin 6-hydroxydopamine to produce selective depletions of dopamine. Locomotor activity changed with time after lesion. At 2 weeks postoperative less spontaneous rearings were observed ...

journal_title：Neuropsychobiology

authors： Carey RJ,Schwarting R

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND/AIMS:Suicidal behavior (SB) in bipolar disorder (BD) is a complex multifactorial event resulting from an interaction of genetic, neurobiological and psychosocial factors. Recent studies identified new possible mechanisms, suggesting a role for sirtuins (SIRTs 1-7), a family of nicotinamide adenine dinucleoti...

journal_title：Neuropsychobiology

authors： Nivoli A,Porcelli S,Albani D,Forloni G,Fusco F,Colom F,Vieta E,Serretti A

更新日期：2016-01-01 00:00:00

abstract：:Recent studies suggest that the eye blink response to intense acoustic stimuli consists of two components that may occasionally result in waveforms with two peaks. In the present study, the prevalence, peak latencies, and peak magnitudes in responses exhibiting one or two peaks were investigated in healthy subjects in...

journal_title：Neuropsychobiology

authors： Meincke U,Light GA,Geyer MA,Braff DL

更新日期：2005-01-01 00:00:00

abstract：:Evidence from preclinical studies, preliminary clinical reports, pharmacologic challenge studies and a small number of controlled trials suggests that several antiepileptic agents--valproate, carbamazepine, and clonazepam--may have therapeutic effects in the treatment of patients with panic disorder. We review the the...

journal_title：Neuropsychobiology

authors： Keck PE Jr,McElroy SL,Tugrul KC,Bennett JA,Smith JM

更新日期：1993-01-01 00:00:00

abstract：:Eight patients with chronic obsessive-compulsive neurosis were subjected to trazodone, an antidepressant acting on the serotonergic system. After 4 weeks of treatment, 6 showed significant reduction in the obsessional symptoms which was sustained after a 6-week follow-up. The 2 patients who did not show improvement ha...

journal_title：Neuropsychobiology

authors： Prasad A

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVES:Corticotropin-releasing factor (CRF) plays a prominent role in mediating the effect of stressors on the hypothalamic-pituitary-adrenal axis. In this study, we examined the effects of chronic administration of second-generation antipsychotic drug ziprasidone on CRF mRNA expression in the hypothalamic paravent...

journal_title：Neuropsychobiology

authors： Park SW,Choi SM,Lee JG,Lee CH,Lee SJ,Kim NR,Kim YH

更新日期：2011-01-01 00:00:00

abstract：:Disturbances in the serotonergic neurotransmission system have been implicated in the etiology of attention deficit/hyperactivity disorder (ADHD). As the importance of genetic factors is well established, genes encoding for proteins of the serotonergic pathway are important candidates to unravel the underlying genetic...

journal_title：Neuropsychobiology

authors： Zoroglu SS,Erdal ME,Erdal N,Ozen S,Alasehirli B,Sivasli E

更新日期：2003-01-01 00:00:00