Soporific effect of the neurosteroid pregnanolone in relation to the substance's plasma level: a pilot study.

abstract：:Isolation causes important changes in the behavioral reactivity of rats to environmental stimuli. These changes include deficit in sensorimotor gating and altered fear-like responses to aversive stimuli. Measures of ultrasound vocalizations at 20-22 kHz when rats are exposed to threatening conditions, such as novelty,...

journal_title：Neuropsychobiology

authors： Nunes Mamede Rosa ML,Nobre MJ,Ribeiro Oliveira A,Brandão ML

更新日期：2005-01-01 00:00:00

abstract：:In the present study all available young social alcohol abusers in the capital of Iceland are compared with a control group matched for age and intellectual level. Certain behaviour and social characteristics were found to occur more often during childhood among the abusers. Boys showing these characteristics should b...

journal_title：Neuropsychobiology

authors： Helgason T,Asmundsson G

更新日期：1975-01-01 00:00:00

abstract：:The genotypes of the CYP2E1 loci of 35 alcoholic and 130 nonalcoholic (healthy controls) Japanese were investigated to determine the relationship between CYP2E1 (C/D) polymorphism and susceptibility to alcohol dependence. There was a significant (d.f. = 1, chi2 = 11.0, p < 0.001) difference in the CYP2E1 C gene freque...

journal_title：Neuropsychobiology

authors： Iwahashi K,Ameno S,Ameno K,Okada N,Kinoshita H,Sakae Y,Nakamura K,Watanabe M,Ijiri I,Harada S

更新日期：1998-11-01 00:00:00

abstract：:It is known that P-4502E1 metabolizes both ethanol and acetaldehyde, and that it can be induced after birth by inducers such as ethanol. Genetic polymorphisms in the 5'-flanking region change its transcriptional regulation. Persons who are either hetereozygous or mutant homozygous for CYP2E1 (C1/C2 or C2/C2) can drink...

journal_title：Neuropsychobiology

authors： Nakamura K,Iwahashi K,Ameno K,Sekine Y,Suzuki K,Minabe Y,Mori N

更新日期：2003-01-01 00:00:00

abstract：:An electric potential measurement tells us only about the difference between two electrode locations. When prior experiments or present measurements prove that an electrode's location is inactive (especially in 'mono-polar' or scalp-to-reference technique), then EEG records and EEG maps can be interpreted regionally n...

journal_title：Neuropsychobiology

authors： Walter DO,Etevenon P,Pidoux B,Tortrat D,Guillou S

更新日期：1984-01-01 00:00:00

abstract：:Little information exists on the concentrations of recent antidepressants and their metabolites in cerebrospinal fluid (CSF). Using a stereoselective method, we measured plasma and CSF levels of mirtazapine (MIR), N-demethylmirtazapine and 8-OH-MIR in 3 depressed patients treated with racemic MIR (45 mg/day) for 4 wee...

journal_title：Neuropsychobiology

authors： Baumann P,Jonzier-Perey M,Paus E,Nikisch G

更新日期：2006-01-01 00:00:00

abstract：:Human personality traits, which are substantially heritable, may be modulated by monoamine neurotransmitters. It has been demonstrated that the catechol-O-methyltransferase (COMT) Val158Met genetic polymorphism, a functional polymorphism that may affect monoamine metabolism, is possibly associated with specific person...

journal_title：Neuropsychobiology

authors： Tsai SJ,Hong CJ,Yu YW,Chen TJ

更新日期：2004-01-01 00:00:00

abstract：:Growth hormone (GH) possesses multiple metabolic effects, in particular with regard to glucose and lipid homeostasis. Studies on the effects of GH on body weight and food and water intake are scarce and have yielded controversial results. We investigated the effects of different modes of GH administration on the param...

journal_title：Neuropsychobiology

authors： Schulz C,Wieczorek I,Reschke K,Lehnert H

更新日期：2002-01-01 00:00:00

abstract：:Marked hostility toward relatives, therapists and friends is very frequently observed in anorexia nervosa (AN) as expression of outward-directed aggressiveness which interferes with the therapeutic programs of the patients. With the purpose to investigate this aspect of the disorder and its biological background, we s...

journal_title：Neuropsychobiology

authors： Brambilla F,Bellodi L,Arancio C,Limonta D,Ferrari E,Solerte B

更新日期：2001-01-01 00:00:00

abstract：:The cerebrospinal fluid (CSF) concentrations of the monoamine metabolites 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA) and 3-methoxy-4-hydroxyphenylglycol (MHPG) as well as their ratios and correlations were analyzed in relation to the season of birth. The sample consisted of 241 drug-free patients par...

journal_title：Neuropsychobiology

authors： Chotai J,Asberg M

更新日期：1999-01-01 00:00:00

abstract：:The prevalence of an abnormal response to the 1 mg dexamethasone suppression test (DST) was examined in 40 inpatients suffering from a major depressive disorder (MDD), 17 inpatients suffering from schizophrenia, and 30 normal controls. 23.5% of the schizophrenics were DST nonsuppressors compared to 52.5% of MDD patien...

journal_title：Neuropsychobiology

authors： Asnis GM,Eisenberg J,Lemus CZ,Halbreich U

更新日期：1986-01-01 00:00:00

abstract：:Like the industry, the medical profession takes now an interest in quality assurance programs. In the field of psychiatry, the quality assessment of antidepressive drug prescriptions is an ideal target. A brief review of previous studies reveals a high prevalence of the use of psychotropes among the general population...

journal_title：Neuropsychobiology

authors： Wilmotte J

更新日期：1989-01-01 00:00:00

abstract：:Despite being the most widely consumed psychoactive substance in the world, there is considerable confusion regarding the effects of caffeine. This study examined objective indices of performance, and self-reported mood, headache, and sleep in 36 healthy male and female habitual caffeine consumers exposed to a pattern...

journal_title：Neuropsychobiology

authors： James JE

更新日期：1998-01-01 00:00:00

abstract：:To clarify the circadian aspects of delayed sleep phase syndrome (DSPS) in 4 patients with DSPS, we recorded polysomnograms and rectal temperature before and after chronotherapy. The time interval (2.7 h) between sleep onset and rectal temperature minimum before chronotherapy was shorter than the time interval after c...

journal_title：Neuropsychobiology

authors： Ozaki N,Iwata T,Itoh A,Kogawa S,Ohta T,Okada T,Kasahara Y

更新日期：1988-01-01 00:00:00

abstract：:The popular recreational drug, (+/-)3, 4-methylenedioxymethamphetamine (MDMA; 'Ecstasy') is a potent and selective brain serotonin (5-HT) neurotoxin in animals. MDMA-induced 5-HT neurotoxicity can be demonstrated using a variety of neurochemical, neuroanatomical and, more recently, functional measures of 5-HT neurons....

journal_title：Neuropsychobiology

authors： Ricaurte GA,Yuan J,McCann UD

更新日期：2000-01-01 00:00:00

abstract：:The influence of restraint stress on potential aluminum (Al)-induced behavioral changes was assessed in CD-1 mice. Three groups of adult mice were given 0, 300 and 600 mg Al/kg body weight per day in drinking water for 2 weeks. One-half of the animals in each group were concurrently subjected to restraint stress durin...

journal_title：Neuropsychobiology

authors： Colomina MT,Sanchez DJ,Sanchez-Turet M,Domingo JL

更新日期：1999-09-01 00:00:00

abstract：:The effects of the dopaminergic agonists (L-dopa, pergolide) and antagonists (haloperidol, clozapin) and a cholinergic agonist (tacrine) and antagonist (mecamylamine) on the voluntary intake of nicotine were investigated with the 2-bottle paradigm with the test drugs being dissolved directly in the drinking fluid of t...

journal_title：Neuropsychobiology

authors： Kameda G,Dadmarz M,Vogel WH

更新日期：2000-01-01 00:00:00

abstract：:The relationship between physical activity and mental health has been widely investigated, and several hypotheses have been formulated about it. Specifically, during the aging process, physical exercise might represent a potential adjunctive treatment for neuropsychiatric disorders and cognitive impairment, helping de...

journal_title：Neuropsychobiology

authors： Deslandes A,Moraes H,Ferreira C,Veiga H,Silveira H,Mouta R,Pompeu FA,Coutinho ES,Laks J

更新日期：2009-01-01 00:00:00

abstract：:The antidepressive and anxiolytic efficacy of flupenthixol has been investigated in numerous controlled and open trials involving patients with endogenous, reactive as well as senile depressions. When administered at a mean daily single or multiple dose of 1-2 mg, flupenthixol proved to be a very effective and well-to...

journal_title：Neuropsychobiology

authors： Pöldinger W,Sieberns S

更新日期：1983-01-01 00:00:00

abstract：:Recent studies suggest that the eye blink response to intense acoustic stimuli consists of two components that may occasionally result in waveforms with two peaks. In the present study, the prevalence, peak latencies, and peak magnitudes in responses exhibiting one or two peaks were investigated in healthy subjects in...

journal_title：Neuropsychobiology

authors： Meincke U,Light GA,Geyer MA,Braff DL

更新日期：2005-01-01 00:00:00

abstract：:Electrovestibulography (EVestG) recordings have been previously applied toward classifying and/or measuring the severity of several neurological disorders including depression with and without anxiety. This study's objectives were to: (1) extract EVestG features representing physiological differences of healthy women ...

journal_title：Neuropsychobiology

authors： Lithgow BJ,Moussavi Z

更新日期：2017-01-01 00:00:00

abstract：:The authors recorded contingent negative variation (CNV) in a group of subjects affected by presenile dementia, at the onset of the symptoms, with a slight degree of intellectual deterioration. Recordings were carried out in rest basal conditions and upon administration of an insignificant distracting stimulus. Result...

journal_title：Neuropsychobiology

authors： Rizzo PA,Albani G,Cicardi C,Spadaro M,Morocutti C

更新日期：1984-01-01 00:00:00

abstract：:To evaluate the effect of the odor of incense on brain activity, electroencephalograms (EEGs) and event-related potentials (ERPs) in a push/wait paradigm were recorded in 10 healthy adults (aged 23-39 years) with normal olfactory function. EEG was recorded from 21 electrodes on the scalp, according to the Internationa...

journal_title：Neuropsychobiology

authors： Iijima M,Osawa M,Nishitani N,Iwata M

更新日期：2009-01-01 00:00:00

abstract：:Saliva cortisol was measured at 11 p.m. in a sample of 74 psychiatric inpatients composed of 24 primary endogenous depressives, 40 secondary depressives and 20 nondepressives (DSM III and Saint-Louis criteria). Primary depressives had significantly higher 11 p.m. saliva cortisol levels than nondepressives (p less than...

journal_title：Neuropsychobiology

authors： Guéchot J,Lépine JP,Cohen C,Fiet J,Lempérière T,Dreux C

更新日期：1987-01-01 00:00:00

abstract：:Clozapine is an effective atypical antipsychotic that has high affinity for many neurotransmitter receptors. Among the adverse effects of clozapine, urinary incontinence is commonly found and is suggested to be caused by alpha-adrenergic blockade. We tested the hypothesis that clozapine-induced urinary incontinence is...

journal_title：Neuropsychobiology

authors： Hsu JW,Wang YC,Lin CC,Bai YM,Chen JY,Chiu HJ,Tsai SJ,Hong CJ

更新日期：2000-01-01 00:00:00

abstract：:Fifteen general practitioners treated 21 newly diagnosed insomniac patients with benzodiazepines. In 15 cases, a short-acting benzodiazepine was prescribed without regard to the type, severity, duration and probable cause of insomnia. Sleep-wake ambulatory recordings were made at the respective homes of the patients b...

journal_title：Neuropsychobiology

authors： Wauquier A,Declerck A

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVE:We examined striatal dopamine transporter (DAT) binding in bipolar and unipolar depressed patients and compared these values to those obtained from healthy control subjects using the selective DAT radioligand [(99m)Tc]TRODAT-1 and single photon emission computed tomography imaging. We hypothesized that DAT le...

journal_title：Neuropsychobiology

authors： Amsterdam JD,Newberg AB

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Women have twice the rate of depression and anxiety disorders as men. Some studies suggest that this could be caused by women's greater sensitivity to negative emotions. Few brain imaging studies have compared the brain activity of men to women during a presentation of emotional stimuli. Our objective was to...

journal_title：Neuropsychobiology

authors： Thomas M,Gaudeau-Bosma C,Bouaziz N,Schenin-King Andrianisaina P,Benadhira R,Januel D,Moulier V

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Time of onset of antipsychotic action is still a debated matter. We aimed to replicate and extend previous findings that early response can predict subsequent non-response. METHODS:86 acutely psychotic patients treated with haloperidol were studied. RESULTS:A PANSS reduction ≤16% at 1 week predict...

journal_title：Neuropsychobiology

authors： Giegling I,Porcelli S,Balzarro B,Andrisano C,Schäfer M,Möller HJ,Rujescu D,Serretti A

更新日期：2012-01-01 00:00:00

abstract：:This report presents the results of a retrospective analysis of pooled efficacy data from eight studies in which buspirone was compared to placebo in 520 patients with generalized anxiety disorder (GAD). In addition to evaluating overall efficacy in the composite patient data base, four criteria were used to identify ...

journal_title：Neuropsychobiology

authors： Gammans RE,Stringfellow JC,Hvizdos AJ,Seidehamel RJ,Cohn JB,Wilcox CS,Fabre LF,Pecknold JC,Smith WT,Rickels K

更新日期：1992-01-01 00:00:00