Nardostachys jatamansi Targets BDNF-TrkB to Alleviate Ketamine-Induced Schizophrenia-Like Symptoms in Rats.

Abstract:

OBJECTIVE:Schizophrenia, a common neurological disorder appearing in the late teens or early adulthood, is characterized by disorganized thinking, behaviour, and perception of emotions. Aberrant N-methyl-D-aspartate (NMDA) receptor-mediated synaptic plasticity is a major pathological event here due to dysfunction of dopamine and glutamate transmission at NMDA receptors. De-regulated brain-derived neurotrophic factor (BDNF), i.e., its signalling through the tropomyosin receptor kinase B (TrkB) receptor, is a major feature of schizophrenia. With recent global awareness of traditional plant medicines in reducing side effects, the aim of our study was to evaluate the efficacy of the ethanolic root extract of a herb belonging to the Valerianacea family, Nardostachys jatamansi, against ketamine-induced schizophrenia-like model in rats. METHODS:The effect of the N. jatamansi drug (oral dosage of 500 mg/kg body weight for 14 days) in ketamine-administered male Wistar albino rats (30 mg/kg body weight for 5 days) on modulating behaviour and the level of neurotransmitters like dopamine and glutamate was studied in whole-brain homogenates, and its influence on BDNF and TrkB levels in 2 relevant brain regions, the hippocampus and prefrontal cortex, was assessed. RESULTS:We observed that N. jatamansi treatment exhibited encouraging results in the modulation of ketamine-induced schizophrenia-like behaviours, principally the positive symptoms. Our drug both significantly upregulated the glutamate level and downregulated the dopamine level in whole-brain homogenates and retained the normal levels of BDNF (in the hippocampus but not in the prefrontal cortex) and TrkB (in both hippocampus and prefrontal cortex) induced by ketamine in rats. CONCLUSION:These findings suggest a neuroprotective effect of the ethanolic root extract of N. jatamansi against ketamine-induced schizophrenia-like symptoms in rats; possibly, regarding its effect on TrkB signalling. Further research is warranted in the treatment of schizophrenic symptoms.

journal_name

Neuropsychobiology

journal_title

Neuropsychobiology

authors

Janardhanan A,Sadanand A,Vanisree AJ

doi

10.1159/000454985

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

104-114

issue

2

eissn

0302-282X

issn

1423-0224

pii

000454985

journal_volume

74

pub_type

杂志文章
  • Study of nocturnal sleep and the carryover effects of triazolam and brotizolam using neurophysiological and subjective methods.

    abstract::In the present study, the effects of short-acting benzodiazepines on nocturnal sleep and the carryover effects of these drugs were studied. The study involved 10 young, healthy male subjects who had given their written informed consent to participate. Either a placebo (PLA), 0.125 mg triazolam (TRZ), 0.25 mg TRZ or 0....

    journal_title:Neuropsychobiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000070586

    authors: Suzuki H,Yamadera H,Asayama K,Kudo Y,Ito T,Tamura Y,Endo S

    更新日期:2003-01-01 00:00:00

  • Dexamethasone suppression test in schizophrenia. A study and review.

    abstract::The prevalence of an abnormal response to the 1 mg dexamethasone suppression test (DST) was examined in 40 inpatients suffering from a major depressive disorder (MDD), 17 inpatients suffering from schizophrenia, and 30 normal controls. 23.5% of the schizophrenics were DST nonsuppressors compared to 52.5% of MDD patien...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000118252

    authors: Asnis GM,Eisenberg J,Lemus CZ,Halbreich U

    更新日期:1986-01-01 00:00:00

  • Biological heterogeneity of major depressive disorder: indications by sleep EEG and TRH stimulation test findings.

    abstract::A group of 27 patients with definite (n = 20) or probable (n = 7) RDC major depressive disorder underwent 2 sleep EEGs and 1 TRH test while in a drug-free depressive phase. A short mean REM latency (less than 60 min) identified 55.5% of major depressives while added use of blunted TSH responses (delta max. less than 5...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000118350

    authors: Pugnetti L,Scarone S,Brambilla F

    更新日期:1987-01-01 00:00:00

  • Relationship between alcoholism and CYP2E1 C/D polymorphism.

    abstract::The genotypes of the CYP2E1 loci of 35 alcoholic and 130 nonalcoholic (healthy controls) Japanese were investigated to determine the relationship between CYP2E1 (C/D) polymorphism and susceptibility to alcohol dependence. There was a significant (d.f. = 1, chi2 = 11.0, p < 0.001) difference in the CYP2E1 C gene freque...

    journal_title:Neuropsychobiology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000026544

    authors: Iwahashi K,Ameno S,Ameno K,Okada N,Kinoshita H,Sakae Y,Nakamura K,Watanabe M,Ijiri I,Harada S

    更新日期:1998-11-01 00:00:00

  • Opipramol improves subjective quality of sleep the night prior to surgery: confirmatory testing of a double-blind, randomized clinical trial.

    abstract:OBJECTIVE:Due to its pharmacological properties, opipramol may be useful in the context of evening premedication in anaesthesiology. This trial examines whether quality of sleep the night prior to surgery can be improved by opipramol and whether this effect is dose dependent. A second objective of this study is to exam...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000323799

    authors: Hueppe M,Hartge D,Stoll KD,Ros A,Schmucker P,Gerlach K

    更新日期:2011-01-01 00:00:00

  • Salivary Testosterone Is Consistently and Positively Associated with Extraversion: Results from The Netherlands Study of Depression and Anxiety.

    abstract:BACKGROUND:Testosterone has been postulated as a 'social' hormone, but the relationship between testosterone and personality traits linked with socially oriented behaviors such as extraversion remains unclear. The objective of our study was to investigate the association between baseline salivary testosterone levels an...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000369024

    authors: Smeets-Janssen MM,Roelofs K,van Pelt J,Spinhoven P,Zitman FG,Penninx BW,Giltay EJ

    更新日期:2015-01-01 00:00:00

  • Serum leptin and cholesterol values in suicide attempters.

    abstract::The growing number of studies examining the relationship between suicide and lipid metabolism are based upon studies suggesting that cholesterol-lowering procedures may increase the risk of death due to suicide or impulsive-aggressive behavior. Leptin seems to be strongly associated with lipid metabolism. In the prese...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000054950

    authors: Atmaca M,Kuloglu M,Tezcan E,Ustundag B,Gecici O,Firidin B

    更新日期:2002-01-01 00:00:00

  • Acute and chronic effects of caffeine on performance, mood, headache, and sleep.

    abstract::Despite being the most widely consumed psychoactive substance in the world, there is considerable confusion regarding the effects of caffeine. This study examined objective indices of performance, and self-reported mood, headache, and sleep in 36 healthy male and female habitual caffeine consumers exposed to a pattern...

    journal_title:Neuropsychobiology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000026514

    authors: James JE

    更新日期:1998-01-01 00:00:00

  • The link between high-sensitivity C-reactive protein and orbitofrontal cortex in euthymic bipolar disorder.

    abstract:OBJECTIVE:C-reactive protein (CRP), a marker of underlying low-grade inflammation, has been associated with the pathophysiology of bipolar disorder. Additionally, bipolar disorder may be accompanied by functional or structural cerebral alterations. We attempted to discover whether serum high-sensitivity CRP (hs-CRP) le...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000353613

    authors: Chung KH,Huang SH,Wu JY,Chen PH,Hsu JL,Tsai SY

    更新日期:2013-01-01 00:00:00

  • Biochemical and diagnostic classification and serum drug levels: relation to antidepressive effect of imipramine.

    abstract::The relationship between clinical effect of imipramine (IP) in 39 depressed patients and biochemical distinction, serum drug levels, and diagnostic classification was investigated retrospectively. Based on pretreatment plasma ratios of tryptophan and tyrosine to competing amino acids, which reflect the availability of...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000118182

    authors: Møller SE,Reisby N,Elley J,Krautwald O,Ortmann J,Larsen OB

    更新日期:1985-01-01 00:00:00

  • Drugs as tools for research in neuropsychobiology: a historical perspective.

    abstract::Knowledge in neuropsychobiology continues to benefit from the use of drugs as 'tools' to alter neurochemical events as a means of studying interactions between the events and behaviour. Before drugs could play such a role, concepts about basic properties of living organism had to be refined. Techniques had to be inven...

    journal_title:Neuropsychobiology

    pub_type: 历史文章,杂志文章

    doi:10.1159/000118407

    authors: Russell RW

    更新日期:1987-01-01 00:00:00

  • Reactivity to incoming stimuli and the experience of life-events.

    abstract::In 60 patients, hospitalized for a depressive syndrome, visual average evoked potentials (V .AEP) to stimuli of different intensities and the occurrence of life-events during the last year, as assessed by means of a specially constructed questionnaire, were investigated. Patients with an augmenter response in V .AEP, ...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000117773

    authors: von Knorring L,Jacobsson L,Perris C,Perris H

    更新日期:1980-01-01 00:00:00

  • A Twelve-Week Moderate Exercise Programme Improved Symptoms of Depression, Insomnia, and Verbal Learning in Post-Aneurysmal Subarachnoid Haemorrhage Patients: A Comparison with Meningioma Patients and Healthy Controls.

    abstract:OBJECTIVES:Deficits in psychological functioning, cognitive functioning, and sleep are frequently experienced by individuals who have survived aneurysmal subarachnoid haemorrhage (aSAH). Exercise has been shown to improve these domains; to date, it has never been explored in patients following aSAH. The aim of this exp...

    journal_title:Neuropsychobiology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000486903

    authors: Colledge F,Brand S,Pühse U,Holsboer-Trachsler E,Zimmerer S,Schleith R,Gerber M

    更新日期:2017-01-01 00:00:00

  • Isolation-induced changes in ultrasonic vocalization, fear-potentiated startle and prepulse inhibition in rats.

    abstract::Isolation causes important changes in the behavioral reactivity of rats to environmental stimuli. These changes include deficit in sensorimotor gating and altered fear-like responses to aversive stimuli. Measures of ultrasound vocalizations at 20-22 kHz when rats are exposed to threatening conditions, such as novelty,...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000085820

    authors: Nunes Mamede Rosa ML,Nobre MJ,Ribeiro Oliveira A,Brandão ML

    更新日期:2005-01-01 00:00:00

  • Polymorphism of the 5'-upstream region of the human SNAP-25 gene: an association analysis with schizophrenia.

    abstract::Recent studies have suggested that synaptic abnormalities may be part of the pathophysiology of schizophrenia. SNAP-25 (synaptosomal-associated protein of 25 kD) is one of the synaptic proteins responsible for presynaptic neurotransmission, axonal elongation and synaptogenesis. Genetic variation in the 5'-upstream reg...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000054880

    authors: Tachikawa H,Harada S,Kawanishi Y,Okubo T,Suzuki T

    更新日期:2001-01-01 00:00:00

  • Female Gender, Marital and Family Problems, and Feelings of Guilt Are Related to Self-Immolation Suicide Attempts.

    abstract:BACKGROUND:Self-immolation (SI) is considered one of the most painful, dramatic, and at the same time most inexplicable methods of suicide, with a high social impact. Prevalence rates are particularly high in Iran, and in north-western Iran specifically. Here, we report sociodemographic, psychological, and psychiatric ...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000487859

    authors: Ahmadpanah M,Rahighi AH,Haghighi M

    更新日期:2017-01-01 00:00:00

  • Sydenham's chorea and psychosis.

    abstract::The medical histories of 600 psychotic and 369 nonpsychotic subjects were examined for the occurrence of rheumatic chorea. There was significantly more rheumatic chorea in the histories of psychotic patients than in nonpsychotics (p less than 0.01, chi-square). Neuropathological associations are discussed. ...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000118234

    authors: Wilcox JA,Nasrallah HA

    更新日期:1986-01-01 00:00:00

  • Adverse effects of anticholinergic antiparkinsonian drugs in tardive dyskinesia. An investigation of mechanism.

    abstract::10 long-term schizophrenic patients with tardive dyskinesia were studied over 14 weeks and maintained on their usual neuroleptic medications while anticholinergic antiparkinson drugs were employed and then discontinued, and the cycle then repeated. Discontinuation of anticholinergic medications resulted in improvement...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000117742

    authors: Burnett GB,Prange AJ Jr,Wilson IC,Jolliff LA,Creese IC,Synder SH

    更新日期:1980-01-01 00:00:00

  • Female genital disorder as adverse symptom of lamotrigine treatment. A serotoninergic effect?

    abstract::The new anticonvulsant, lamotrigine, is becoming an important tool in the treatment of bipolar disorder, including bipolar depression. Its efficacy in bipolar depression might be linked to its inhibition of serotonin uptake. We present the case of a female schizoaffective patient successfully treated with 400 mg of la...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000026538

    authors: Erfurth A,Amann B,Grunze H

    更新日期:1998-10-01 00:00:00

  • Relationship between 3-methoxy-4-hydroxyphenylglycol and suicide.

    abstract::Urinary 3-methoxy-4-hydroxyphenylglycol (MHPG) levels in 53 depressed women were compared to current suicidal thoughts or activity. Comparisons were also made between MHPG and past suicide attempts, number of past attempts, and seriousness of the worst attempt. There was a weak trend for current but not past suicidali...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000119072

    authors: Garvey MJ,Hollon SD,Tuason VB

    更新日期:1994-01-01 00:00:00

  • Cortisol responses of depressed children and adolescents to clonidine administration.

    abstract::The responses of cortisol to acute administration of saline and of clonidine (2.5 micrograms/kg B.W.) were examined in 10 children and adolescents with major depressive disorder and in 10 age- and sex-matched controls. Clonidine administration did not inhibit cortisol secretion in controls or in patients, contrary to ...

    journal_title:Neuropsychobiology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000119022

    authors: Brambilla F,Guareschi-Cazzullo A,Musetti C,Nobile P,Tacchini C

    更新日期:1993-01-01 00:00:00

  • Evolution of blood magnesium, sodium and potassium in depressed patients followed for three months.

    abstract::No consensus has been obtained about blood electrolyte status, especially about magnesium, in affective disorders. This is mainly due to the lack of information about the distribution of the patients in clinical subgroups, sex, type of treatment and about the severity of their illnesses. Most of these studies concerne...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000118914

    authors: Widmer J,Bovier P,Karege F,Raffin Y,Hilleret H,Gaillard JM,Tissot R

    更新日期:1992-01-01 00:00:00

  • Receptor test (pupillary dilatation after application of 0.01% tropicamide solution) and determination of central nervous activation (Fourier analysis of pupillary oscillations) in patients with Alzheimer's disease.

    abstract::Memory loss and severe cognitive deficits in Alzheimer patients are supposed to be related to a reduction of acetylcholine as well as to central nervous deactivation. For the investigation of cholinergic deficits and deactivation, we used computer-assisted pupillometry. Cholinergic deficits caused by a particularly se...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000026595

    authors: Grünberger J,Linzmayer L,Walter H,Rainer M,Masching A,Pezawas L,Saletu-Zyhlarz G,Stöhr H,Grünberger M

    更新日期:1999-01-01 00:00:00

  • Working memory performance is associated with common glucocorticoid receptor gene polymorphisms.

    abstract::Cortisol has a modulatory influence on cognitive functions in humans. Both impairing and enhancing effects of cortisol administration have been shown for hippocampus-dependent declarative memory, and impairing effects have been shown for prefrontal-cortex-dependent working memory function. Given the high density of gl...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000262180

    authors: Kumsta R,Entringer S,Koper JW,van Rossum EF,Hellhammer DH,Wüst S

    更新日期:2010-01-01 00:00:00

  • Antipsychotic response in the first week predicts later efficacy.

    abstract:BACKGROUND AND AIMS:Time of onset of antipsychotic action is still a debated matter. We aimed to replicate and extend previous findings that early response can predict subsequent non-response. METHODS:86 acutely psychotic patients treated with haloperidol were studied. RESULTS:A PANSS reduction ≤16% at 1 week predict...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000337739

    authors: Giegling I,Porcelli S,Balzarro B,Andrisano C,Schäfer M,Möller HJ,Rujescu D,Serretti A

    更新日期:2012-01-01 00:00:00

  • Schizophrenia susceptibility and HL-A antigen.

    abstract::The phenotype frequencies of HL-A specificities have been investigated in 47 chronic schizophrenics subdivided in an older and a younger group. The frequency of HL-A 9 was significantly increased in the psychotics as compared to a reference group of 1,263 healthy blood donors, pregnant women and potential kidney donor...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000117496

    authors: Eberhard G,Franzén G,Löw B

    更新日期:1975-01-01 00:00:00

  • Somatosensory event-related potentials and selective attention impairment in young chronic schizophrenics.

    abstract::Somatosensory event-related potentials (SERP) were recorded in 30 chronic young schizophrenic patients and in 15 age-matched controls. Objective SERP parameters were latencies, amplitudes and the determination of areas of the cognitive components N1 and P3 by integration. Highly significantly reduced areas and prolong...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000118568

    authors: Böning J,Drechsler F,Neuhauser B

    更新日期:1989-01-01 00:00:00

  • Naloxone reduces alcohol intake in a free-choice procedure even when both drinking bottles contain saccharin sodium or quinine substances.

    abstract::Male Wistar rats were able to drink water and different percentages of ethyl alcohol in a free-choice paradigm. Our results showed a clear-cut preference for 2 and 3% ethanol concentration. Addition of quinine in both drinking bottles increased preference for alcohol, while dilution of saccharin in both bottles totall...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000118113

    authors: De Witte P

    更新日期:1984-01-01 00:00:00

  • Platelet 5-HT and plasma cortisol concentrations after dexamethasone suppression test in patients with different time course of schizophrenia.

    abstract::Platelet 5-HT and plasma cortisol concentrations were determined in 59 schizophrenic patients with different time course of illness before and after dexamethasone suppression test (DST). An abnormal DST (nonsuppression) was observed in 51% of patients. In these patients basal cortisol and platelet 5-HT concentrations ...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000026493

    authors: Jakovljević M,Mück-Seler D,Pivac N,Crncević Z

    更新日期:1998-01-01 00:00:00

  • A Prospective Open-Label Pilot Study of Transcranial Direct Current Stimulation in High-Functioning Autistic Patients with a Dysexecutive Syndrome.

    abstract:BACKGROUND:Executive functions (EF) are often impaired in autism spectrum disorder (ASD). Such dysfunctions are associated with anxiety, depression, and a lack of autonomy. Transcranial direct current stimulation (tDCS) has been shown to enhance EF in healthy adults and clinical populations and to improve working memor...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000501025

    authors: Rothärmel M,Moulier V,Vasse M,Isaac C,Faerber M,Bendib B,Mirea-Grivel I,Opolczynski G,Rosier A,Guillin O

    更新日期:2019-01-01 00:00:00