Abstract:
OBJECTIVE:C-reactive protein (CRP), a marker of underlying low-grade inflammation, has been associated with the pathophysiology of bipolar disorder. Additionally, bipolar disorder may be accompanied by functional or structural cerebral alterations. We attempted to discover whether serum high-sensitivity CRP (hs-CRP) levels are linked to the structural volume change of a specific brain region along with cognitive performance. METHODS:We recruited 17 physically healthy patients with bipolar I disorder (DSM-IV), aged 18-45 years and euthymic, to undergo the Wisconsin Card Sorting Test (WCST) and volumetric magnetic resonance imaging at 1.5 T. The analytic method was based on the hidden Markov random field model with an expectation-maximization algorithm, and the volume of each brain region was presented as a percentage of the total intracranial volume. RESULTS:Among the various regions, only the orbitofrontal cortex had a significantly negative correlation with serum hs-CRP levels after adjustment for age and gender (left and right orbitofrontal cortex: r = -0.62, p < 0.01, and r = -0.67, p < 0.005, respectively). Regarding cognitive function, poor WCST performance was also associated with certain subregions of the orbitofrontal cortex. CONCLUSION:Elevation of serum hs-CRP levels, an indicator of inflammation, may be associated with reduced volume of the orbitofrontal cortex. Persistent inflammation in the euthymic phase of bipolar disorder may involve the pathogenesis or pathophysiology of alteration of the frontal pathway.
journal_name
Neuropsychobiologyjournal_title
Neuropsychobiologyauthors
Chung KH,Huang SH,Wu JY,Chen PH,Hsu JL,Tsai SYdoi
10.1159/000353613subject
Has Abstractpub_date
2013-01-01 00:00:00pages
168-73issue
3eissn
0302-282Xissn
1423-0224pii
000353613journal_volume
68pub_type
杂志文章abstract::The effects of zolpidem or zaleplon on sleep architecture, respiratory patterns and performance were assessed at a simulated altitude of 4,000 m. Twelve male healthy subjects spent 4 nights in a decompression chamber, 1 at sea level (baseline), 3 at 4,000 m to test zolpidem (10 mg), zaleplon (10 mg) and placebo, given...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000076723
更新日期:2004-01-01 00:00:00
abstract::We examined the chronic effects of desipramine and mianserin on increases of intracellular Ca2+ concentration ([Ca2+]i) induced by noradrenaline (NA), acetylcholine (ACh), or high K+ in cultured neurons of rat frontal cortex, using fluoromicroscopic analysis with Ca(2+)-sensitive dye fura-2. NA- and ACh-induced [Ca2+]...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119251
更新日期:1996-01-01 00:00:00
abstract::Administration of progesterone produces sleep EEG patterns that resemble those of agonistic modulators at the GABAA receptor. Previous studies evaluating the effects of an oral progesterone administration on attention performance in females pointed to putative sedative effects of progesterone at high dosages. However,...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000119336
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:The failure to inhibit pleasurable but inappropriate urges is associated with frontal lobe pathology and has been suggested as a possible cause of pedophilic behavior. However, imaging and neuropsychological findings about frontal pathology in pedophilia are heterogeneous. In our study we therefore address i...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000355295
更新日期:2013-01-01 00:00:00
abstract::Schizophrenia is a heterogeneous and multidimensional disorder. The different syndromes or dimensions of this disorder represent distinct pathophysiological processes. Evidence is growing that each of the composite syndromes or dimensions of this disorder is associated with specific validators. This article reviewed n...
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000119310
更新日期:1996-01-01 00:00:00
abstract::In a double-blind, placebo-controlled, multiple-ascending-dose study, the encephalotropic and psychotropic properties of ABIO-08/01, a new potentially anxiolytic and nootropic isoxazoline, were studied in 16 young healthy males. In a randomized nonbalanced phase 1 study, they received 3 oral drug doses (10, 20, 40 mg)...
journal_title:Neuropsychobiology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000212379
更新日期:2009-01-01 00:00:00
abstract::The medical histories of a group of 511 patients hospitalized for schizophrenia were examined for the occurrence of perinatal distress. These patients were part of a 40-year follow-up study, so that their prognostic outcome was known at the time of this study. In this way, 200 cases of chronic schizophrenia were compa...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118359
更新日期:1987-01-01 00:00:00
abstract::Cephalosporins may induce nonconvulsive status epilepticus (NCSE), a potentially reversible condition. Despite the wide use of these antibiotics, there are only few reported cases, because this condition is probably underestimated. We report two new cases of NCSE occurring during treatment with cefepime and ceftazidim...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000077370
更新日期:2004-01-01 00:00:00
abstract::The new anticonvulsant, lamotrigine, is becoming an important tool in the treatment of bipolar disorder, including bipolar depression. Its efficacy in bipolar depression might be linked to its inhibition of serotonin uptake. We present the case of a female schizoaffective patient successfully treated with 400 mg of la...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000026538
更新日期:1998-10-01 00:00:00
abstract::Volunteers who develop a cold following virus challenge were significantly slower on choice reaction time tasks than those with no illness. This effect was still observed after the clinical symptoms had gone. In contrast to this, influenza illnesses only impaired performance in tasks in which subjects were uncertain w...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118558
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:The characterization of an individual's hypothalamic-pituitary-adrenal axis stress response is a main research topic in neuropsychobiology since alterations have been causally linked to several disease states. Over the last years, several studies focused on the identification of sources of inter- and intrain...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000115783
更新日期:2007-01-01 00:00:00
abstract::Substance P (SP) is a neuropeptide which is abundant in the periphery and the central nervous system, where it is colocalized with other neurotransmitters such as serotonin or dopamine. SP has been proposed to play a role in the regulation of pain including migraine and fibromyalgia, asthma, inflammatory bowel disease...
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000049254
更新日期:2002-01-01 00:00:00
abstract::Quantitative pharmaco-EEG has become a useful technique for determining pharmacodynamic parameters after CNS-active drug administration. Nevertheless, one of the most important problems faced by practitioners of pharmaco-EEG is the difficulty in evaluating drug-specific effects. In this article, a methodology for comp...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119068
更新日期:1994-01-01 00:00:00
abstract::Saliva cortisol was measured at 11 p.m. in a sample of 74 psychiatric inpatients composed of 24 primary endogenous depressives, 40 secondary depressives and 20 nondepressives (DSM III and Saint-Louis criteria). Primary depressives had significantly higher 11 p.m. saliva cortisol levels than nondepressives (p less than...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118384
更新日期:1987-01-01 00:00:00
abstract::In this study, we examined the effect of the 5-HT2A,C receptor agonist (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) on locomotor activity and the head twitch response in rats by the repeated (twice daily for 4 days) subcutaneous administration of 0.9% saline (1 ml/kg) or (+/-)-3,4-Methylenedioxymethamphet...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000026474
更新日期:1998-01-01 00:00:00
abstract::The lithium RBC/plasma ratio was determined in 59 patients during prophylactic lithium therapy -- 10 cycloid psychotics, 28 unipolars and 21 bipolars -- as well as in 20 patients during lithium therapy in phase of illness -- 8 cycloid psychotics, 5 unipolars and 7 bipolars. The lithium ratio was found to be normally d...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117533
更新日期:1976-01-01 00:00:00
abstract::Hallucinogenic drug-induced states are considered as models for acute schizophrenic disorders (experimental psychoses). In a double-blind study with healthy volunteers we investigated the influence of the serotonergic hallucinogen psilocybin, the ecstasy-like drug 3,4-methylenedioxyethylamphetamine (MDE), the stimulan...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000063672
更新日期:2002-01-01 00:00:00
abstract::The brain activity of 13 right-handed students (6 men and 7 women) was determined using high resolution (99m)Tc-HMPAO brain SPECT images during visuospatial tasks. The results showed that there was no significant gender-specific difference in solving the visuospatial tasks and that no meaningful statistical difference...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000026639
更新日期:2000-01-01 00:00:00
abstract::Despite being the most widely consumed psychoactive substance in the world, there is considerable confusion regarding the effects of caffeine. This study examined objective indices of performance, and self-reported mood, headache, and sleep in 36 healthy male and female habitual caffeine consumers exposed to a pattern...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000026514
更新日期:1998-01-01 00:00:00
abstract::The effects of lithium treatment on serotonin (5-HT) receptors in rat frontal cortex and hippocampus were investigated. Long-term lithium treatment strongly blocked 5-hydroxytryptophan-induced head twitches, while acute lithium administration by itself induced head twitches in rats, and ketanserin blocked this acute l...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118292
更新日期:1986-01-01 00:00:00
abstract::Plasma noradrenaline (NA), adrenaline (Ad), dopamine (DA), platelet serotonin (p5HT), free serotonin (f5HT), glucose, heart rate (HR) and blood pressure (BP) were measured before and after an oral load of glucose (OGTT) in 100 normal humans. One sham-feeding test was performed in every subject 2-3 weeks before OGTT. A...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118889
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Panic disorder (PD) is a common and often chronic psychiatric condition that can lead to considerable disability in daily life. Using [(18)F]fluorodeoxyglucose-PET, we examined brain baseline glucose metabolism in PD patients in comparison with normal controls and the changes in glucose metabolism after 12 w...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000337740
更新日期:2012-01-01 00:00:00
abstract::Gamma oscillations (>30 Hz) in the brain are involved in attention, perception and memory. They are altered in various pathological states, as well as by neuropharmaceuticals, so that they are of interest in drug and clinical investigations. However, when the human electroencephalogram is recorded on the scalp, this n...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000382023
更新日期:2015-01-01 00:00:00
abstract::Eight patients with chronic obsessive-compulsive neurosis were subjected to trazodone, an antidepressant acting on the serotonergic system. After 4 weeks of treatment, 6 showed significant reduction in the obsessional symptoms which was sustained after a 6-week follow-up. The 2 patients who did not show improvement ha...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118274
更新日期:1986-01-01 00:00:00
abstract::Marked hostility toward relatives, therapists and friends is very frequently observed in anorexia nervosa (AN) as expression of outward-directed aggressiveness which interferes with the therapeutic programs of the patients. With the purpose to investigate this aspect of the disorder and its biological background, we s...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000054894
更新日期:2001-01-01 00:00:00
abstract::In the past, some researchers found increased cortisol and prolactin responses to the administration of fenfluramine in major-depressed patients. It was believed that the fenfluramine test could prove to constitute another challenge probe to reflect the central serotonergic function. The present study was conducted in...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118576
更新日期:1989-01-01 00:00:00
abstract::Past epidemiological and clinical research has identified depression as the most common psychiatric disorder associated with headache. The present study carried out in a neurology headache clinic showed that the major associations were with current anxiety disorders, especially panic and related conditions. These find...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119182
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVE:Due to its pharmacological properties, opipramol may be useful in the context of evening premedication in anaesthesiology. This trial examines whether quality of sleep the night prior to surgery can be improved by opipramol and whether this effect is dose dependent. A second objective of this study is to exam...
journal_title:Neuropsychobiology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000323799
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND/AIMS:Suicidal behavior (SB) in bipolar disorder (BD) is a complex multifactorial event resulting from an interaction of genetic, neurobiological and psychosocial factors. Recent studies identified new possible mechanisms, suggesting a role for sirtuins (SIRTs 1-7), a family of nicotinamide adenine dinucleoti...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000446921
更新日期:2016-01-01 00:00:00
abstract::Performance on temporal discrimination of time intervals in the range of milliseconds is interpreted by the assumption of an internal clock; the higher the clock rate the better the temporal resolution of the internal clock will be, which is equivalent to more accuracy in timing of brief intervals. Although there is s...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000118899
更新日期:1992-01-01 00:00:00